L H Opie

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. ncbi request reprint H-89, a non-specific inhibitor of protein kinase A, promotes post-ischemic cardiac contractile recovery and reduces infarct size
    Siyanda Makaula
    Hatter Institute for Cardiology Research and Servier Heart Failure Laboratory, University of Cape Town Faculty of Health Sciences, South Africa
    J Cardiovasc Pharmacol 45:341-7. 2005
  2. ncbi request reprint Controversies in cardiology
    Lionel H Opie
    Hatter Heart Research Institute, Chris Barnard Building, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town 7925, South Africa
    Lancet 367:13-4. 2006
  3. ncbi request reprint Controversies in ventricular remodelling
    Lionel H Opie
    Hatter Institute for Heart Research, Cape Heart Centre and Department of Medicine, University of Cape Town Faculty of Health Sciences, Observatory 7925, Cape Town, South Africa
    Lancet 367:356-67. 2006
  4. pmc Signal transducer and activator of transcription 3 is involved in the cardioprotective signalling pathway activated by insulin therapy at reperfusion
    Britt N Fuglesteg
    Dept of Medical Physiology, Faculty of Medicine, University of Tromsø, 9037, Tromsø, Norway
    Basic Res Cardiol 103:444-53. 2008
  5. ncbi request reprint Metabolic plasticity and the promotion of cardiac protection in ischemia and ischemic preconditioning
    Lionel H Opie
    Hatter Institute for Cardiology Research and Medical Research Council Inter University Cape Heart Group, Cape Heart Centre, University of Cape Town Medical School, South Africa
    J Mol Cell Cardiol 34:1077-89. 2002
  6. ncbi request reprint Antihypertensive effects of angiotensin converting enzyme inhibition by lisinopril in post-transplant patients
    Lionel H Opie
    Hypertension Clinic, Department of Medicine, Groote Schuur Hospital and Cape Heart Centre, University of Cape Town, Observatory, South Africa
    Am J Hypertens 15:911-6. 2002
  7. ncbi request reprint Calcium channel blockers in hypertension: reappraisal after new trials and major meta-analyses
    L H Opie
    Cape Heart Centre, University of Cape Town, South Africa
    Am J Hypertens 14:1074-81. 2001
  8. ncbi request reprint Enhanced angiotensin II activity in heart failure: reevaluation of the counterregulatory hypothesis of receptor subtypes
    L H Opie
    Hatter Institute and Medical Research Council Inter University Cape Heart Group, University of Cape Town Medical School, Cape Town, South Africa
    Circ Res 88:654-8. 2001
  9. ncbi request reprint First line drugs in chronic stable effort angina--the case for newer, longer-acting calcium channel blocking agents
    L H Opie
    Heart Research Unit and Hatter Institute, Cape Heart Center, University of Cape Town, South Africa
    J Am Coll Cardiol 36:1967-71. 2000
  10. ncbi request reprint Controversies in stable coronary artery disease
    Lionel H Opie
    Hatter Institute for Heart Research, Cape Heart Centre and Department of Medicine, University of Cape Town Medical School, Observatory 7925, South Africa
    Lancet 367:69-78. 2006

Collaborators

Detail Information

Publications84

  1. ncbi request reprint H-89, a non-specific inhibitor of protein kinase A, promotes post-ischemic cardiac contractile recovery and reduces infarct size
    Siyanda Makaula
    Hatter Institute for Cardiology Research and Servier Heart Failure Laboratory, University of Cape Town Faculty of Health Sciences, South Africa
    J Cardiovasc Pharmacol 45:341-7. 2005
    ..PKA-inhibition by H-89 further decreased infarct size beyond preconditioning or forskolin. Despite the reservation that H-89 could be non-selective in its actions, we propose H-89 as a candidate cardioprotective agent...
  2. ncbi request reprint Controversies in cardiology
    Lionel H Opie
    Hatter Heart Research Institute, Chris Barnard Building, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town 7925, South Africa
    Lancet 367:13-4. 2006
  3. ncbi request reprint Controversies in ventricular remodelling
    Lionel H Opie
    Hatter Institute for Heart Research, Cape Heart Centre and Department of Medicine, University of Cape Town Faculty of Health Sciences, Observatory 7925, Cape Town, South Africa
    Lancet 367:356-67. 2006
    ....
