James A McIntyre

Summary

Affiliation: University of the Witwatersrand
Country: South Africa

Publications

  1. pmc What can we do to reduce mother to child transmission of HIV?
    James Mcintyre
    Perinatal HIV Research Unit, University of the Witwatersrand, Chris Hani Baragwanath Hospital, PO Bertsham, Johannesburg 2013, South Africa
    BMJ 324:218-21. 2002
  2. ncbi request reprint A randomized trial of two postexposure prophylaxis regimens to reduce mother-to-child HIV-1 transmission in infants of untreated mothers
    Glenda E Gray
    Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg South Africa
    AIDS 19:1289-97. 2005
  3. ncbi request reprint Prevention of mother-to-child transmission of HIV: treatment options
    James Mcintyre
    Perinatal HIV Research Unit, University of the Witwatersrand, PO Box 114, Diepkloof, Johannesburg 1864, South Africa
    Expert Rev Anti Infect Ther 3:971-80. 2005
  4. doi request reprint Can devices for adult male circumcision help bridge the implementation gap for HIV prevention services?
    James A McIntyre
    Anova Health Institute, Johannesburg, South Africa
    J Acquir Immune Defic Syndr 58:506-8. 2011
  5. ncbi request reprint Sex, pregnancy, hormones, and HIV
    James A McIntyre
    Perinatal HIV Research Unit, University of the Witwatersrand, Diepkloof, Johannesburg, South Africa
    Lancet 366:1141-2. 2005
  6. ncbi request reprint Strategies to prevent mother-to-child transmission of HIV
    James Mcintyre
    University of the Witwatersrand, Diepkloof, Johannesburg, South Africa
    Curr Opin Infect Dis 19:33-8. 2006
  7. ncbi request reprint Maternal health and HIV
    James Mcintyre
    Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
    Reprod Health Matters 13:129-35. 2005
  8. ncbi request reprint Controversies in the use of nevirapine for prevention of mother-to-child transmission of HIV
    James A McIntyre
    Perinatal HIV Research Unit, University of the Witwatersrand, PO Box 114, Diepkloof, Johannesburg 1864, South Africa
    Expert Opin Pharmacother 7:677-85. 2006
  9. doi request reprint Preventing mother-to-child transmission of HIV
    C N Mnyani
    Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
    BJOG 116:71-6. 2009
  10. pmc Use of antiretrovirals during pregnancy and breastfeeding in low-income and middle-income countries
    James Mcintyre
    Anova Health Institute, Parktown, Johannesburg, South Africa
    Curr Opin HIV AIDS 5:48-53. 2010

