Research Topics
Genomes and GenesSpecies | Michael PosthumusSummaryAffiliation: University of Cape Town Country: South Africa Publications
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Detail Information
Publications
A functional variant within the MMP3 gene does not associate with human range of motionMichael Posthumus
The Division of Health and Life Sciences, University of Northampton, Northampton, United Kingdom
J Sci Med Sport 13:630-2. 2010..494; R-SLR, P=0.435; SR, P=0.266). Furthermore, there was no evidence of an interaction between the COL5A1 BstUI RFLP and the MMP3 rs679620 variant. Our study suggests that the MMP3 rs679620 variant does not associate with passive ROM...- Components of the transforming growth factor-beta family and the pathogenesis of human Achilles tendon pathology--a genetic association studyMichael Posthumus
The Division of Health and Life Sciences, School of Health, University of Northampton, Park Campus, Northampton, UK
Rheumatology (Oxford) 49:2090-7. 2010.... - The intrinsic risk factors for ACL ruptures: an evidence-based reviewMichael Posthumus
UCT MRC Research Unit for Exercise Science and Sports Medicine, University of Cape Town, Cape Town, South Africa
Phys Sportsmed 39:62-73. 2011..These data should be used to establish multifactorial risk factor models designed to identify individuals at high risk of sustaining an ACL injury... - The association between the COL12A1 gene and anterior cruciate ligament rupturesMichael Posthumus
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Br J Sports Med 44:1160-5. 2010..Type XII collagen, similarly to types I and V collagen, is a structural component of the ligament fibril and is encoded by a single gene, COL12A1... - The COL5A1 gene is associated with increased risk of anterior cruciate ligament ruptures in female participantsMichael Posthumus
Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Am J Sports Med 37:2234-40. 2009..The COL5A1 gene, which encodes for the alpha1 chain of type V collagen, has been shown to be associated with Achilles tendon injuries... - The COL1A1 gene and acute soft tissue rupturesMalcolm Collins
South African Medical Research Council, Cape Town, South Africa
Br J Sports Med 44:1063-4. 2010..0001) groups. This combined analysis indicates that the TT genotype appears to be protective against acute soft tissue ruptures and should be incorporated into multifactorial models determining risk of acute soft tissue ruptures... 
The COL5A1 gene, ultra-marathon running performance, and range of motionJames C Brown
Department of Human Biology, University of Cape Town, Cape Town, South Africa
Int J Sports Physiol Perform 6:485-96. 2011..The aim of this study was to investigate whether COL5A1 is associated with ultra-marathon running performance and whether this relationship could be partly explained by prerace SR ROM...- Investigation of the Sp1-binding site polymorphism within the COL1A1 gene in participants with Achilles tendon injuries and controlsMichael Posthumus
UCT MRC Research Unit for Exercise Science and Sports Medicine of the Department of Human Biology, Faculty of Health Sciences, University of Cape Town, South Africa
J Sci Med Sport 12:184-9. 2009..In conclusion, this study has shown that there is no association between the Sp1-binding site polymorphism within the first intron of COL1A1 and Achilles tendinopathy or Achilles tendon rupture within the population studied... - The COL5A1 gene: a novel marker of endurance running performanceMichael Posthumus
UCT MRC Research Unit for Exercise Science and Sports Medicine of the Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Med Sci Sports Exerc 43:584-9. 2011..Type V collagen is a quantitatively minor fibrillar collagen, which is believed to regulate fibrillogenesis within tendons and other connective tissue... - Type V collagen genotype and exercise-related phenotype relationships: a novel hypothesisMalcolm Collins
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town and the South African Medical Research Council, Newlands 7925, South Africa
Exerc Sport Sci Rev 39:191-8. 2011..We therefore hypothesize that variants in the COL5A1 gene alter fibril architecture and structure and, thereby, mechanical properties... - The COL5A1 Gene, Ultra-Marathon Running Performance, and Range of MotionJames C Brown
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Int J Sports Physiol Perform 6:485-96. 2011..The aim of this study was to investigate whether COL5A1 is associated with ultra-marathon running performance and whether this relationship could be partly explained by prerace SR ROM... - Collagen genes and exercise-associated muscle crampingKEVIN O'CONNELL
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Clin J Sport Med 23:64-9. 2013..Specifically, the aim of this study was to investigate if the COL5A1 rs12722 (C/T), COL3A1 rs1800255 (G/A), COL6A1 rs35796750 (T/C), and COL12A1 rs970547 (A/G) polymorphisms are associated with a history of EAMC...