Affiliation: University of Cape Town
Country: South Africa
- PKCε promotes cardiac mitochondrial and metabolic adaptation to chronic hypobaric hypoxia by GSK3β inhibitionJoy McCarthy
Hatter Institute for Cardiovascular Research, University of Cape Town Medical School, Cape Town, South Africa
J Cell Physiol 226:2457-68. 2011..Moreover, we propose that preferential glucose utilization by PKCε hearts is orchestrated by a p-GSK3β/HIF-1α-mediated mechanism, playing a crucial role to sustain contractile function in response to chronic hypobaric hypoxia...
- PKCepsilon activation augments cardiac mitochondrial respiratory post-anoxic reserve--a putative mechanism in PKCepsilon cardioprotectionJoy McCarthy
Hatter Institute for Cardiology Research, University of Cape Town Medical School, Cape Town, South Africa
J Mol Cell Cardiol 38:697-700. 2005....
- TNFα protects cardiac mitochondria independently of its cell surface receptorsLydia Lacerda
Cardioprotection Group, Hatter Cardiovascular Research Institute, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
Basic Res Cardiol 105:751-62. 2010..This effect appears to be independent of its cell surface receptors, but is likely to be mediated by ROS and sphingolipids...
- Classic ischemic but not pharmacologic preconditioning is abrogated following genetic ablation of the TNFalpha geneRobert M Smith
Hatter Institute for Cardiology Research, MRC Inter University Cape Heart Group, University of Cape Town Medical School, Observatory 7925, South Africa
Cardiovasc Res 55:553-60. 2002..Moreover, whether TNFalpha is required to induce the ischemic preconditioning phenotype has not been determined...