Frederick J Raal

Summary

Affiliation: University of the Witwatersrand
Country: South Africa

Publications

  1. doi request reprint Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial
    Frederick J Raal
    Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
    Lancet 375:998-1006. 2010
  2. doi request reprint Homozygous familial hypercholesterolemia: current perspectives on diagnosis and treatment
    Frederick J Raal
    Carbohydrate and Lipid Metabolism Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    Atherosclerosis 223:262-8. 2012
  3. pmc Carotid intima-media thickness is a predictor of coronary artery disease in South African black patients
    Zaiboonnisa Holland
    Department of Radiology, University of the Witwatersrand, Johannesburg, South Africa
    Cardiovasc J Afr 20:237-9. 2009
  4. pmc Elevated PCSK9 levels in untreated patients with heterozygous or homozygous familial hypercholesterolemia and the response to high-dose statin therapy
    Frederick Raal
    Carbohydrate and Lipid Metabolism Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
    J Am Heart Assoc 2:e000028. 2013
  5. pmc A longitudinal study of stavudine-associated toxicities in a large cohort of South African HIV infected subjects
    Colin N Menezes
    Infectious Diseases Unit, Department of Medicine, Helen Joseph Hospital, University of the Witwatersrand, Johannesburg, South Africa
    BMC Infect Dis 11:244. 2011
  6. pmc CEPHEUS SA: a South African survey on the undertreatment of hypercholesterolaemia
    F Raal
    Department of Medicine, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa
    Cardiovasc J Afr 22:234-40. 2011
  7. doi request reprint Pathogenesis and management of the dyslipidemia of the metabolic syndrome
    Frederick J Raal
    Division of Endocrinology and Metabolism, Department of Medicine, Johannesburg Hospital, Johannesburg, South Africa
    Metab Syndr Relat Disord 7:83-8. 2009
  8. doi request reprint Reduction in mortality in subjects with homozygous familial hypercholesterolemia associated with advances in lipid-lowering therapy
    Frederick J Raal
    Carbohydrate and Lipid Metabolism Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
    Circulation 124:2202-7. 2011
  9. ncbi request reprint Leptin, adiponectin, and high-sensitivity C-reactive protein in relation to the metabolic syndrome in urban South African blacks with and without coronary artery disease
    Lucas Ntyintyane
    Carbohydrate and Lipid Metabolism Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
    Metab Syndr Relat Disord 7:243-8. 2009
  10. ncbi request reprint High-dose atorvastatin therapy is required for significant improvement of endothelial function in heterozygous familial hypercholesterolaemic patients
    Susan L Brown
    Carbohydrate and Lipid Metabolism Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg
    Cardiovasc J S Afr 15:70-5. 2004