  4. pmc Signal transducer and activator of transcription 3 is involved in the cardioprotective signalling pathway activated by insulin therapy at reperfusion
    Britt N Fuglesteg
    Dept of Medical Physiology, Faculty of Medicine, University of Tromsø, 9037, Tromsø, Norway
    Basic Res Cardiol 103:444-53. 2008
    ..To evaluate the significance of the JAK-STAT pathway in insulin-induced cardioprotection from reperfusion injury...
  5. ncbi request reprint Metabolic plasticity and the promotion of cardiac protection in ischemia and ischemic preconditioning
    Lionel H Opie
    Hatter Institute for Cardiology Research and Medical Research Council Inter University Cape Heart Group, Cape Heart Centre, University of Cape Town Medical School, South Africa
    J Mol Cell Cardiol 34:1077-89. 2002
    ..In this review we discuss studies that demonstrate how metabolic plasticity can promote cardioprotection against ischemia and reperfusion injury and highlight areas that require further characterization...
  6. ncbi request reprint Antihypertensive effects of angiotensin converting enzyme inhibition by lisinopril in post-transplant patients
    Lionel H Opie
    Hypertension Clinic, Department of Medicine, Groote Schuur Hospital and Cape Heart Centre, University of Cape Town, Observatory, South Africa
    Am J Hypertens 15:911-6. 2002
    ..The secondary objective was to monitor echocardiographic and hemodynamic end points...
  7. ncbi request reprint Calcium channel blockers in hypertension: reappraisal after new trials and major meta-analyses
    L H Opie
    Cape Heart Centre, University of Cape Town, South Africa
    Am J Hypertens 14:1074-81. 2001
    ..In conclusion, overall CCB are neither better nor worse than conventional therapy, allowing for possible small differences in stroke and MI. The ACE inhibitors may protect better, although data are incomplete...
  8. ncbi request reprint Enhanced angiotensin II activity in heart failure: reevaluation of the counterregulatory hypothesis of receptor subtypes
    L H Opie
    Hatter Institute and Medical Research Council Inter University Cape Heart Group, University of Cape Town Medical School, Cape Town, South Africa
    Circ Res 88:654-8. 2001
    ..In this review, we conclude that the collective evidence does not strongly support a net beneficial effect of AT(2) stimulation in the diseased myocardium...
  9. ncbi request reprint First line drugs in chronic stable effort angina--the case for newer, longer-acting calcium channel blocking agents
    L H Opie
    Heart Research Unit and Hatter Institute, Cape Heart Center, University of Cape Town, South Africa
    J Am Coll Cardiol 36:1967-71. 2000
    ..The choice of drug should be keyed to the needs and the pathophysiology of the individual patient...
  10. ncbi request reprint Controversies in stable coronary artery disease
    Lionel H Opie
    Hatter Institute for Heart Research, Cape Heart Centre and Department of Medicine, University of Cape Town Medical School, Observatory 7925, South Africa
    Lancet 367:69-78. 2006
    ..Thus, effort angina needs comprehensive assessment, lifestyle changes, and treatment tailored to the individual patient...
  11. ncbi request reprint Old antihypertensives and new diabetes
    Lionel H Opie
    Hypertension Clinic, Department of Medicine, Groote Schuur Hospital and Hatter Institute, Cape Heart Centre, University of Cape Town Faculty of Health Sciences, Observatory, Cape Town, South Africa
    J Hypertens 22:1453-8. 2004
    ..Therefore endothelial changes could help to explain the benefits of 'modern' treatment compared with the defects of conventional therapy...
  12. ncbi request reprint Preconditioning and metabolic anti-ischaemic agents
    Lionel H Opie
    Hatter Institute for Cardiology Research, University of Cape Town Faculty of Health Sciences, Cape Town, South Africa
    Eur Heart J 24:1854-6. 2003
    ..By lessening the oxygen-wasting effects of fatty acids, they are mitochondrial protective and oxygen-sparing. These qualities should help in the therapy of myocardial ischemia and also heart failure...
