Bongani M Mayosi

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. pmc Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous pericarditis compared to adenosine deaminase and unstimulated interferon-γ in a high burden setting: a prospective study
    Shaheen Pandie
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Groote Schuur Drive, Observatory, Cape Town 7925, South Africa
    BMC Med 12:101. 2014
  2. pmc HIV infection is associated with a lower incidence of constriction in presumed tuberculous pericarditis: a prospective observational study
    Mpiko Ntsekhe
    Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 3:e2253. 2008
  3. pmc Genetic susceptibility to acute rheumatic fever: a systematic review and meta-analysis of twin studies
    Mark E Engel
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    PLoS ONE 6:e25326. 2011
  4. pmc The Pan-African Society of Cardiology (PASCAR) in 2013 and beyond
    Anastase Dzudie
    Department of Internal Medicine, DOUALA General Hospital, Cameroon
    Cardiovasc J Afr 24:151-3. 2013
  5. pmc A systematic overview of prospective cohort studies of cardiovascular disease in sub-Saharan Africa
    Andre Pascal Kengne
    The George Institute for International Health, University of Sydney, Sydney, Australia
    Cardiovasc J Afr 23:103-12. 2012
  6. pmc The history of the Pan-African Society of Cardiology (PASCAR): the first 30 years, 1981-2011
    D A Watkins
    Department of Medicine, University of Cape Town, South Africa
    Cardiovasc J Afr 22:122-3. 2011
  7. doi request reprint Rationale and design of the Investigation of the Management of Pericarditis (IMPI) trial: a 2 × 2 factorial randomized double-blind multicenter trial of adjunctive prednisolone and Mycobacterium w immunotherapy in tuberculous pericarditis
    Bongani M Mayosi
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital, Cape Town, South Africa
    Am Heart J 165:109-15.e3. 2013
  8. pmc Systems medicine and integrated care to combat chronic noncommunicable diseases
    Jean Bousquet
    Department of Respiratory Diseases, Arnaud de Villeneuve Hospital, CHU Montpellier, INSERM CESP U1018, Villejuif, France
    Genome Med 3:43. 2011
  9. pmc STK39 polymorphisms and blood pressure: an association study in British Caucasians and assessment of cis-acting influences on gene expression
    Michael S Cunnington
    Institute of Human Genetics, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK
    BMC Med Genet 10:135. 2009
  10. pmc The mitochondrial DNA T16189C polymorphism and HIV-associated cardiomyopathy: a genotype-phenotype association study
    Gasnat Shaboodien
    Department of Clinical Neurology, University of Oxford, The West Wing, The John Radcliffe Hospital, Oxford, OX3 9DU, UK
    BMC Med Genet 10:37. 2009

Detail Information

Publications78

  1. pmc Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous pericarditis compared to adenosine deaminase and unstimulated interferon-γ in a high burden setting: a prospective study
    Shaheen Pandie
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Groote Schuur Drive, Observatory, Cape Town 7925, South Africa
    BMC Med 12:101. 2014
    ..This study sought to evaluate the diagnostic accuracy of the Xpert MTB/RIF test compared to pericardial adenosine deaminase (ADA) and unstimulated interferon-gamma (uIFNγ) in suspected TBP...
  2. pmc HIV infection is associated with a lower incidence of constriction in presumed tuberculous pericarditis: a prospective observational study
    Mpiko Ntsekhe
    Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 3:e2253. 2008
    ..The impact of human immunodeficiency virus (HIV) infection on the incidence of constrictive pericarditis following tuberculous pericardial effusion is unknown...
  3. pmc Genetic susceptibility to acute rheumatic fever: a systematic review and meta-analysis of twin studies
    Mark E Engel
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    PLoS ONE 6:e25326. 2011
    ..The objective of this study was to conduct a systematic review and meta-analysis of twin studies of concordance of acute rheumatic fever in order to derive quantitative estimates of the size of the genetic effect...
  4. pmc The Pan-African Society of Cardiology (PASCAR) in 2013 and beyond
    Anastase Dzudie
    Department of Internal Medicine, DOUALA General Hospital, Cameroon
    Cardiovasc J Afr 24:151-3. 2013
    ....
  5. pmc A systematic overview of prospective cohort studies of cardiovascular disease in sub-Saharan Africa
    Andre Pascal Kengne
    The George Institute for International Health, University of Sydney, Sydney, Australia
    Cardiovasc J Afr 23:103-12. 2012
    ..Cardiovascular diseases (CVDs) are becoming increasingly significant in sub-Saharan Africa (SSA). Reliable measures of the contribution of major determinants are essential for informing health services and policy solutions...
