Bongani M Mayosi

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. ncbi Rationale and design of the Investigation of the Management of Pericarditis (IMPI) trial: a 2 × 2 factorial randomized double-blind multicenter trial of adjunctive prednisolone and Mycobacterium w immunotherapy in tuberculous pericarditis
    Bongani M Mayosi
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital, Cape Town, South Africa
    Am Heart J 165:109-15.e3. 2013
  2. ncbi Systems medicine and integrated care to combat chronic noncommunicable diseases
    Jean Bousquet
    Department of Respiratory Diseases, Arnaud de Villeneuve Hospital, CHU Montpellier, INSERM CESP U1018, Villejuif, France
    Genome Med 3:43. 2011
  3. ncbi STK39 polymorphisms and blood pressure: an association study in British Caucasians and assessment of cis-acting influences on gene expression
    Michael S Cunnington
    Institute of Human Genetics, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK
    BMC Med Genet 10:135. 2009
  4. ncbi The mitochondrial DNA T16189C polymorphism and HIV-associated cardiomyopathy: a genotype-phenotype association study
    Gasnat Shaboodien
    Department of Clinical Neurology, University of Oxford, The West Wing, The John Radcliffe Hospital, Oxford, OX3 9DU, UK
    BMC Med Genet 10:37. 2009
  5. ncbi Africa's burden of disease: The University of Cape Town Sub-Saharan Africa Centre for Chronic Disease
    K C Househam
    University of Cape Town
    S Afr Med J 100:94-5. 2010
  6. ncbi The burden of non-communicable diseases in South Africa
    Bongani M Mayosi
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Lancet 374:934-47. 2009
  7. ncbi Contemporary trends in the epidemiology and management of cardiomyopathy and pericarditis in sub-Saharan Africa
    Bongani M Mayosi
    Department of Medicine, J Floor Old Main Building, Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa
    Heart 93:1176-83. 2007
  8. ncbi Incidence of acute rheumatic fever in the world: a systematic review of population-based studies
    K B Tibazarwa
    Department of Medicine, J Floor Old Main Building, Groote Schuur Hospital, Cape Town, South Africa
    Heart 94:1534-40. 2008
  9. ncbi Mortality in patients treated for tuberculous pericarditis in sub-Saharan Africa
    Bongani M Mayosi
    Department of Medicine, University of Cape Town
    S Afr Med J 98:36-40. 2008
  10. ncbi Clinical characteristics and initial management of patients with tuberculous pericarditis in the HIV era: the Investigation of the Management of Pericarditis in Africa (IMPI Africa) registry
    Bongani M Mayosi
    The Cardiac Clinic, Department of Medicine, University of Cape Town, E25 Groote Schuur Hospital, Observatory 7925, South Africa
    BMC Infect Dis 6:2. 2006

Detail Information

Publications59

  1. ncbi Rationale and design of the Investigation of the Management of Pericarditis (IMPI) trial: a 2 × 2 factorial randomized double-blind multicenter trial of adjunctive prednisolone and Mycobacterium w immunotherapy in tuberculous pericarditis
    Bongani M Mayosi
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital, Cape Town, South Africa
    Am Heart J 165:109-15.e3. 2013
    ..w) can safely reduce mortality and morbidity...
  2. ncbi Systems medicine and integrated care to combat chronic noncommunicable diseases
    Jean Bousquet
    Department of Respiratory Diseases, Arnaud de Villeneuve Hospital, CHU Montpellier, INSERM CESP U1018, Villejuif, France
    Genome Med 3:43. 2011
    ..This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems...
  3. ncbi STK39 polymorphisms and blood pressure: an association study in British Caucasians and assessment of cis-acting influences on gene expression
    Michael S Cunnington
    Institute of Human Genetics, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK
    BMC Med Genet 10:135. 2009
    ..However, other large studies have not implicated STK39 in hypertension. We determined whether reported SNPs influenced STK39 expression in vivo, or were associated with BP in a large British Caucasian cohort...
  4. ncbi The mitochondrial DNA T16189C polymorphism and HIV-associated cardiomyopathy: a genotype-phenotype association study
    Gasnat Shaboodien
    Department of Clinical Neurology, University of Oxford, The West Wing, The John Radcliffe Hospital, Oxford, OX3 9DU, UK
    BMC Med Genet 10:37. 2009
    ..We hypothesized that this variant may predispose to dilated cardiomyopathy in people who are infected with the human immunodeficiency virus (HIV)...