  13. ncbi request reprint Angina pectoris: the evolution of concepts
    Lionel H Opie
    Faculty of Health Sciences, University of Cape Town, South Africa
    J Cardiovasc Pharmacol Ther 9:S3-9. 2004
  14. ncbi request reprint Evidence-based evaluation of calcium channel blockers for hypertension: equality of mortality and cardiovascular risk relative to conventional therapy
    Lionel H Opie
    Hatter Institute, Department of Medicine, Cape Heart Center, University of Cape Town Medical School, Cape Town, South Africa
    J Am Coll Cardiol 39:315-22. 2002
    ....
  15. ncbi request reprint Hypertension in sub-Saharan African populations
    Lionel H Opie
    Hatter Institute for Cardiology Research, University of Cape Town, Cape Town, South Africa
    Circulation 112:3562-8. 2005
    ..Hypertension in sub-Saharan Africa is a widespread problem of immense economic importance because of its high prevalence in urban areas, its frequent underdiagnosis, and the severity of its complications...
  16. ncbi request reprint The metabolic vicious cycle in heart failure
    Lionel H Opie
    Hatter Institute, Department of Medicine, Faculty of Health Sciences, University of Cape Town Medical School, Cape Town, South Africa
    Lancet 364:1733-4. 2004
  17. ncbi request reprint Tedisamil in coronary disease: additional benefits in the therapy of atrial fibrillation?
    Lionel H Opie
    Hatter Institute, Cape Heart Center, University of Cape Town Medical School, South Africa
    J Cardiovasc Pharmacol Ther 8:S33-7. 2003
    ..Hence, the double properties of tedisamil as a drug that both inhibits atrial fibrillation and acts in an anti-ischemic mode are an attractive basis for future clinical research...
  18. ncbi request reprint Glucose delivery is a major determinant of glucose utilisation in the ischemic myocardium with a residual coronary flow
    L M King
    MRC UCT Ischemic Heart Disease Research Unit, UCT Medical School, Observatory, Cape Town, South Africa
    Cardiovasc Res 39:381-92. 1998
    ..To resolve this contradiction, we investigated glucose uptake at very low coronary flows in the isolated rat heart model...
  19. doi request reprint Dual activation of STAT-3 and Akt is required during the trigger phase of ischaemic preconditioning
    Naushaad Suleman
    Hatter Cardiovascular Research Institute, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Private Bag 3, 7935 Observatory, South Africa
    Cardiovasc Res 79:127-33. 2008
    ..Conversely, we proposed that there would be no such interaction when preconditioning was induced by TNFalpha (TNF-PC)...
  20. ncbi request reprint Effects of mibefradil, a novel calcium channel blocking agent with T-type activity, in acute experimental myocardial ischemia: maintenance of ventricular fibrillation threshold without inotropic compromise
    C A Muller
    Medical Research Council Heart Research Group, Cape Heart Centre, University of Cape Town, South Africa
    J Am Coll Cardiol 32:268-74. 1998
    ....
  21. ncbi request reprint Qualities of an ideal beta-adrenoceptor antagonist and comparison of existing agents with a new cardioselective hydrophilic vasodilator beta-adrenoceptor antagonist, celiprolol
    L H Opie
    Department of Medicine, University of Cape Town, Observatory, South Africa
    Am J Cardiol 61:8C-13C. 1988
    ..Further testing is indicated, particularly in relation to effects on epinephrine-induced hypokalemia, blood lipid profiles, clinical vasodilatory properties and effects on the quality of life, especially in geriatric patients...
  22. ncbi request reprint Hypertension, the changing pattern of drug usage
    L H Opie
    Hatter Institute for Cardiovascular Research, Department of Medicine, Chris Barnard Building, Faculty of Health Sciences, University of Cape Town, Observatory
    Cardiovasc J Afr 20:52-6. 2009
    ..In assessing the value of potentially conflicting evidence, attention should be paid to the hierarchy of evidence, which works its way up through 10 steps from isolated case reports to integrated knowledge...
  23. ncbi request reprint Combination of a calcium antagonist, verapamil, with an angiotensin converting enzyme inhibitor, trandolapril, in experimental myocardial ischemia and reperfusion: antiarrhythmic and hemodynamic effects of chronic oral pretreatment
    C A Muller
    Medical Research Council Heart Research Group, Cape Heart Centre, University of Cape Town, South Africa
    Cardiovasc Drugs Ther 12:449-55. 1998
    ..Thus the addition of the ACE inhibitor trandolapril to the calcium antagonist verapamil resulted in antiarrhythmic activity during ischemia and reperfusion, and produced a better hemodynamic profile...
