Graeme Meintjes

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. ncbi Patient and provider delay in tuberculosis suspects from communities with a high HIV prevalence in South Africa: a cross-sectional study
    Graeme Meintjes
    Division of Infectious Diseases, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, 7925, South Africa
    BMC Infect Dis 8:72. 2008
  2. ncbi Immune reconstitution inflammatory syndrome in a large multicenter cohort study: case definition and comparability
    Graeme Meintjes
    Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, Western Cape, South Africa
    Expert Rev Anti Infect Ther 10:737-41. 2012
  3. ncbi Corticosteroid-modulated immune activation in the tuberculosis immune reconstitution inflammatory syndrome
    Graeme Meintjes
    Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Am J Respir Crit Care Med 186:369-77. 2012
  4. ncbi Management of the immune reconstitution inflammatory syndrome
    Graeme Meintjes
    Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Curr HIV/AIDS Rep 9:238-50. 2012
  5. ncbi Outcome of AIDS-associated cryptococcal meningitis initially treated with 200 mg/day or 400 mg/day of fluconazole
    C F Schaars
    Division of Infectious Diseases, University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 6:118. 2006
  6. ncbi Early severe morbidity and resource utilization in South African adults on antiretroviral therapy
    Teresa K Smith de Cherif
    Department of Medicine, Division of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 9:205. 2009
  7. ncbi Tuberculosis-associated immune reconstitution inflammatory syndrome and unmasking of tuberculosis by antiretroviral therapy
    Graeme Meintjes
    Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, South Africa
    Clin Chest Med 30:797-810, x. 2009
  8. ncbi Randomized placebo-controlled trial of prednisone for paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome
    Graeme Meintjes
    Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South
    AIDS 24:2381-90. 2010
  9. ncbi Novel relationship between tuberculosis immune reconstitution inflammatory syndrome and antitubercular drug resistance
    Graeme Meintjes
    Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Clin Infect Dis 48:667-76. 2009
  10. ncbi Adjunctive interferon-γ immunotherapy for the treatment of HIV-associated cryptococcal meningitis: a randomized controlled trial
    Joseph N Jarvis
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Infectious Diseases Unit, GF Jooste Hospital, Cape Town, South Africa
    AIDS 26:1105-13. 2012

Detail Information

Publications50

  1. ncbi Patient and provider delay in tuberculosis suspects from communities with a high HIV prevalence in South Africa: a cross-sectional study
    Graeme Meintjes
    Division of Infectious Diseases, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, 7925, South Africa
    BMC Infect Dis 8:72. 2008
    ..The aim was to describe patient and provider delay in the diagnosis of TB in patients with suspected TB requiring admission, and to determine the risk factors for this delay and the consequences...
  2. ncbi Immune reconstitution inflammatory syndrome in a large multicenter cohort study: case definition and comparability
    Graeme Meintjes
    Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, Western Cape, South Africa
    Expert Rev Anti Infect Ther 10:737-41. 2012
    ....
  3. ncbi Corticosteroid-modulated immune activation in the tuberculosis immune reconstitution inflammatory syndrome
    Graeme Meintjes
    Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Am J Respir Crit Care Med 186:369-77. 2012
    ..Prednisone reduces morbidity in TB-IRIS, but the mechanisms are unclear...
  4. ncbi Management of the immune reconstitution inflammatory syndrome
    Graeme Meintjes
    Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Curr HIV/AIDS Rep 9:238-50. 2012
    ..When considering corticosteroid treatment clinicians should be aware of their side effects and only use them when the diagnosis of IRIS is certain. In viral forms of IRIS corticosteroids are generally avoided...
  5. ncbi Outcome of AIDS-associated cryptococcal meningitis initially treated with 200 mg/day or 400 mg/day of fluconazole
    C F Schaars
    Division of Infectious Diseases, University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 6:118. 2006
    ..In 2001 donated fluconazole became available, allowing us to use standard doses (400 mg daily initially). Antiretroviral therapy was not available during the study period...
  6. ncbi Early severe morbidity and resource utilization in South African adults on antiretroviral therapy
    Teresa K Smith de Cherif
    Department of Medicine, Division of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 9:205. 2009
    ..There is limited data on the causes of early morbidity on HAART and the associated resource utilization...