  5. ncbi Africa's burden of disease: The University of Cape Town Sub-Saharan Africa Centre for Chronic Disease
    K C Househam
    University of Cape Town
    S Afr Med J 100:94-5. 2010
    ..It will focus on surveillance, advocacy and prevention...
  6. ncbi The burden of non-communicable diseases in South Africa
    Bongani M Mayosi
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Lancet 374:934-47. 2009
    ....
  7. ncbi Contemporary trends in the epidemiology and management of cardiomyopathy and pericarditis in sub-Saharan Africa
    Bongani M Mayosi
    Department of Medicine, J Floor Old Main Building, Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa
    Heart 93:1176-83. 2007
    ....
  8. ncbi Incidence of acute rheumatic fever in the world: a systematic review of population-based studies
    K B Tibazarwa
    Department of Medicine, J Floor Old Main Building, Groote Schuur Hospital, Cape Town, South Africa
    Heart 94:1534-40. 2008
    ..There is no systematic overview of prospective studies of incidence of acute rheumatic fever (ARF) in the world...
  9. ncbi Mortality in patients treated for tuberculous pericarditis in sub-Saharan Africa
    Bongani M Mayosi
    Department of Medicine, University of Cape Town
    S Afr Med J 98:36-40. 2008
    ..To determine the mortality rate and its predictors in patients with a presumptive diagnosis of tuberculous pericarditis in sub-Saharan Africa...
  10. ncbi Clinical characteristics and initial management of patients with tuberculous pericarditis in the HIV era: the Investigation of the Management of Pericarditis in Africa (IMPI Africa) registry
    Bongani M Mayosi
    The Cardiac Clinic, Department of Medicine, University of Cape Town, E25 Groote Schuur Hospital, Observatory 7925, South Africa
    BMC Infect Dis 6:2. 2006
    ....
  11. ncbi Achieving the health Millennium Development Goals for South Africa: challenges and priorities
    Mickey Chopra
    Health Systems Research Unit, Medical Research Council, Cape Town, South Africa
    Lancet 374:1023-31. 2009
    ..The South African Government, installed in April, 2009, has the mandate and potential to address the public health emergencies facing the country--will they do so or will another opportunity and many more lives be lost?..
  12. ncbi Health in South Africa: changes and challenges since 2009
    Bongani M Mayosi
    Department of Medicine, Groote Schuur Hospital, Cape Town, South Africa
    Lancet 380:2029-43. 2012
    ....
  13. ncbi Beta-blockers for hypertension
    Charles Shey Wiysonge
    Division of Medical Microbiology and Institute of Infectious Disease andMolecular Medicine, University of Cape Town, Observatory, South Africa
    Cochrane Database Syst Rev 11:CD002003. 2012
    ..This review is an update of the Cochrane Review published in 2007, which assessed the role of beta-blockade as first-line therapy for hypertension...
  14. ncbi HIV-1 infection alters CD4+ memory T-cell phenotype at the site of disease in extrapulmonary tuberculosis
    Kerryn Matthews
    Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory, South Africa
    Eur J Immunol 42:147-57. 2012
    ..These results indicate that HIV-1 infection results in altered phenotype and function of MTB-specific CD4+ T cells at the disease site, which may contribute to the increased risk of developing TB at all stages of HIV-1 infection...
  15. ncbi HIV infection is associated with a lower incidence of constriction in presumed tuberculous pericarditis: a prospective observational study
    Mpiko Ntsekhe
    Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 3:e2253. 2008
    ..The impact of human immunodeficiency virus (HIV) infection on the incidence of constrictive pericarditis following tuberculous pericardial effusion is unknown...
  16. ncbi Cardiac manifestations of HIV infection: an African perspective
    Mpiko Ntsekhe
    Division of Cardiology at Groote Schuur Hospital, Cape Town, South Africa
    Nat Clin Pract Cardiovasc Med 6:120-7. 2009
    ..Herein, we review the cardiac manifestations of HIV in sub-Saharan Africa...
  17. ncbi Clinical characteristics and outcomes of familial and idiopathic dilated cardiomyopathy in Cape Town: a comparative study of 120 cases followed up over 14 years
    Ntobeko B A Ntusi
    Cardiac Clinic, Department of Medicine, Groote Schuur Hospital, University of Cape Town
    S Afr Med J 101:399-404. 2011
    ..It is not known whether there are differences in clinical characteristics and outcomes of patients with familial and idiopathic dilated cardiomyopathy (DCM) in an African setting...
  18. ncbi A modern approach to tuberculous pericarditis
    Faisal F Syed
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Prog Cardiovasc Dis 50:218-36. 2007
    ....