  24. ncbi request reprint Current status of safety and efficacy of calcium channel blockers in cardiovascular diseases: a critical analysis based on 100 studies
    L H Opie
    University of Cape Town, South Africa
    Prog Cardiovasc Dis 43:171-96. 2000
    ....
  25. ncbi request reprint Cardiac metabolism in ischemic heart disease
    L H Opie
    Heart Research Unit, Cape Heart Centre, University of Cape Town, Medical School, South Africa
    Arch Mal Coeur Vaiss 92:1755-60. 1999
    ..Metabolic therapy acting to protect the ischemic cell deserves more attention...
  26. ncbi request reprint Calcium channel blockers for hypertension: dissecting the evidence for adverse effects
    L H Opie
    MRC Unit for Ischaemic Heart Disease, University of Cape Town, South Africa
    Am J Hypertens 10:565-77. 1997
    ....
  27. ncbi request reprint Dinitrophenol, cyclosporin A, and trimetazidine modulate preconditioning in the isolated rat heart: support for a mitochondrial role in cardioprotection
    J Minners
    The Hatter Institute for Cardiology Research, Interuniversity Cape Heart Research Group of the Medical Research Council, University of Cape Town Medical School, Observatory, 7925, Cape Town, South Africa
    Cardiovasc Res 47:68-73. 2000
    ..We hypothesized that the modulation of mitochondrial homeostasis might confer preconditioning-like cardioprotection...
  28. ncbi request reprint Comparison of respiratory effects of two cardioselective beta-blockers, celiprolol and atenolol, in asthmatics with mild to moderate hypertension
    A I van Zyl
    Ischaemic Heart Disease Research Unit, University of Cape Town, South Africa
    Chest 95:209-13. 1989
    ..When given acutely, celiprolol appeared to have acute bronchosparing properties, possibly providing a greater margin of respiratory safety than atenolol...
  29. ncbi request reprint The choice of first-line therapy: rationale for low-dose combinations of an angiotensin converting enzyme inhibitor and a diuretic
    L H Opie
    Heart Research Unit, University of Cape Town, Medical School Observatory, South Africa
    J Hypertens Suppl 19:S17-21. 2001
    ..The two drug classes may have a synergistic effect on hypertensive target organ disease and blood pressure. Triple therapy with a calcium antagonist may be needed to achieve blood pressure control in more severely hypertensive patients...
  30. ncbi request reprint TNFalpha is required to confer protection in an in vivo model of classical ischaemic preconditioning
    Graeme A Deuchar
    Hatter Institute for Cardiology Research, Department of Medicine, Cape Heart Centre, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa
    Life Sci 80:1686-91. 2007
    ..In addition, exogenous TNFalpha mimics IPC by providing a dose-dependent cardioprotective effect against ischaemia-reperfusion injury in vivo...
  31. ncbi request reprint Diazoxide-induced respiratory inhibition - a putative mitochondrial K(ATP) channel independent mechanism of pharmacological preconditioning
    Jan Minners
    Hatter Institute for Cardiology Research, MRC Inter University Cape Heart Group, University of Cape Town Medical School, Cape Town, South Africa
    Mol Cell Biochem 294:11-8. 2007
    ..Collectively these data support the hypothesis that diazoxide-mediated cytoprotection is independent of the conductance of the mK(ATP) channel and rather implicate mitochondrial respiratory inhibition-triggered ROS signaling...
  32. ncbi request reprint Efficacy and tolerability of nisoldipine coat-core formulation in the treatment of essential hypertension: The South African Multicenter ANCHOR Study. Ambulatory Nisoldipine Coat-Core Hypertension Outpatient Response (ANCHOR) Investigators
    L H Opie
    Heart Research Unit and Hypertension Clinic, University of Cape Town Medical School, South Africa
    Am J Hypertens 10:250-60. 1997
    ..In conclusion, once-daily nisoldipine CC at doses of 10 to 30 mg was an effective and well tolerated antihypertensive agent, providing 24-h control of blood pressure without any increase in heart rate...