Research Grants

  1. Soweto Clinical Trials Unit
    James Mcintyre; Fiscal Year: 2007

Detail Information

Publications47

  1. pmc What can we do to reduce mother to child transmission of HIV?
    James Mcintyre
    Perinatal HIV Research Unit, University of the Witwatersrand, Chris Hani Baragwanath Hospital, PO Bertsham, Johannesburg 2013, South Africa
    BMJ 324:218-21. 2002
  2. ncbi request reprint A randomized trial of two postexposure prophylaxis regimens to reduce mother-to-child HIV-1 transmission in infants of untreated mothers
    Glenda E Gray
    Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg South Africa
    AIDS 19:1289-97. 2005
    ..Where women do not access antenatal care or HIV testing, postexposure prophylaxis to the infant may be an important preventative strategy...
  3. ncbi request reprint Prevention of mother-to-child transmission of HIV: treatment options
    James Mcintyre
    Perinatal HIV Research Unit, University of the Witwatersrand, PO Box 114, Diepkloof, Johannesburg 1864, South Africa
    Expert Rev Anti Infect Ther 3:971-80. 2005
    ..While the long-term implications of this are not completely clear, this selection can be reduced by the addition of short courses of postpartum zidovudine and lamivudine...
  4. doi request reprint Can devices for adult male circumcision help bridge the implementation gap for HIV prevention services?
    James A McIntyre
    Anova Health Institute, Johannesburg, South Africa
    J Acquir Immune Defic Syndr 58:506-8. 2011
    ..The rapid introduction of new and promising biomedical strategies for HIV prevention, including antiretrovirals for HIV prevention, will require early consideration of delivery systems and service design...
  5. ncbi request reprint Sex, pregnancy, hormones, and HIV
    James A McIntyre
    Perinatal HIV Research Unit, University of the Witwatersrand, Diepkloof, Johannesburg, South Africa
    Lancet 366:1141-2. 2005
  6. ncbi request reprint Strategies to prevent mother-to-child transmission of HIV
    James Mcintyre
    University of the Witwatersrand, Diepkloof, Johannesburg, South Africa
    Curr Opin Infect Dis 19:33-8. 2006
    ....
  7. ncbi request reprint Maternal health and HIV
    James Mcintyre
    Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
    Reprod Health Matters 13:129-35. 2005
    ..A more comprehensive approach is needed. The current focus on preventing new infections in children must be broadened to include appropriate care for pregnant women and the prevention of new infections in women and men...
  8. ncbi request reprint Controversies in the use of nevirapine for prevention of mother-to-child transmission of HIV
    James A McIntyre
    Perinatal HIV Research Unit, University of the Witwatersrand, PO Box 114, Diepkloof, Johannesburg 1864, South Africa
    Expert Opin Pharmacother 7:677-85. 2006
    ..An increased risk of severe hepatotoxicity has been reported with long-term nevirapine-containing triple-therapy treatment regimens in women with CD4+ counts > 250 cells/mm3...
  9. doi request reprint Preventing mother-to-child transmission of HIV
    C N Mnyani
    Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
    BJOG 116:71-6. 2009
    ..Access to HIV testing and antiretroviral treatment or prophylaxis remain very limited in low resource settings and needs to be expanded...
  10. pmc Use of antiretrovirals during pregnancy and breastfeeding in low-income and middle-income countries
    James Mcintyre
    Anova Health Institute, Parktown, Johannesburg, South Africa
    Curr Opin HIV AIDS 5:48-53. 2010
    ..The purpose of the study was to review recent evidence on the use of antiretrovirals during pregnancy and breastfeeding in low-income and middle-income settings...
  11. ncbi request reprint Mothers infected with HIV
    James Mcintyre
    Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
    Br Med Bull 67:127-35. 2003
    ..Without such efforts and increased HIV prevention, the gains achieved by safe motherhood programmes will be lost in the future...
  12. doi request reprint CD8/CD38 activation yields important clinical information of effective antiretroviral therapy: findings from the first year of the CIPRA-SA cohort
    Deborah K Glencross
    Department of Molecular Medicine and Haematology, University of the Witwatersrand, Johannesburg, South Africa
    Cytometry B Clin Cytom 74:S131-40. 2008
    ..Cheaper and quicker alternatives to VL such as CD38 tests on CD8+ T cells may therefore play a role in securing the continuation of ART programs in high-volume resource-restricted settings...
  13. pmc Efficacy of short-course AZT plus 3TC to reduce nevirapine resistance in the prevention of mother-to-child HIV transmission: a randomized clinical trial
    James A McIntyre
    Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