  7. ncbi Tuberculosis-associated immune reconstitution inflammatory syndrome and unmasking of tuberculosis by antiretroviral therapy
    Graeme Meintjes
    Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, South Africa
    Clin Chest Med 30:797-810, x. 2009
    ..In this review the incidence, clinical features, risk factors, treatment, and prevention of TB-IRIS in adult and pediatric patients are discussed...
  8. ncbi Randomized placebo-controlled trial of prednisone for paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome
    Graeme Meintjes
    Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South
    AIDS 24:2381-90. 2010
    ..We aimed to assess whether a 4-week course of prednisone would reduce morbidity in patients with paradoxical TB-IRIS without excess adverse events...
  9. ncbi Novel relationship between tuberculosis immune reconstitution inflammatory syndrome and antitubercular drug resistance
    Graeme Meintjes
    Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Clin Infect Dis 48:667-76. 2009
    ..The differential diagnosis of TB IRIS includes deterioration caused by other human immunodeficiency virus-related morbidities and drug-resistant TB...
  10. ncbi Adjunctive interferon-γ immunotherapy for the treatment of HIV-associated cryptococcal meningitis: a randomized controlled trial
    Joseph N Jarvis
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Infectious Diseases Unit, GF Jooste Hospital, Cape Town, South Africa
    AIDS 26:1105-13. 2012
    ..We performed a randomized controlled trial to determine whether addition of IFNγ to standard therapy increased the rate of clearance of cryptococcal infection in HIV-associated cryptococcal meningitis...
  11. ncbi Clinical deterioration during antituberculosis treatment in Africa: incidence, causes and risk factors
    Dominique J Pepper
    Infectious Diseases Unit, GF Jooste Hospital, Cape Town, South Africa
    BMC Infect Dis 10:83. 2010
    ..We therefore determined the incidence, causes and risk factors for clinical deterioration...
  12. ncbi Neurologic manifestations of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome: a case series
    Dominique J Pepper
    Infectious Diseases Unit, GF Jooste Hospital, Cape Town, South Africa
    Clin Infect Dis 48:e96-107. 2009
    ..The reports in the published literature are anecdotal, and the prevalence and outcomes of neurologic TB-IRIS are unknown...
  13. ncbi Dissection of regenerating T-Cell responses against tuberculosis in HIV-infected adults sensitized by Mycobacterium tuberculosis
    Katalin A Wilkinson
    Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Room S3 13, Wernher and Beit Building South, Observatory 7925, Republic of South Africa
    Am J Respir Crit Care Med 180:674-83. 2009
    ..Therefore a novel approach to gain insight into protection against tuberculosis is to analyze the T cells that expand in people sensitized by Mycobacterium tuberculosis (MTB) during cART...
  14. ncbi Comparison of the early fungicidal activity of high-dose fluconazole, voriconazole, and flucytosine as second-line drugs given in combination with amphotericin B for the treatment of HIV-associated cryptococcal meningitis
    Angela Loyse
    Infectious Diseases Unit, GF Jooste Hospital, Cape Town, South Africa
    Clin Infect Dis 54:121-8. 2012
    ..Alternative, more widely available, and/or more effective antifungal combination treatment regimens are urgently needed...
  15. ncbi High-dose amphotericin B with flucytosine for the treatment of cryptococcal meningitis in HIV-infected patients: a randomized trial
    Tihana Bicanic
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Clin Infect Dis 47:123-30. 2008
    ..A dosage range for AmB of 0.7-1 mg/kg per day is noted in current guidelines, but there are no data comparing 0.7 mg/kg per day with 1 mg/kg per day...
  16. ncbi Immune reconstitution inflammatory syndrome in HIV-associated cryptococcal meningitis: a prospective study
    Tihana Bicanic
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    J Acquir Immune Defic Syndr 51:130-4. 2009
    ..Prospective data on incidence, characteristics, and risk factors for cryptococcal meningitis immune reconstitution inflammatory syndrome (CM-IRIS) are lacking...