  33. pmc TNFα protects cardiac mitochondria independently of its cell surface receptors
    Lydia Lacerda
    Cardioprotection Group, Hatter Cardiovascular Research Institute, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    Basic Res Cardiol 105:751-62. 2010
    ..This effect appears to be independent of its cell surface receptors, but is likely to be mediated by ROS and sphingolipids...
  34. ncbi request reprint Effect of losartan versus candesartan on uric acid, renal function, and fibrinogen in patients with hypertension and hyperuricemia associated with diuretics
    Brian L Rayner
    Division of Hypertension, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa
    Am J Hypertens 19:208-13. 2006
    ..Hyperuricemia may counter benefits of blood pressure (BP) reduction, although this is controversial...
  35. doi request reprint Beta-blockade should not be among several choices for initial therapy of hypertension
    Lionel H Opie
    Hypertension Clinic, Department of Medicine, Groote Schuur Hospital and Hatter Institute, Cape Heart Centre, University of Cape Town Faculty of Health Sciences, Observatory, Cape Town, 7925, South Africa
    J Hypertens 26:161-3. 2008
  36. ncbi request reprint Ceramide attenuates hypoxic cell death via reactive oxygen species signaling
    Sandrine Lecour
    Hatter Institute for Cardiology Research, University of Cape Town, South Africa
    J Cardiovasc Pharmacol 47:158-63. 2006
    ..Collectively, these data demonstrate that ceramide induces a cell survival program through ROS signaling activated, in part, via cyclooxygenase and the mitochondrial respiratory chain...
  37. ncbi request reprint Pharmacological preconditioning with tumor necrosis factor-alpha activates signal transducer and activator of transcription-3 at reperfusion without involving classic prosurvival kinases (Akt and extracellular signal-regulated kinase)
    Sandrine Lecour
    Department of Medicine, Hatter Institute for Cardiology Research, Cape Heart Centre, Faculty of Health Sciences, University of Cape Town, South Africa
    Circulation 112:3911-8. 2005
    ....
  38. doi request reprint Ethanolamine is a novel STAT-3 dependent cardioprotective agent
    Roisin F Kelly
    Hatter Cardiovascular Research Institute, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Basic Res Cardiol 105:763-70. 2010
    ..75 ± 0.08 vs. Etn 1.50 ± 0.09 arbitrary units; P < 0.05]. Our findings suggest a novel cardioprotective role for ethanolamine against I/R injury via activation of STAT-3...
  39. ncbi request reprint Ceramide-induced preconditioning involves reactive oxygen species
    Sandrine Lecour
    Hatter Institute for Cardiology Research, Department of Medicine, University of Cape Town Medical School, Cape Town, South Africa
    Life Sci 78:1702-6. 2006
    ..Ceramide is known to generate reactive oxygen species (ROS) in cells. Since mechanisms triggering the ceramide-induced cardioprotection remain unknown, we investigated the role of ROS in the genesis of this protective mechanism...
  40. ncbi request reprint Acute myocardial infarction and diabetes
    Lionel H Opie
    Hatter Cardiovascular Research Institute, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town 7925, South Africa
    Lancet 370:634-5. 2007
  41. ncbi request reprint The red wine hypothesis: from concepts to protective signalling molecules
    Lionel H Opie
    Department of Medicine, Faculty of Health Sciences, Hatter Cardiovascular Research Institute, University of Cape Town, Private Bag 3, Observatory, South Africa
    Eur Heart J 28:1683-93. 2007
    ..Mechanistic feasibility strengthens the case for prospective therapeutic trials of alcohol vs. red wine vs. resveratrol, for example in those with heart failure...
  42. doi request reprint Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway
    Lydia Lacerda
    Hatter Cardiovascular Research Institute, Cardioprotection Group, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Observatory 7925, Cape Town, South Africa
    Cardiovasc Res 84:201-8. 2009
    ....
  43. doi request reprint The adrenergic-fatty acid load in heart failure
    Lionel H Opie
    Hatter Cardiovascular Research Institute, Department of Medicine, University of Cape Town, South Africa
    J Am Coll Cardiol 54:1637-46. 2009
    ..Other future therapies may include malonyl-coenzyme A regulators to inhibit fatty acid oxidation, fish oil omega-3, and activators of protein kinase C-epsilon...
