Soraya Seedat

Summary

Affiliation: University of Stellenbosch
Country: South Africa

Publications

  1. doi request reprint A clinical approach to the assessment and management of co-morbid eating disorders and substance use disorders
    Claire Gregorowski
    Department of Psychiatry, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa
    BMC Psychiatry 13:289. 2013
  2. pmc The impact of voluntary exercise on relative telomere length in a rat model of developmental stress
    Martmari Botha
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa
    BMC Res Notes 5:697. 2012
  3. doi request reprint Interventions to improve psychological functioning and health outcomes of HIV-infected individuals with a history of trauma or PTSD
    Soraya Seedat
    Department of Psychiatry, Faculty of Health Sciences, Stellenbosch University, PO Box 19063, Tygerberg, 7505, Cape Town, South Africa
    Curr HIV/AIDS Rep 9:344-50. 2012
  4. pmc Mental health outcomes in HIV and childhood maltreatment: a systematic review
    Georgina Spies
    South African Research Chairs Initiative SARChI, PTSD Program, Francie van Zijl Drive, Department of Psychiatry, University of Stellenbosch, Cape Town, 7505, South Africa
    Syst Rev 1:30. 2012
  5. pmc Validation of brief screening tools for depressive and alcohol use disorders among TB and HIV patients in primary care in Zambia
    Nathaniel Chishinga
    Zambia AIDS Related TB Project, School of Medicine, Ridgeway Campus, Lusaka, Zambia
    BMC Psychiatry 11:75. 2011
  6. pmc Comparison of pain, cortisol levels, and psychological distress in women undergoing surgical termination of pregnancy under local anaesthesia versus intravenous sedation
    Sharain Suliman
    MRC Research Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    BMC Psychiatry 7:24. 2007
  7. pmc Twelve-month treatment of psychiatric disorders in the South African Stress and Health Study (World Mental Health Survey Initiative)
    Soraya Seedat
    MRC Unit on Anxiety Disorders, University of Stellenbosch, PO Box 19063, Tygerberg, 7505, Cape Town, South Africa
    Soc Psychiatry Psychiatr Epidemiol 43:889-97. 2008
  8. ncbi request reprint Reboxetine and citalopram in panic disorder: a single-blind, cross-over, flexible-dose pilot study
    Soraya Seedat
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, PO Box 19063, Tygerberg 7505, Cape Town, South Africa
    Int Clin Psychopharmacol 18:279-84. 2003
  9. ncbi request reprint Single photon emission computed tomography in posttraumatic stress disorder before and after treatment with a selective serotonin reuptake inhibitor
    Soraya Seedat
    Department of Psychiatry, University of Stellenbosch, Tygerberg, 7505, Cape Town, South Africa
    J Affect Disord 80:45-53. 2004
  10. ncbi request reprint Disability and quality of life in post-traumatic stress disorder: impact of drug treatment
    Soraya Seedat
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Pharmacoeconomics 24:989-98. 2006

Collaborators

Detail Information

Publications126 found, 100 shown here

  1. doi request reprint A clinical approach to the assessment and management of co-morbid eating disorders and substance use disorders
    Claire Gregorowski
    Department of Psychiatry, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa
    BMC Psychiatry 13:289. 2013
    ..This article provides a broad overview of the prevalence, aetiology, assessment and management of co-morbid EDs and substance use disorders (SUDs)...
  2. pmc The impact of voluntary exercise on relative telomere length in a rat model of developmental stress
    Martmari Botha
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa
    BMC Res Notes 5:697. 2012
    ..Behavioural analyses were conducted to assess anxiety-like behaviour and memory performance in the rats, after which relative telomere length was measured using qPCR...
  3. doi request reprint Interventions to improve psychological functioning and health outcomes of HIV-infected individuals with a history of trauma or PTSD
    Soraya Seedat
    Department of Psychiatry, Faculty of Health Sciences, Stellenbosch University, PO Box 19063, Tygerberg, 7505, Cape Town, South Africa
    Curr HIV/AIDS Rep 9:344-50. 2012
    ..Group cognitive-behavioral strategies, including prolonged exposure, coping skills training, and stress management have, to date, shown some evidence for efficacy in HIV-positive individuals with childhood trauma and in those with PTSD...
  4. pmc Mental health outcomes in HIV and childhood maltreatment: a systematic review
    Georgina Spies
    South African Research Chairs Initiative SARChI, PTSD Program, Francie van Zijl Drive, Department of Psychiatry, University of Stellenbosch, Cape Town, 7505, South Africa
    Syst Rev 1:30. 2012
    ..The present systematic review assessed mental health outcomes in HIV-positive individuals who were victims of childhood maltreatment...
  5. pmc Validation of brief screening tools for depressive and alcohol use disorders among TB and HIV patients in primary care in Zambia
    Nathaniel Chishinga
    Zambia AIDS Related TB Project, School of Medicine, Ridgeway Campus, Lusaka, Zambia
    BMC Psychiatry 11:75. 2011
    ....
  6. pmc Comparison of pain, cortisol levels, and psychological distress in women undergoing surgical termination of pregnancy under local anaesthesia versus intravenous sedation
    Sharain Suliman
    MRC Research Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    BMC Psychiatry 7:24. 2007
    ..This study compared the effects of local anaesthesia and intravenous sedation, administered for elective surgical termination, on outcomes of pain, cortisol, and psychological distress...
