Genomes and Genes
David J R Pugh
Affiliation: University of the Western Cape
Country: South Africa
- DWNN, a novel ubiquitin-like domain, implicates RBBP6 in mRNA processing and ubiquitin-like pathwaysDavid J R Pugh
Biotechnology Department, University of the Western Cape, Modderdam Road, Bellville 7535, South Africa
BMC Struct Biol 6:1. 2006..RBBP6 has recently been shown to be highly up-regulated in oesophageal cancer, and to be a promising target for immunotherapy against the disease...
- Solution structure of RING finger-like domain of retinoblastoma-binding protein-6 (RBBP6) suggests it functions as a U-boxMautin A Kappo
Biotechnology Department, University of the Western Cape, Bellville 7535, South Africa
J Biol Chem 287:7146-58. 2012..Taken together with the structural similarities to U-box-containing proteins, our data suggest that RBBP6 plays a role in chaperone-mediated ubiquitination and possibly in protein quality control...
- RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1Moredreck Chibi
Biotechnology Department, University of the Western Cape, Bellville, South Africa
J Mol Biol 384:908-16. 2008..In the light of the important role that YB-1 appears to play in tumourigenesis, our results suggest that RBBP6 may be a relevant target for therapeutic drugs aimed at modifying the activity of YB-1...