N Novitzky

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. ncbi request reprint Basic fibroblast growth factor corrects proliferative derangement of bone marrow stroma and CD34(+) population following allogeneic stem cell transplantation
    N Novitzky
    The University of Cape Town Leukaemia Centre and the Department of Haematology, Groote Schuur Hospital, Observatory, Cape, Cape Town, South Africa
    Exp Hematol 29:1432-8. 2001
  2. ncbi request reprint Increased apoptosis of bone marrow cells and preserved proliferative capacity of selected progenitors predict for clinical response to anti-inflammatory therapy in myelodysplastic syndromes
    N Novitzky
    The University of Cape Town Leukemia Centre and the Department of Haematology, Groote Schuur Hospital, Observatory, Cape Town, South Africa
    Exp Hematol 28:941-9. 2000
  3. ncbi request reprint Bone marrow transplantation depleted of T cells followed by repletion with incremental doses of donor lymphocytes for relapsing patients with chronic myeloid leukemia: a therapeutic strategy
    N Novitzky
    University of Cape Town Leukaemia Centre and the Department of Haematology, Groote Schuur Hospital, Cape, South Africa
    Transplantation 69:1358-63. 2000
  4. ncbi request reprint Myelodysplastic syndromes in children. A critical review of the clinical manifestations and management
    N Novitzky
    The University of Cape Town Leukemia Centre, Department of Haematology, Groote Schuur Hospital, Observatory, Cape, Cape Town, South Africa
    Am J Hematol 63:212-22. 2000
  5. ncbi request reprint In aplastic anemia progenitor cells have a reduced sensitivity to the effects of growth factors
    N Novitzky
    The University of Cape Town Leukaemia Centre and the Department of Haematology, Groote Schuur Hospital, Observatory, Cape, South Africa
    Eur J Haematol 63:141-8. 1999
  6. ncbi request reprint Ex vivo depletion of T cells from bone marrow grafts with CAMPATH-1 in acute leukemia: graft-versus-host disease and graft-versus-leukemia effect
    N Novitzky
    The University of Cape Town Leukaemia Centre and the Department of Haematology, Groote Schuur Hospital, Cape Town, South Africa
    Transplantation 67:620-6. 1999
  7. doi request reprint Prevention of graft vs. host disease with alemtuzumab 'in the bag' decreases early toxicity of stem cell transplantation and in multiple myeloma is associated with improved long-term outcome
    N Novitzky
    Groote Schuur Hospital, Observatory, University of Cape Town Leukaemia Centre and Department of Haematology, Cape Town, South Africa
    Cytotherapy 10:45-53. 2008
  8. ncbi request reprint Radiotherapy-based conditioning is effective immunosuppression for patients undergoing transplantation with T-cell depleted stem cell grafts for severe aplasia
    N Novitzky
    The University of Cape Town Leukaemia Centre and the Division of Haematology, Cape Town, South Africa
    Cytotherapy 6:450-6. 2004
  9. ncbi request reprint Myeloablative conditioning is well tolerated by older patients receiving T-cell-depleted grafts
    N Novitzky
    The University of Cape Town Leukaemia Centre and the Department of Haematology, Groote Schuur Hospital, Observatory, Cape, Cape Town, South Africa
    Bone Marrow Transplant 36:675-82. 2005
  10. doi request reprint Reduced-intensity conditioning for severe aplasia using fludarabine and CY followed by infusion of ex vivo T-cell-depleted grafts leads to excellent engraftment and absence of GVHD
    N Novitzky
    The University of Cape Town Leukaemia Unit, the Division of Haematology, Groote Schuur Hospital, Observatory, Cape Town, South Africa
    Bone Marrow Transplant 43:779-85. 2009

Detail Information

Publications21

  1. ncbi request reprint Basic fibroblast growth factor corrects proliferative derangement of bone marrow stroma and CD34(+) population following allogeneic stem cell transplantation
    N Novitzky
    The University of Cape Town Leukaemia Centre and the Department of Haematology, Groote Schuur Hospital, Observatory, Cape, Cape Town, South Africa
    Exp Hematol 29:1432-8. 2001
    ..We studied the effects of basic fibroblast growth factor (bFGF) on the proliferation of clonogenic progenitors and bone marrow stroma from patients receiving cytokine-mobilized allogeneic stem cell transplants (SCT)...