  7. pmc Twelve-month treatment of psychiatric disorders in the South African Stress and Health Study (World Mental Health Survey Initiative)
    Soraya Seedat
    MRC Unit on Anxiety Disorders, University of Stellenbosch, PO Box 19063, Tygerberg, 7505, Cape Town, South Africa
    Soc Psychiatry Psychiatr Epidemiol 43:889-97. 2008
    ..The proportion of people with mental disorders in treatment is relatively small in low and middle income countries. However, little is known about patterns of recent service use in a country like South Africa...
  8. ncbi request reprint Reboxetine and citalopram in panic disorder: a single-blind, cross-over, flexible-dose pilot study
    Soraya Seedat
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, PO Box 19063, Tygerberg 7505, Cape Town, South Africa
    Int Clin Psychopharmacol 18:279-84. 2003
    ..These data also suggest an advantage for citalopram in treating comorbid depressive symptoms, although some patients may respond preferentially to an SSRI and other patients to an NRI...
  9. ncbi request reprint Single photon emission computed tomography in posttraumatic stress disorder before and after treatment with a selective serotonin reuptake inhibitor
    Soraya Seedat
    Department of Psychiatry, University of Stellenbosch, Tygerberg, 7505, Cape Town, South Africa
    J Affect Disord 80:45-53. 2004
    ..However, the neural substrates of PTSD remain poorly understood and the effect of selective serotonin reuptake inhibition on regional cerebral activity is deserving of further investigation...
  10. ncbi request reprint Disability and quality of life in post-traumatic stress disorder: impact of drug treatment
    Soraya Seedat
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Pharmacoeconomics 24:989-98. 2006
    ..Further investigation of the relationship of QOL to PTSD symptom severity, disability, treatment outcome and cost, among the different drug treatment modalities, is clearly needed...
  11. ncbi request reprint Association between physical partner violence, posttraumatic stress, childhood trauma, and suicide attempts in a community sample of women
    Soraya Seedat
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Violence Vict 20:87-98. 2005
    ..These results suggest that in women who endorse IPV, careful inquiry of past abuse, trauma-related symptoms, suicidal behavior, and drug use may be important, so that interventions can be both timely and appropriate...
  12. ncbi request reprint Trauma exposure and post-traumatic stress symptoms in urban African schools. Survey in CapeTown and Nairobi
    S Seedat
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Capetown, South Africa
    Br J Psychiatry 184:169-75. 2004
    ..There is a lack of comparative data on the prevalence and effects of exposure to violence in African youth...
  13. ncbi request reprint Double-blind, placebo-controlled assessment of combined clonazepam with paroxetine compared with paroxetine monotherapy for generalized social anxiety disorder
    Soraya Seedat
    Anxiety and Traumatic Stress Disorders Program, Psychiatry Service, VA San Diego Healthcare System, San Diego, CA, USA
    J Clin Psychiatry 65:244-8. 2004
    ..Monotherapy with the benzodiazepine clonazepam is also efficacious for GSAD, but the adjunctive use of clonazepam with an SSRI to potentially improve outcomes has not been studied to date...
  14. ncbi request reprint Measuring anxiety in patients with schizophrenia
    Soraya Seedat
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    J Nerv Ment Dis 195:320-4. 2007
    ..Accurate assessment is challenging yet important. More reliable measures of anxiety disorders in patients with schizophrenia and other psychotic disorders are clearly needed to allow for timely identification and treatment...
  15. ncbi request reprint Single voxel proton magnetic resonance spectroscopy in women with and without intimate partner violence-related posttraumatic stress disorder
    Soraya Seedat
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, P O Box 19063, Tygerberg, 7505 Cape Town, South Africa
    Psychiatry Res 139:249-58. 2005
    ..In contrast to other studies, we found an increase in Cho/Cr rather than a decrease in NAA/Cr, indicating alterations in glia, instead of neuronal dropout...
  16. ncbi request reprint Ethics of research on survivors of trauma
    Soraya Seedat
    Medical Research Council Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, PO Box 19063, Tygerberg, Cape Town 7505, South Africa
    Curr Psychiatry Rep 6:262-7. 2004
    ....
  17. ncbi request reprint Post-traumatic stress disorder in women: epidemiological and treatment issues
    Soraya Seedat
    Department of Psychiatry, MRC Unit on Anxiety and Stress Disorders, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    CNS Drugs 19:411-27. 2005
    ..However, additional innovative treatments are needed for traumatised women and for female children/adolescents presenting with acute stress reactions and PTSD...
  18. ncbi request reprint Benefits of consumer psychoeducation: a pilot program in South Africa
    Soraya Seedat
    University of Stellenbosch, South Africa
    Int J Psychiatry Med 38:31-42. 2008
    ..There is, however, little published data on adherence in the South African context. In this pilot study we explore the possible benefits of a consumer psychoeducation program...
