Michael Posthumus

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. doi The intrinsic risk factors for ACL ruptures: an evidence-based review
    Michael Posthumus
    UCT MRC Research Unit for Exercise Science and Sports Medicine, University of Cape Town, Cape Town, South Africa
    Phys Sportsmed 39:62-73. 2011
  2. doi A functional variant within the MMP3 gene does not associate with human range of motion
    Michael Posthumus
    The Division of Health and Life Sciences, University of Northampton, Northampton, United Kingdom
    J Sci Med Sport 13:630-2. 2010
  3. doi Components of the transforming growth factor-beta family and the pathogenesis of human Achilles tendon pathology--a genetic association study
    Michael Posthumus
    The Division of Health and Life Sciences, School of Health, University of Northampton, Park Campus, Northampton, UK
    Rheumatology (Oxford) 49:2090-7. 2010
  4. doi Association of type XI collagen genes with chronic Achilles tendinopathy in independent populations from South Africa and Australia
    Melanie Hay
    MRC UCT Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa
    Br J Sports Med 47:569-74. 2013
  5. doi The association between the COL12A1 gene and anterior cruciate ligament ruptures
    Michael Posthumus
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Br J Sports Med 44:1160-5. 2010
  6. doi Investigation of variants within the COL27A1 and TNC genes and Achilles tendinopathy in two populations
    Colleen J Saunders
    MRC UCT Research Unit for Exercise Science and Sports Medicine of the Department of Human Biology, Faculty of Health Sciences, University of Cape Town, PO Box 115, Newlands 7725, South Africa
    J Orthop Res 31:632-7. 2013
  7. doi The COL5A1 gene is associated with increased risk of anterior cruciate ligament ruptures in female participants
    Michael Posthumus
    Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Am J Sports Med 37:2234-40. 2009
  8. doi The COL1A1 gene and acute soft tissue ruptures
    Malcolm Collins
    South African Medical Research Council, Cape Town, South Africa
    Br J Sports Med 44:1063-4. 2010
  9. ncbi The COL5A1 gene, ultra-marathon running performance, and range of motion
    James C Brown
    Department of Human Biology, University of Cape Town, Cape Town, South Africa
    Int J Sports Physiol Perform 6:485-96. 2011
  10. doi No association between COL3A1, COL6A1 or COL12A1 gene variants and range of motion
    KEVIN O'CONNELL
    MRC UCT Research Unit for Exercise Science and Sports Medicine, University of Cape Town, Human Biology, Cape Town, South Africa
    J Sports Sci 31:181-7. 2013