    PLoS Med 6:e1000172. 2009
    ....
  14. pmc Inferior quantitative and qualitative immune responses to pneumococcal conjugate vaccine in infants with nasopharyngeal colonization by Streptococcus pneumoniae during the primary series of immunization
    Shabir A Madhi
    University of the Witwatersrand, Department of Science and Technology National Research Foundation Vaccine Preventable Diseases and Respiratory and Meningeal Pathogens Research Unit, Johannesburg, South Africa
    Vaccine 29:6994-7001. 2011
    ....
  15. pmc Progression and regression of premalignant cervical lesions in HIV-infected women from Soweto: a prospective cohort
    Tanvier Omar
    Department of Anatomical Pathology, University of the Witwatersrand, Johannesburg, South Africa
    AIDS 25:87-94. 2011
    ..To ascertain progression and regression of cervical dysplasia in HIV-infected women in Soweto...
  16. pmc HIV and pregnancy
    Glenda E Gray
    Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
    BMJ 334:950-3. 2007
  17. pmc Early antiretroviral therapy and mortality among HIV-infected infants
    Avy Violari
    Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
    N Engl J Med 359:2233-44. 2008
    ..We investigated antiretroviral-treatment strategies in the Children with HIV Early Antiretroviral Therapy (CHER) trial...
  18. ncbi request reprint Combining PMTCT with active case finding for tuberculosis
    Paula B N Kali
    Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
    J Acquir Immune Defic Syndr 42:379-81. 2006
    ..We conclude that rates of TB in HIV-infected pregnant women are high, and screening for TB during routine antenatal care should be implemented in high HIV-prevalence settings...
  19. pmc Effect of HIV infection status and anti-retroviral treatment on quantitative and qualitative antibody responses to pneumococcal conjugate vaccine in infants
    Shabir A Madhi
    Department of Science National Research Foundation, Vaccine Preventable Diseases, University of the Witwatersrand, Johannesburg, South Africa
    J Infect Dis 202:355-61. 2010
    ..Nevertheless, M-/I- infants had superior OPA responses, compared with those in HIV+/ART+ infants, who in turn had better OPA responses, compared with those in HIV+/ART- infants...
  20. ncbi request reprint Low frequency of the V106M mutation among HIV-1 subtype C-infected pregnant women exposed to nevirapine
    Lynn Morris
    AIDS Virus Research Unit, National Institute for Communicable Diseases, Sandringham, Johannesburg, South Africa
    AIDS 17:1698-700. 2003
    ..V106M is a novel resistance mutation found in subtype C viruses exposed to efavirenz. This mutation is thus also induced at a low frequency in subtype C viruses exposed to single dose nevirapine...
  21. pmc Predictors of persistent cytologic abnormalities after treatment of cervical intraepithelial neoplasia in Soweto, South Africa: a cohort study in a HIV high prevalence population
    Yasmin Adam
    Department of Obstetrics and Gynaecology, Chris Hani Baragwanath Hospital, Johannesburg, South Africa
    BMC Cancer 8:211. 2008
    ..We investigated clinical predictors of persistent cytological abnormalities in women who had had a large loop excision of the transformation zone (LLETZ)...
  22. ncbi request reprint Preventing mother-to-child transmission of HIV: successes and challenges
    James Mcintyre
    Perinatal HIV Research Unit, University of Witwatersrand, Johannesburg, South Africa
    BJOG 112:1196-203. 2005
    ..Women who need antiretroviral therapy for their own health should receive it in pregnancy, and access for pregnant women needs to be expanded urgently. The reduction of transmission through breastfeeding remains a challenge...
  23. pmc Linking the global positioning system (GPS) to a personal digital assistant (PDA) to support tuberculosis control in South Africa: a pilot study
    Barry Dwolatzky
    School of Electrical and Information Engineering, University of the Witwatersrand, PO Box 542 Wits 2050 Johannesburg, South Africa
    Int J Health Geogr 5:34. 2006
    ..Additionally, we assessed the feasibility of using aerial photographs to locate homes...
  24. doi request reprint Sexual lubricants in South Africa may potentially disrupt mucosal surfaces and increase HIV transmission risk among men who have sex with men
    Kevin Brian Rebe
    Anova Health Institute, Johannesburg and Cape Town, South Africa
    S Afr Med J 104:49-51. 2014
    ..Concern has been raised about the potential toxicity of lubricants used during anal sex. Epithelial injury is related to the osmolality of the lubricant product...
  25. ncbi request reprint HIV prevention and treatment for South African men who have sex with men
    Kevin B Rebe
    Health4men, Anova Health Institute, Cape Town, South Africa