  44. ncbi request reprint Metabolic syndrome
    Lionel H Opie
    Cape Heart Center, Hatter Institute and Department of Medicine, University of Cape Town Medical School, Observatory, Cape Town 7925, South Africa
    Circulation 115:e32-5. 2007
  45. ncbi request reprint The chest radiograph. A useful investigation in the evaluation of hypertensive patients
    Brian L Rayner
    Division of Hypertension, University of Cape Town, Cape Town, South Africa
    Am J Hypertens 17:507-10. 2004
    ..The aim of our study was to determine the usefulness of the chest radiograph in the assessment of target organ damage in hypertensive patients...
  46. ncbi request reprint Principles of combination therapy for hypertension: what we learn from the HOT and other studies--a personal point of view
    L H Opie
    Medical Research Council Heart Research Group, Cape Heart Centre, University of Cape Town, South Africa
    Cardiovasc Drugs Ther 12:425-9. 1998
    ..To achieve such low levels requires combination therapy in the majority. Combination therapy is set to become standard practice in the management of hypertension, so that it is now appropriate to consider the principles involved...
  47. pmc A role for the RISK pathway and K(ATP) channels in pre- and post-conditioning induced by levosimendan in the isolated guinea pig heart
    E F Du Toit
    Department of Biomedical Sciences, Faculty of Health Sciences, University of Stellenbosch, Western Cape, South Africa
    Br J Pharmacol 154:41-50. 2008
    ....
  48. ncbi request reprint Diuretic downsides--but in low doses they still seem among the best authenticated antihypertensives
    L H Opie
    Heart Research Unit, Cape Heart Centre, University of Cape Town Medical School, South Africa
    Cardiovasc Drugs Ther 14:407-9. 2000
    ..Thus, it is argued, low- but not high-dose diuretics retain their primacy in the ranking of antihypertensive therapy...
  49. ncbi request reprint Endothelin release during ischaemia and reperfusion of isolated perfused rat hearts
    F Brunner
    Department of Medicine, Groote Schuur Hospital, South Africa
    J Mol Cell Cardiol 24:1291-305. 1992
    ....
  50. ncbi request reprint Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning
    Robert M Smith
    Hatter Institute for Cardiology Research, Faculty of Health Sciences, University of Cape Town Observatory, Cape Heart Centre, Chris Barnard Building, Cape Town 7925, South Africa
    Cardiovasc Res 63:611-6. 2004
    ..To evaluate the functional requirement of signal transducer and activator of transcription-3 (STAT-3) in cardiac myocyte tolerance to ischemia (I) and in classical preconditioning...
  51. ncbi request reprint Identification of a novel role for sphingolipid signaling in TNF alpha and ischemic preconditioning mediated cardioprotection
    Sandrine Lecour
    Hatter Institute for Cardiology Research, MRC Inter University Cape Heart Group, University of Cape Town Medical School, South Africa
    J Mol Cell Cardiol 34:509-18. 2002
    ..In conclusion, TNF alpha activates preconditioning-like tolerance against infarction and contractile dysfunction. This cardioprotection is mediated, in part, via activation of novel sphingolipid signaling intermediates...
  52. ncbi request reprint [Sphingolipid signaling: a potential pathway for TNF-alpha induced preconditioning]
    S Lecour
    Hatter Institute for Cardiology Research, MRC Inter University Cape Heart Group, Chris Barnard Building, University of Cape Town Medical School, Cape Town 7925, Afrique du Sud
    Ann Cardiol Angeiol (Paris) 52:363-9. 2003
    ..Moreover, new studies have given the evidence that the exploration of cytokine-activated sphingolipid signalling pathways may enhance our understanding of the preconditioning program...
  53. ncbi request reprint Decreased rates of release of atrial natriuretic peptide from isolated hearts from aging hypertensive rats
    L H Opie
    Ischaemic Heart Disease Research Unit, Medical Research Council, Cape Town, South Africa
    Am J Hypertens 5:748-53. 1992
    ..Therefore, in rats with genetic hypertension, there is an impairment of release of ANP from the isolated heart in response to left atrial distention...