Collaborators

Detail Information

Publications17

  1. doi The intrinsic risk factors for ACL ruptures: an evidence-based review
    Michael Posthumus
    UCT MRC Research Unit for Exercise Science and Sports Medicine, University of Cape Town, Cape Town, South Africa
    Phys Sportsmed 39:62-73. 2011
    ..These data should be used to establish multifactorial risk factor models designed to identify individuals at high risk of sustaining an ACL injury...
  2. doi A functional variant within the MMP3 gene does not associate with human range of motion
    Michael Posthumus
    The Division of Health and Life Sciences, University of Northampton, Northampton, United Kingdom
    J Sci Med Sport 13:630-2. 2010
    ..494; R-SLR, P=0.435; SR, P=0.266). Furthermore, there was no evidence of an interaction between the COL5A1 BstUI RFLP and the MMP3 rs679620 variant. Our study suggests that the MMP3 rs679620 variant does not associate with passive ROM...
  3. doi Components of the transforming growth factor-beta family and the pathogenesis of human Achilles tendon pathology--a genetic association study
    Michael Posthumus
    The Division of Health and Life Sciences, School of Health, University of Northampton, Park Campus, Northampton, UK
    Rheumatology (Oxford) 49:2090-7. 2010
    ....
  4. doi Association of type XI collagen genes with chronic Achilles tendinopathy in independent populations from South Africa and Australia
    Melanie Hay
    MRC UCT Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa
    Br J Sports Med 47:569-74. 2013
    ..We investigated the association of these three polymorphisms with Achilles tendinopathy (AT) and whether these polymorphisms interact with COL5A1 to modulate the risk of AT...
  5. doi The association between the COL12A1 gene and anterior cruciate ligament ruptures
    Michael Posthumus
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Br J Sports Med 44:1160-5. 2010
    ..Type XII collagen, similarly to types I and V collagen, is a structural component of the ligament fibril and is encoded by a single gene, COL12A1...
  6. doi Investigation of variants within the COL27A1 and TNC genes and Achilles tendinopathy in two populations
    Colleen J Saunders
    MRC UCT Research Unit for Exercise Science and Sports Medicine of the Department of Human Biology, Faculty of Health Sciences, University of Cape Town, PO Box 115, Newlands 7725, South Africa
    J Orthop Res 31:632-7. 2013
    ..This region may have functional effects on the transcription, structure and properties of tenascin-C and the alpha-1 chain of type XXVII collagen...
  7. doi The COL5A1 gene is associated with increased risk of anterior cruciate ligament ruptures in female participants
    Michael Posthumus
    Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Am J Sports Med 37:2234-40. 2009
    ..The COL5A1 gene, which encodes for the alpha1 chain of type V collagen, has been shown to be associated with Achilles tendon injuries...
  8. doi The COL1A1 gene and acute soft tissue ruptures
    Malcolm Collins
    South African Medical Research Council, Cape Town, South Africa
    Br J Sports Med 44:1063-4. 2010
    ..0001) groups. This combined analysis indicates that the TT genotype appears to be protective against acute soft tissue ruptures and should be incorporated into multifactorial models determining risk of acute soft tissue ruptures...
  9. ncbi The COL5A1 gene, ultra-marathon running performance, and range of motion
    James C Brown
    Department of Human Biology, University of Cape Town, Cape Town, South Africa
    Int J Sports Physiol Perform 6:485-96. 2011
    ..The aim of this study was to investigate whether COL5A1 is associated with ultra-marathon running performance and whether this relationship could be partly explained by prerace SR ROM...
  10. doi No association between COL3A1, COL6A1 or COL12A1 gene variants and range of motion
    KEVIN O'CONNELL
    MRC UCT Research Unit for Exercise Science and Sports Medicine, University of Cape Town, Human Biology, Cape Town, South Africa
    J Sports Sci 31:181-7. 2013
    ..Further studies are required to identify additional intrinsic and extrinsic factors that may determine range of motion, including the genetic component...
  11. doi Collagen genes and exercise-associated muscle cramping
    KEVIN O'CONNELL
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Clin J Sport Med 23:64-9. 2013
    ..Specifically, the aim of this study was to investigate if the COL5A1 rs12722 (C/T), COL3A1 rs1800255 (G/A), COL6A1 rs35796750 (T/C), and COL12A1 rs970547 (A/G) polymorphisms are associated with a history of EAMC...
  12. doi Investigation of the Sp1-binding site polymorphism within the COL1A1 gene in participants with Achilles tendon injuries and controls
    Michael Posthumus
    UCT MRC Research Unit for Exercise Science and Sports Medicine of the Department of Human Biology, Faculty of Health Sciences, University of Cape Town, South Africa
    J Sci Med Sport 12:184-9. 2009
    ..In conclusion, this study has shown that there is no association between the Sp1-binding site polymorphism within the first intron of COL1A1 and Achilles tendinopathy or Achilles tendon rupture within the population studied...
  13. doi The COL5A1 gene: a novel marker of endurance running performance
    Michael Posthumus
    UCT MRC Research Unit for Exercise Science and Sports Medicine of the Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Med Sci Sports Exerc 43:584-9. 2011
    ..Type V collagen is a quantitatively minor fibrillar collagen, which is believed to regulate fibrillogenesis within tendons and other connective tissue...
  14. doi Polymorphic variation within the ADAMTS2, ADAMTS14, ADAMTS5, ADAM12 and TIMP2 genes and the risk of Achilles tendon pathology: A genetic association study
    Louis El Khoury
    The Division of Health and Life Sciences, University of Northampton, Northampton, UK
    J Sci Med Sport 16:493-8. 2013
    ..We sought to determine whether single nucleotide polymorphisms (SNPs) within the ADAMTS2, ADAMTS5, ADAMTS14, ADAM12 and TIMP2 genes were associated with the risk of ATP in two independent populations...
  15. doi Type V collagen genotype and exercise-related phenotype relationships: a novel hypothesis
    Malcolm Collins
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town and the South African Medical Research Council, Newlands 7925, South Africa
    Exerc Sport Sci Rev 39:191-8. 2011
    ..We therefore hypothesize that variants in the COL5A1 gene alter fibril architecture and structure and, thereby, mechanical properties...
  16. ncbi The COL5A1 Gene, Ultra-Marathon Running Performance, and Range of Motion
    James C Brown
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Int J Sports Physiol Perform 6:485-96. 2011
    ..The aim of this study was to investigate whether COL5A1 is associated with ultra-marathon running performance and whether this relationship could be partly explained by prerace SR ROM...
  17. doi Risk factors for sports concussion: an evidence-based systematic review
    Shameemah Abrahams
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa
    Br J Sports Med 48:91-7. 2014
    ..Although several risk factors were identified from the appraised studies, prospective cohort studies, larger sample sizes, consistent and robust measures of risk should be employed in future research. ..