U Ripamonti

Summary

Affiliation: University of the Witwatersrand
Country: South Africa

Publications

  1. ncbi Regenerative frontiers in craniofacial reconstruction: grand challenges and opportunities for the mammalian transforming growth factor-β proteins
    Ugo Ripamonti
    Bone Research Unit, Medical Research Council University of the Witwatersrand Johannesburg, South Africa
    Front Physiol 1:143. 2010
  2. ncbi Osteoinductive hydroxyapatite-coated titanium implants
    Ugo Ripamonti
    Bone Research Laboratory, School of Physiology, Medical Research Council University of the Witwatersrand, Johannesburg, 2193 Parktown, South Africa
    Biomaterials 33:3813-23. 2012
  3. ncbi Recapitulating development: a template for periodontal tissue engineering
    U Ripamonti
    Bone Research Unit, Medical Research Council University of the Witwatersrand, Johannesburg, South Africa
    Tissue Eng 13:51-71. 2007
  4. ncbi Biomimetism, biomimetic matrices and the induction of bone formation
    Ugo Ripamonti
    Bone Research Unit, Medical Research Council University of the Witwatersrand, Johannesburg, South Africa
    J Cell Mol Med 13:2953-72. 2009
  5. ncbi Induction of cementogenesis and periodontal ligament regeneration by recombinant human transforming growth factor-beta3 in Matrigel with rectus abdominis responding cells
    U Ripamonti
    Bone Research Unit, Medical Research Council University of the Witwatersrand, Johannesburg, South Africa
    J Periodontal Res 44:81-7. 2009
  6. ncbi Soluble and insoluble signals and the induction of bone formation: molecular therapeutics recapitulating development
    Ugo Ripamonti
    Bone Research Unit, Medical Research Council University of the Witwatersrand, Johannesburg, South Africa
    J Anat 209:447-68. 2006
  7. ncbi Cementogenesis and the induction of periodontal tissue regeneration by the osteogenic proteins of the transforming growth factor-beta superfamily
    U Ripamonti
    Bone Research Unit, Medical Research Council University of the Witwatersrand, 7 York Road Medical School, 2193 Parktown, Johannesburg, South Africa
    J Periodontal Res 44:141-52. 2009
  8. ncbi The induction of endochondral bone formation by transforming growth factor-beta(3): experimental studies in the non-human primate Papio ursinus
    Ugo Ripamonti
    Bone Research Unit, Medical Research Council University of the Witwatersrand, Johannesburg, South Africa
    J Cell Mol Med 12:1029-48. 2008
  9. ncbi The induction of bone formation by smart biphasic hydroxyapatite tricalcium phosphate biomimetic matrices in the non-human primate Papio ursinus
    U Ripamonti
    Bone Research Unit, Medical Research Council University of the Witwatersrand, Johannesburg, South Africa
    J Cell Mol Med 12:2609-21. 2008
  10. ncbi Self-inducing shape memory geometric cues embedded within smart hydroxyapatite-based biomimetic matrices
    Ugo Ripamonti
    Bone Research Unit, Medical Research Council at the University of the Witwatersrand, Parktown, South Africa
    Plast Reconstr Surg 120:1796-807. 2007

Collaborators

  • C Ferretti
  • Hari A Reddi
  • A H Reddi
  • J A Teare
  • L N Ramoshebi
  • I Dal Mas
  • J Crooks
  • Ilario Dal Mas
  • Lentsha N Ramoshebi
  • J C Petit
  • T Matsaba
  • G Thomadakis
  • A Biscardi
  • C M Schnitzler
  • N Duneas
  • Thato N Matsaba
  • Janet Patton
  • Anna Biscardi
  • June Teare
  • Louise Renton
  • D C Rueger