  2. ncbi request reprint Increased apoptosis of bone marrow cells and preserved proliferative capacity of selected progenitors predict for clinical response to anti-inflammatory therapy in myelodysplastic syndromes
    N Novitzky
    The University of Cape Town Leukemia Centre and the Department of Haematology, Groote Schuur Hospital, Observatory, Cape Town, South Africa
    Exp Hematol 28:941-9. 2000
    ..004). In some patients with MDS, ineffective hematopoiesis is related to high apoptotic index despite proliferation of the CD34(+) precursors. These patients seem to benefit from CPD cytokine modulatory therapeutic strategy...
  3. ncbi request reprint Bone marrow transplantation depleted of T cells followed by repletion with incremental doses of donor lymphocytes for relapsing patients with chronic myeloid leukemia: a therapeutic strategy
    N Novitzky
    University of Cape Town Leukaemia Centre and the Department of Haematology, Groote Schuur Hospital, Cape, South Africa
    Transplantation 69:1358-63. 2000
    ..Relapsing patients respond to donor lymphocyte infusion (DLI) but develop life-threatening complications...
  4. ncbi request reprint Myelodysplastic syndromes in children. A critical review of the clinical manifestations and management
    N Novitzky
    The University of Cape Town Leukemia Centre, Department of Haematology, Groote Schuur Hospital, Observatory, Cape, Cape Town, South Africa
    Am J Hematol 63:212-22. 2000
    ..Finally, BMT remains the treatment of choice for those with primary MDS, as intensive chemotherapy is no better than supportive measures...
  5. ncbi request reprint In aplastic anemia progenitor cells have a reduced sensitivity to the effects of growth factors
    N Novitzky
    The University of Cape Town Leukaemia Centre and the Department of Haematology, Groote Schuur Hospital, Observatory, Cape, South Africa
    Eur J Haematol 63:141-8. 1999
    ..However, for all colony types, responses to effective concentrations of c-kit ligand corresponded with those of controls. These data suggest abnormalities at the receptor or signal transduction levels...
  6. ncbi request reprint Ex vivo depletion of T cells from bone marrow grafts with CAMPATH-1 in acute leukemia: graft-versus-host disease and graft-versus-leukemia effect
    N Novitzky
    The University of Cape Town Leukaemia Centre and the Department of Haematology, Groote Schuur Hospital, Cape Town, South Africa
    Transplantation 67:620-6. 1999
    ..Preventing graft-versus-host disease (GVHD) by depletion of T lymphocytes from the stem cell graft for transplantation remains controversial, mainly because of the perceived increase in disease recurrence...
  7. doi request reprint Prevention of graft vs. host disease with alemtuzumab 'in the bag' decreases early toxicity of stem cell transplantation and in multiple myeloma is associated with improved long-term outcome
    N Novitzky
    Groote Schuur Hospital, Observatory, University of Cape Town Leukaemia Centre and Department of Haematology, Cape Town, South Africa
    Cytotherapy 10:45-53. 2008
    ..Allogeneic stem cell transplantation in multiple myeloma (MM) is controversial because treatment-related mortality and relapse remain a substantial challenge...
  8. ncbi request reprint Radiotherapy-based conditioning is effective immunosuppression for patients undergoing transplantation with T-cell depleted stem cell grafts for severe aplasia
    N Novitzky
    The University of Cape Town Leukaemia Centre and the Division of Haematology, Cape Town, South Africa
    Cytotherapy 6:450-6. 2004
    ..We studied the outcome of individuals with aplastic anemia conditioned with a radiation-containing regimen followed by an infusion of stem cell grafts that had been depleted of lymphocytes with CAMPATH-1H (antiCD52; humanised)...
  9. ncbi request reprint Myeloablative conditioning is well tolerated by older patients receiving T-cell-depleted grafts
    N Novitzky
    The University of Cape Town Leukaemia Centre and the Department of Haematology, Groote Schuur Hospital, Observatory, Cape, Cape Town, South Africa
    Bone Marrow Transplant 36:675-82. 2005
    ..This information is useful to more precisely select patients who would benefit most from reduced intensity conditioning schedules...
  10. doi request reprint Reduced-intensity conditioning for severe aplasia using fludarabine and CY followed by infusion of ex vivo T-cell-depleted grafts leads to excellent engraftment and absence of GVHD
    N Novitzky
    The University of Cape Town Leukaemia Unit, the Division of Haematology, Groote Schuur Hospital, Observatory, Cape Town, South Africa
    Bone Marrow Transplant 43:779-85. 2009
    ..This strategy of reduced-intensity conditioning has low toxicity, does not compromise engraftment and seems effective for prevention of GVHD...