  17. ncbi Clinical deterioration during antitubercular treatment at a district hospital in South Africa: the importance of drug resistance and AIDS defining illnesses
    Dominique J Pepper
    Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 4:e4520. 2009
    ..We undertook this study among tuberculosis (TB) patients referred to an adult district level hospital situated in a high HIV-1 prevalence setting to determine the frequency, reasons and outcome for such clinical deterioration...
  18. ncbi Management of individuals requiring antiretroviral therapy and TB treatment
    Karen Cohen
    Division of Clinical Pharmacology, Department of Medicine, Cape Town, South Africa
    Curr Opin HIV AIDS 5:61-9. 2010
    ..The incidence of TB in patients established on ART remains high. Co-treatment presents several management challenges. Recent data on these management issues are reviewed...
  19. ncbi Relationship of cerebrospinal fluid pressure, fungal burden and outcome in patients with cryptococcal meningitis undergoing serial lumbar punctures
    Tihana Bicanic
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    AIDS 23:701-6. 2009
    ....
  20. ncbi Symptomatic relapse of HIV-associated cryptococcal meningitis in South Africa: the role of inadequate secondary prophylaxis
    Joseph N Jarvis
    Infectious Diseases Unit, GF Jooste Hospital, Cape Town, South Africa
    S Afr Med J 100:378-82. 2010
    ..We carried out a study to examine the contribution of inadequate secondary fluconazole prophylaxis to symptomatic relapses of cryptococcal meningitis...
  21. ncbi Barriers to initiation of antiretrovirals during antituberculosis therapy in Africa
    Dominique J Pepper
    Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 6:e19484. 2011
    ..The initiation of antiretroviral therapy (ART) during TB therapy significantly improves survival, however it is not known which barriers prevent eligible TB patients from initiating life-saving ART...
  22. ncbi Fungal burden, early fungicidal activity, and outcome in cryptococcal meningitis in antiretroviral-naive or antiretroviral-experienced patients treated with amphotericin B or fluconazole
    Tihana Bicanic
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Cape Town, South Africa
    Clin Infect Dis 45:76-80. 2007
    ....
  23. ncbi Altered ratio of IFN-γ/IL-10 in patients with drug resistant Mycobacterium tuberculosis and HIV- Tuberculosis Immune Reconstitution Inflammatory Syndrome
    Keira H Skolimowska
    Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 7:e46481. 2012
    ..02). Since host immune responses are dependent on the bacterial load, we hypothesise that the impaired cytokine balance is likely to be caused by the poorly controlled bacterial growth in these patients...
  24. ncbi Corticosteroid therapy, vitamin D status, and inflammatory cytokine profile in the HIV-tuberculosis immune reconstitution inflammatory syndrome
    Anali Conesa-Botella
    Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory, South Africa
    Clin Infect Dis 55:1004-11. 2012
    ..As adjunctive corticosteroid therapy and vitamin D have immunomodulatory properties, we investigated the relationship between cytokine/chemokine profiles, corticosteroid use, and vitamin D deficiency in TB-IRIS patients...
  25. ncbi Severe hyperlactataemia complicating stavudine first-line antiretroviral therapy in South Africa
    David Stead
    GF Jooste Hospital, Cape Town, South Africa
    Antivir Ther 13:937-43. 2008
    ..In the public sector antiretroviral therapy (ART) programme in South Africa the standardized first-line regimen includes stavudine (d4T). Severe symptomatic hyperlactataemia (SHL) is a potentially life-threatening complication of d4T...
  26. ncbi Burden of antituberculosis and antiretroviral drug-induced liver injury at a secondary hospital in South Africa
    Charlotte Schutz
    Department of Medicine, Faculty of Health Sciences, University of Cape Town
    S Afr Med J 102:506-11. 2012
    ..G F Jooste Hospital (GFJH) is a secondary-level referral hospital in a high HIV and tuberculosis (TB) co-infection setting...
  27. ncbi Assessment at antiretroviral clinics during TB treatment reduces loss to follow-up among HIV-infected patients
    Dominique J Pepper
    Department of Medicine, Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Western Province, South Africa
    PLoS ONE 7:e37634. 2012
    ..A South African township clinic where loss to follow-up during TB treatment may prevent HIV-infected TB patients from receiving life-saving ART...