  6. pmc The history of the Pan-African Society of Cardiology (PASCAR): the first 30 years, 1981-2011
    D A Watkins
    Department of Medicine, University of Cape Town, South Africa
    Cardiovasc J Afr 22:122-3. 2011
    ..This article celebrates the hard work and dedication of PASCAR's founders and subsequent leaders, and challenges the present and future generations to carry on the charge of furthering the health of Africans...
  7. doi request reprint Rationale and design of the Investigation of the Management of Pericarditis (IMPI) trial: a 2 × 2 factorial randomized double-blind multicenter trial of adjunctive prednisolone and Mycobacterium w immunotherapy in tuberculous pericarditis
    Bongani M Mayosi
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital, Cape Town, South Africa
    Am Heart J 165:109-15.e3. 2013
    ..w) can safely reduce mortality and morbidity...
  8. pmc Systems medicine and integrated care to combat chronic noncommunicable diseases
    Jean Bousquet
    Department of Respiratory Diseases, Arnaud de Villeneuve Hospital, CHU Montpellier, INSERM CESP U1018, Villejuif, France
    Genome Med 3:43. 2011
    ..This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems...
  9. pmc STK39 polymorphisms and blood pressure: an association study in British Caucasians and assessment of cis-acting influences on gene expression
    Michael S Cunnington
    Institute of Human Genetics, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK
    BMC Med Genet 10:135. 2009
    ..However, other large studies have not implicated STK39 in hypertension. We determined whether reported SNPs influenced STK39 expression in vivo, or were associated with BP in a large British Caucasian cohort...
  10. pmc The mitochondrial DNA T16189C polymorphism and HIV-associated cardiomyopathy: a genotype-phenotype association study
    Gasnat Shaboodien
    Department of Clinical Neurology, University of Oxford, The West Wing, The John Radcliffe Hospital, Oxford, OX3 9DU, UK
    BMC Med Genet 10:37. 2009
    ..We hypothesized that this variant may predispose to dilated cardiomyopathy in people who are infected with the human immunodeficiency virus (HIV)...
  11. ncbi request reprint Africa's burden of disease: The University of Cape Town Sub-Saharan Africa Centre for Chronic Disease
    K C Househam
    University of Cape Town
    S Afr Med J 100:94-5. 2010
    ..It will focus on surveillance, advocacy and prevention...
  12. ncbi request reprint Mortality in patients treated for tuberculous pericarditis in sub-Saharan Africa
    Bongani M Mayosi
    Department of Medicine, University of Cape Town
    S Afr Med J 98:36-40. 2008
    ..To determine the mortality rate and its predictors in patients with a presumptive diagnosis of tuberculous pericarditis in sub-Saharan Africa...
  13. doi request reprint The burden of non-communicable diseases in South Africa
    Bongani M Mayosi
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Lancet 374:934-47. 2009
    ....
  14. pmc Contemporary trends in the epidemiology and management of cardiomyopathy and pericarditis in sub-Saharan Africa
    Bongani M Mayosi
    Department of Medicine, J Floor Old Main Building, Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa
    Heart 93:1176-83. 2007
    ....
  15. doi request reprint Incidence of acute rheumatic fever in the world: a systematic review of population-based studies
    K B Tibazarwa
    Department of Medicine, J Floor Old Main Building, Groote Schuur Hospital, Cape Town, South Africa
    Heart 94:1534-40. 2008
    ..There is no systematic overview of prospective studies of incidence of acute rheumatic fever (ARF) in the world...
  16. pmc Clinical characteristics and initial management of patients with tuberculous pericarditis in the HIV era: the Investigation of the Management of Pericarditis in Africa (IMPI Africa) registry
    Bongani M Mayosi
    The Cardiac Clinic, Department of Medicine, University of Cape Town, E25 Groote Schuur Hospital, Observatory 7925, South Africa
    BMC Infect Dis 6:2. 2006
    ....
  17. pmc Prevalence, hemodynamics, and cytokine profile of effusive-constrictive pericarditis in patients with tuberculous pericardial effusion
    Mpiko Ntsekhe
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, Western Cape, South Africa
    PLoS ONE 8:e77532. 2013
    ..We conducted a prospective study of prevalence and cytokine profile of effusive-constrictive disease in patients with tuberculous pericardial effusion...
