Keren Middelkoop

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. ncbi request reprint Impact of HIV infection on the epidemiology of tuberculosis in a peri-urban community in South Africa: the need for age-specific interventions
    Stephen D Lawn
    Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    Clin Infect Dis 42:1040-7. 2006
  2. ncbi request reprint Adolescent and adult participation in an HIV vaccine trial preparedness cohort in South Africa
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    J Adolesc Health 43:8-14. 2008
  3. ncbi request reprint Factors affecting tuberculosis strain success over 10 years in a high TB- and HIV-burdened community
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa, Department of Medicine, University of Cape Town, Cape Town, South Africa, Department of Epidemiology, Mailman School of Public Health, Columbia University, NY, New York, USA, Public Health Research Institute, Tuberculosis Center, New Jersey Medical School, Rutgers, State University of New Jersey, Newark, USA, Division of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa, National Health Laboratory Service, Cape Town, South Africa, Division of Medical Microbiology, Department of Clinical Laboratory Sciences, University of Cape Town, Cape Town, South Africa and Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, USADesmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa, Department of Medicine, University of Cape Town, Cape Town, South Africa, Department of Epidemiology, Mailman School of Public Health, Columbia University, Australia
    Int J Epidemiol 43:1114-22. 2014
  4. pmc Decreasing household contribution to TB transmission with age: a retrospective geographic analysis of young people in a South African township
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 14:221. 2014
  5. pmc Retreatment tuberculosis in a South African community: the role of re-infection, HIV and antiretroviral treatment
    K Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Int J Tuberc Lung Dis 16:1510-6. 2012
  6. pmc Force of tuberculosis infection among adolescents in a high HIV and TB prevalence community: a cross-sectional observation study
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 11:156. 2011
  7. pmc Antiretroviral program associated with reduction in untreated prevalent tuberculosis in a South African township
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Am J Respir Crit Care Med 182:1080-5. 2010
  8. pmc Molecular epidemiology of Mycobacterium tuberculosis in a South African community with high HIV prevalence
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, Cape Town, South Africa
    J Infect Dis 200:1207-11. 2009
  9. pmc Childhood tuberculosis infection and disease: a spatial and temporal transmission analysis in a South African township
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, Department of Medicine, University of Cape Town
    S Afr Med J 99:738-43. 2009
  10. pmc Undiagnosed tuberculosis in a community with high HIV prevalence: implications for tuberculosis control
    Robin Wood
    The Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Health Science Faculty, UCT Observatory, Cape Town 7925, South Africa
    Am J Respir Crit Care Med 175:87-93. 2007

Detail Information

Publications25

  1. ncbi request reprint Impact of HIV infection on the epidemiology of tuberculosis in a peri-urban community in South Africa: the need for age-specific interventions
    Stephen D Lawn
    Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    Clin Infect Dis 42:1040-7. 2006
    ..Evaluation of additional control interventions requires detailed understanding of the epidemiological relationship between these diseases at the community level...
  2. ncbi request reprint Adolescent and adult participation in an HIV vaccine trial preparedness cohort in South Africa
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    J Adolesc Health 43:8-14. 2008
    ..We analyzed adult and adolescent data from a cohort study conducted to assess the feasibility of involving adolescents and adults in HIV vaccine-related studies...
  3. ncbi request reprint Factors affecting tuberculosis strain success over 10 years in a high TB- and HIV-burdened community
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa, Department of Medicine, University of Cape Town, Cape Town, South Africa, Department of Epidemiology, Mailman School of Public Health, Columbia University, NY, New York, USA, Public Health Research Institute, Tuberculosis Center, New Jersey Medical School, Rutgers, State University of New Jersey, Newark, USA, Division of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa, National Health Laboratory Service, Cape Town, South Africa, Division of Medical Microbiology, Department of Clinical Laboratory Sciences, University of Cape Town, Cape Town, South Africa and Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, USADesmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa, Department of Medicine, University of Cape Town, Cape Town, South Africa, Department of Epidemiology, Mailman School of Public Health, Columbia University, Australia
    Int J Epidemiol 43:1114-22. 2014
    ..Factors associated with Mycobacterium tuberculosis (Mtb) strain success over time in high burdened communities are unknown...