  19. pmc Mental health service use among South Africans for mood, anxiety and substance use disorders
    Soraya Seedat
    MRC Stress and Anxiety Disorders Unit, Department of Psychiatry, Stellenbosch University, Tygerberg, W Cape
    S Afr Med J 99:346-52. 2009
    ..Europe and North America have low rates of mental health service use despite high rates of mental disorder. Little is known about mental health service use among South Africans...
  20. pmc Life stress and mental disorders in the South African stress and health study
    Soraya Seedat
    MRC Stress and Anxiety Disorders Unit, Department of Psychiatry, Stellenbosch University, Tygerberg, W Cape
    S Afr Med J 99:375-82. 2009
    ..We examined the association of recent life events and past adversities to mood, anxiety, substance use and impulse control disorders in South Africa...
  21. ncbi request reprint Hoarding in obsessive-compulsive disorder: clinical and genetic correlates
    Christine Lochner
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    J Clin Psychiatry 66:1155-60. 2005
    ..The clinical and genetic correlates of hoarding in OCD therefore deserve additional investigation...
  22. ncbi request reprint Cluster analysis of obsessive-compulsive spectrum disorders in patients with obsessive-compulsive disorder: clinical and genetic correlates
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, PO Box 19063, Tygerberg, 7505, Cape Town, South Africa
    Compr Psychiatry 46:14-9. 2005
    ..Comorbidity of the putative OCSDs in OCD has, however, not often been systematically investigated...
  23. ncbi request reprint Genetic correlates in trichotillomania--A case-control association study in the South African Caucasian population
    Sian M J Hemmings
    MRC US Centre for Molecular and Cellular Biology, University of Stellenbosch, Tygerberg, South Africa
    Isr J Psychiatry Relat Sci 43:93-101. 2006
    ..Some have argued, however, that TTM is an obsessive-compulsive spectrum disorder (OCSD). There is some evidence that both disorders (OCD and TTM) are mediated by serotonergic (5-HT) and dopaminergic pathways...
  24. doi request reprint Cumulative effect of multiple trauma on symptoms of posttraumatic stress disorder, anxiety, and depression in adolescents
    Sharain Suliman
    Department of Psychiatry, Stellenbosch University, Cape Town, South Africa
    Compr Psychiatry 50:121-7. 2009
    ..Against the backdrop of stressful life events and childhood abuse and neglect, we investigated the cumulative effect of multiple trauma exposure on PTSD, anxiety, and depression in an adolescent sample...
  25. pmc Disability and treatment of psychiatric and physical disorders in South Africa
    Sharain Suliman
    MRC Anxiety and Stress Disorders Unit, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    J Nerv Ment Dis 198:8-15. 2010
    ..Despite high rates of mental disorders and associated disability in South Africa, they are less likely to be treated than physical disorders...
  26. pmc Intermittent explosive disorder in South Africa: prevalence, correlates and the role of traumatic exposures
    Dylan Fincham
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Stellenbosch, South Africa
    Psychopathology 42:92-8. 2009
    ..In South Africa, given the high rates of violence and trauma, there is particular interest in traumatic exposures as potential risk factors for IED...
  27. pmc The impact of the Truth and Reconciliation Commission on psychological distress and forgiveness in South Africa
    Dan J Stein
    University of Cape Town, Cape Town, South Africa
    Soc Psychiatry Psychiatr Epidemiol 43:462-8. 2008
    ..However, there was also a concern that individuals with TRC relevant experience would simply be re-traumatized by participation in the process. To date, there has been little empirical data for either hypothesis...
  28. ncbi request reprint Trauma and posttraumatic stress disorder in an urban Xhosa primary care population: prevalence, comorbidity, and service use patterns
    Paul D Carey
    MRC Unit for Stress and Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, PO Box 19063, Tygerberg 7505, Cape Town, South Africa
    J Nerv Ment Dis 191:230-6. 2003
    ..In this population, trauma and PTSD were highly prevalent and associated with significant unidentified morbidity and comorbidity. Patients remain untreated for years in the current system of primary care consultations...
  29. doi request reprint Common mental disorders among HIV-infected individuals in South Africa: prevalence, predictors, and validation of brief psychiatric rating scales
    Landon Myer
    Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    AIDS Patient Care STDS 22:147-58. 2008
    ..More generally, HIV care and treatment services represent an important venue to identify and manage individuals with common mental disorders in resource-limited settings...
  30. pmc Social determinants of psychological distress in a nationally-representative sample of South African adults
    Landon Myer
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    Soc Sci Med 66:1828-40. 2008
    ....
  31. doi request reprint Comorbid obsessive-compulsive personality disorder in obsessive-compulsive disorder (OCD): a marker of severity
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    Prog Neuropsychopharmacol Biol Psychiatry 35:1087-92. 2011
    ..It remains unclear, however, whether OCPD in OCD represents a distinct subtype of OCD or whether it is simply a marker of severity in OCD...
  32. pmc Quetiapine augmentation of SRIs in treatment refractory obsessive-compulsive disorder: a double-blind, randomised, placebo-controlled study [ISRCTN83050762]
    Paul D Carey
    MRC Research Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa
    BMC Psychiatry 5:5. 2005
    ..Quetiapine is generally well tolerated and previous open-label data has produced mixed results in OCD and additional controlled data is needed...