  54. ncbi request reprint Myocardial stunning--we do not know the mechanism nor is there "overwhelming evidence" for a major role of free radicals
    L H Opie
    University of Cape Town Medical School, South Africa
    Basic Res Cardiol 93:152-5. 1998
    ....
  55. doi request reprint AMPK activation represses the human gene promoter of the cardiac isoform of acetyl-CoA carboxylase: Role of nuclear respiratory factor-1
    Tasneem Adam
    Hatter Cardiovascular Research Institute, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa
    Biochem Biophys Res Commun 398:495-9. 2010
    ..2% (p<0.001 vs. control). This study demonstrates that NRF-1 is a novel transcriptional inhibitor of the human ACCbeta gene promoter in the mammalian heart. Our data extends AMPK regulation of ACCbeta to the transcriptional level...
  56. ncbi request reprint The neuroendocrinology of congestive heart failure
    Lionel H Opie
    Cape Heart Centre, Department of Medicine, University of Cape Town, South Africa
    Cardiovasc J S Afr 13:171-8. 2002
    ..Current therapies of heart failure are largely based on inhibition of the neuroendocrine response...
  57. ncbi request reprint Errors: incompetence, ineptitude or failure
    Lionel H Opie
    Hatter Institute, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa
    Lancet 362:731. 2003
  58. ncbi request reprint Letter by Opie and Selker regarding article, "Reperfusion starts in the ambulance"
    Lionel H Opie
    Circulation 114:e640; author reply e641. 2006
  59. ncbi request reprint Introduction to JMCC symposium on myocardial energy metabolism in health and disease
    Gary D Lopaschuk
    Cardiovascular Research Group, University of Alberta Faculty of Med Dentist, 423 Heritage Medical Research Centre, Edmonton, AB, T6G 2S2, Canada
    J Mol Cell Cardiol 34:1075-6. 2002
  60. ncbi request reprint A challenge to the metabolic approach to myocardial ischaemia
    Carl S Apstein
    Cardiac Muscle Research Laboratory, Boston University School of Medicine, Boston, MA, USA
    Eur Heart J 26:956-9. 2005
    ....
  61. doi request reprint Metabolic management of acute myocardial infarction comes to the fore and extends beyond control of hyperglycemia
    Lionel H Opie
    Circulation 117:2172-7. 2008
  62. ncbi request reprint Diabetic nephropathy: can renoprotection be extrapolated to cardiovascular protection?
    Lionel H Opie
    Circulation 106:643-5. 2002
  63. ncbi request reprint Free fatty acid depletion acutely decreases cardiac work and efficiency in cardiomyopathic heart failure
    Helena Tuunanen
    Turku PET Centre, Turku, Finland
    Circulation 114:2130-7. 2006
    ..We studied the effect of acute FFA withdrawal on cardiac function in patients with heart failure caused by idiopathic dilated cardiomyopathy (IDCM)...
  64. ncbi request reprint Metabolic therapy for heart failure
    M Faadiel Essop
    Eur Heart J 25:1765-8. 2004
  65. ncbi request reprint How strong is the evidence for use of beta-blockers as first-line therapy for hypertension? Systematic review and meta-analysis
    Hazel A Bradley
    School of Public Health, University of the Western Cape, South Africa
    J Hypertens 24:2131-41. 2006
    ..To quantify the effect of first-line antihypertensive treatment with beta-blockers on mortality, morbidity and withdrawal rates, compared with the other main classes of antihypertensive agents...
  66. ncbi request reprint Cost-effectiveness analysis of hypertension guidelines in South Africa: absolute risk versus blood pressure level
    Thomas A Gaziano
    Division of Social Medicine and Health Inequalities, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 112:3569-76. 2005
    ..Guidelines based on blood pressure level for initiation of treatment of hypertension may be too costly compared with an approach based on absolute cardiovascular disease (CVD) risk, especially in developing countries...
  67. pmc Angiotensin receptor blockers and myocardial infarction: direct comparative studies are needed
    Lionel H Opie
    BMJ 330:1270; author reply 1270-1. 2005
  68. ncbi request reprint Myocardial perfusion in type 2 diabetes with left ventricular hypertrophy: normalisation by acute angiotensin-converting enzyme inhibition
    Birger Hesse
    Department of Clinical Physiology and Nuclear Medicine, KF 4011, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark
    Eur J Nucl Med Mol Imaging 31:362-8. 2004
    ..It is concluded that acute ACE inhibition with perindoprilat improves maximal achieved myocardial perfusion in non-hypertensive patients with diabetes and LVH...
