Sam W Moore

Summary

Affiliation: University of Stellenbosch
Country: South Africa

Publications

  1. pmc The Hirschsprung's-multiple endocrine neoplasia connection
    Sam W Moore
    Division of Pediatric Surgery, Faculty of Medicine, University of Stellenbosch, Tygerberg, South Africa
    Clinics (Sao Paulo) 67:63-7. 2012
  2. ncbi Tissue specific somatic mutations and aganglionosis in Hirschsprung's disease
    Sam W Moore
    Division of Pediatric Surgery, Department of Surgical Sciences, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa Electronic address
    J Pediatr Surg 49:258-61. 2014
  3. ncbi Neonatal tumours
    S W Moore
    Department of Paediatric Surgery, Faculty of Medicine and Health Sciences, University of Stellenbosch, P O Box 19063, Tygerberg, 7505, South Africa
    Pediatr Surg Int 29:1217-29. 2013
  4. ncbi Anorectal atresia with gross terminal colonic distension in Africa
    S W Moore
    Division of Paediatric Surgery, University of Stellenbosch, PO Box 19063, Tygerberg, 7505, South Africa
    Pediatr Surg Int 29:1287-91. 2013
  5. doi Associations of anorectal malformations and related syndromes
    Sam W Moore
    Department of Pediatric Surgery, Faculty of Medicine, University of Stellenbosch, PO Box 19063, Tygerberg 7505, South Africa
    Pediatr Surg Int 29:665-76. 2013
  6. doi Segmental aganglionosis (zonal aganglionosis or "skip" lesions) in Hirschsprungs disease: a report of 2 unusual cases
    S W Moore
    Division of Pediatric Surgery, Department of Surgical Sciences, Faculty of Health Sciences, University of Stellenbosch, PO Box 19063, Tygerberg 7505, South Africa
    Pediatr Surg Int 29:495-500. 2013
  7. ncbi Necrotizing enterocolitis and the placenta - a key etiological link
    Sam W Moore
    Divisions of Pediatric Surgery, University of Stellenbosch, Tygerberg, Western Cape Tygerberg 7505, South Africa
    J Pediatr Surg 48:359-62. 2013
  8. doi Problems related to CMV infection and biliary atresia
    Samuel W Moore
    University of Stellenbosch, South Africa
    S Afr Med J 102:890-2. 2012
  9. doi Lessons from the hepatoblastoma-familial polyposis connection
    S W Moore
    Stellenbosch University, South Africa
    S Afr Med J 102:888-9. 2012
  10. doi Chromosomal and related Mendelian syndromes associated with Hirschsprung's disease
    S W Moore
    Division of Pediatric Surgery, Department of Surgical Sciences, Faculty of Health Sciences, University of Stellenbosch, P O Box 19063, Tygerberg, South Africa
    Pediatr Surg Int 28:1045-58. 2012

Detail Information

Publications44

  1. pmc The Hirschsprung's-multiple endocrine neoplasia connection
    Sam W Moore
    Division of Pediatric Surgery, Faculty of Medicine, University of Stellenbosch, Tygerberg, South Africa
    Clinics (Sao Paulo) 67:63-7. 2012
    ..In addition, novel approaches to treatment based on this genetic knowledge have already shown early promise in randomized clinical trials...
  2. ncbi Tissue specific somatic mutations and aganglionosis in Hirschsprung's disease
    Sam W Moore
    Division of Pediatric Surgery, Department of Surgical Sciences, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa Electronic address
    J Pediatr Surg 49:258-61. 2014
    ..Although activating somatic RET rearrangements have been identified in certain tumours, this is the first study to confirm somatic gene variation in HSCR...
  3. ncbi Neonatal tumours
    S W Moore
    Department of Paediatric Surgery, Faculty of Medicine and Health Sciences, University of Stellenbosch, P O Box 19063, Tygerberg, 7505, South Africa
    Pediatr Surg Int 29:1217-29. 2013
    ..Further study of the provocative differences in tumour behaviour in neonates provides insights into the natural history of cancer in humans and promotes novel cancer therapies. ..
