Lyndy Joy McGaw

Summary

Affiliation: University of Pretoria
Country: South Africa

Publications

  1. Ondua M, Njoya E, Abdalla M, McGaw L. Anti-inflammatory and antioxidant properties of leaf extracts of eleven South African medicinal plants used traditionally to treat inflammation. J Ethnopharmacol. 2018;234:27-35 pubmed publisher
    ..Other species including Ficus elastica, Carpobrotus edulis, Cotyledon orbiculata and Senna italica also had good activity worthy of further investigation. ..
  2. Abdalla M, McGaw L. Natural Cyclic Peptides as an Attractive Modality for Therapeutics: A Mini Review. Molecules. 2018;23: pubmed publisher
    ..Recently isolated naturally occurring cyclic peptides from microorganisms, sponges, and other sources with a wide range of pharmacological properties are reviewed herein. ..
  3. Mphahlele M, Mmonwa M, Aro A, McGaw L, Choong Y. Synthesis, Biological Evaluation and Molecular Docking of Novel Indole-Aminoquinazoline Hybrids for Anticancer Properties. Int J Mol Sci. 2018;19: pubmed publisher
    ..7 nM) inhibitory activity towards epidermal growth factor receptor (EGFR) against gefitinib (IC50 = 38.9 nM). Molecular docking suggests that 4a⁻h could bind to the ATP region of EGFR like erlotinib. ..
  4. Dzoyem J, Tsamo A, Melong R, Mkounga P, Nkengfack A, McGaw L, et al. Cytotoxicity, nitric oxide and acetylcholinesterase inhibitory activity of three limonoids isolated from Trichilia welwitschii (Meliaceae). Biol Res. 2015;48:57 pubmed publisher
    ..This study provided further examples of the importance of limonoids compounds as potential AChE inhibitors and anti-inflammatory agents targeting the inhibition of NO production. ..
  5. Adenubi O, McGaw L, Eloff J, Naidoo V. In vitro bioassays used in evaluating plant extracts for tick repellent and acaricidal properties: A critical review. Vet Parasitol. 2018;254:160-171 pubmed publisher
    ..These aspects will need further evaluation. Standardized laboratory methods are required to enable the valid comparisons between results from different laboratories. ..
  6. Madikizela B, McGaw L. Scientific rationale for traditional use of plants to treat tuberculosis in the eastern region of the OR Tambo district, South Africa. J Ethnopharmacol. 2018;224:250-260 pubmed publisher
    ..73). The results indicate that Heteromorpha trifoliata and Phymaspermum acerosum should be investigated further for antimycobacterial efficacy against drug resistant strains of Mycobacterium. ..
  7. Malongane F, McGaw L, Nyoni H, Mudau F. Metabolic profiling of four South African herbal teas using high resolution liquid chromatography-mass spectrometry and nuclear magnetic resonance. Food Chem. 2018;257:90-100 pubmed publisher
    ..The findings showed that South African herbal teas could play a vital role as health promoting drinks, and that bush tea and special tea are phytochemically comparable with other commercialized herbal teas. ..
  8. McGaw L, Bagla V, Steenkamp P, Fouche G, Olivier J, Eloff J, et al. Antifungal and antibacterial activity and chemical composition of polar and non-polar extracts of Athrixia phylicoides determined using bioautography and HPLC. BMC Complement Altern Med. 2013;13:356 pubmed publisher
    ..There were notable differences in chemical composition and bioactivity between the organic and aqueous extracts. Further research is necessary to fully characterize the active components of the extracts. ..
  9. McGaw L, Eloff J. Ethnoveterinary use of southern African plants and scientific evaluation of their medicinal properties. J Ethnopharmacol. 2008;119:559-74 pubmed publisher
    ..Only a small percentage of EVM plants have been analysed for biological activity or toxic effects, and hence research in this field offers fertile possibilities for future investigation. ..