    S Afr Med J 101:708, 710. 2011
    ..Prevention interventions for MSM are more limited than for heterosexual individuals. Prevention programmes should embrace early their programming. High transmission risk groups such as MSM will benefit from such interventions...
  26. ncbi request reprint Effect of HIV on women
    Glenda E Gray
    Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
    AIDS Read 16:365-8, 373-7. 2006
    ..In addition, women are more likely to have antiretroviral treatment side effects, and certain antiretroviral regimens may impair contraceptive efficacy. Prevention strategies are presently not female-controlled...
  27. ncbi request reprint High rates of HIV in surgical patients in Soweto, South Africa: impact on resource utilisation and recommendations for HIV testing
    Neil A Martinson
    Perinatal HIV Research Unit, University of Witwatersrand, Johannesburg, South Africa
    Trans R Soc Trop Med Hyg 101:176-82. 2007
    ..WHO clinical staging of HIV should include anal sepsis as an indicator of advanced HIV disease...
  28. ncbi request reprint Viral dynamics and CD4+ T cell counts in subtype C human immunodeficiency virus type 1-infected individuals from southern Africa
    Clive M Gray
    National Institute for Communicable Diseases, Johannesburg, South Africa
    AIDS Res Hum Retroviruses 21:285-91. 2005
    ....
  29. ncbi request reprint Antiviral activity of nucleoside analogues during short-course monotherapy or dual therapy: its role in preventing HIV infection in infants
    Glenda Gray
    Perinatal HIV Research Unit, University of the Witwatersrand, South Africa
    J Acquir Immune Defic Syndr 42:169-76. 2006
    ....
  30. doi request reprint Development of phenotypic HIV-1 drug resistance after exposure to single-dose nevirapine
    Adriaan E Basson
    AIDS Virus Research Unit, National Institute for Communicable Diseases, Johannesburg, South Africa
    J Acquir Immune Defic Syndr 49:538-43. 2008
    ..To assess the levels of phenotypic resistance conferred by these mutations, we examined the ability of sample-derived HIV-1 reverse transcriptase to function in the presence of nevirapine (NVP)...
  31. ncbi request reprint Clinical performance of an in-house real-time RT-PCR assay using a fluorogenic LUX primer for quantitation of human immunodeficiency virus type-1 (HIV-1)
    Natela Rekhviashvili
    Department of Molecular Medicine and Hematology, National Health Laboratory Service NHLS, University of the Witwatersrand WITS, Faculty of Health Science, Medical School, 7 York Road, Parktown, Johannesburg 2193, South Africa
    J Virol Methods 146:14-21. 2007
    ..Viral rebound was detected in 5 patients out of 55 by both assays. Thus, the LUX assay compares well to the gold standard and represents an affordable alternative for high volume testing in resource limited settings...
  32. doi request reprint The reliability of point-of-care CD4 testing in identifying HIV-infected pregnant women eligible for antiretroviral therapy
    Coceka N Mnyani
    Anova Health Institute, Johannesburg, South Africa
    J Acquir Immune Defic Syndr 60:260-4. 2012
    ..However, there have been no evaluations of POC CD4 testing in pregnant women. We compared the performance of the PIMA POC analyzer with laboratory-based testing in identifying pregnant women eligible for ART...
  33. pmc Knowledge and attitudes towards HIV vaccines among Soweto adolescents
    Guy de Bruyn
    Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
    BMC Res Notes 1:76. 2008
    ..All pupils within the selected schools from whom parental consent and child assent could be obtained were eligible for participation. A self-administered, facilitated questionnaire was completed by all participants...
  34. doi request reprint Large-scale affordable PanLeucogated CD4+ testing with proactive internal and external quality assessment: in support of the South African national comprehensive care, treatment and management programme for HIV and AIDS
    Deborah K Glencross
    Department of Molecular Medicine and Haematology, University of the Witwatersrand, Johannesburg, South Africa
    Cytometry B Clin Cytom 74:S40-51. 2008
    ....
  35. pmc Hierarchical targeting of subtype C human immunodeficiency virus type 1 proteins by CD8+ T cells: correlation with viral load
    Agatha Masemola
    National Institute for Communicable Diseases, Johannesburg, South Africa
    J Virol 78:3233-43. 2004
    ..These data have significance for the design of vaccines and for interpretation of vaccine-induced responses...
  36. pmc Nurse versus doctor management of HIV-infected patients receiving antiretroviral therapy (CIPRA-SA): a randomised non-inferiority trial
    Ian Sanne
    Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    Lancet 376:33-40. 2010