  4. ncbi Anorectal atresia with gross terminal colonic distension in Africa
    S W Moore
    Division of Paediatric Surgery, University of Stellenbosch, PO Box 19063, Tygerberg, 7505, South Africa
    Pediatr Surg Int 29:1287-91. 2013
    ..The problem seems to revolve around the gross terminal distension of the distal pouch which remains a significant surgical challenge to surgeons resulting in poorer postoperative continence in many instances...
  5. doi Associations of anorectal malformations and related syndromes
    Sam W Moore
    Department of Pediatric Surgery, Faculty of Medicine, University of Stellenbosch, PO Box 19063, Tygerberg 7505, South Africa
    Pediatr Surg Int 29:665-76. 2013
    ..As a result, it may be expressed as a "field developmental defect" with many associated abnormalities. The role of environmental factors in the development of ARM is probably less...
  6. doi Segmental aganglionosis (zonal aganglionosis or "skip" lesions) in Hirschsprungs disease: a report of 2 unusual cases
    S W Moore
    Division of Pediatric Surgery, Department of Surgical Sciences, Faculty of Health Sciences, University of Stellenbosch, PO Box 19063, Tygerberg 7505, South Africa
    Pediatr Surg Int 29:495-500. 2013
    ..Normally described as "a skip area" of normally ganglionated bowel, surrounded proximally and distally by aganglionosis with variations may occur...
  7. ncbi Necrotizing enterocolitis and the placenta - a key etiological link
    Sam W Moore
    Divisions of Pediatric Surgery, University of Stellenbosch, Tygerberg, Western Cape Tygerberg 7505, South Africa
    J Pediatr Surg 48:359-62. 2013
    ..g. vascular insufficiency and antenatal infections) may be important factors in "priming" the inflammatory cascade, thus predisposing to the disease. This study explores the role of placental pathology in predisposing to NEC pathogenesis...
  8. doi Problems related to CMV infection and biliary atresia
    Samuel W Moore
    University of Stellenbosch, South Africa
    S Afr Med J 102:890-2. 2012
    ..When related to biliary atresia CMV IGM positive patients appear to have more liver damage thus affecting outcome. Methods We carried out a retrospective chart review on 74 patients diagnosed with hepatobiliary disease (2000-2011)...
  9. doi Lessons from the hepatoblastoma-familial polyposis connection
    S W Moore
    Stellenbosch University, South Africa
    S Afr Med J 102:888-9. 2012
    ..This correlation may be missed if not actively sought, with implications for long-term outcome and management...
  10. doi Chromosomal and related Mendelian syndromes associated with Hirschsprung's disease
    S W Moore
    Division of Pediatric Surgery, Department of Surgical Sciences, Faculty of Health Sciences, University of Stellenbosch, P O Box 19063, Tygerberg, South Africa
    Pediatr Surg Int 28:1045-58. 2012
    ..In this review, we look at the chromosomal and Mendelian associations and their underlying signalling pathways, to obtain a better understanding of the pathogenetic mechanisms involved in developing aganglionosis of the distal bowel...
  11. doi Total colonic aganglionosis in Hirschsprung disease
    Samuel W Moore
    Division of Paediatric Surgery, University of Stellenbosch, Tygerberg, South Africa
    Semin Pediatr Surg 21:302-9. 2012
    ..Moreover, it reviews current outcomes to find consensus on management...
  12. doi Intronic RET gene variants in Down syndrome-associated Hirschsprung disease in an African population
    Samuel W Moore
    Division of Paediatric Surgery, Faculty of Medicine, University of Stellenbosch, P O Box 19063, 7505, Tygerberg, South Africa
    J Pediatr Surg 47:299-302. 2012
    ..The intronic single-nucleotide polymorphism 2 (SNP2 [rs2435357]) has been associated with DS-associated HD (DS-HD). This study focuses on variations of specific RET intron, 1 SNPs (viz, SNP1 [rs2506004] and SNP2 [rs2435357]) in DS-HD...
  13. ncbi Hirschsprung's disease in the neurologically challenged child
    Sam W Moore
    Division of Pediatric Surgery, University of Stellenbosch, Tygerberg, South Africa
    Int J Adolesc Med Health 23:223-7. 2011
    ..This group of patients present with neurological challenges and have special challenges in management especially in the older child and adolescent...