  28. ncbi Central nervous system disorders after starting antiretroviral therapy in South Africa
    Valerie Asselman
    Department of Medicine, GF Jooste Hospital, Cape Town, South Africa
    AIDS 24:2871-6. 2010
    ..To describe the spectrum of central nervous system (CNS) disease during the first year of antiretroviral therapy (ART) and to determine the contribution of neurological immune reconstitution inflammatory syndrome (IRIS)...
  29. ncbi Complications of antiretroviral therapy initiation in hospitalised patients with HIV-associated tuberculosis
    Helen van der Plas
    Division of Infectious Diseases and HIV Medicine, Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 8:e54145. 2013
    ....
  30. ncbi Frequency, severity, and prediction of tuberculous meningitis immune reconstitution inflammatory syndrome
    Suzaan Marais
    Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa
    Clin Infect Dis 56:450-60. 2013
    ..Potentially life-threatening neurological involvement occurs frequently and has been suggested as a reason to defer ART...
  31. ncbi Management of patients with the immune reconstitution inflammatory syndrome
    Suzaan Marais
    Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory, 7925, South Africa
    Curr HIV/AIDS Rep 6:162-71. 2009
    ..Therapeutic procedures (eg, aspiration of pus collections) play an important role in some patients. Interruption of ART may be considered in life-threatening forms of IRIS...
  32. ncbi Type 1 helper T cells and FoxP3-positive T cells in HIV-tuberculosis-associated immune reconstitution inflammatory syndrome
    Graeme Meintjes
    F R C P, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa
    Am J Respir Crit Care Med 178:1083-9. 2008
    ..Objectives: To investigate the role of type 1 helper T cell expansions and regulatory T cells in HIV-TB IRIS...
  33. ncbi Adult meningitis in a setting of high HIV and TB prevalence: findings from 4961 suspected cases
    Joseph N Jarvis
    Infectious Diseases Unit, GF Jooste Hospital, Cape Town, South Africa
    BMC Infect Dis 10:67. 2010
    ..We performed a retrospective study to determine these findings in a setting of high HIV and TB prevalence in Cape Town...
  34. ncbi Complications of antiretroviral therapy in patients with tuberculosis: drug interactions, toxicity, and immune reconstitution inflammatory syndrome
    Helen McIlleron
    Division of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa
    J Infect Dis 196:S63-75. 2007
    ..These complexities of coadministration of antitubercular and antiretroviral agents are reviewed, and research priorities are highlighted...
  35. ncbi Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings
    Graeme Meintjes
    Institute of Infectious Diseases and Molecular Medicine and Department of Medicine, University of Cape Town, Cape Town, South Africa
    Lancet Infect Dis 8:516-23. 2008
    ..It is envisaged that these definitions could be used by clinicians and researchers in a variety of settings to promote standardisation and comparability of data...
  36. ncbi Pathogenesis and prevention of immune reconstitution disease during antiretroviral therapy
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Expert Rev Anti Infect Ther 9:415-30. 2011
    ..In addition, use of a range of pharmacological agents with immunosuppressive and immunomodulatory activity is being explored...
  37. ncbi Heart failure and cardiogenic shock associated with the TB-immune reconstitution inflammatory syndrome
    Chris Kenyon
    Department of Medicine, GF Jooste Hospital, Cape Town, South Africa
    Cardiovasc J Afr 23:e14-7. 2012
    ..Possible aetiologies and pathophysiology as well as suggested diagnostic and therapeutic approaches to this problem are discussed...
  38. ncbi Presentation and outcome of tuberculous meningitis in a high HIV prevalence setting
    Suzaan Marais
    Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 6:e20077. 2011
    ..We undertook this study to describe causes of meningitis at a secondary-level hospital in a high HIV/TB co-infection setting and to determine predictors of mortality in patients with TBM...
  39. ncbi Pulmonary cryptococcosis misdiagnosed as smear-negative pulmonary tuberculosis with fatal consequences
    Joseph N Jarvis
    Infectious Diseases Unit, GF Jooste Hospital, Cape Town, South Africa
    Int J Infect Dis 14:e310-2. 2010
    ..Serum cryptococcal antigen testing may facilitate diagnosis in such cases...