Detail Information

Publications42

  1. ncbi Regenerative frontiers in craniofacial reconstruction: grand challenges and opportunities for the mammalian transforming growth factor-β proteins
    Ugo Ripamonti
    Bone Research Unit, Medical Research Council University of the Witwatersrand Johannesburg, South Africa
    Front Physiol 1:143. 2010
    ..2006)...
  2. ncbi Osteoinductive hydroxyapatite-coated titanium implants
    Ugo Ripamonti
    Bone Research Laboratory, School of Physiology, Medical Research Council University of the Witwatersrand, Johannesburg, 2193 Parktown, South Africa
    Biomaterials 33:3813-23. 2012
    ..These data in non-human primates indicate that geometrically-constructed plasma-sprayed titanium implants are per se osteogenic, the concavities providing a unique microenvironment to initiate bone differentiation by induction...
  3. ncbi Recapitulating development: a template for periodontal tissue engineering
    U Ripamonti
    Bone Research Unit, Medical Research Council University of the Witwatersrand, Johannesburg, South Africa
    Tissue Eng 13:51-71. 2007
    ..Periodontal tissue regeneration develops as a mosaic structure in which the OPs of the TGF-beta superfamily singly, synergistically, and synchronously initiate and maintain tissue induction and morphogenesis...
  4. ncbi Biomimetism, biomimetic matrices and the induction of bone formation
    Ugo Ripamonti
    Bone Research Unit, Medical Research Council University of the Witwatersrand, Johannesburg, South Africa
    J Cell Mol Med 13:2953-72. 2009
    ....
  5. ncbi Induction of cementogenesis and periodontal ligament regeneration by recombinant human transforming growth factor-beta3 in Matrigel with rectus abdominis responding cells
    U Ripamonti
    Bone Research Unit, Medical Research Council University of the Witwatersrand, Johannesburg, South Africa
    J Periodontal Res 44:81-7. 2009
    ..Two regenerative treatments using human recombinant transforming growth factor-b3 were examined after implantation in mandibular furcation defects of the nonhuman primate, Papio ursinus...
  6. ncbi Soluble and insoluble signals and the induction of bone formation: molecular therapeutics recapitulating development
    Ugo Ripamonti
    Bone Research Unit, Medical Research Council University of the Witwatersrand, Johannesburg, South Africa
    J Anat 209:447-68. 2006
    ....
  7. ncbi Cementogenesis and the induction of periodontal tissue regeneration by the osteogenic proteins of the transforming growth factor-beta superfamily
    U Ripamonti
    Bone Research Unit, Medical Research Council University of the Witwatersrand, 7 York Road Medical School, 2193 Parktown, Johannesburg, South Africa
    J Periodontal Res 44:141-52. 2009
    ....
  8. ncbi The induction of endochondral bone formation by transforming growth factor-beta(3): experimental studies in the non-human primate Papio ursinus
    Ugo Ripamonti
    Bone Research Unit, Medical Research Council University of the Witwatersrand, Johannesburg, South Africa
    J Cell Mol Med 12:1029-48. 2008
    ....
  9. ncbi The induction of bone formation by smart biphasic hydroxyapatite tricalcium phosphate biomimetic matrices in the non-human primate Papio ursinus
    U Ripamonti
    Bone Research Unit, Medical Research Council University of the Witwatersrand, Johannesburg, South Africa
    J Cell Mol Med 12:2609-21. 2008
    ....
  10. ncbi Self-inducing shape memory geometric cues embedded within smart hydroxyapatite-based biomimetic matrices
    Ugo Ripamonti
    Bone Research Unit, Medical Research Council at the University of the Witwatersrand, Parktown, South Africa
    Plast Reconstr Surg 120:1796-807. 2007
    ....
  11. ncbi Bone morphogenetic proteins and the induction of bone formation: from laboratory to patients
    Ugo Ripamonti
    Bone Research Unit, Medical Research Council University of the Witwatersrand, Medical School, 2193 Parktown, Johannesburg, South Africa
    Oral Maxillofac Surg Clin North Am 19:575-89, vii. 2007
    ....
  12. ncbi Transforming growth factor-beta isoforms and the induction of bone formation: implications for reconstructive craniofacial surgery
    Ugo Ripamonti
    Bone Research Unit, Medical School, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg, South Africa
    J Craniofac Surg 20:1544-55. 2009
