Ann E Meyers

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. pmc HIV-1 sub-type C chimaeric VLPs boost cellular immune responses in mice
    Sirika Pillay
    Department of Molecular and Cell Biology, Faculty of Science, University of Cape Town, University Ave, Rondebosch 7701, South Africa
    J Immune Based Ther Vaccines 8:7. 2010
  2. pmc Expression of HIV-1 antigens in plants as potential subunit vaccines
    Ann Meyers
    Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa
    BMC Biotechnol 8:53. 2008
  3. pmc Robust immunity to an auxotrophic Mycobacterium bovis BCG-VLP prime-boost HIV vaccine candidate in a nonhuman primate model
    Gerald K Chege
    Division of Medical Virology, Department of Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Virol 87:5151-60. 2013
  4. pmc Stability studies of HIV-1 Pr55gag virus-like particles made in insect cells after storage in various formulation media
    Alisson Lynch
    Department of Molecular and Cell Biology, Faculty of Science, University of Cape Town, University Ave, Rondebosch, 7701, South Africa
    Virol J 9:210. 2012
  5. pmc Abrogation of contaminating RNA activity in HIV-1 Gag VLPs
    Ziyaad Valley-Omar
    Department of Molecular and Cell Biology, Faculty of Science, University of Cape Town, University Ave, Rondebosch 7701, South Africa
    Virol J 8:462. 2011
  6. doi request reprint Expression in tobacco and purification of beak and feather disease virus capsid protein fused to elastin-like polypeptides
    Lucian Duvenage
    Department of Molecular and Cell Biology, University of Cape Town, Rondebosch 7700, South Africa
    J Virol Methods 191:55-62. 2013
  7. doi request reprint Optimization of chimeric HIV-1 virus-like particle production in a baculovirus-insect cell expression system
    Sirika Pillay
    Department of Molecular and Cell Biology, University of Cape Town, PB X3, Rondebosch 7701, South Africa
    Biotechnol Prog 25:1153-60. 2009
  8. pmc Human papillomavirus (HPV) type 16 E7 protein bodies cause tumour regression in mice
    Mark Whitehead
    Department of Molecular and Cell Biology, University of Cape Town, Private Bag X3, Cape Town, Rondebosch 7700, South Africa
    BMC Cancer 14:367. 2014
  9. doi request reprint A prime-boost immunisation regimen using recombinant BCG and Pr55(gag) virus-like particle vaccines based on HIV type 1 subtype C successfully elicits Gag-specific responses in baboons
    Gerald K Chege
    Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town, South Africa
    Vaccine 27:4857-66. 2009
  10. doi request reprint HIV-1 subtype C Pr55gag virus-like particle vaccine efficiently boosts baboons primed with a matched DNA vaccine
    Gerald K Chege
    Medical Virology, Department of Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town, Rondebosch, Cape Town, South Africa
    J Gen Virol 89:2214-27. 2008

Collaborators

Detail Information

Publications11

  1. pmc HIV-1 sub-type C chimaeric VLPs boost cellular immune responses in mice
    Sirika Pillay
    Department of Molecular and Cell Biology, Faculty of Science, University of Cape Town, University Ave, Rondebosch 7701, South Africa
    J Immune Based Ther Vaccines 8:7. 2010
    ..The results demonstrate the promising potential of these chimaeric VLPs as vaccine candidates against HIV-1...
  2. pmc Expression of HIV-1 antigens in plants as potential subunit vaccines
    Ann Meyers
    Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa
    BMC Biotechnol 8:53. 2008
    ..We partially purified a selected vaccine candidate and tested its stimulation of a humoral and cellular immune response in mice...
  3. pmc Robust immunity to an auxotrophic Mycobacterium bovis BCG-VLP prime-boost HIV vaccine candidate in a nonhuman primate model
    Gerald K Chege
    Division of Medical Virology, Department of Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Virol 87:5151-60. 2013
    ..This report further indicates the feasibility of developing a BCG-based HIV vaccine that is safe for childhood HIV immunization...
  4. pmc Stability studies of HIV-1 Pr55gag virus-like particles made in insect cells after storage in various formulation media
    Alisson Lynch
    Department of Molecular and Cell Biology, Faculty of Science, University of Cape Town, University Ave, Rondebosch, 7701, South Africa
    Virol J 9:210. 2012
    ..The medium in which the VLPs are formulated and the temperature at which they are stored are two important factors affecting their stability...
  5. pmc Abrogation of contaminating RNA activity in HIV-1 Gag VLPs
    Ziyaad Valley-Omar
    Department of Molecular and Cell Biology, Faculty of Science, University of Cape Town, University Ave, Rondebosch 7701, South Africa
    Virol J 8:462. 2011
    ..This suggests that HIV-1 Gag VLPs produced using this system facilitate uptake and subsequent expression of encapsidated RNA in mammalian cells - an unfavourable characteristic for a vaccine...
  6. doi request reprint Expression in tobacco and purification of beak and feather disease virus capsid protein fused to elastin-like polypeptides
    Lucian Duvenage
    Department of Molecular and Cell Biology, University of Cape Town, Rondebosch 7700, South Africa
    J Virol Methods 191:55-62. 2013
    ..The ELP fusion proteins were purified by inverse transition cycling (ITC) and it was found that a membrane filtration-based ITC method improved the recovery of ΔN40 CP-ELP51 fusion protein relative to a centrifugation-based method...
  7. doi request reprint Optimization of chimeric HIV-1 virus-like particle production in a baculovirus-insect cell expression system
    Sirika Pillay
    Department of Molecular and Cell Biology, University of Cape Town, PB X3, Rondebosch 7701, South Africa
    Biotechnol Prog 25:1153-60. 2009
    ..This work provides a potentially valuable guideline for HIV-1 protein vaccine optimization, as well as for general optimization of a baculovirus-based expression system to produce complex recombinant proteins...
  8. pmc Human papillomavirus (HPV) type 16 E7 protein bodies cause tumour regression in mice
    Mark Whitehead
    Department of Molecular and Cell Biology, University of Cape Town, Private Bag X3, Cape Town, Rondebosch 7700, South Africa
    BMC Cancer 14:367. 2014
    ..Additionally, there remains a need to treat women that are already infected with HPV, and who have high-grade lesions or cervical cancer...
  9. doi request reprint A prime-boost immunisation regimen using recombinant BCG and Pr55(gag) virus-like particle vaccines based on HIV type 1 subtype C successfully elicits Gag-specific responses in baboons
    Gerald K Chege
    Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town, South Africa
    Vaccine 27:4857-66. 2009
    ..In addition, a Gag-specific humoral response was elicited. These data support the development of HIV-1 vaccines based on rBCG and Pr55(gag) VLPs...
  10. doi request reprint HIV-1 subtype C Pr55gag virus-like particle vaccine efficiently boosts baboons primed with a matched DNA vaccine
    Gerald K Chege
    Medical Virology, Department of Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town, Rondebosch, Cape Town, South Africa
    J Gen Virol 89:2214-27. 2008
    ....
  11. doi request reprint Chimaeric HIV-1 subtype C Gag molecules with large in-frame C-terminal polypeptide fusions form virus-like particles
    Richard J Halsey
    Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, PO Observatory 7925, Cape Town, South Africa
    Virus Res 133:259-68. 2008
    ....