  33. pmc Single photon emission computed tomography (SPECT) of anxiety disorders before and after treatment with citalopram
    Paul D Carey
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, 7505, Cape Town, South Africa
    BMC Psychiatry 4:30. 2004
    ..This paper further examines the notion of overlap in the neurocircuitry of treatment and indeed treatment response across anxiety disorders with SSRI treatment...
  34. ncbi request reprint Investigating the possible effects of trauma experiences and 5-HTT on the dissociative experiences of patients with OCD using path analysis and multiple regression
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    Neuropsychobiology 56:6-13. 2007
    ..Here, two different but related statistical techniques (multiple regression and partial least squares), confirmed that physical neglect and the 5-HTT genotype jointly play a role in predicting dissociation in OCD...
  35. ncbi request reprint Cluster analysis of obsessive-compulsive symptomatology: identifying obsessive-compulsive disorder subtypes
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    Isr J Psychiatry Relat Sci 45:164-76. 2008
    ..There is increasing evidence that obsessive-compulsive disorder (OCD) is a heterogeneous disorder. Different clinical subtypes may be characterized by differing pathophysiological mechanisms and treatment outcomes...
  36. ncbi request reprint Persistence of psychiatric disorders in a cohort of HIV/AIDS patients in South Africa: a 6-month follow-up study
    Benjamin O Olley
    Department of Psychiatry, MRC Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa
    J Psychosom Res 61:479-84. 2006
    ..However, there are few prospective studies on the rates of psychiatric disorders in HIV/AIDS, particularly in the context of the developing world...
  37. ncbi request reprint Obsessive compulsive disorder--prevalence in Xhosa-speaking schizophrenia patients
    Dana J H Niehaus
    Department of Psychiatry, Stellenbosch University, Tygerberg, W Cape
    S Afr Med J 95:120-2. 2005
    ..No concordance for OCD was noted in the sibship group. Our findings differ from those in other parts of the world, and if replicated, might suggest unique protective environmental or genetic factors for OCD in certain ethnic groups...
  38. pmc Shorter telomere length - A potential susceptibility factor for HIV-associated neurocognitive impairments in South African women [corrected]
    Stefanie Malan-Müller
    Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa
    PLoS ONE 8:e58351. 2013
    ..Our results suggest that reduced LTL is associated with worse learning performance in HIV-positive individuals, indicating that TL could act as a susceptibility factor in increasing neurocognitive decline in HIV-infected individuals...
  39. doi request reprint Recall of early non-fatal suicidality in a nationally representative sample of South Africans
    Ermien van Pletzen
    Centre for Higher Education Development, University of Cape Town, Cape Town, South Africa
    Ethn Health 17:149-59. 2012
    ..We investigated the prevalence of self-reported early suicidality (suicidal ideation, planning and attempts) in a nationally representative sample of South Africans...
  40. pmc Obsessive-compulsive disorder and trichotillomania: a phenomenological comparison
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    BMC Psychiatry 5:2. 2005
    ..Nevertheless, there is evidence of important differences between these two disorders. Some authors have conceptualized the disorders as lying on an OCD spectrum of conditions...
  41. doi request reprint Investigating SAPAP3 variants in the etiology of obsessive-compulsive disorder and trichotillomania in the South African white population
    Leigh Boardman
    Division of Molecular Biology and Human Genetics, Department Biomedical Sciences, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa
    Compr Psychiatry 52:181-7. 2011
    ..Results from a recent knockout animal model suggest that SAP90/PSD95-associated protein 3 (SAPAP3) may be involved in the pathophysiology of both disorders...
  42. ncbi request reprint Escitalopram in obsessive-compulsive disorder: response of symptom dimensions to pharmacotherapy
    Dan J Stein
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    CNS Spectr 13:492-8. 2008
    ..The response of OCD symptom dimensions to 12 weeks of treatment with escitalopram or placebo was investigated...
  43. ncbi request reprint Posttraumatic stress disorder and occupational disability in South African Security Force members
    Robin A Emsley
    Department of Psychiatry and Medical Research Council Unit for Anxiety and Stress Disorders, University of Stellenbosch, PO Box 19063, Tygerberg 7505, Cape Town, South Africa
    J Nerv Ment Dis 191:237-41. 2003
    ..These findings suggest that posttrauma factors may be as important as pretrauma and peritrauma variables in the development of PTSD...
  44. doi request reprint Chronic hair-pulling: phenomenology-based subtypes
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    J Anxiety Disord 24:196-202. 2010
    ..Future work, incorporating further investigation of the role of gender and psychobiological and treatment outcomes, is needed before definitive conclusions about hair-pulling subtypes can be drawn...
  45. pmc Barriers to mental health care and predictors of treatment dropout in the South African Stress and Health Study
    Belinda Bruwer
    Department of Psychiatry, University of Stellenbosch, P O Box 19063, Tygerberg, 7505, South Africa
    Psychiatr Serv 62:774-81. 2011
    ....
  46. pmc Patterns of substance use in South Africa: results from the South African Stress and Health study
    Margaretha S van Heerden
    Department of Psychiatry, Stellenbosch University, Tygerberg, W Cape
    S Afr Med J 99:358-66. 2009
    ..There are limited data on substance use in South Africa. We describe patterns of substance use based on recent, nationally representative data...