    ..ursinus without the exogenous application of the osteogenic soluble molecular signals of the TGF-beta superfamily...
  13. ncbi Bone morphogenetic proteins, cementogenesis, myoblastic stem cells and the induction of periodontal tissue regeneration
    Ugo Ripamonti
    Bone Research Unit, Medical Research Council University of the Witwatersrand, 7 York Road Medical School, 2193 Parktown, Johannesburg, South Africa
    Cytokine Growth Factor Rev 20:489-99. 2009
    ....
  14. ncbi The induction of bone formation by coral-derived calcium carbonate/hydroxyapatite constructs
    Ugo Ripamonti
    Bone Research Unit, Medical Research Council at the University of the Witwatersrand, Johannesburg, Medical School, 2193 Parktown, South Africa
    Biomaterials 30:1428-39. 2009
    ..This study demonstrates for the first time that partially converted HA/CC constructs also induce spontaneous differentiation of bone, albeit only seen one year post-implantation...
  15. ncbi Biomimetic matrices self-initiating the induction of bone formation
    Ugo Ripamonti
    Bone Research Laboratory, Medical Research Council University of the Witwatersrand, Johannesburg, South Africa
    J Craniofac Surg 22:1859-70. 2011
    ....
  16. ncbi Induction of bone formation by transforming growth factor-beta2 in the non-human primate Papio ursinus and its modulation by skeletal muscle responding stem cells
    U Ripamonti
    Bone Research Unit, Medical Research Council University of the Witwatersrand, Johannesburg, South Africa
    Cell Prolif 43:207-18. 2010
    ..Four adult non-human primates Papio ursinus were used to study induction of bone formation by recombinant human transforming growth factor-beta(2) (hTGF-beta(2)) together with muscle-derived stem cells...
  17. ncbi Biomimetics for the induction of bone formation
    Ugo Ripamonti
    Medical Research Council University of the Witwatersrand, Johannesburg, 2193 Parktown, South Africa
    Expert Rev Med Devices 7:469-79. 2010
    ....
  18. ncbi Synergistic induction of bone formation by hOP-1, hTGF-beta3 and inhibition by zoledronate in macroporous coral-derived hydroxyapatites
    Ugo Ripamonti
    Bone Research Unit, Medical Research Council University of the Witwatersrand, Johannesburg, South Africa
    Biomaterials 31:6400-10. 2010
    ....
  19. ncbi Synergistic induction of periodontal tissue regeneration by binary application of human osteogenic protein-1 and human transforming growth factor-β3 in Class II furcation defects of Papio ursinus
    J A Teare
    Bone Research Unit, Medical Research Council, University of Witwatersrand, Johannesburg, South Africa
    J Periodontal Res 47:336-44. 2012
    ..To induce periodontal tissue regeneration, binary applications of hOP-1 and hTGF-β(3) were implanted in Class II furcation defects of the Chacma baboon, Papio ursinus...
  20. ncbi Periodontal tissue regeneration by combined applications of recombinant human osteogenic protein-1 and bone morphogenetic protein-2. A pilot study in Chacma baboons (Papio ursinus)
    U Ripamonti
    Bone Research Unit, Medical Research Council University of the Witwatersrand, Medical School, Johannesburg, South Africa
    Eur J Oral Sci 109:241-8. 2001
    ..The demonstration of therapeutic mosaicism in periodontal regeneration will require extensive testing of ratios and doses of recombinant morphogen combinations for optimal tissue engineering in clinical contexts...
  21. ncbi Induction of endochondral bone formation by recombinant human transforming growth factor-beta2 in the baboon (Papio ursinus)
    U Ripamonti
    Bone Research Laboratory, Medical Research Council University of the Witwatersrand, Medical School, Johannesburg, South Africa
    Growth Factors 17:269-85. 2000
    ....
  22. ncbi Bone induction by BMPs/OPs and related family members in primates
    U Ripamonti
    Bone Research Unit, South African Medical Research Council University of the Witwatersrand, Medical School, Johannesburg
    J Bone Joint Surg Am 83:S116-27. 2001
    ..In particular, we focus on the geometric induction of bone formation by sintered porous hydroxyapatite (SPHA) discs with concavities on their planar surfaces, which elicit bone formation without exogenously applied BMPs/OPs...