  19. ncbi The prevalence and outcome of effusive constrictive pericarditis: a systematic review of the literature
    Mpiko Ntsekhe
    Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Cardiovasc J Afr 23:281-5. 2012
    ..Appropriate studies are needed to determine the epidemiology of ECP in tuberculous pericarditis, which is one of the leading causes of pericardial disease in the world...
  20. ncbi Clinical features, survival experience, and profile of plakophylin-2 gene mutations in participants of the arrhythmogenic right ventricular cardiomyopathy registry of South Africa
    David A Watkins
    Cardiovascular Genetics Laboratory, Hatter Institute for Cardiovascular Research, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Heart Rhythm 6:S10-7. 2009
    ..PKP2 gene mutations are common, have an allele dose effect, and a novel founder effect in white South Africans...
  21. ncbi The burden of antenatal heart disease in South Africa: a systematic review
    David A Watkins
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, J Floor Old Main Building, Groote Schuur Hospital, Observatory, Cape Town 7925, South Africa
    BMC Cardiovasc Disord 12:23. 2012
    ..Maternal mortality in South Africa is rising, and heart conditions currently account for 41 per cent of indirect causes of deaths. Little is known about the burden of heart disease in pregnant South Africans...
  22. ncbi Tuberculous pericarditis
    Bongani M Mayosi
    The Cardiac Clinic, Department of Medicine, University of Cape Town, Groote Schuur Hospital, Cape Town, South Africa
    Circulation 112:3608-16. 2005
    ..The primary objective of this article was to review and summarize the literature on the pathogenesis, diagnosis, and management of tuberculous pericarditis...
  23. ncbi Quantification of echodensities in tuberculous pericardial effusion using fractal geometry: a proof of concept study
    Mpiko Ntsekhe
    Department of Medicine, The Cardiac Clinic, Groote Schuur Hospital and University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    Cardiovasc Ultrasound 10:30. 2012
    ....
  24. ncbi Frequency and clinical genetics of familial dilated cardiomyopathy in Cape Town: implications for the evaluation of patients with unexplained cardiomyopathy
    Ntobeko B A Ntusi
    Cardiac Clinic and Cardiovascular Genetics Laboratory, Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, Groote Schuur Hospital, University of Cape Town
    S Afr Med J 101:394-8. 2011
    ..Studies from Europe and North America suggest that 20 - 50% of patients with dilated cardiomyopathy (DCM) may have familial disease. There is little information on the frequency and clinical genetics of familial DCM in Africa...
  25. ncbi Antibiotics for the primary prevention of acute rheumatic fever: a meta-analysis
    Katharine A Robertson
    Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    BMC Cardiovasc Disord 5:11. 2005
    ....
  26. ncbi Genetic variation at selected SNPs in the leptin gene and association of alleles with markers of kidney disease in a Xhosa population of South Africa
    Ikechi G Okpechi
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    PLoS ONE 5:e9086. 2010
    ..A number of clinical and experimental studies have suggested a link between serum leptin and kidney disease. We hypothesised that variants in the leptin gene (LEP) may be associated with markers of CKD in indigenous black Africans...
  27. ncbi Genotype at the -174G/C polymorphism of the interleukin-6 gene is associated with common carotid artery intimal-medial thickness: family study and meta-analysis
    Bongani M Mayosi
    Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom
    Stroke 36:2215-9. 2005
    ..We have used a family-based genetic association design to assess the heritability of carotid IMT and to investigate the hypothesized association of carotid IMT with the IL-6 to -174G/C polymorphism...
  28. ncbi Measured haplotype analysis of the aldosterone synthase gene and heart size
    Bongani M Mayosi
    Department of Cardiovascular Medicine, University of Oxford, The Wellcome Trust Centre for Human Genetics, Oxford, UK
    Eur J Hum Genet 11:395-401. 2003
    ..These results point to the importance of analysing the full extent of genetic variation that captures the haplotype structure of a locus in gene association studies...
  29. ncbi Epidemiology of heart failure in sub-Saharan Africa
    Ntobeko B A Ntusi
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Expert Rev Cardiovasc Ther 7:169-80. 2009
    ....
  30. ncbi Cardiomyopathy in Africa: heredity versus environment
    Bongani M Mayosi
    Department of Medicine, University of Cape Town, Groote Schuur Hospital, Cape Town
    Cardiovasc J Afr 18:175-9. 2007
    ..There is a need for renewed effort to identify genetic and non-genetic factors in EMF and other forms of heart muscle disease that are prevalent on the continent of Africa...