  40. ncbi Pulmonary manifestations of the immune reconstitution inflammatory syndrome
    Gregory Calligaro
    Division of Pulmonology, Department of Medicine, University of Cape Town, Groote Schuur Hospital, Cape Town, South Africa
    Curr Opin Pulm Med 17:180-8. 2011
    ..Pulmonologists need an awareness of the timing, presentation and treatment of pulmonary IRIS...
  41. ncbi Improved survival and antiretroviral treatment outcomes in adults receiving community-based adherence support: 5-year results from a multicentre cohort study in South Africa
    Geoffrey Fatti
    Kheth Impilo, Cape Town, South Africa
    J Acquir Immune Defic Syndr 61:e50-8. 2012
    ..However, little effectiveness data of the large-scale implementation of these programs is available. We evaluated the effect of a community-based adherence-support (CBAS) program on ART outcomes across 57 South African sites...
  42. ncbi Failure to eradicate Isospora belli diarrhoea despite immune reconstitution in adults with HIV--a case series
    Tom H Boyles
    Division of Infectious Diseases and HIV Medicine, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa
    PLoS ONE 7:e42844. 2012
    ..Mortality was high and pending more data we recommend extended treatment with high-dose co-trimoxazole in similar cases...
  43. ncbi Reduced referral and case fatality rates for severe symptomatic hyperlactataemia in a South African public sector antiretroviral programme: a retrospective observational study
    Charlotte Schutz
    Infectious Diseases Unit, GF Jooste Hospital, Duinefontein Road, Manenberg, 7764, Cape Town, South Africa
    AIDS Res Ther 7:13. 2010
    ..This study assessed trends in referral rate, severity at presentation and case fatality rate for severe SHL...
  44. ncbi Hypoxia induces an immunodominant target of tuberculosis specific T cells absent from common BCG vaccines
    Hannah Priyadarshini Gideon
    Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory, South Africa
    PLoS Pathog 6:e1001237. 2010
    ....
  45. ncbi Dermatologic manifestations of the immune reconstitution inflammatory syndrome
    Rannakoe Lehloenya
    Division of Dermatology, Department of Medicine, University of Cape Town, Groote Schuur Hospital, Observatory, 7925, South Africa
    Dermatol Clin 24:549-70, vii. 2006
    ..This article covers certain general issues related to IRIS and then focuses on the spectrum of dermatologic manifestations...
  46. ncbi Uniquely South African: time to consider offering HIV-positive donor kidneys to HIV-infected renal failure patients?
    W D Francois Venter
    Reproductive Health and HIV Research Unit, Cape Town, South Africa
    S Afr Med J 98:182-3. 2008
  47. ncbi Symptomatic relapse of HIV-associated cryptococcal meningitis after initial fluconazole monotherapy: the role of fluconazole resistance and immune reconstitution
    Tihana Bicanic
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Clin Infect Dis 43:1069-73. 2006
    ..Therefore, we conducted a study to assess the contribution of these factors to CM relapse in this context...
  48. ncbi Effect of treatment of latent tuberculosis infection on the T cell response to Mycobacterium tuberculosis antigens
    Katalin A Wilkinson
    Wellcome Trust Center for Research in Clinical Tropical Medicine, Division of Medicine, Imperial College London, Wright Fleming Institute, UK
    J Infect Dis 193:354-9. 2006
    ..These results suggest that the integrity of the bacterial cell wall is important for M. tuberculosis in avoiding immune recognition by T cells and favor a dynamic model of LTBI...
  49. ncbi Antiretroviral roll-out, antifungal roll-back: access to treatment for cryptococcal meningitis
    Tihana Bicanic
    Lancet Infect Dis 5:530-1. 2005
  50. ncbi Immune reconstitution inflammatory syndrome in HIV-infected patients receiving antiretroviral therapy : pathogenesis, clinical manifestations and management
    Devesh J Dhasmana
    Department of Respiratory Medicine, Harefield Hospital, Middlesex, UK
    Drugs 68:191-208. 2008
    ..In this review, we discuss research relating to pathogenesis, the range of clinical manifestations, treatment options and prevention issues...