  11. ncbi request reprint Immune reconstitution following hematopoietic stem-cell transplantation
    N Novitzky
    The University of Cape Town Leukaemia Centre and the Department of Haematology, Groote Schuur Hospital, Cape Town, South Africa
    Cytotherapy 3:211-20. 2001
    ..Future research needs to be concentrated on improving the capacity of the thymus to reconstitute a functional naive population...
  12. ncbi request reprint Increasing dose intensity of anthracycline antibiotics improves outcome in patients with acute myelogenous leukemia
    N Novitzky
    The University of Cape Town Leukaemia Centre and the Department of Haematology Groote Schuur Hospital, Observatory, Cape Town, South Africa
    Am J Hematol 76:319-29. 2004
    ..This therapeutic modification is also likely to result in substantial reduction in patient stay in hospital and in the overall expenditure...
  13. ncbi request reprint Cryopreservation of the bone marrow from patients with acute myeloid leukaemia leads to functional abnormalities
    N Novitzky
    The University of Cape Town Leukaemia Centre, The Department of Haematology, Groote Schuur Hospital, Observatory, South Africa
    Eur J Haematol 62:83-9. 1999
    ..We conclude that cryopreservation of the bone marrow of patients in CR of AML results in an inhibition of the proliferation of the CD34+ precursors. It also modifies the stroma, leading to reductions in the support of normal clones...
  14. doi request reprint In the absence of clinically significant graft vs. host disease, myeloablative conditioning may allow an effective graft vs. leukaemia effect
    N Novitzky
    Leukaemia Unit and the Division of Haematology, Department Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Leuk Res 36:104-9. 2012
    ..At a median of 1018 days 65% are alive. Grade >1 GvHD was seen in 11%. GvHD and adverse karyotype were associated with treatment failure. In younger patients preservation of the dose intensity may improve cure rates...
  15. ncbi request reprint Campath-1 Abs 'in the bag' for hematological malignancies: the Cape Town experience
    N Novitzky
    The University of Cape Town Leukaemia Centre and the Department of Haematology, Groote Schuur Hospital, Observatory, Cape Town, South Africa
    Cytotherapy 6:172-81. 2004
    ..We examined the strategy of T-cell depletion of HLA-identical sibling grafts for the prevention of GvHD, as well as disease control and overall survival...
  16. ncbi request reprint Infectious complications following T-cell depleted hematopoietic stem-cell transplantation
    N Novitzky
    The University of Cape Town Leukaemia Centre, Department of Haematology, Groote Schuur Hospital, Cape Town, South Africa
    Cytotherapy 3:165-73. 2001
    ..Once the BM has recovered, the main morbidity is by viral infections, but Gram+ organisms still remain common bacterial pathogens...
  17. ncbi request reprint Hematopoietic stem cell transplantation for adults with acute promyelocytic leukemia in the ATRA era: a survey of the European Cooperative Group for Blood and Marrow Transplantation
    M A Sanz
    Hematology Service, Hospital Universitario La Fe, Valencia, Spain
    Bone Marrow Transplant 39:461-9. 2007
    ..Female recipient, a female donor to male recipient and transplants performed before 1997 were associated with decreased RI. In conclusion, HSCT still appears to have a role in APL, especially for patients in CR2...
  18. doi request reprint Combined pegylated liposomal doxorubicin and bortezomib is highly effective in patients with recurrent or refractory multiple myeloma who received prior thalidomide/lenalidomide therapy
    Pieter Sonneveld
    Department of Hematology, Erasmus Medical Center, Rotterdam, Netherlands
    Cancer 112:1529-37. 2008
    ....
  19. ncbi request reprint The South African Bone Marrow Registry (SABMR) and allogeneic bone marrow transplantation
    Paul Ruff
    Medical Oncology, University of the Witwatersrand Faculty of Health Sciences and Donald Gordon Medical Centre, Johannesburg
    S Afr Med J 98:516, 518, 520. 2008
  20. ncbi request reprint CAMPATH-1 antibodies in stem-cell transplantation
    G Hale
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Cytotherapy 3:145-64. 2001
    ..Future studies will seek to understand the mechanism of the CYA effect and to improve the quality of immune reconstitution...
  21. ncbi request reprint Intensified myeloablative therapy and autologous stem-cell transplantation for patients with AML: single center experience
    N Novitzky
    Department of Haematology, University of Cape Town Medical School, Cape Town, South Africa
    Cytotherapy 5:139-46. 2003
    ..Thirty-seven consecutive individuals in CR of AML received intensified conditioning and autologous stem-cell transplantation...