  47. pmc Predictors of transitions across stages of alcohol use and alcohol-use disorders in South Africa
    Sharain Suliman
    Medical Research Council Anxiety and Stress Disorders Unit, Department of Psychiatry, University of Stellenbosch, P O Box 19063, Tygerberg 7505, Cape Town, South Africa
    J Stud Alcohol Drugs 71:695-703. 2010
    ....
  48. ncbi request reprint Prevalence of dissociative experiences in a community sample: relationship to gender, ethnicity, and substance use
    Soraya Seedat
    Department of Psychiatry, University of California San Diego, 8950 Villa La Jolla Drive, Suite 2243, La Jolla, California 92037, USA
    J Nerv Ment Dis 191:115-20. 2003
    ..Further assessment of the link between demographic factors and the severity and expression of dissociative phenomena in nonclinical samples is warranted...
  49. doi request reprint Reliability of the lay adherence counsellor administered substance abuse and mental illness symptoms screener (SAMISS) and the International HIV Dementia Scale (IHDS) in a primary care HIV clinic in Cape Town, South Africa
    Erica Breuer
    Centre for Public Mental Health, Department of Psychiatry and Mental Health, University of Cape Town, Rondebosch, Cape Town, South Africa
    AIDS Behav 16:1464-71. 2012
    ....
  50. pmc Evidence for fractional anisotropy and mean diffusivity white matter abnormalities in the internal capsule and cingulum in patients with obsessive-compulsive disorder
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    J Psychiatry Neurosci 37:193-9. 2012
    ..In this study, we used diffusion tensor imaging (DTI) to examine white matter integrity in specific regions of interest (ROIs) in patients with OCD...
  51. ncbi request reprint Functional brain imaging and pharmacotherapy in trichotillomania. Single photon emission computed tomography before and after treatment with the selective serotonin reuptake inhibitor citalopram
    Dan J Stein
    Department of Psychiatry, University of Stellenbosch, P O Box 19063, Tygerberg 7505, Cape Town, South Africa
    Prog Neuropsychopharmacol Biol Psychiatry 26:885-90. 2002
    ..Pharmacotherapeutic response to SSRIs in trichotillomania may not be as robust as in OCD. Further research is necessary to determine the neurobiological underpinnings of these differences...
  52. pmc Traditional healers in the treatment of common mental disorders in South Africa
    Katherine Sorsdahl
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    J Nerv Ment Dis 197:434-41. 2009
    ..Alternative practitioners, including traditional healers and religious advisors, appear to play a notable role in the delivery of mental health care in South Africa...
  53. pmc The association between hypertension and depression and anxiety disorders: results from a nationally-representative sample of South African adults
    Anna Grimsrud
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 4:e5552. 2009
    ..We examined the association between hypertension and depression and anxiety in South Africa...
  54. ncbi request reprint Genetics and personality traits in patients with social anxiety disorder: a case-control study in South Africa
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    Eur Neuropsychopharmacol 17:321-7. 2007
    ..to compare differences in temperament dimensions between carriers of different (dominant vs. recessive) alleles for selected polymorphisms in SAD patients...
  55. ncbi request reprint Escitalopram in the treatment of multisomatoform disorder: a double-blind, placebo-controlled trial
    Jacqueline E Muller
    Department of Psychiatry, Stellenbosch University, South Africa
    Int Clin Psychopharmacol 23:43-8. 2008
    ..Compared with placebo, escitalopram was associated with lower symptom scores, increased response and remission rates, and improved functioning...
  56. doi request reprint Clinical correlates of HIV-associated neurocognitive disorders in South Africa
    John A Joska
    Department of Psychiatry and Mental Health, University of Cape Town, South Africa, Anzio Road, Observatory, Cape Town 7925, South Africa
    AIDS Behav 14:371-8. 2010
    ..This underlines the impact of HIV on the nervous system and the importance of screening for co morbid mental health conditions...
  57. doi request reprint Psychometric properties of the Multidimensional Scale of Perceived Social Support in youth
    Belinda Bruwer
    Department of Psychiatry, University of Stellenbosch, Cape Town 7505, South Africa
    Compr Psychiatry 49:195-201. 2008
    ..The psychometric properties of the MSPSS have been demonstrated in diverse samples, although its reproducibility in the South African youth has not yet been investigated...
  58. pmc Impact of childhood trauma on functionality and quality of life in HIV-infected women
    Zyrhea C E Troeman
    South African Research Chairs Initiative SARChI, PTSD Program, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Health Qual Life Outcomes 9:84. 2011
    ..While there are many published studies on HIV and functional limitations, there are few in the context of early abuse and its impact on functionality and Quality of Life (QoL) in HIV...
  59. doi request reprint BDNF Val66Met and DRD2 Taq1A polymorphisms interact to influence PTSD symptom severity: a preliminary investigation in a South African population
    Sian M J Hemmings
    Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa
    Prog Neuropsychopharmacol Biol Psychiatry 40:273-80. 2013
    ..We also investigated the interaction between the genetic variants to determine whether these variables and the interactions between the variables influenced the severity of PTSD symptoms...