  18. doi request reprint Achieving the health Millennium Development Goals for South Africa: challenges and priorities
    Mickey Chopra
    Health Systems Research Unit, Medical Research Council, Cape Town, South Africa
    Lancet 374:1023-31. 2009
    ..The South African Government, installed in April, 2009, has the mandate and potential to address the public health emergencies facing the country--will they do so or will another opportunity and many more lives be lost?..
  19. doi request reprint Health in South Africa: changes and challenges since 2009
    Bongani M Mayosi
    Department of Medicine, Groote Schuur Hospital, Cape Town, South Africa
    Lancet 380:2029-43. 2012
    ....
  20. ncbi request reprint A cost-effective strategy for primary prevention of acute rheumatic fever and rheumatic heart disease in children with pharyngitis
    James H Irlam
    Primary Health Care Directorate, University of Cape Town, South Africa
    S Afr Med J 103:894-5. 2013
    ..The CDR2+ strategy is the most cost-effective for primary prevention of ARF and RHD in urban SA and should complement primordial and secondary prevention efforts. ..
  21. doi request reprint Beta-blockers for hypertension
    Charles Shey Wiysonge
    Division of Medical Microbiology and Institute of Infectious Disease andMolecular Medicine, University of Cape Town, Observatory, South Africa
    Cochrane Database Syst Rev 11:CD002003. 2012
    ..This review is an update of the Cochrane Review published in 2007, which assessed the role of beta-blockade as first-line therapy for hypertension...
  22. pmc HIV-1 infection alters CD4+ memory T-cell phenotype at the site of disease in extrapulmonary tuberculosis
    Kerryn Matthews
    Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory, South Africa
    Eur J Immunol 42:147-57. 2012
    ..These results indicate that HIV-1 infection results in altered phenotype and function of MTB-specific CD4+ T cells at the disease site, which may contribute to the increased risk of developing TB at all stages of HIV-1 infection...
  23. ncbi request reprint Primary prevention of acute rheumatic fever and rheumatic heart disease with penicillin in South African children with pharyngitis: a cost-effectiveness analysis
    James Irlam
    Primary Health Care Directorate, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Circ Cardiovasc Qual Outcomes 6:343-51. 2013
    ..We describe a cost-effective analysis of 7 strategies for the primary prevention of acute rheumatic fever and rheumatic heart disease in children presenting with pharyngitis in urban primary care clinics in South Africa...
  24. doi request reprint Cardiac manifestations of HIV infection: an African perspective
    Mpiko Ntsekhe
    Division of Cardiology at Groote Schuur Hospital, Cape Town, South Africa
    Nat Clin Pract Cardiovasc Med 6:120-7. 2009
    ..Herein, we review the cardiac manifestations of HIV in sub-Saharan Africa...
  25. ncbi request reprint Readmission and death after an acute heart failure event: predictors and outcomes in sub-Saharan Africa: results from the THESUS-HF registry
    Karen Sliwa
    Department of Medicine, Faculty of Health Sciences, Hatter Institute for Cardiovascular Research in Africa and the Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Eur Heart J 34:3151-9. 2013
    ..We sought to describe factors prognostic of re-admission and death in this developing population...
  26. doi request reprint Clinical features, survival experience, and profile of plakophylin-2 gene mutations in participants of the arrhythmogenic right ventricular cardiomyopathy registry of South Africa
    David A Watkins
    Cardiovascular Genetics Laboratory, Hatter Institute for Cardiovascular Research, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Heart Rhythm 6:S10-7. 2009
    ..PKP2 gene mutations are common, have an allele dose effect, and a novel founder effect in white South Africans...
  27. ncbi request reprint A modern approach to tuberculous pericarditis
    Faisal F Syed
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Prog Cardiovasc Dis 50:218-36. 2007
    ....
  28. ncbi request reprint Clinical characteristics and outcomes of familial and idiopathic dilated cardiomyopathy in Cape Town: a comparative study of 120 cases followed up over 14 years
    Ntobeko B A Ntusi
    Cardiac Clinic, Department of Medicine, Groote Schuur Hospital, University of Cape Town
    S Afr Med J 101:399-404. 2011
    ..It is not known whether there are differences in clinical characteristics and outcomes of patients with familial and idiopathic dilated cardiomyopathy (DCM) in an African setting...
