John M Pettifor

Summary

Affiliation: University of the Witwatersrand
Country: South Africa

Publications

  1. ncbi Rickets
    John M Pettifor
    MRC Mineral Metabolism Research Unit, Department of Paediatrics, University of the Witwatersrand, P O Bertsham 2013, South Africa
    Calcif Tissue Int 70:398-9. 2002
  2. ncbi Vitamin D metabolism in a frugivorous nocturnal mammal, the Egyptian fruit bat (Rousettus aegyptiacus)
    Meropi Cavaleros
    Department of Paediatrics, University of the Witwatersrand, Johannesburg, 7 York Road, 2193, South Africa
    Gen Comp Endocrinol 133:109-17. 2003
  3. ncbi Nutritional rickets: deficiency of vitamin D, calcium, or both?
    John M Pettifor
    Medical Research Council Mineral Metabolism Research Unit, Department of Paediatrics, Chris Hani Baragwanath Hospital and the University of the Witwatersrand, Johannesburg, South Africa
    Am J Clin Nutr 80:1725S-9S. 2004
  4. ncbi Rickets and vitamin D deficiency in children and adolescents
    John M Pettifor
    Department of Paediatrics, Chris Hani Baragwanath Hospital, Soweto 2013, South Africa
    Endocrinol Metab Clin North Am 34:537-53, vii. 2005
  5. ncbi Comment: childhood nutrition and social support
    John M Pettifor
    Department of Paediatrics, University of Witwatersrand and Chris Hani Baragwanath Hospital, South Africa
    Scand J Public Health Suppl 69:128-9. 2007
  6. ncbi Nutritional rickets: pathogenesis and prevention
    John M Pettifor
    MRC Wits Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    Pediatr Endocrinol Rev 10:347-53. 2013
  7. doi Hypophosphatemic rickets: unraveling the role of FGF23
    John M Pettifor
    MRC Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, Faculty of Health Sciences, University of the Witwatersrand, 7 York Rd, Parktown, Johannesburg 2193, South Africa
    Calcif Tissue Int 91:297-306. 2012
  8. pmc What's new in hypophosphataemic rickets?
    John M Pettifor
    MRC Mineral Metabolism Research Unit, Department of Paediatrics, Chris Hani Baragwanath Hospital, University of the Witwatersrand, PO Bertsham 2013, Johannesburg, South Africa
    Eur J Pediatr 167:493-9. 2008
  9. ncbi Vitamin D &/or calcium deficiency rickets in infants & children: a global perspective
    John M Pettifor
    Department of Paediatrics, Chris Hani Baragwanath Hospital and the University of the Witwatersrand Johannesburg, South Africa
    Indian J Med Res 127:245-9. 2008
  10. doi The role of vitamin D in paediatric bone health
    John M Pettifor
    MRC Mineral Metabolism Research Unit, Department of Paediatrics, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, York Road, Parktown 2193, Johannesburg, South Africa
    Best Pract Res Clin Endocrinol Metab 25:573-84. 2011

Collaborators

Detail Information

Publications47

  1. ncbi Rickets
    John M Pettifor
    MRC Mineral Metabolism Research Unit, Department of Paediatrics, University of the Witwatersrand, P O Bertsham 2013, South Africa
    Calcif Tissue Int 70:398-9. 2002
  2. ncbi Vitamin D metabolism in a frugivorous nocturnal mammal, the Egyptian fruit bat (Rousettus aegyptiacus)
    Meropi Cavaleros
    Department of Paediatrics, University of the Witwatersrand, Johannesburg, 7 York Road, 2193, South Africa
    Gen Comp Endocrinol 133:109-17. 2003
    ....
  3. ncbi Nutritional rickets: deficiency of vitamin D, calcium, or both?
    John M Pettifor
    Medical Research Council Mineral Metabolism Research Unit, Department of Paediatrics, Chris Hani Baragwanath Hospital and the University of the Witwatersrand, Johannesburg, South Africa
    Am J Clin Nutr 80:1725S-9S. 2004
    ..Dietary calcium deficiency and vitamin D deficiency represent 2 ends of the spectrum for the pathogenesis of nutritional rickets, with a combination of the 2 in the middle...