Collaborators

Detail Information

Publications14

  1. doi request reprint Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial
    Frederick J Raal
    Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
    Lancet 375:998-1006. 2010
    ..This study investigated whether an antisense inhibitor of apolipoprotein B synthesis, mipomersen, is effective and safe as an adjunctive agent to lower LDL cholesterol concentrations in patients with this disease...
  2. doi request reprint Homozygous familial hypercholesterolemia: current perspectives on diagnosis and treatment
    Frederick J Raal
    Carbohydrate and Lipid Metabolism Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    Atherosclerosis 223:262-8. 2012
    ..The purpose of this review is to provide current perspectives on diagnosis and therapy in an effort to encourage early recognition and treatment of this rare but severe disease...
  3. pmc Carotid intima-media thickness is a predictor of coronary artery disease in South African black patients
    Zaiboonnisa Holland
    Department of Radiology, University of the Witwatersrand, Johannesburg, South Africa
    Cardiovasc J Afr 20:237-9. 2009
    ..The present study aimed at investigating whether CIMT is a predictor of CAD in South African black patients...
  4. pmc Elevated PCSK9 levels in untreated patients with heterozygous or homozygous familial hypercholesterolemia and the response to high-dose statin therapy
    Frederick Raal
    Carbohydrate and Lipid Metabolism Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
    J Am Heart Assoc 2:e000028. 2013
    ..Patients with familial hypercholesterolemia (FH) have reduced or absent LDL receptors and should therefore have elevated PCSK9 levels...
  5. pmc A longitudinal study of stavudine-associated toxicities in a large cohort of South African HIV infected subjects
    Colin N Menezes
    Infectious Diseases Unit, Department of Medicine, Helen Joseph Hospital, University of the Witwatersrand, Johannesburg, South Africa
    BMC Infect Dis 11:244. 2011
    ..This has brought new challenges which include the effects of stavudine-related toxicities...
  6. pmc CEPHEUS SA: a South African survey on the undertreatment of hypercholesterolaemia
    F Raal
    Department of Medicine, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa
    Cardiovasc J Afr 22:234-40. 2011
    ....
  7. doi request reprint Pathogenesis and management of the dyslipidemia of the metabolic syndrome
    Frederick J Raal
    Division of Endocrinology and Metabolism, Department of Medicine, Johannesburg Hospital, Johannesburg, South Africa
    Metab Syndr Relat Disord 7:83-8. 2009
    ..However, in very high-risk patients, such as those with established cardiovascular disease, an LDL-C goal of below 70 mg/dL is recommended...
  8. doi request reprint Reduction in mortality in subjects with homozygous familial hypercholesterolemia associated with advances in lipid-lowering therapy
    Frederick J Raal
    Carbohydrate and Lipid Metabolism Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
    Circulation 124:2202-7. 2011
    ....
  9. ncbi request reprint Leptin, adiponectin, and high-sensitivity C-reactive protein in relation to the metabolic syndrome in urban South African blacks with and without coronary artery disease
    Lucas Ntyintyane
    Carbohydrate and Lipid Metabolism Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
    Metab Syndr Relat Disord 7:243-8. 2009
    ..Inflammation is frequently associated with metabolic syndrome and CAD. This study evaluated markers of inflammation in black CAD patients, some of whom had metabolic syndrome...
  10. ncbi request reprint High-dose atorvastatin therapy is required for significant improvement of endothelial function in heterozygous familial hypercholesterolaemic patients
    Susan L Brown
    Carbohydrate and Lipid Metabolism Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg
    Cardiovasc J S Afr 15:70-5. 2004
    ..There was no correlation between the changes in FMD and LDL-C, suggesting either a LDLC-independent effect on ED, or that a marked reduction in LDL-C is required to normalise ED in FH...
  11. ncbi request reprint Avasimibe, an ACAT inhibitor, enhances the lipid lowering effect of atorvastatin in subjects with homozygous familial hypercholesterolemia
    Frederick J Raal
    Carbohydrate and Lipid Metabolism Research Unit, University of the Witwatersrand, Johannesburg Hospital, Johannesburg, South Africa
    Atherosclerosis 171:273-9. 2003
    ..Avasimibe may modestly enhance the lipid-reducing effect of atorvastatin by further inhibiting the production of intracellular cholesterol through mechanisms that appear to be compatible in this population...
  12. ncbi request reprint Autosomal recessive hypercholesterolaemia: discrimination of ARH protein and LDLR function in the homozygous FH phenotype
    Aron B Abera
    Department of Medicine, University of Cape Town, UCT NHLS, Cape Town, South Africa
    Clin Chim Acta 378:33-7. 2007
    ..An effective strategy is thus required to identify the appropriate mechanism for the disorder...
  13. pmc Different lipid profiles according to ethnicity in the Heart of Soweto study cohort of de novo presentations of heart disease
    Karen Sliwa
    Hatter Institute for Cardiovascular Research in Africa and IIDMM, Faculty of Health Sciences, University of Cape Town, South Africa
    Cardiovasc J Afr 23:389-95. 2012
    ..Historically, sub-Saharan Africa has reported low levels of atherosclerotic cardiovascular disease (CVD). However as these populations undergo epidemiological transition, this may change...
  14. pmc Prevalence of dyslipidaemia in statin-treated patients in South Africa: results of the DYSlipidaemia International Study (DYSIS)
    Frederick J Raal
    Carbohydrate and Lipid Metabolism Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
    Cardiovasc J Afr 24:330-8. 2013
    ..We evaluated lipid goal attainment in statin-treated patients in South Africa and analysed variables contributing to poor goal attainment as part of the DYSlipidaemia International Study (DYSIS)...