  14. doi Hirschsprung's disease and the brain
    S W Moore
    Division of Paediatric Surgery, University of Stellenbosch, Tygerberg, South Africa
    Pediatr Surg Int 27:347-52. 2011
    ..We recognise that this group of patients remain a challenge from a clinical and functional management point of view, and suggest possible management guidelines...
  15. ncbi Clinical and genetic differences in total colonic aganglionosis in Hirschsprung's disease
    Samuel W Moore
    Division of Pediatric Surgery, University of Stellenbosch, Faculty of Health Sciences, Tygerberg, South Africa
    J Pediatr Surg 44:1899-903. 2009
    ....
  16. ncbi Total colonic aganglionosis and Hirschsprung's disease: shades of the same or different?
    Sam W Moore
    Department of Paediatric Surgery, Faculty of Medicine, University of Stellenbosch, P O Box 19063, Tygerberg, 7505, South Africa
    Pediatr Surg Int 25:659-66. 2009
    ....
  17. doi Developmental genes and cancer in children
    Sam W Moore
    Division of Pediatric Surgery, University of Stellenbosch, Cape Town, South Africa
    Pediatr Blood Cancer 52:755-60. 2009
    ..The developmental and perinatal periods appears important as a window of opportunity for cancer research...
  18. doi Familial associations in medullary thyroid carcinoma with Hirschsprung disease: the role of the RET-C620 "Janus" genetic variation
    Sam W Moore
    Division of Paediatric Surgery, Faculty of Health Sciences, University of Stellenbosch, PO Box 19063, Tygerberg 7505, South Africa
    J Pediatr Surg 45:393-6. 2010
    ..Specifically, HSCR-MEN2 cosegregation mostly relates to the cysteine-rich area at the RET-620 (the "Janus gene")...
  19. ncbi The ITGB2 immunomodulatory gene (CD18), enterocolitis, and Hirschsprung's disease
    Sam W Moore
    Division of Paediatric Surgery, Faculty of Health Sciences, University of Stellenbosch, PO Box 19063, 7505 Tygerberg, South Africa
    J Pediatr Surg 43:1439-44. 2008
    ..There is therefore a fairly compelling case for the potential involvement of the ITGB2 (CD18) in HAEC pathogenesis...
  20. ncbi Down syndrome and the enteric nervous system
    S W Moore
    Division of Paediatric Surgery, Department of Surgical Sciences, Faculty of Health Sciences, University of Stellenbosch, P O Box 19063, Tygerberg, 7505, South Africa
    Pediatr Surg Int 24:873-83. 2008
    ..Although the role of the triplicated chromosome 21 and genetic dosage remain important, the additional role of other chromosome 21 genes in the etiology of ENS developmental anomalies remains undetermined and requires ongoing research...
  21. doi The spectrum of anorectal malformations in Africa
    S W Moore
    Division of Paediatric Surgery, Department of Surgical Sciences, Faculty of Health Sciences, University of Stellenbosch, P O Box 19063, Tygerberg, 7505, South Africa
    Pediatr Surg Int 24:677-83. 2008
    ..This study illustrates the need for more objective data from developing countries to assess geographical differences...
  22. ncbi Diagnostic aspects of cervical lymphadenopathy in children in the developing world: a study of 1,877 surgical specimens
    S W Moore
    Department of Paediatric Surgery, University of Stellenbosch, Cape Town, South Africa
    Pediatr Surg Int 19:240-4. 2003
    ..tuberculosis. The incidence of serious pathology in more than one-half of the cervical LNs examined justifies aggressive surgical investigation...
  23. ncbi The epidemiology of neonatal tumours. Report of an international working group
    S W Moore
    Department of Paediatric Surgery, University of Stellenbosch, P O Box 19063, Tygerberg, 7505 Cape Town, South Africa
    Pediatr Surg Int 19:509-19. 2003
    ..Other environmental associations include ionizing radiation, drugs taken during pregnancy, infections, tumours in the mother and environmental exposure...
  24. ncbi Hepatocellular carcinoma and liver tumors in South African children: a case for increased prevalence
    Samuel W Moore
    Department of Pediatric Surgery, University of Stellenbosch, Tygerberg, South Africa
    Cancer 101:642-9. 2004
    ..The objective of this study was to assess the incidence and probable causes of HCC in South African children...