    ..We compared outcomes of nurse versus doctor management of ART care for HIV-infected patients...
  37. ncbi request reprint Patient factors to target for elimination of mother-to-child transmission of HIV
    Coceka N Mnyani
    Department of Obstetrics and Gynaecology, and School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    Global Health 10:36. 2014
    ..Structured interviews were conducted with a focus on history of HIV infection, antenatal, intrapartum and immediate postpartum management of the mother-infant pair. Patient-related risk factors for MTCT were identified...
  38. pmc Efavirenz-induced gynecomastia in a prepubertal girl with human immunodeficiency virus infection: a case report
    Mette S van Ramshorst
    Anova Health Institute, Khutso Kurhula Project, Johannesburg, South Africa
    BMC Pediatr 13:120. 2013
    ..We report the first case of prepubertal gynecomastia in a young girl attributed to efavirenz use...
  39. ncbi request reprint Tuberculosis active case-finding in a mother-to-child HIV transmission prevention programme in Soweto, South Africa
    Jean Nachega
    Perinatal HIV Research Unit, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa
    AIDS 17:1398-400. 2003
  40. ncbi request reprint HIV-1 subtype C reverse transcriptase sequences from drug-naive pregnant women in South Africa
    Candice Pillay
    AIDS Virus Research Unit, National Institute for Communicable Diseases, Sandringham 2131, Johannesburg, South Africa
    AIDS Res Hum Retroviruses 18:605-10. 2002
    ....
  41. ncbi request reprint Novel and promiscuous CTL epitopes in conserved regions of Gag targeted by individuals with early subtype C HIV type 1 infection from southern Africa
    Agatha M Masemola
    National Institute for Communicable Diseases, University of Witwatersrand, Johannesburg, South Africa
    J Immunol 173:4607-17. 2004
    ....
  42. ncbi request reprint Selection and persistence of viral resistance in HIV-infected children after exposure to single-dose nevirapine
    Neil A Martinson
    Johns Hopkins University Center for Tuberculosis Research, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 44:148-53. 2007
    ..Exposure to sd-NVP selects for resistance mutations, however. We longitudinally assessed these mutations in HIV-1-infected infants from Soweto and Durban, South Africa...
  43. ncbi request reprint Transmission rates in consecutive pregnancies exposed to single-dose nevirapine in Soweto, South Africa and Abidjan, Côte d'Ivoire
    Neil A Martinson
    School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 45:206-9. 2007
    ..Because sdNVP selects resistance in a high percentage of women, we compared the effectiveness of sdNVP in preventing peripartum MTCT in successive pregnancies...
  44. pmc Predicting the impact of a partially effective HIV vaccine and subsequent risk behavior change on the heterosexual HIV epidemic in low- and middle-income countries: A South African example
    Kyeen M Andersson
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06510, USA
    J Acquir Immune Defic Syndr 46:78-90. 2007
    ..Even modestly effective HIV vaccines can confer enormous benefits in terms of HIV infections averted and decreased HIV prevalence. However, programs to reduce risk behavior may be important components of successful vaccination campaigns...
  45. ncbi request reprint Studies of a prophylactic HIV-1 vaccine candidate based on modified vaccinia virus Ankara (MVA) with and without DNA priming: effects of dosage and route on safety and immunogenicity
    Barry S Peters
    Kings College London, UK
    Vaccine 25:2120-7. 2007
    ..Modified vaccinia virus Ankara (MVA) and plasmid DNA (pTHr) expressed HIV-1 clade A gag p24 and p17 fused to a string of 25 overlapping CD8+ T cell epitopes (HIVA)...
  46. ncbi request reprint Prevalence and patterns of gender-based violence and revictimization among women attending antenatal clinics in Soweto, South Africa
    Kristin L Dunkle
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48104 3028, USA
    Am J Epidemiol 160:230-9. 2004
    ..92, 4.98). This study confirms the need for increased attention by the public health community to primary and secondary prevention of gender-based violence, with a specific need to reduce risk among South African adolescents...
  47. ncbi request reprint Injectable progestin contraceptive use and risk of HIV infection in a South African family planning cohort
    Immo Kleinschmidt
    London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Contraception 75:461-7. 2007
    ....

Research Grants6

  1. Soweto Clinical Trials Unit
    James Mcintyre; Fiscal Year: 2007
    ..This research will impact on the burden of HIV in southern Africa by focusing on prevention of new infections and optimizing care of those infected with HIV. ADMINISTRATIVE COMPONENT: ..