  4. ncbi Rickets and vitamin D deficiency in children and adolescents
    John M Pettifor
    Department of Paediatrics, Chris Hani Baragwanath Hospital, Soweto 2013, South Africa
    Endocrinol Metab Clin North Am 34:537-53, vii. 2005
    ..The worldwide nature of the problem is described. Preventive strategies are discussed, and various treatment options are provided...
  5. ncbi Comment: childhood nutrition and social support
    John M Pettifor
    Department of Paediatrics, University of Witwatersrand and Chris Hani Baragwanath Hospital, South Africa
    Scand J Public Health Suppl 69:128-9. 2007
  6. ncbi Nutritional rickets: pathogenesis and prevention
    John M Pettifor
    MRC Wits Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    Pediatr Endocrinol Rev 10:347-53. 2013
    ....
  7. doi Hypophosphatemic rickets: unraveling the role of FGF23
    John M Pettifor
    MRC Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, Faculty of Health Sciences, University of the Witwatersrand, 7 York Rd, Parktown, Johannesburg 2193, South Africa
    Calcif Tissue Int 91:297-306. 2012
    ..Phase 1 and phase 2 trials in humans with X-linked hypophosphatemic rickets are currently under way...
  8. pmc What's new in hypophosphataemic rickets?
    John M Pettifor
    MRC Mineral Metabolism Research Unit, Department of Paediatrics, Chris Hani Baragwanath Hospital, University of the Witwatersrand, PO Bertsham 2013, Johannesburg, South Africa
    Eur J Pediatr 167:493-9. 2008
    ..Although our understanding of the interrelationships is far from complete, it raises the possibilities of improved therapeutic agents in the long-term, and has resulted in improved diagnostic abilities in the short-term...
  9. ncbi Vitamin D &/or calcium deficiency rickets in infants & children: a global perspective
    John M Pettifor
    Department of Paediatrics, Chris Hani Baragwanath Hospital and the University of the Witwatersrand Johannesburg, South Africa
    Indian J Med Res 127:245-9. 2008
    ..Yet we are still unclear as to the factors which predispose some children to the disease...
  10. doi The role of vitamin D in paediatric bone health
    John M Pettifor
    MRC Mineral Metabolism Research Unit, Department of Paediatrics, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, York Road, Parktown 2193, Johannesburg, South Africa
    Best Pract Res Clin Endocrinol Metab 25:573-84. 2011
    ..Further studies are needed in these areas prior to definitive conclusions are drawn about the optimal vitamin D requirements and circulating 25(OH)D concentrations for foetal, infant and childhood bone health...
  11. doi Investigation into longitudinal dietary behaviours and household socio-economic indicators and their association with BMI Z-score and fat mass in South African adolescents: the Birth to Twenty (Bt20) cohort
    Alison B Feeley
    MRC Wits Developmental Pathways for Health Research Unit, School of Medicine, University of the Witwatersrand, 7 York Road, Parktown, 2193 Johannesburg, South Africa
    Public Health Nutr 16:693-703. 2013
    ..The present study aimed to assess the relationship between dietary habits, change in socio-economic status and BMI Z-score and fat mass in a cohort of South African adolescents...
  12. pmc Nutritional status and HIV in rural South African children
    Elizabeth W Kimani-Murage
    MRC Wits Rural Public Health and Health Transitions Research Unit Agincourt, School of Public Health, Faculty of Health Sciences, University of Witwatersrand, South Africa
    BMC Pediatr 11:23. 2011
    ..This study describes HIV prevalence in children, patterns of malnutrition by HIV status and determinants of nutritional status...
  13. doi Heterogeneity of fracture pathogenesis in urban South African children: the birth to twenty cohort
    Kebashni Thandrayen
    MRC Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa
    J Bone Miner Res 26:2834-42. 2011
    ..No contributing factors in black males and females were found, and needs further elucidation...