  25. ncbi Acetylcholinesterase in Hirschsprung's disease
    S W Moore
    Department of Paediatric Surgery, University of Stellenbosch, Cape Town, South Africa
    Pediatr Surg Int 21:255-63. 2005
    ..Evidence suggests that this AChE is functioning in a nonenzymatic capacity to promote cell adhesion and differentiation and that the hypertrophied nerves and neurofibrils may be the result of this increased AChE expression...
  26. ncbi The contribution of associated congenital anomalies in understanding Hirschsprung's disease
    S W Moore
    Division of Pediatric Surgery, Department of Surgical Sciences, Faculty of Health Sciences, University of Stellenbosch, P O Box 19063, 7505, Tygerberg, South Africa
    Pediatr Surg Int 22:305-15. 2006
    ..In addition, potential "modifying" associations exist with chromosome 2, 9, 20, 21 and 22, and we explore the importance of certain flanking genes of critical areas in the final phenotypic expression of HSCR...
  27. ncbi Familial medullary carcinoma prevention, risk evaluation, and RET in children of families with MEN2
    Samuel W Moore
    Department of Pediatric Surgery, University of Stellenbosch Medical Faculty, PO Box 19063, Tygerberg 7505, South Africa
    J Pediatr Surg 42:326-32. 2007
    ..The 918 mutation associated with MEN2B is associated with early aggressive behaviour and distant metastatic spread. This has led to active screening of affected families underlining the need for specific intervention strategies...
  28. ncbi Head and neck masses and fistulae children
    S W Moore
    Department of Paediatric Surgery, University of Stellenbosch
    SADJ 62:138, 140. 2007
  29. doi Multiple endocrine neoplasia syndromes, children, Hirschsprung's disease and RET
    S W Moore
    Faculty of Health Sciences, University of Stellenbosch, 7505, Tygerberg, South Africa
    Pediatr Surg Int 24:521-30. 2008
    ..The future appears full of promise and the current evaluation of RET-targeting tyrosine kinase and other inhibitors are of considerable interest in the management of these conditions...
  30. ncbi Association of endothelin-beta receptor (EDNRB) gene variants in anorectal malformations
    Sam W Moore
    Division of Paediatric Surgery, Faculty of Medicine, University of Stellenbosch, P O Box 19063, Tygerberg 7505, South Africa
    J Pediatr Surg 42:1266-70. 2007
    ..01, chi2 with Yates correction = 8.24) compared to controls. Potential disease-related mutations were identified in South African patients with ARM, raising the question of its potential role in the pathogenesis of this condition...
  31. ncbi Malignant liver tumors in South African children: a national audit
    S W Moore
    Department of Pediatric Surgery, University of Stellenbosch, 19063, Tygerberg 7505, South Africa
    World J Surg 32:1389-95. 2008
    ..g., hepatitis B/retroviral disease (HIV). This study aimed to assess recent changes in the prevalence and surgical management of liver tumors in South African children...
  32. doi A review of genetic mutation in familial Hirschsprung's disease in South Africa: towards genetic counseling
    Samuel W Moore
    Division of Pediatric Surgery, University of Stellenbosch, Tygerberg, South Africa
    J Pediatr Surg 43:325-9. 2008
    ..This study evaluated a set of patients affected by HSCR with familial recurrence to evaluate factors of greatest value in genetic counseling...
  33. ncbi Laparoscopic resection of esophageal stricture with transgastric stapled anastomosis in a child with AIDS
    Daniel Sidler
    Department of Paediatric Surgery, Tygerberg Children s Hospital, Stellenbosch University, Cape Town, South Africa
    J Laparoendosc Adv Surg Tech A 16:331-4. 2006
    ..A laparoscopically assisted resection of the esophageal stricture with a primary stapled anastomosis was performed with good results. At follow-up 8 months postoperative the child was tolerating feeds well and thriving...
  34. ncbi Catalytic antibodies with acetylcholinesterase activity
    Glynis Johnson
    Department of Pediatric Surgery Medical Biochemistry, University of Stellenbosch, P O Box 19063, Tygerberg 7505, South Africa
    J Immunol Methods 269:13-28. 2002
    ....