  29. doi request reprint Prognostic significance of ECG abnormalities for mortality risk in acute heart failure: insight from the Sub-Saharan Africa Survey of Heart Failure (THESUS-HF)
    Anastase Dzudie
    DOUALA General Hospital, Douala, and Buea Faculty of Health Sciences, Buea, Cameroon Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Card Fail 20:45-52. 2014
    ..The aim of this study was to assess the predictive utility of 12-lead electrocardiogram (ECG) abnormalities among Africans with acute heart failure (HF)...
  30. pmc Genetic variation at selected SNPs in the leptin gene and association of alleles with markers of kidney disease in a Xhosa population of South Africa
    Ikechi G Okpechi
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    PLoS ONE 5:e9086. 2010
    ..A number of clinical and experimental studies have suggested a link between serum leptin and kidney disease. We hypothesised that variants in the leptin gene (LEP) may be associated with markers of CKD in indigenous black Africans...
  31. ncbi request reprint Frequency and clinical genetics of familial dilated cardiomyopathy in Cape Town: implications for the evaluation of patients with unexplained cardiomyopathy
    Ntobeko B A Ntusi
    Cardiac Clinic and Cardiovascular Genetics Laboratory, Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, Groote Schuur Hospital, University of Cape Town
    S Afr Med J 101:394-8. 2011
    ..Studies from Europe and North America suggest that 20 - 50% of patients with dilated cardiomyopathy (DCM) may have familial disease. There is little information on the frequency and clinical genetics of familial DCM in Africa...
  32. doi request reprint Tuberculous pericarditis with and without HIV
    Mpiko Ntsekhe
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, E 17 New Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa
    Heart Fail Rev 18:367-73. 2013
    ....
  33. pmc The prevalence and outcome of effusive constrictive pericarditis: a systematic review of the literature
    Mpiko Ntsekhe
    Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Cardiovasc J Afr 23:281-5. 2012
    ..Appropriate studies are needed to determine the epidemiology of ECP in tuberculous pericarditis, which is one of the leading causes of pericardial disease in the world...
  34. ncbi request reprint Cardiomyopathy in Africa: heredity versus environment
    Bongani M Mayosi
    Department of Medicine, University of Cape Town, Groote Schuur Hospital, Cape Town
    Cardiovasc J Afr 18:175-9. 2007
    ..There is a need for renewed effort to identify genetic and non-genetic factors in EMF and other forms of heart muscle disease that are prevalent on the continent of Africa...
  35. doi request reprint Recent advances in the epidemiology, pathogenesis and prognosis of acute heart failure and cardiomyopathy in Africa
    Karen Sliwa
    Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Heart 99:1317-22. 2013
    ..The key challenges of management of heart failure are the urgent need to increase the use of proven treatments by physicians, and the control of hypertension in primary care and at the population level...
  36. pmc Quantification of echodensities in tuberculous pericardial effusion using fractal geometry: a proof of concept study
    Mpiko Ntsekhe
    Department of Medicine, The Cardiac Clinic, Groote Schuur Hospital and University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    Cardiovasc Ultrasound 10:30. 2012
    ....
  37. ncbi request reprint Tuberculous pericarditis
    Bongani M Mayosi
    The Cardiac Clinic, Department of Medicine, University of Cape Town, Groote Schuur Hospital, Cape Town, South Africa
    Circulation 112:3608-16. 2005
    ..The primary objective of this article was to review and summarize the literature on the pathogenesis, diagnosis, and management of tuberculous pericarditis...
  38. pmc The burden of antenatal heart disease in South Africa: a systematic review
    David A Watkins
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, J Floor Old Main Building, Groote Schuur Hospital, Observatory, Cape Town 7925, South Africa
    BMC Cardiovasc Disord 12:23. 2012
    ..Maternal mortality in South Africa is rising, and heart conditions currently account for 41 per cent of indirect causes of deaths. Little is known about the burden of heart disease in pregnant South Africans...
  39. pmc Antibiotics for the primary prevention of acute rheumatic fever: a meta-analysis
    Katharine A Robertson
    Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    BMC Cardiovasc Disord 5:11. 2005
    ....
  40. ncbi request reprint Genotype at the -174G/C polymorphism of the interleukin-6 gene is associated with common carotid artery intimal-medial thickness: family study and meta-analysis
    Bongani M Mayosi
    Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom
    Stroke 36:2215-9. 2005
    ..We have used a family-based genetic association design to assess the heritability of carotid IMT and to investigate the hypothesized association of carotid IMT with the IL-6 to -174G/C polymorphism...