  23. ncbi Recombinant transforming growth factor-beta1 induces endochondral bone in the baboon and synergizes with recombinant osteogenic protein-1 (bone morphogenetic protein-7) to initiate rapid bone formation
    U Ripamonti
    Bone Research Laboratory, Medical Research Council University of the Witwatersrand, Johannesburg, South Africa
    J Bone Miner Res 12:1584-95. 1997
    ..These results provide evidence for a novel function of TGF-beta1 in the primate and the scientific basis for synergistic molecular therapeutics for the rapid regeneration of cartilage and bone...
  24. ncbi Transforming growth factor-beta 1: induction of bone morphogenetic protein genes expression during endochondral bone formation in the baboon, and synergistic interaction with osteogenic protein-1 (BMP-7)
    N Duneas
    Bone Research Laboratory, Medical Research Council University of the Witwatersrand, Medical School, Johannesburg, South Africa
    Growth Factors 15:259-77. 1998
    ..The present findings may provide the basis for synergistic molecular therapeutics for cartilage and bone regeneration in clinical contexts...
  25. ncbi Periodontal tissue regeneration by recombinant human transforming growth factor-beta 3 in Papio ursinus
    J A Teare
    Bone Research Unit, Medical Research Council University of the Witwatersrand, Johannesburg, South Africa
    J Periodontal Res 43:1-8. 2008
    ..In the present study, recombinant human transforming growth factor-beta 3 was examined for its ability to induce periodontal tissue regeneration in the nonhuman primate, Papio ursinus...
  26. ncbi Bone induction by recombinant human osteogenic protein-1 (hOP-1, BMP-7) in the primate Papio ursinus with expression of mRNA of gene products of the TGF-beta superfamily
    U Ripamonti
    Bone Research Unit, Medical Research Council University of the Witwatersrand, Johannesburg, Medical School, Parktown, South Africa
    J Cell Mol Med 9:911-28. 2005
    ....
  27. ncbi Induction of bone formation by recombinant human osteogenic protein-1 and sintered porous hydroxyapatite in adult primates
    U Ripamonti
    Bone Research Unit, the Medical Research Council at the University of the Witwatersrand, Johannesburg, South Africa
    Plast Reconstr Surg 107:977-88. 2001
    ....
  28. ncbi Transforming growth factor-beta1 supports the rapid morphogenesis of heterotopic endochondral bone initiated by human osteogenic protein-1 via the synergistic upregulation of molecular markers
    T Matsaba
    Bone Research Laboratory, Medical Research Council, University of the Witwatersrand, Medical School, Johannesburg, South Africa
    Growth Factors 19:73-86. 2001
    ..The present data provides insights to the mechanisms of synergistic molecular therapeutics for endochondral bone formation in clinical contexts...
  29. ncbi Complete regeneration of bone in the baboon by recombinant human osteogenic protein-1 (hOP-1, bone morphogenetic protein-7)
    U Ripamonti
    Bone Research Laboratory, Medical Research Council University of the Witwatersrand, Medical School, Johannesburg, South Africa
    Growth Factors 13:273-89,color plates III-VIII,pre.bk. 1996
    ..These results in the primate may form the scientific basis for future clinical applications of hOP-1...
  30. ncbi Immunolocalization of Bone Morphogenetic Protein-2 and -3 and Osteogenic Protein-1 during murine tooth root morphogenesis and in other craniofacial structures
    G Thomadakis
    Bone Research Laboratory, Medical Research Council University of the Witwatersrand, Medical School, Johannesburg, South Africa
    Eur J Oral Sci 107:368-77. 1999
    ..The composite expression of BMPs/OPs during periodontal tissue morphogenesis suggests that optimal therapeutic regeneration may entail the combined use of different BMPs/OPs...
  31. ncbi Osteogenic protein-1, a bone morphogenetic protein, induces angiogenesis in the chick chorioallantoic membrane and synergizes with basic fibroblast growth factor and transforming growth factor-beta1
    L N Ramoshebi
    Bone Research Laboratory, Medical Research Council University of the Witwatersrand, Medical School, Johannesburg 2193, South Africa
    Anat Rec 259:97-107. 2000
    ..The cooperative interaction of the different morphogens in the CAM assay may provide important biological clues towards the control of clinical angiogenesis...