  35. ncbi Human acetylcholinesterase binds to mouse laminin-1 and human collagen IV by an electrostatic mechanism at the peripheral anionic site
    Glynis Johnson
    Department of Pediatric Surgery, University of Stellenbosch, Faculty of Health Sciences, Tygerberg, South Africa
    Neurosci Lett 337:37-40. 2003
    ....
  36. ncbi Functional idiotypic mimicry of an adhesion- and differentiation-promoting site on acetylcholinesterase
    Glynis Johnson
    Departments of Pediatric Surgery and Medical Biochemistry, University of Stellenbosch, Tygerberg, South Africa
    J Cell Biochem 91:999-1009. 2004
    ..Implications of these findings for differentiation-promoting cancer therapy are discussed...
  37. ncbi Identification of a structural site on acetylcholinesterase that promotes neurite outgrowth and binds laminin-1 and collagen IV
    Glynis Johnson
    Department of Pediatric Surgery Medical Biochemistry, Faculty of Health Sciences, University of Stellenbosch, P O Box 19063, Tygerberg 7505, South Africa
    Biochem Biophys Res Commun 319:448-55. 2004
    ....
  38. doi Investigations into the development of catalytic activity in anti-acetylcholinesterase idiotypic and anti-idiotypic antibodies
    Glynis Johnson
    Divisions of Pediatric Surgery Molecular Biology and Human Genetics, Faculty of Health Sciences, University of Stellenbosch, P O Box 19063, Tygerberg 7505, South Africa
    J Mol Recognit 22:188-96. 2009
    ....
  39. doi Interaction of acetylcholinesterase with the G4 domain of the laminin alpha1-chain
    Glynis Johnson
    Divisions of General Surgery Molecular Biology and Human Genetics, Faculty of Health Sciences, University of Stellenbosch, P O Box 19063, Tygerberg 7505, South Africa
    Biochem J 411:507-14. 2008
    ..They also suggest the strong probability of functional redundancy between AChE and other molecules in early development, particularly heparan sulfate proteoglycans, which may explain the survival of the AChE-knockout mouse...
  40. ncbi Idiotypic mimicry of a catalytic antibody active site
    Glynis Johnson
    Department of Paediatric Surgery, University of Stellenbosch, P O Box 19063, 7505, Tygerberg, South Africa
    Mol Immunol 39:273-88. 2002
    ..Further studies are required to determine the structural features of this ground state antigen responsible for the development of catalytic activity...
  41. ncbi Acetylcholinesterase readthrough peptide shares sequence similarity to the 28-53 peptide sequence of the acetylcholinesterase adhesion-mediating site and competes for ligand binding in vitro
    Glynis Johnson
    Departments of Pediatric Surgery, Medical Biochemistry, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa
    J Mol Neurosci 31:113-26. 2007
    ..It therefore appears likely that the ARP's structural similarity to the AChE adhesion-mediating site is the basis for the observed competition for ligand binding and might account for the antiadhesive characteristics of AChE-R...
  42. ncbi Non-enzymatic developmental functions of acetylcholinesterase--the question of redundancy
    Glynis Johnson
    Divisions of Paediatric Surgery Molecular Biology and Human Genetics, University of Stellenbosch, Tygerberg, South Africa
    FEBS J 275:5129-38. 2008
    ....
  43. doi Compound colonic intussusception: a reason for failure of pneumatic reduction
    Marion Arnold
    Division of Pediatric Surgery, Department of Surgical Sciences, Faculty of Health Sciences, University of Stellenbosch, P O Box 19063, Tygerberg, 7505, South Africa
    J Pediatr Surg 45:e25-8. 2010
    ..The literature is reviewed, and the terminology was discussed...
  44. ncbi A comparison of laparoscopic-assisted (LAARP) and posterior sagittal (PSARP) anorectoplasty in the outcome of intermediate and high anorectal malformations
    C De Vos
    Division of Paediatrics Surgery, Stellenbosch University, Tugersberg, W Cape
    S Afr J Surg 49:39-43. 2011
    ..Laparoscopic-assisted ano-rectoplasty (LAARP) has gained popularity since its introduction in 2000. Further evidence is needed to compare its outcome with the gold standard of posterior sagittal ano-rectoplasty (PSARP)...