J Savitz

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. ncbi The stroop color-word interference test as an indicator of ADHD in poor readers
    J B Savitz
    Department of Psychology, University of the Witwatersrand, Johannesburg, South Africa
    J Genet Psychol 164:319-33. 2003
  2. ncbi Personality: is it a viable endophenotype for genetic studies of bipolar affective disorder?
    Jonathan B Savitz
    MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Bipolar Disord 8:322-37. 2006
  3. ncbi The molecular genetics of cognition: dopamine, COMT and BDNF
    J Savitz
    MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    Genes Brain Behav 5:311-28. 2006
  4. ncbi Trends in suicidology: personality as an endophenotype for molecular genetic investigations
    Jonathan B Savitz
    UCT/MRC Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    PLoS Med 3:e107. 2006
  5. ncbi Apolipoprotein E variants and cognition in healthy individuals: a critical opinion
    Jonathan Savitz
    MRC UCT Human Genetics Research Unit, University of Cape Town Medical School, Observatory 7925, South Africa
    Brain Res Rev 51:125-35. 2006
  6. ncbi Neuropsychological dysfunction in bipolar affective disorder: a critical opinion
    Jonathan Savitz
    MRC UCT Human Genetics Research Unit, University of Cape Town, Cape Town, South Africa
    Bipolar Disord 7:216-35. 2005
  7. ncbi Dissociative identity disorder associated with mania and change in handedness
    Jonathan Savitz
    MRC UCT Human Genetics Research Unit, University of Cape Town Medical School, Observatory, 7925, South Africa
    Cogn Behav Neurol 17:233-7. 2004
  8. ncbi Genetic variants implicated in personality: a review of the more promising candidates
    Jonathan B Savitz
    MRC UCT Human Genetics Research Unit, Divison of Human Genetics, University of Cape Town, Cape Town, South Africa
    Am J Med Genet B Neuropsychiatr Genet 131:20-32. 2004
  9. ncbi Personality endophenotypes for bipolar affective disorder: a family-based genetic association analysis
    J Savitz
    UCT MRC Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Genes Brain Behav 7:869-76. 2008
  10. ncbi Lateralization of hand skill in bipolar affective disorder
    J Savitz
    Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    Genes Brain Behav 6:698-705. 2007