  32. ncbi Pleiotropism of bone morphogenetic proteins: from bone induction to cementogenesis and periodontal ligament regeneration
    Ugo Ripamonti
    Bone Research Unit, Medical Research Council University of the Witwatersrand, Johannesburg, South Africa
    J Int Acad Periodontol 8:23-32. 2006
    ....
  33. ncbi Human segmental mandibular defects treated with naturally derived bone morphogenetic proteins
    Carlo Ferretti
    Division of Maxillofacial and Oral Surgery, Baragwanath Hospital and University of the Witwatersrand, Johannesburg, South Africa
    J Craniofac Surg 13:434-44. 2002
    ..Whilst this trial provides valuable insights for the use of BMPs in mandibular reconstruction further work is required to produce an OD that will perform reliably in clinical contexts...
  34. ncbi Bone morphogenetic proteins and the induction of periodontal tissue regeneration
    Ugo Ripamonti
    Bone Research Unit, Medical Research Council/University of the Witwatersand, Parktown, Johannesburg, South Africa
    Periodontol 2000 41:73-87. 2006
  35. ncbi A supernumerary tooth in a 1.7 million-year-old Australopithecus robustus from Swartkrans, South Africa
    U Ripamonti
    Bone Research Laboratory, Medical Research Council University of the Witwatersrand, Johannesburg, South Africa
    Eur J Oral Sci 107:317-21. 1999
    ..This is the first description of a supernumerary tooth found in Plio-Pleistocene hominid fossils from South African cave deposits...
  36. ncbi Bone loss in the ovariectomized baboon Papio ursinus: densitometry, histomorphometry and biochemistry
    I Dal Mas
    Bone Research Unit, Medical Research Council, University of the Witwatersrand, Faculty of Health Sciences, 7 York Road, Parktown 2193, Johannesburg, South Africa
    J Cell Mol Med 11:852-67. 2007
    ..Since these changes resemble those in post-menopausal women, the non-human primate Papio ursinus is suitable for the study of bone loss in post-menopausal women...
  37. ncbi Soluble osteogenic molecular signals and the induction of bone formation
    Ugo Ripamonti
    Bone Research Unit, Medical Research Council University of the Witwatersrand, Medical School, 7 York Road, Parktown, Johannesburg 2193, South Africa
    Biomaterials 27:807-22. 2006
    ....
  38. ncbi Bone morphogenetic proteins in craniofacial and periodontal tissue engineering: experimental studies in the non-human primate Papio ursinus
    Ugo Ripamonti
    Bone Research Unit, MRC University of the Witwatersrand, Medical School, 7 York Road, 2193 Parktown, South Africa
    Cytokine Growth Factor Rev 16:357-68. 2005
    ..The induction of bone develops a mosaic structure in which members of the TGF-beta superfamily singly, synergistically and synchronously initiate and maintain tissue induction and morphogenesis...
  39. ncbi Soluble, insoluble and geometric signals sculpt the architecture of mineralized tissues
    U Ripamonti
    Bone Research Unit, MRC University of the Witwatersrand, Johannesburg, 7 York Road, 2193 Parktown, South Africa
    J Cell Mol Med 8:169-80. 2004
    ..The above findings in the primate indicate enormous potential for the bioengineering industry. Of particular interest is that biomimetic matrices with intrinsic osteoinductivity would be an affordable option in the local context...
  40. ncbi Tissue engineering: TGF-beta superfamily members and delivery systems in bone regeneration
    Lentsha N Ramoshebi
    Bone Research Laboratory, Medical Research Council of South Africa and the University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa
    Expert Rev Mol Med 4:1-11. 2002
    ..This review outlines the basis of bone tissue engineering by members of the TGF-beta superfamily, focusing on their delivery systems and the intrinsic induction of bone formation by specific biomimetic matrices with a defined geometry...
  41. ncbi Advances in biotechnology for tissue engineering of bone
    U Ripamonti
    Bone Research Unit, MRC University of the Witwatersrand, Johannesburg, South Africa
    Curr Pharm Biotechnol 1:47-55. 2000
    ....
  42. ncbi Comparison of two Hologic DXA systems (QDR 1000 and QDR 4500/A) for in vivo bone mass measurement in the baboon (Papio ursinus)
    Ilario Dal Mas
    Bone Research Unit, Medical Research Council/University of the Witwatersrand, Parktown, Johannesburg, South Africa
    J Clin Densitom 5:313-8. 2002
    ....