  69. ncbi request reprint Controversies in hypertension
    Norman M Kaplan
    University of Texas Southwestern Medical Center, Dallas, TX, USA
    Lancet 367:168-76. 2006
    ..We provide the background for these controversies, followed by some opinions on how to guide practitioners to offer more effective management of hypertension...
  70. ncbi request reprint Controversies in atrial fibrillation
    Stanley Nattel
    Department of Medicine and Research Centre, Montreal Heart Institute, University of Montreal, Montreal, Quebec H1T 1C8, Canada
    Lancet 367:262-72. 2006
    ..The background of every controversy is reviewed and our opinions expressed. Here, we hope to inform physicians about the most important controversies in this specialty and stimulate investigators to address unresolved issues...
  71. ncbi request reprint Adverse effects of free fatty acid associated with increased oxidative stress in postischemic isolated rat hearts
    Ségolène Gambert
    Faculties of Medicine and Pharmacy, Dijon, France
    Mol Cell Biochem 283:147-52. 2006
    ..The novel conclusion is that adverse effects of fatty acids on ischemic-reperfusion injury may be mediated, at least in part, by oxygen-derived free radicals...
  72. ncbi request reprint Cellular basis for therapeutic choices in heart failure
    Lionel H Opie
    Circulation 110:2559-61. 2004
  73. pmc Cardiovascular disease prevention with a multidrug regimen in the developing world: a cost-effectiveness analysis
    Thomas A Gaziano
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Lancet 368:679-86. 2006
    ..We therefore aimed to establish whether use of evidence-based multidrug regimens for patients at high risk for cardiovascular disease would be cost-effective in low-income and middle-income countries...
  74. ncbi request reprint Beta-blockers and the treatment of hypertension: it is time to move on
    Charles Shey Wiysonge
    Cardiovasc J Afr 18:351-2. 2007
  75. ncbi request reprint Postconditioning: a simple, clinically applicable procedure to improve revascularization in acute myocardial infarction
    Jakob Vinten-Johansen
    Circulation 112:2085-8. 2005
  76. ncbi request reprint HIV/AIDS in South Africa
    Lionel H Opie
    Lancet 366:291. 2005
  77. ncbi request reprint What vitamins should I be taking?
    Lionel H Opie
    N Engl J Med 346:1914-6; author reply 1914-6. 2002
  78. ncbi request reprint Heart disease in Africa
    Lionel H Opie
    Lancet 368:449-50. 2006
  79. doi request reprint Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy
    Helena Tuunanen
    Turku PET Centre, PO Box 52, FI 20521 Turku, Finland
    Circulation 118:1250-8. 2008
    ..However, FFA oxidation remains unmeasured in humans. We investigated the effects of trimetazidine on cardiac perfusion, efficiency of work, and FFA oxidation in idiopathic dilated cardiomyopathy...
  80. doi request reprint Glucose-insulin-potassium therapy in patients with STEMI
    Lionel H Opie
    JAMA 299:2385-6; author reply 2387-8. 2008
  81. ncbi request reprint Postconditioning for protection of the infarcting heart
    Derek M Yellon
    The Hatter Cardiovascular Institute, University College of London Hospital and Medical School, London WC1E 6DB, UK
    Lancet 367:456-8. 2006
  82. ncbi request reprint A new mutation, R563Q, of the beta subunit of the epithelial sodium channel associated with low-renin, low-aldosterone hypertension
    Brian L Rayner
    Departments of aMedicine and bLaboratory Medicine, Groote Schuur Hospital and University of Cape Town, South Africa
    J Hypertens 21:921-6. 2003
    ..To determine the relationship between R563Q, a mutation of the renal epithelial sodium channel, and hypertension...
  83. ncbi request reprint Medicine and conflict
    Lionel H Opie
    Lancet 361:1130. 2003
  84. ncbi request reprint Cardiovascular disease in sub-Saharan Africa
    Lionel H Opie
    Circulation 112:3536-40. 2005