  60. doi request reprint Olanzapine monotherapy in posttraumatic stress disorder: efficacy in a randomized, double-blind, placebo-controlled study
    Paul Carey
    MRC Research Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Hum Psychopharmacol 27:386-91. 2012
    ..Limited evidence suggests that second generation antipsychotics may have a role to play as monotherapy in PTSD...
  61. ncbi request reprint Mass murders: implications for mental health professionals
    Lisa Aitken
    Department of Psychiatry, University of Stellenbosch, South Africa
    Int J Psychiatry Med 38:261-9. 2008
    ....
  62. ncbi request reprint Risk indicators and psychopathology in traumatised children and adolescents with a history of sexual abuse
    Paul D Carey
    MRC Research Unit for Anxiety and Stress, Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, Cape Town 7505, South Africa
    Eur Child Adolesc Psychiatry 17:93-8. 2008
    ..Childhood sexual abuse (CSA) is widespread amongst South African (SA) children, yet data on risk factors and psychiatric consequences are limited and mixed...
  63. pmc Lifetime prevalence of psychiatric disorders in South Africa
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    Br J Psychiatry 192:112-7. 2008
    ....
  64. ncbi request reprint Prevalence and characteristics of trauma and post-traumatic stress symptoms in operational members of the South African National Defence Force
    Soraya Seedat
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, P O Box 19063, Tygerberg, 7505, Cape Town, South Africa
    Mil Med 168:71-5. 2003
    ..These findings highlight the high rates of exposure to multiple, noncombat-related trauma in military personnel, the potentially high rates of PTSD, and the role of inflicted trauma as an additional risk factor for PTSD...
  65. doi request reprint Posttraumatic stress disorder symptoms in adolescents: risk factors versus resilience moderation
    Dylan S Fincham
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, PO Box 19063, Tygerberg, Cape Town 7505, South Africa
    Compr Psychiatry 50:193-9. 2009
    ..Although evidence suggests that resilience may moderate the relationship between some of these risk factors and PTSD symptoms, no studies to date have examined these risk factors collectively...
  66. pmc Cross-national associations between gender and mental disorders in the World Health Organization World Mental Health Surveys
    Soraya Seedat
    Medical Research Council Research Unit on Anxiety and Stress Disorder, Cape Town, South Africa
    Arch Gen Psychiatry 66:785-95. 2009
    ..The gender roles hypothesis suggests that these differences narrow as the roles of women and men become more equal...
  67. ncbi request reprint Dissociative experiences in obsessive-compulsive disorder and trichotillomania: clinical and genetic findings
    Christine Lochner
    Medical Research Council Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenboch, Cape Town, South Africa
    Compr Psychiatry 45:384-91. 2004
    ..g., lower age) and comorbidity profile (e.g., increased incidence of impulse dyscontrol disorders). Additional work is necessary before conclusions about the role of monoaminergic systems in mediating such dissociation can be drawn...
  68. ncbi request reprint Social anxiety disorder : current treatment recommendations
    Jacqueline E Muller
    Medical Research Council s Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    CNS Drugs 19:377-91. 2005
    ..Over the past two decades, cognitive behavioural therapies for SAD have gained increasing empirical support. The optimal approach to the management of treatment-refractory SAD patients requires additional study...
  69. ncbi request reprint Childhood trauma in obsessive-compulsive disorder, trichotillomania, and controls
    Christine Lochner
    MRC Unit on Stress and Anxiety Disorders, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    Depress Anxiety 15:66-8. 2002
    ....
  70. doi request reprint The DSM-IV-based Generalized Anxiety Disorder Severity Scale: preliminary validation using data from a trial of agomelatine versus placebo
    Dan J Stein
    Department of Psychiatry, University of Cape Town, South Africa
    J Nerv Ment Dis 197:391-4. 2009
    ..The most robust DGSS items were derived, and an exploratory factor analysis yielded a 2-factor structure of the DGSS. The DGSS is potentially a useful scale for the assessment of GAD in clinical trials of this disorder...
  71. ncbi request reprint Psychopathology and coping in recently diagnosed HIV/AIDS patients--the role of gender
    Benjamin O Olley
    Medical Research Council Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, W Cape
    S Afr Med J 93:928-31. 2003
    ..This study compared psychiatric morbidity, coping responses, and disability in male and female outpatients recently diagnosed with HIV/AIDS...
  72. pmc The mental health impact of AIDS-related mortality in South Africa: a national study
    L Myer
    School of Public Health and Family Medicine, University of Cape Town, Anzio Road, Cape Town, South Africa
    J Epidemiol Community Health 63:293-8. 2009
    ..Few data exist on how the HIV/AIDS epidemic may influence population mental health. The associations were examined between knowing someone who died of HIV/AIDS and common mental disorders among South African adults...
  73. ncbi request reprint Hoarding in obsessive-compulsive disorder and related disorders: a preliminary report of 15 cases
    Soraya Seedat
    Medical Research Council Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Psychiatry Clin Neurosci 56:17-23. 2002
    ..While a range of pharmacologic and behavioral treatments have been tried, their effectiveness in managing hoarding behaviors requires additional research...