  4. pmc Decreasing household contribution to TB transmission with age: a retrospective geographic analysis of young people in a South African township
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 14:221. 2014
    ..We explored the relationship between residential exposure to adult TB cases and infection in children and adolescents in a South African community with high burdens of TB and HIV...
  5. pmc Retreatment tuberculosis in a South African community: the role of re-infection, HIV and antiretroviral treatment
    K Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Int J Tuberc Lung Dis 16:1510-6. 2012
    ..Limited data exist on the impact of human immunodeficiency virus (HIV) or antiretroviral treatment (ART) on retreatment tuberculosis (TB)...
  6. pmc Force of tuberculosis infection among adolescents in a high HIV and TB prevalence community: a cross-sectional observation study
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 11:156. 2011
    ..However, there are little data assessing incidence of TB infection in adolescents in these settings...
  7. pmc Antiretroviral program associated with reduction in untreated prevalent tuberculosis in a South African township
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Am J Respir Crit Care Med 182:1080-5. 2010
    ..Prevalent untreated TB is the main source of transmission. In settings with large burdens of human immunodeficiency virus (HIV) and TB, highly active antiretroviral therapy (HAART) may contribute to TB control...
  8. pmc Molecular epidemiology of Mycobacterium tuberculosis in a South African community with high HIV prevalence
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, Cape Town, South Africa
    J Infect Dis 200:1207-11. 2009
    ..The strong association between W-Beijing and HIV infection may have important implications for tuberculosis control...
  9. pmc Childhood tuberculosis infection and disease: a spatial and temporal transmission analysis in a South African township
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, Department of Medicine, University of Cape Town
    S Afr Med J 99:738-43. 2009
    ..While adult TB results from both recent and past infection, childhood TB results from recent infection and reflects ongoing transmission despite current TB control strategies...
  10. pmc Undiagnosed tuberculosis in a community with high HIV prevalence: implications for tuberculosis control
    Robin Wood
    The Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Health Science Faculty, UCT Observatory, Cape Town 7925, South Africa
    Am J Respir Crit Care Med 175:87-93. 2007
    ..We conducted a cross-sectional survey of pulmonary TB (PTB) and HIV infection in a community of 13,000 with high HIV prevalence and high TB notification rate and a well-functioning DOTS TB control program...
  11. pmc Rates of tuberculosis transmission to children and adolescents in a community with a high prevalence of HIV infection among adults
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, School of Public Health and Family Medicine, University of Cape Town, Mowbray, Cape Town, South Africa
    Clin Infect Dis 47:349-55. 2008
    ....
  12. pmc Burden of new and recurrent tuberculosis in a major South African city stratified by age and HIV-status
    Robin Wood
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 6:e25098. 2011
    ....
  13. pmc Indoor social networks in a South African township: potential contribution of location to tuberculosis transmission
    Robin Wood
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 7:e39246. 2012
    ..We therefore quantified time spent and contacts met in indoor locations and public transport by residents of a South African township with a very high TB burden...
  14. doi request reprint Changing patterns in HIV/AIDS stigma and uptake of voluntary counselling and testing services: the results of two consecutive community surveys conducted in the Western Cape, South Africa
    Sumaya Mall
    Department of Psychology, University of Stellenbosch, Cape Town, South Africa
    AIDS Care 25:194-201. 2013
    ..Given the role of HIV/AIDS-associated stigma in influencing choices to access HIV testing, and the benefits associated with HIV testing, interventions to reduce stigma in communities affected by this disease should be encouraged...
  15. pmc Social mixing patterns within a South African township community: implications for respiratory disease transmission and control
    Simon P Johnstone-Robertson
    Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Western Cape, South Africa
    Am J Epidemiol 174:1246-55. 2011
    ..High numbers of indoor contacts and intergenerational mixing in households and transport may contribute to exceptionally high rates of tuberculosis transmission reported in the community...