  14. pmc In urban South Africa, 16 year old adolescents experience greater health equality than children
    Paula L Griffiths
    Centre for Global Health and Human Development, School of Sport, Exercise and Health Sciences, Loughborough University, UK MRC Wits Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Electronic address
    Econ Hum Biol 11:502-14. 2013
    ..This is in contrast to earlier findings with Bt20 9-10 year olds where SES inequalities in body composition were observed. Findings suggest targeting obesity interventions at females in households where a mother has a high BMI. ..
  15. ncbi Infant programming of bone size and bone mass in 10-year-old black and white South African children
    Linda Vidulich
    MRC Mineral Metabolism Research Unit, Department of Paediatrics, University of the Witwatersrand, Johannesburg, South Africa
    Paediatr Perinat Epidemiol 21:354-62. 2007
    ....
  16. doi Factors influencing the vitamin D status of 10-year-old urban South African children
    Machuene A Poopedi
    MRC Mineral Metabolism Research Unit and Birth to Twenty Research Programme, Department of Paediatrics and Child Health, Chris Hani Baragwanath Hospital, The University of the Witwatersrand, PO Bertsham, 2013 Johannesburg, South Africa
    Public Health Nutr 14:334-9. 2011
    ..Assessment of vitamin D status in a cohort of healthy 10-year-old urban children and the factors that influence vitamin D status in these children...
  17. pmc Predictors of adolescent weight status and central obesity in rural South Africa
    Elizabeth W Kimani-Murage
    MRC Wits Rural Public Health and Health Transitions Research Unit Agincourt, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    Public Health Nutr 14:1114-22. 2011
    ..To investigate predictors of adolescent obesity in rural South Africa...
  18. ncbi Maternal vitamin D status: implications for the development of infantile nutritional rickets
    Kebashni Thandrayen
    MRC Mineral Metabolism Research Unit, Department of Pediatrics, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa
    Endocrinol Metab Clin North Am 39:303-20, table of contents. 2010
    ..Operational research studies are needed to understand the best methods of implementing supplementation programs and the factors that are likely to impede their success...
  19. ncbi Current socio-economic measures, and not those measured during infancy, affect bone mass in poor urban South african children
    Shane A Norris
    Department of Paediatrics, MRC Mineral Metabolism Research Unit, University of the Witwatersrand, Johannesburg, South Africa
    J Bone Miner Res 23:1409-16. 2008
    ..SES has a significant independent effect on whole body BMC through its impact on BA. This suggests that poverty alleviation policies in South Africa could have a positive effect on bone health...
  20. doi Changes in dietary habits and eating practices in adolescents living in urban South Africa: the birth to twenty cohort
    Alison Feeley
    Department of Paediatrics, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    Nutrition 28:e1-6. 2012
    ..To assess changes in the dietary habits and eating practices of a longitudinal cohort of adolescents over a 5-y period living in Soweto and Johannesburg...
  21. doi Implications of adopting the WHO 2006 Child Growth Standards: case study from urban South Africa, the Birth to Twenty cohort
    Shane A Norris
    MRC Mineral Metabolism Research Unit, Paediatrics, University of Witwatersrand and Chris Hani Baragwanath Hospital, Johannesburg, South Africa
    Ann Hum Biol 36:21-7. 2009
    ..The World Health Organization (WHO) recently developed growth standards to overcome the limitations of previous references...
  22. doi Determinants of bone size and strength in 13-year-old South African children: the influence of ethnicity, sex and pubertal maturation
    Lisa K Micklesfield
    MRC Mineral Metabolism Research Unit, Department of Paediatrics, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa
    Bone 48:777-85. 2011
    ..South African black children have wider diaphyseal regions of appendicular bones with greater measures of bone strength...
  23. pmc The prevalence of stunting, overweight and obesity, and metabolic disease risk in rural South African children
    Elizabeth W Kimani-Murage
    MRC Wits Rural Public Health and Health Transitions Research Unit Agincourt, School of Public Health, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa
    BMC Public Health 10:158. 2010
    ..This study aimed to investigate the prevalence and patterns of stunting and overweight/obesity, and hence risk for metabolic disease, in a group of children and adolescents in rural South Africa...
  24. ncbi Comparisons of body size, composition, and whole body bone mass between North American and South African children
    Lisa K Micklesfield
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, South Africa
    J Bone Miner Res 22:1869-77. 2007
    ..Our findings support the role of genetic and environmental influences in the determination of bone mass in prepubertal children...