  74. ncbi request reprint Serotonin transporter gene promoter polymorphism predicts SSRI response in generalized social anxiety disorder
    Murray B Stein
    Department of Psychiatry, University of California, 9500 Gilman Drive 0985, La Jolla, San Diego, CA 92093 0985, USA
    Psychopharmacology (Berl) 187:68-72. 2006
    ..To determine whether variation in the serotonin transporter gene promoter (5HTTLPR) influences the efficacy of selective serotonin reuptake inhibitors (SSRIs) in generalized social anxiety disorder (GSAD)...
  75. ncbi request reprint A brain-behaviour initiative for South Africa: the time is right
    Dan J Stein
    University of Cape Town, Observatory, Cape Town, South Africa
    Metab Brain Dis 21:279-84. 2006
    ..However, there has been less focus on the value of basic and clinical neuroscience research in this context. The current paper focuses on the relevance of a brain-behaviour research initiative in South Africa...
  76. ncbi request reprint SPECT imaging of body dysmorphic disorder
    Paul Carey
    MRC Unit for Stress and Anxiety Disorders, University of Stellenbosch, P O Box 19063, Tygerberg, Cape Town, South Africa
    J Neuropsychiatry Clin Neurosci 16:357-9. 2004
    ..Nevertheless, involvement of parietal regions is consistent with the characteristic altered body perception of BDD. These preliminary data highlight the need for further systematic functional imaging studies of this condition...
  77. ncbi request reprint Unresolved questions about treatment-resistant anxiety disorders
    Dan J Stein
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    CNS Spectr 9:715. 2004
  78. doi request reprint Trauma and posttraumatic stress disorder in South African adolescents: a case-control study of cognitive deficits
    Renata Schoeman
    Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    J Nerv Ment Dis 197:244-50. 2009
    ..As this effect appears to be stronger than the impact of trauma alone, more studies on the long-term consequences of PTSD on youth cognitive development are crucial...
  79. ncbi request reprint Exploratory and confirmatory factor analysis of the Multidimensional Anxiety Scale for Children among adolescents in the Cape Town metropole of South Africa
    Dylan Fincham
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Depress Anxiety 25:E147-53. 2008
    ..The MASC seems to be a useful tool for assessing and distinguishing anxiety symptoms among adolescents in the Cape Town metropole of South Africa...
  80. ncbi request reprint Comparison of response to a selective serotonin reuptake inhibitor in children, adolescents, and adults with posttraumatic stress disorder
    Soraya Seedat
    Department of Psychiatry, MRC Unit on Anxiety and Stress Disorders, Tygerberg, Cape Town, South Africa
    J Child Adolesc Psychopharmacol 12:37-46. 2002
    ....
  81. ncbi request reprint Topiramate in the treatment of trichotillomania: an open-label pilot study
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    Int Clin Psychopharmacol 21:255-9. 2006
    ..These results suggest that topiramate may be useful in the treatment of TTM. Future studies should investigate the efficacy of topiramate in an appropriately powered randomized placebo-controlled trial...
  82. doi request reprint Validity of the Kessler 10 (K-10) in detecting DSM-IV defined mood and anxiety disorders among pregnant women
    G Spies
    Department of Psychiatry, South African Research Chairs Initiative SARChI, PTSD Program, University of Stellenbosch, Cape Town, South Africa
    Arch Womens Ment Health 12:69-74. 2009
    ..66), posttraumatic stress disorder (0.69), panic disorder (0.71), and social phobia (0.76). The K-10 may be a useful screening measure for mood and anxiety disorders in pregnant women...
  83. ncbi request reprint Post-traumatic stress disorder among recently diagnosed patients with HIV/AIDS in South Africa
    B O Olley
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    AIDS Care 17:550-7. 2005
    ..In some cases, PTSD is secondary to the diagnosis of HIV/AIDS but in most cases it is seen after other traumas, with sexual violation and intimate partner violence in women being particularly important...
  84. ncbi request reprint Self-disclosure of HIV serostatus in recently diagnosed patients with HIV in South Africa
    B O Olley
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Afr J Reprod Health 8:71-6. 2004
    ..83, 1.88) were significantly associated with non-disclosure of HIV serostatus. Preventive strategies among HIV-positive patients should place emphasis on the management of self-disclosure and its importance in safe sexual behaviour...
  85. ncbi request reprint Mental health and sexual risk behaviours in a South African township: a community-based cross-sectional study
    J Smit
    Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa
    Public Health 120:534-42. 2006
    ..The objective of this study was to examine the association between mental illness and HIV risk behaviours in a South African township...
  86. pmc Socio-behaviour challenges to phase III HIV vaccine trials in Sub-Saharan Africa
    Joalida Smit
    MRC Unit for Anxiety and Stress Disorders, University of Stellenbosch, Cape Town, South Africa
    Afr Health Sci 5:198-206. 2005
    ..There is a need for a review of the literature to help focus such research efforts in Sub-Saharan Africa...
  87. ncbi request reprint Social and behavioral aspects of child and adolescent participation in HIV vaccine trials
    Leslie Swartz
    Sociobehavioural Group, South African AIDS Vaccine Initiative SAAVI, South Africa
    J Int Assoc Physicians AIDS Care (Chic) 4:89-92. 2005
    ....