  16. pmc Antiretroviral therapy and TB notification rates in a high HIV prevalence South African community
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    J Acquir Immune Defic Syndr 56:263-9. 2011
    ..Antiretroviral therapy (ART) has been proposed as an intervention for reducing tuberculosis (TB) burdens in areas with high HIV prevalence. However, little data is available on the impact of ART on population-level TB...
  17. ncbi request reprint Low acceptability of medical male circumcision as an HIV/AIDS prevention intervention within a South African community that practises traditional circumcision
    Daniella Mark
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town
    S Afr Med J 102:571-3. 2012
    ..The acceptability of circumcision as a biomedical intervention mirroring an ingrained cultural practice, as well as the age and extent of the procedure, are poorly understood...
  18. pmc Tuberculosis transmission to young children in a South African community: modeling household and community infection risks
    Robin Wood
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Faculty of Health Sciences, Cape Town, South Africa
    Clin Infect Dis 51:401-8. 2010
    ..A model was used to explore the interactions between prevalence of adult tuberculosis infection, adult-to-child contacts, and household ventilation, which could result in such a high annual risk of tuberculosis infection...
  19. doi request reprint Epidemiology of HIV-1 subtypes among men who have sex with men in Cape Town, South Africa
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town, Cape Town, South Africa Division of Medical Virology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa Division of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa Center for Learning and Innovation, San Francisco Department of Public Health, San Francisco, CA University of California, San Francisco and National Health Laboratory Services, Cape Town, South Africa
    J Acquir Immune Defic Syndr 65:473-80. 2014
    ..However, few recent HIV-1 subtype data are available for MSM in South Africa. We examined HIV-1 subtypes among MSM in Cape Town...
  20. pmc Socio-behaviour challenges to phase III HIV vaccine trials in Sub-Saharan Africa
    Joalida Smit
    MRC Unit for Anxiety and Stress Disorders, University of Stellenbosch, Cape Town, South Africa
    Afr Health Sci 5:198-206. 2005
    ..There is a need for a review of the literature to help focus such research efforts in Sub-Saharan Africa...
  21. pmc Sexual health, HIV risk, and retention in an adolescent HIV-prevention trial preparatory cohort
    Heather B Jaspan
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    J Adolesc Health 49:42-6. 2011
    ..Although adolescents are at high risk for human immunodeficiency virus (HIV) infection, they have not been, included in HIV vaccine trials...
  22. ncbi request reprint Design and evaluation of a drama-based intervention to promote voluntary counseling and HIV testing in a South African community
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Sex Transm Dis 33:524-6. 2006
    ..Voluntary counseling and testing (VCT) services are a major component of HIV prevention and treatment efforts. We developed a drama-based intervention to promote VCT services in a peri-urban community in South Africa...
  23. pmc Lipoarabinomannan in urine during tuberculosis treatment: association with host and pathogen factors and mycobacteriuria
    Robin Wood
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town Faculty of Health Sciences, Cape Town, South Africa
    BMC Infect Dis 12:47. 2012
    ..However, the LAM-ELISA assay has demonstrated variable sensitivity in diagnosing TB in diverse clinical populations. We therefore explored pathogen and host factors potentially impacting LAM detection...
  24. ncbi request reprint Impact of ART on TB Case Fatality Stratified by CD4 Count for HIV-Positive TB Patients in Cape Town, South Africa (2009-2011)
    Richard Kaplan
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Science, University of Cape Town, Cape Town, South Africa City Health Directorate, City of Cape Town, South Africa and Department of Medicine, University of Cape Town, Cape Town, South Africa
    J Acquir Immune Defic Syndr 66:487-94. 2014
    ..To identify determinants of tuberculosis (TB) case fatality including the impact of antiretroviral therapy (ART) at different CD4 thresholds for HIV-positive adult and adolescent TB patients...
  25. ncbi request reprint Identifying at-risk populations in Kenya and South Africa: HIV incidence in cohorts of men who report sex with men, sex workers, and youth
    Matthew A Price
    Department of Medical Affairs, International AIDS Vaccine Initiative, New York, NY, USA
    J Acquir Immune Defic Syndr 59:185-93. 2012
    ..To identify and describe populations at risk for HIV in 3 clinical research centers in Kenya and South Africa...