  25. pmc Dietary intake and body composition in HIV-positive and -negative South African women
    Stephanie V Wrottesley
    1MRC Wits, Developmental Pathways for Health Research Unit DPHRU, Faculty of Health Sciences, University of the Witwatersrand Medical School, 7 York Road, Parktown 2193, Johannesburg, South Africa
    Public Health Nutr 17:1603-13. 2014
    ..The present paper examines dietary intake and body composition in antiretroviral (ARV)-naïve HIV-positive compared with HIV-negative South African women, as well as the impact of disease severity on these variables...
  26. ncbi Nutritional rickets in developing countries
    John M Pettifor
    Department of Paediatrics, Chris Hani Baragwanath Hospital, Johannesburg, South Africa
    Forum Nutr 56:176-8. 2003
  27. pmc Genetic factors influencing bone mineral content in a black South African population
    Andrew May
    Division of Human Genetics, School of Pathology, Faculty of Health Sciences, National Health Laboratory Service, University of the Witwatersrand, Watkins Pitchford Building, Room 109, Cnr Hospital and De Korte Street, Braamfontein, 2000, Johannesburg, South Africa
    J Bone Miner Metab 31:708-16. 2013
    ..Hence, our results support the existence of a strong genetic effect acting at the femoral neck in black South African children, whilst simultaneously highlighting possible causes that account for inter-ethnic bone mass diversity. ..
  28. pmc Physical activity and sedentary behavior among adolescents in rural South Africa: levels, patterns and correlates
    Lisa K Micklesfield
    MRC Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    BMC Public Health 14:40. 2014
    ..This study examines physical activity and sedentary behavior patterns, and explores associations with individual, maternal, household, and community factors amongst rural South African adolescents...
  29. ncbi Effect of ethnicity and sex on the growth of the axial and appendicular skeleton of children living in a developing country
    Lukhanyo H Nyati
    Medical Research Council Mineral Metabolism Research Unit, Department of Pediatrics and Child Health, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa
    Am J Phys Anthropol 130:135-41. 2006
    ..In conclusion, there is a differential effect of ethnicity and sex on the growth of the axial and appendicular skeletons, and regional segment length is a better predictor of site-specific bone mass than stature...
  30. ncbi Effect of adiposity, season, diet and calcium or vitamin D supplementation on the vitamin D status of healthy urban African and Asian-Indian adults
    Jaya A George
    National Health Laboratory Service, Department of Chemical Pathology, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg2193, South Africa
    Br J Nutr 112:590-9. 2014
    ..In conclusion, factors such as sun exposure, dietary supplement use and ethnicity are important determinants of plasma 25(OH)D concentrations. ..
  31. ncbi Maternal vitamin D status: implications for the development of infantile nutritional rickets
    Kebashni Thandrayen
    MRC Developmental Pathways for Health Research Unit, Deptartment of Pediatrics, Chris Hani Baragwanath Hospital, PO Bertsham, Johannesburg 2013, South Africa
    Rheum Dis Clin North Am 38:61-79. 2012
    ..Operational research studies also need to be conducted to understand the best methods of implementing supplementation programs and the factors that are likely to impede their success...
  32. ncbi Calcium absorption in Nigerian children with rickets
    Mariaelisa Graff
    Department of Foods and Nutrition, University of Utah, Salt Lake City and Chemical Pathology, University of Jos, Jos, Nigeria
    Am J Clin Nutr 80:1415-21. 2004
    ..Nutritional rickets is common in Nigerian children and responds to calcium supplementation. Low dietary calcium intakes are also common in Nigerian children with and without rickets...
  33. ncbi Nutritional rickets in ichthyosis and response to calcipotriene
    Tom D Thacher
    Department of Family Medicine, Jos University Teaching Hospital, Jos, Nigeria
    Pediatrics 114:e119-23. 2004
    ..Calcipotriene does not seem to be effective in reversing systemic vitamin D deficiency but can be effective in improving the severity of skin disease in children with ichthyosis...