  88. ncbi request reprint Paroxetine in the treatment of post-traumatic stress disorder: pooled analysis of placebo-controlled studies
    Dan J Stein
    MRC Unit on Anxiety Disorders, University of Stellenbosch, PO Box 19063, Tygerberg 7505, Cape Town, South Africa
    Expert Opin Pharmacother 4:1829-38. 2003
    ..The medication is effective in both male and female PTSD patients and whether or not there are comorbid disorders such as depression...
  89. ncbi request reprint Predictors of major depression in recently diagnosed patients with HIV/AIDS in South Africa
    B O Olley
    MRC Unit on Anxiety Disorders, Department of Psychiatry University of Stellenbosch, Cape Town, South Africa
    AIDS Patient Care STDS 18:481-7. 2004
    ..51, CI, 1.28, 1.80) predicted current major depression. It is well known from non-HIV populations that female gender and increased negative life events predict depression. These data also emphasize the importance of these links in HIV...
  90. ncbi request reprint Pathological gambling behaviour: emergence secondary to treatment of Parkinson's disease with dopaminergic agents
    S Seedat
    Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    Depress Anxiety 11:185-6. 2000
    ..Pharmacotherapeutic management of pathological gambling secondary to medical causes deserves further study...
  91. ncbi request reprint Violent trauma among child and adolescent girls: current knowledge and implications for clinicians
    D Kaminer
    University of Stellenbosch, Cape Town, South Africa
    Int Clin Psychopharmacol 15:S51-9. 2000
    ..The implications of current findings for clinical practice are discussed, in order to facilitate optimal assessment and treatment of young female victims of violence...
  92. ncbi request reprint Occupational disability on psychiatric grounds in South African school-teachers
    R Emsley
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Afr J Psychiatry (Johannesbg) 12:223-6. 2009
    ..This study investigated factors associated with occupational disability due to psychiatric disorders in teachers in South Africa...
  93. doi request reprint The relationship between behavioural inhibition, anxiety disorders, depression and CD4 counts in HIV-positive adults: a cross-sectional controlled study
    D Fincham
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    AIDS Care 20:1279-83. 2008
    ..While BI was linked to certain anxiety disorders, we found no evidence to suggest that BI, a diagnosis of an anxiety disorder, and/or depressive symptoms were associated with CD4 counts among HIV-positive adults...
  94. ncbi request reprint Trauma and post-traumatic stress disorder in women: a review
    S Seedat
    Department of Psychiatry, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    Int Clin Psychopharmacol 15:S25-33. 2000
    ..This article reviews gender differences in exposure to trauma and subsequent PTSD, emphasizing those features that characterize trauma and PTSD in women...
  95. ncbi request reprint Gender differences in the prevalence of childhood sexual abuse and in the development of pediatric PTSD
    J L Walker
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Arch Womens Ment Health 7:111-21. 2004
    ..Further work is needed to explore the mechanisms that underlie these differences...
  96. ncbi request reprint Single photon emission computed tomography (SPECT) in obsessive-compulsive disorder before and after treatment with inositol
    P D Carey
    MRC Research Unit for Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    Metab Brain Dis 19:125-34. 2004
    ..They may support the idea that inositol effects a clinical response through alternate neuronal circuitry to the SSRIs and may complement animal work proposing an overlapping but distinct mechanism of action...
  97. doi request reprint DSM-IV personality disorders and their axis I correlates in the South African population
    S Suliman
    MRC Anxiety and Stress Disorders Unit, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Psychopathology 41:356-64. 2008
    ..The prevalence of personality disorders (PD) in the South African population is largely unknown. Thus, we undertook to estimate prevalence, demographic correlates, co-morbidity and treatment rates of DSM-IV PD among South Africans...
  98. doi request reprint Validity of the K-10 in detecting DSM-IV-defined depression and anxiety disorders among HIV-infected individuals
    G Spies
    South African Research Chairs Initiative SARChI, PTSD Program, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    AIDS Care 21:1163-8. 2009
    ..77), generalized anxiety disorder (0.78), and posttraumatic stress disorder (PTSD) (0.77). The K-10 may be a useful screening measure for detecting mood and anxiety disorders, including PTSD, in patients with HIV/AIDS...
  99. ncbi request reprint Sexual risk factors associated with volunteering for HIV vaccine research in South Africa
    J Smit
    University of Cape Town, Cape Town, South Africa
    AIDS Care 18:569-73. 2006
    ..These findings suggest that volunteers for vaccine-related research may be at greater risk of HIV infection than the general population from which they are recruited...
  100. ncbi request reprint Determinants of unprotected sex among HIV-positive patients in South Africa
    B O Olley
    Medical Research Council Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    AIDS Care 17:1-9. 2005
    ..6, 95% CI = 0.45-0.96) were significantly associated with unprotected sex. These data suggest the need for interventions to further reduce sexual risk behaviours in HIV-positive patients in South Africa...
  101. ncbi request reprint Obsessive-compulsive disorder and a novel polymorphism adjacent to the oestrogen response element (ERE 6) upstream from the COMT gene
    C Kinnear
    MRC US Centre for Molecular and Cellular Biology, University of Stellenbosch, Tygerberg, South Africa
    Psychiatr Genet 11:85-7. 2001
    ..93) or gender (P = 0.67). These findings, although limited by a small sample size, suggest that the novel polymorphism adjacent to ERE 6 in the promoter area of COMT does not play a major role in the genetic predisposition to OCD...