  31. ncbi Cardiac involvement in HIV-infected people living in Africa: a review
    Nombulelo P Magula
    Infectious Disease Unit, Department of Medicine, Nelson R. Mandela School of Medicine, University of Natal, Durban, South Africa
    Cardiovasc J S Afr 14:231-7. 2003
    ....
  32. ncbi Beta-blockers for hypertension
    Charles Shey Wiysonge
    Institute of Infectious Disease and Molecular Medicine and Division of Medical Microbiology, University of Cape Town, Anzio Road, Observatory, South Africa, 7925
    Cochrane Database Syst Rev 8:CD002003. 2012
    ..This review is an update of the Cochrane Review published in 2007, which assessed the role of beta-blockade as first-line therapy for hypertension...
  33. ncbi Genetic susceptibility to acute rheumatic fever: a systematic review and meta-analysis of twin studies
    Mark E Engel
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    PLoS ONE 6:e25326. 2011
    ..The objective of this study was to conduct a systematic review and meta-analysis of twin studies of concordance of acute rheumatic fever in order to derive quantitative estimates of the size of the genetic effect...
  34. ncbi Genome-wide linkage analysis of electrocardiographic and echocardiographic left ventricular hypertrophy in families with hypertension
    Bongani M Mayosi
    Department of Medicine, University of Cape Town, J Floor Old Main Building, Groote Schuur Hospital, Anzio Road Observatory, Cape Town 7925, W Cape, South Africa
    Eur Heart J 29:525-30. 2008
    ..To localize chromosomal regions (or quantitative trait loci) that harbour genetic variants influencing the variability of electrocardiographic (ECG) and echocardiographic left ventricular hypertrophy (LVH)...
  35. ncbi Lack of adherence to the national guidelines on the prevention of rheumatic fever
    Katharine A Robertson
    Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town
    S Afr Med J 95:52-6. 2005
    ..CONCLUSIONS: Since the publication of the national guidelines in 1997, little progress has been made towards achieving the implementation of a comprehensive programme for the secondary prevention of RF/RHD...
  36. ncbi Aetiology and risk factors of peripartum cardiomyopathy: a systematic review
    Ntobeko B A Ntusi
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Int J Cardiol 131:168-79. 2009
    ..The primary objective of this review was to summarize the state of knowledge on the pathogenesis of PPCM, especially in light of recent studies...
  37. ncbi Protocols for antibiotic use in primary and secondary prevention of rheumatic fever
    Bongani M Mayosi
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, South Africa
    S Afr Med J 96:240. 2006
  38. ncbi Tuberculous pericarditis with and without HIV
    Mpiko Ntsekhe
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, E 17 New Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa
    Heart Fail Rev 18:367-73. 2013
    ....
  39. ncbi HIV infection, pulmonary arterial hypertension and pregnancy: a fatal triad
    Myat Tun Lin Nyo
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Cardiovasc J Afr 23:e4-6. 2012
    ..Histological features of pulmonary arterial hypertension were present at post mortem. This is the first report of histologically confirmed HIV-associated pulmonary arterial hypertension associated with pregnancy in Africa...
  40. ncbi Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosis
    Kerryn Matthews
    Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa
    Tuberculosis (Edinb) 91:587-93. 2011
    ..We propose that our findings support a role for IL-22 in TB-induced pathology or the resulting repair process...
  41. ncbi Motion-guided segmentation for cine DENSE MRI
    Bruce S Spottiswoode
    UCT MRC Medical Imaging Research Unit, University of Cape Town, South Africa
    Med Image Anal 13:105-15. 2009
    ..Motion-guided segmentation employs the displacement-encoded phase shifts intrinsic to DENSE MRI to accurately propagate a single set of pre-defined contours throughout the remaining cardiac phases...
  42. ncbi 3D myocardial tissue tracking with slice followed cine DENSE MRI
    Bruce S Spottiswoode
    UCT MRC Medical Imaging Research Unit, University of Cape Town, South Africa
    J Magn Reson Imaging 27:1019-27. 2008
    ..To track three-dimensional (3D) myocardial tissue motion using slice followed cine displacement encoded imaging with stimulated echoes (DENSE)...
  43. ncbi Arrhythmogenic right ventricular cardiomyopathy type 6 (ARVC6): support for the locus assignment, narrowing of the critical region and mutation screening of three candidate genes
    Luzuko O Matolweni
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    BMC Med Genet 7:29. 2006
    ..By linkage analysis, ARVC type 6 was previously mapped to a 10.6 cM region on chromosome 10p12-p14 in a large North American kindred. To date, the genetic defect that causes ARVC6 has not been identified...