Detail Information

Publications21

  1. ncbi The stroop color-word interference test as an indicator of ADHD in poor readers
    J B Savitz
    Department of Psychology, University of the Witwatersrand, Johannesburg, South Africa
    J Genet Psychol 164:319-33. 2003
    ..The authors postulated the existence of two different causes of reading problems: phonological deficits and attentional deficits...
  2. ncbi Personality: is it a viable endophenotype for genetic studies of bipolar affective disorder?
    Jonathan B Savitz
    MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Bipolar Disord 8:322-37. 2006
    ..We conclude that personality profiling of probands and their relatives may facilitate molecular genetic work, but given the fact that personality is itself a complex trait, its use as an endophenotype has certain limitations...
  3. ncbi The molecular genetics of cognition: dopamine, COMT and BDNF
    J Savitz
    MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    Genes Brain Behav 5:311-28. 2006
    ..The implications of molecular genetic cognitive research for psychiatry are discussed in light of these data...
  4. ncbi Trends in suicidology: personality as an endophenotype for molecular genetic investigations
    Jonathan B Savitz
    UCT/MRC Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    PLoS Med 3:e107. 2006
  5. ncbi Apolipoprotein E variants and cognition in healthy individuals: a critical opinion
    Jonathan Savitz
    MRC UCT Human Genetics Research Unit, University of Cape Town Medical School, Observatory 7925, South Africa
    Brain Res Rev 51:125-35. 2006
    ..We conclude that the neuropsychological dysfunction reported in non-demented epsilon4 carriers is most likely to be the result of incipient AD...
  6. ncbi Neuropsychological dysfunction in bipolar affective disorder: a critical opinion
    Jonathan Savitz
    MRC UCT Human Genetics Research Unit, University of Cape Town, Cape Town, South Africa
    Bipolar Disord 7:216-35. 2005
    ..The philosophical implications of this conclusion for neuropsychology are briefly discussed...
  7. ncbi Dissociative identity disorder associated with mania and change in handedness
    Jonathan Savitz
    MRC UCT Human Genetics Research Unit, University of Cape Town Medical School, Observatory, 7925, South Africa
    Cogn Behav Neurol 17:233-7. 2004
    ..To investigate the overlap between dissociative and bipolar disorders with reference to their neurophysiological foundations...
  8. ncbi Genetic variants implicated in personality: a review of the more promising candidates
    Jonathan B Savitz
    MRC UCT Human Genetics Research Unit, Divison of Human Genetics, University of Cape Town, Cape Town, South Africa
    Am J Med Genet B Neuropsychiatr Genet 131:20-32. 2004
    ....
  9. ncbi Personality endophenotypes for bipolar affective disorder: a family-based genetic association analysis
    J Savitz
    UCT MRC Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Genes Brain Behav 7:869-76. 2008
    ..We raise the possibility that the 10R allele of the SLC6A3 repeat polymorphism and the short allele of the SLC6A4 promoter variant constitute risk factors for irritable-aggressive and anxious-dysthymic subtypes of BD, respectively...
  10. ncbi Lateralization of hand skill in bipolar affective disorder
    J Savitz
    Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    Genes Brain Behav 6:698-705. 2007
    ..Relative hand skill was significantly associated with a functional variant in the catechol-O-methyltransferase gene. We speculate that this polymorphism may influence brain lateralization...
  11. ncbi Genotype and childhood sexual trauma moderate neurocognitive performance: a possible role for brain-derived neurotrophic factor and apolipoprotein E variants
    Jonathan Savitz
    MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    Biol Psychiatry 62:391-9. 2007
    ..We predicted that memory would be affected by sexual trauma and that a number of functional polymorphisms previously implicated in BPD and cognition would moderate the effect of psychological trauma on memory...
  12. ncbi Bipolar disorder: emotional dysregulation and neuronal vulnerability
    Dan J Stein
    Department of Psychiatry and Mental Health at the University of Cape Town, Cape Town, South Africa
    CNS Spectr 14:122-6. 2009
    ..Furthermore, there is growing data on the cellular mechanisms contributing to neuronal vulnerability in this mediating circuitry...
  13. ncbi Neurocognitive function in an extended Afrikaner-ancestry family with affective illness
    Jonathan Savitz
    Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    J Psychiatry Neurosci 32:116-20. 2007
    ..To characterize the neuropsychological profile of an extended family with unipolar depression (UPD) and other forms of affective illness...
  14. ncbi Neuropsychological status of bipolar I disorder: impact of psychosis
    Jonathan Savitz
    Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    Br J Psychiatry 194:243-51. 2009
    ....
  15. ncbi A linkage and family-based association analysis of a potential neurocognitive endophenotype of bipolar disorder
    Jonathan Savitz
    Division of Human Genetics, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    Neuromolecular Med 9:101-16. 2007
    ..We speculate that polymorphisms at these loci may predispose to a subtype of BPD characterized by memory-related deficits...
  16. ncbi Preliminary evidence for linkage to chromosome 1q31-32, 10q23.3, and 16p13.3 in a South African cohort with bipolar disorder
    Jonathan Savitz
    Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Am J Med Genet B Neuropsychiatr Genet 144:383-7. 2007
    ..Negative results were obtained for the remaining six candidate loci, possibly due to limited statistical power...
  17. ncbi Catechol-o-methyltransferase genotype and childhood trauma may interact to impact schizotypal personality traits
    Jonathan Savitz
    MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Behav Genet 40:415-23. 2010
    ..We raise the possibility that genetically-driven variation in COMT may interact with childhood trauma to contribute to the risk of developing schizotypal personality traits...
  18. ncbi Dysthymic and anxiety-related personality traits in bipolar spectrum illness
    Jonathan Savitz
    Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, USA
    J Affect Disord 109:305-11. 2008
    ..While dysthymic temperament traits conform relatively well to the quantitative genetic model of affective illness, anxious traits as defined by the AT scale, are equally salient in BPD and unipolar depression...
  19. ncbi Hypomanic, cyclothymic and hostile personality traits in bipolar spectrum illness: a family-based study
    Jonathan Savitz
    Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    J Psychiatr Res 42:920-9. 2008
    ..To test whether these traits follow a distribution with the most "pathological" scores in the bipolar disorder I (BPD I) group and the least "pathological" scores in the unaffected relatives...
  20. ncbi Warriors versus worriers: the role of COMT gene variants
    Dan J Stein
    Department of Mental Health and Psychiatry, University of Cape Town, South Africa
    CNS Spectr 11:745-8. 2006
    ..Some evidence suggests that Val158 alleles are associated with schizophrenia, while Met158 alleles are associated with anxiety...
  21. ncbi The subgenual anterior cingulate cortex in mood disorders
    Wayne C Drevets
    Section on Neuroimaging in Mood and Anxiety Disorders, Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA
    CNS Spectr 13:663-81. 2008
    ..These data thus hold important implications for the development of neural models of depression that can account for the abnormal motivational, neuroendocrine, autonomic, and emotional manifestations evident in human mood disorders...