More Information

Publications20

  1. Mehrbod P, Abdalla M, Njoya E, Ahmed A, Fotouhi F, Farahmand B, et al. South African medicinal plant extracts active against influenza A virus. BMC Complement Altern Med. 2018;18:112 pubmed publisher
    ..However, Tabernaemontana ventricosa, Cussonia spicata and Clerodendrum glabrum leaf extracts were ineffective in vitro in this study. ..
  2. Makhafola T, Elgorashi E, McGaw L, Awouafack M, Verschaeve L, Eloff J. Isolation and characterization of the compounds responsible for the antimutagenic activity of Combretum microphyllum (Combretaceae) leaf extracts. BMC Complement Altern Med. 2017;17:446 pubmed publisher
    ..The antimutagenic activity of arjunolic acid may, at least in part, be attributed to its antioxidant activity resulting in the detoxification of reactive oxygen species produced during mutagenesis. ..
  3. Olaokun O, McGaw L, Janse van Rensburg I, Eloff J, Naidoo V. Antidiabetic activity of the ethyl acetate fraction of Ficus lutea (Moraceae) leaf extract: comparison of an in vitro assay with an in vivo obese mouse model. BMC Complement Altern Med. 2016;16:110 pubmed publisher
    ..This is linked to increased glucose uptake within the cells, the most likely mechanism is either an increased insulin response or increased insulin secretion. ..
  4. Elisha I, Botha F, Madikizela B, McGaw L, Eloff J. Acetone leaf extracts of some South African trees with high activity against Escherichia coli also have good antimycobacterial activity and selectivity index. BMC Complement Altern Med. 2017;17:327 pubmed publisher
    ..It may be interesting to investigate extracts against pathogenic M. tuberculosis, M. bovis and M. avium cultures and to isolate active antimycobacterial compounds. ..
  5. Elisha I, Botha F, McGaw L, Eloff J. The antibacterial activity of extracts of nine plant species with good activity against Escherichia coli against five other bacteria and cytotoxicity of extracts. BMC Complement Altern Med. 2017;17:133 pubmed publisher
    ..Further investigation is in progress on C. triflora and H. roeperianum, both of which had promising activities and potential safety based on cytotoxicity. ..
  6. Elisha I, Jambalang A, Botha F, Buys E, McGaw L, Eloff J. Potency and selectivity indices of acetone leaf extracts of nine selected South African trees against six opportunistic Enterobacteriaceae isolates from commercial chicken eggs. BMC Complement Altern Med. 2017;17:90 pubmed publisher
    ..triflora extracts suggests that the plant has potential as a therapeutic agent against some members of the Enterobacteriaceae. Further pharmacological investigations may be interesting in the search for new antimicrobial leads. ..
  7. Olaokun O, McGaw L, Eloff J, Naidoo V. Evaluation of the inhibition of carbohydrate hydrolysing enzymes, antioxidant activity and polyphenolic content of extracts of ten African Ficus species (Moraceae) used traditionally to treat diabetes. BMC Complement Altern Med. 2013;13:94 pubmed publisher
    ..Research is underway to isolate the active compound(s) responsible for the antidiabetic activity and to confirm the in vitro antidiabetic activity and to investigate in vitro toxicity. ..
  8. Dzoyem J, McGaw L, Eloff J. In vitro antibacterial, antioxidant and cytotoxic activity of acetone leaf extracts of nine under-investigated Fabaceae tree species leads to potentially useful extracts in animal health and productivity. BMC Complement Altern Med. 2014;14:147 pubmed publisher
    ..These species are therefore promising candidates for the development of useful antimicrobial/antioxidant preparations with a low cytotoxicity that may be useful in promoting animal health and productivity. ..
  9. Madikizela B, McGaw L. Pittosporum viridiflorum Sims (Pittosporaceae): A review on a useful medicinal plant native to South Africa and tropical Africa. J Ethnopharmacol. 2017;205:217-230 pubmed publisher
    ..viridiflorum gives credence to the use of this plant species against various diseases in ATM, thus steering significant interest towards in vivo studies and further research. ..
  10. McGaw L, Lall N, Meyer J, Eloff J. The potential of South African plants against Mycobacterium infections. J Ethnopharmacol. 2008;119:482-500 pubmed publisher
    ..Many plants are used locally in traditional medicine to treat TB-related symptoms...
  11. request reprint
    McGaw L, Lall N, Hlokwe T, Michel A, Meyer J, Eloff J. Purified compounds and extracts from Euclea species with antimycobacterial activity against Mycobacterium bovis and fast-growing mycobacteria. Biol Pharm Bull. 2008;31:1429-33 pubmed
    ..M. smegmatis appeared to be a better predictor of antimycobacterial activity against pathogenic M. bovis (and M. tuberculosis), while MIC values obtained using M. fortuitum correlated well with those of M. bovis BCG...