  34. ncbi Comparison of cross-sectional geometry of the proximal femur in white and black women from Detroit and Johannesburg
    Dorothy A Nelson
    Department of Internal Medicine, Wayne State University, Detroit, Michigan 48201, USA
    J Bone Miner Res 19:560-5. 2004
    ..S. black (n = 86) and white (n = 151) and South African black (n = 60) and white (n = 48) postmenopausal women. Results are consistent with greater bone strength in the black groups in both countries...
  35. ncbi Regression equations to estimate percentage body fat in African prepubertal children aged 9 y
    Noel Cameron
    Department of Human Sciences, Loughborough University, United Kingdom
    Am J Clin Nutr 80:70-5. 2004
    ..These equations contain methodologic problems that could make them inappropriate for African children...
  36. ncbi Stunting at 2 years in relation to body composition at 9 years in African urban children
    Noel Cameron
    Department of Human Sciences, Loughborough University, Loughborough LE11 3TU, United Kingdom
    Obes Res 13:131-6. 2005
    ..To determine whether African urban children who were stunted at 2 years of age demonstrated an altered body composition by the end of childhood, before entering puberty, at 9 years of age...
  37. doi Adaptation of calcium absorption during treatment of nutritional rickets in Nigerian children
    Gloria E Oramasionwu
    Department of Pediatrics, USDA ARS Children s Nutrition Research Center, Baylor College of Medicine and Texas Children s Hospital, Houston, Texas 77030, USA
    Br J Nutr 100:387-92. 2008
    ..These data demonstrate that although absorptive capacity is regulated by supplementation, recovery from rickets likely occurs through efficient use of both dietary and supplemental Ca...
  38. ncbi Vitamin D and/or calcium deficiency rickets in infants and children: a concern for developing countries?
    John M Pettifor
    Indian Pediatr 44:893-5. 2007
  39. ncbi Pediatric vitamin D and calcium nutrition in developing countries
    Philip R Fischer
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Rev Endocr Metab Disord 9:181-92. 2008
    ....
  40. pmc Rickets: an overview and future directions, with special reference to Bangladesh. A summary of the Rickets Convergence Group meeting, Dhaka, 26-27 January 2006
    Thierry Craviari
    Centre Hospitalier de Gap, Gap, France
    J Health Popul Nutr 26:112-21. 2008
    ..Effective preventive measures that can feasibly reach entire communities are needed, and these may differ between various affected regions...
  41. doi FGF23 is elevated in Gambian children with rickets
    Ann Prentice
    MRC Keneba, The Gambia
    Bone 42:788-97. 2008
    ....
  42. ncbi Rickets: vitamin D and calcium deficiency
    Tom D Thacher
    J Bone Miner Res 22:638; author reply 639. 2007
  43. ncbi Early response to vitamin D2 in children with calcium deficiency rickets
    Tom D Thacher
    Department of Family Medicine, Jos University Teaching Hospital, University of Jos, Jos, Nigeria
    J Pediatr 149:840-4. 2006
    ..To assess the effect of vitamin D(2) administration on serum vitamin D metabolite concentrations in calcium deficiency rickets...
  44. ncbi Case-control study of breast milk calcium in mothers of children with and without nutritional rickets
    Tom D Thacher
    Department of Family Medicine, Jos University Teaching Hospital, Nigeria
    Acta Paediatr 95:826-32. 2006
    ....
  45. ncbi Nutritional rickets around the world: causes and future directions
    Tom D Thacher
    Department of Family Medicine, Jos University Teaching Hospital, Nigeria
    Ann Trop Paediatr 26:1-16. 2006
    ..Nutritional rickets has been described from at least 59 countries in the last 20 years. Its spectrum of causes differs in different regions of the world...
  46. ncbi The usefulness of clinical features to identify active rickets
    Tom D Thacher
    Department of Family Medicine, Jos University Teaching Hospital, Nigeria
    Ann Trop Paediatr 22:229-37. 2002
    ..We conclude that clinical features can be used to identify children with active rickets...
  47. ncbi Vertical HIV transmission in South Africa: translating research into policy and practice
    Salim Abdool Karim
    University of Natal, 4041, South Africa
    Lancet 359:992-3. 2002