  44. ncbi Contemporary use of adjunctive corticosteroids in tuberculous pericarditis
    Charles S Wiysonge
    Int J Cardiol 124:388-90. 2008
    ..These data provide a justification for the establishment of adequately powered randomised clinical trials to assess the effectiveness of adjunctive corticosteroids in patients with tuberculous pericarditis...
  45. ncbi The C-532T polymorphism of the angiotensinogen gene is associated with pulse pressure: a possible explanation for heterogeneity in genetic association studies of AGT and hypertension
    Michelle Baker
    The Institute of Human Genetics, Newcastle University, UK
    Int J Epidemiol 36:1356-62. 2007
    ..We hypothesized that a primary effect of AGT variants on arterial stiffness (and thus pulse pressure) might explain such heterogeneity, and tested for such an effect in a family study...
  46. ncbi Association between common polymorphisms of the proopiomelanocortin gene and body fat distribution: a family study
    Michelle Baker
    Institute of Human Genetics, Central Parkway, Newcastle NE1 3BZ, UK
    Diabetes 54:2492-6. 2005
    ..These data show that genetic variants at the POMC locus influence body fat distribution within the normal range, suggesting a novel role for POMC in metabolic regulation...
  47. ncbi Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein
    Mark A Vickers
    Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, UK
    Cardiovasc Res 53:1029-34. 2002
    ..We hypothesised that plasma CRP would be a heritable phenotype that would be influenced by genotype at this polymorphism...
  48. ncbi Epidemiology and etiology of cardiomyopathy in Africa
    Karen Sliwa
    Department of Cardiology, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa
    Circulation 112:3577-83. 2005
    ....
  49. ncbi Intramuscular penicillin is more effective than oral penicillin in secondary prevention of rheumatic fever--a systematic review
    Juliet Manyemba
    Clinical Age Research Unit, Guy's, King's and St Thomas's School of Medicine, King's College Hospital, London
    S Afr Med J 93:212-8. 2003
    ..Two-weekly or 3-weekly injections appeared to be more effective than 4-weekly injections. However, the evidence is based on poor-quality trials and the use of outdated formulations of oral penicillin...
  50. ncbi Molecular genetics of cardiomyopathy: changing times, shifting paradigms
    Johanna C Moolman-Smook
    US/MRC for Molecular and Cellular Biology, Faculty of Health Science, University of Stellenbosch, Tygerburg, South Africa
    Cardiovasc J S Afr 14:145-55. 2003
    ....
  51. ncbi Rheumatic fever and rheumatic heart disease: primary prevention is the cost effective option
    James Irlam
    Indian J Pediatr 75:86; author reply 86-7. 2008
  52. ncbi Origins of computed tomography
    Christopher L Vaughan
    Lancet 369:1168. 2007
  53. ncbi Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene
    Helen Imrie
    Institute of Human Genetics, Central Parkway, Newcastle NE1 3BZ, United Kingdom
    J Clin Endocrinol Metab 91:5051-6. 2006
    ..However, the relative importance of polymorphisms in CYP11B1 and CYP11B2 in determining these phenotypes is unknown...
  54. ncbi Towards a uniform plan for the control of rheumatic fever and rheumatic heart disease in Africa--the Awareness Surveillance Advocacy Prevention (A.S.A.P.) Programme
    Kate A Robertson
    New York Medical College, USA
    S Afr Med J 96:241. 2006
  55. ncbi Heart failure in sub-saharan Africa: time for action
    Albertino Damasceno
    Faculdade de Medicina, Universidade Eduardo Mondlane, Maputo, Mozambique
    J Am Coll Cardiol 50:1688-93. 2007
  56. ncbi Acute rheumatic fever
    Innocent Monya-Tambi
    Lancet 366:1355; author reply 1355-6. 2005
  57. ncbi Cardiovascular disease in sub-Saharan Africa
    Lionel H Opie
    Circulation 112:3536-40. 2005
  58. ncbi SAMJ--Africa's top open access medical journal
    Bongani M Mayosi
    S Afr Med J 95:809. 2005
  59. ncbi Ambulatory blood pressure is associated with polymorphic variation in P2X receptor genes
    Julian Palomino-Doza
    Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom
    Hypertension 52:980-5. 2008
    ..Other suggestive associations were found, but these were nonsignificant after correction for multiple testing. These genetic data suggest that drugs affecting P2X receptor signaling may have promise as clinical antihypertensive agents...