  41. ncbi request reprint Measured haplotype analysis of the aldosterone synthase gene and heart size
    Bongani M Mayosi
    Department of Cardiovascular Medicine, University of Oxford, The Wellcome Trust Centre for Human Genetics, Oxford, UK
    Eur J Hum Genet 11:395-401. 2003
    ..These results point to the importance of analysing the full extent of genetic variation that captures the haplotype structure of a locus in gene association studies...
  42. pmc Abnormal blood pressure response to exercise occurs more frequently in hypertrophic cardiomyopathy patients with the R92W troponin T mutation than in those with myosin mutations
    Marshall Heradien
    Department of Internal Medicine, University of Stellenbosch Health Sciences Faculty, Tygerberg, South Africa
    Heart Rhythm 6:S18-24. 2009
    ..Therefore, these results show that blood pressure response to exercise is influenced by genotype and gender in patients with HCM...
  43. doi request reprint Genome-wide linkage analysis of electrocardiographic and echocardiographic left ventricular hypertrophy in families with hypertension
    Bongani M Mayosi
    Department of Medicine, University of Cape Town, J Floor Old Main Building, Groote Schuur Hospital, Anzio Road Observatory, Cape Town 7925, W Cape, South Africa
    Eur Heart J 29:525-30. 2008
    ..To localize chromosomal regions (or quantitative trait loci) that harbour genetic variants influencing the variability of electrocardiographic (ECG) and echocardiographic left ventricular hypertrophy (LVH)...
  44. doi request reprint Epidemiology of heart failure in sub-Saharan Africa
    Ntobeko B A Ntusi
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Expert Rev Cardiovasc Ther 7:169-80. 2009
    ....
  45. ncbi request reprint Determinants of PCR performance (Xpert MTB/RIF), including bacterial load and inhibition, for TB diagnosis using specimens from different body compartments
    Grant Theron
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Sci Rep 4:5658. 2014
    ..Mycobacterial load, which displays significant variation across different body compartments, is the main determinant of MTB/RIF-positivity rather than PCR inhibition. MTB/RIF CT is a poor surrogate of load in extrapulmonary specimens. ..
  46. ncbi request reprint Lack of adherence to the national guidelines on the prevention of rheumatic fever
    Katharine A Robertson
    Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town
    S Afr Med J 95:52-6. 2005
    ....
  47. doi request reprint Echocardiographic screening for subclinical rheumatic heart disease remains a research tool pending studies of impact on prognosis
    Liesl Zuhlke
    Division of Paediatric Cardiology, Red Cross War Memorial Children s Hospital and University of Cape Town, Cape Town, South Africa
    Curr Cardiol Rep 15:343. 2013
    ..Therefore, echocardiographic screening for asymptomatic subclinical RHD remains a research tool until studies of impact on prognosis and cost-effectiveness are conducted...
  48. doi request reprint Beta-blockers for hypertension
    Charles Shey Wiysonge
    Institute of Infectious Disease and Molecular Medicine and Division of Medical Microbiology, University of Cape Town, Anzio Road, Observatory, South Africa, 7925
    Cochrane Database Syst Rev 8:CD002003. 2012
    ..This review is an update of the Cochrane Review published in 2007, which assessed the role of beta-blockade as first-line therapy for hypertension...
  49. doi request reprint Aetiology and risk factors of peripartum cardiomyopathy: a systematic review
    Ntobeko B A Ntusi
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Int J Cardiol 131:168-79. 2009
    ..The primary objective of this review was to summarize the state of knowledge on the pathogenesis of PPCM, especially in light of recent studies...
  50. ncbi request reprint Protocols for antibiotic use in primary and secondary prevention of rheumatic fever
    Bongani M Mayosi
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, South Africa
    S Afr Med J 96:240. 2006
  51. pmc Arrhythmogenic right ventricular cardiomyopathy type 6 (ARVC6): support for the locus assignment, narrowing of the critical region and mutation screening of three candidate genes
    Luzuko O Matolweni
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    BMC Med Genet 7:29. 2006
    ..By linkage analysis, ARVC type 6 was previously mapped to a 10.6 cM region on chromosome 10p12-p14 in a large North American kindred. To date, the genetic defect that causes ARVC6 has not been identified...
  52. pmc Reference intervals for the echocardiographic measurements of the right heart in children and adolescents: a systematic review
    Carolina E Lemmer Hunsinger
    Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory, Cape Town, South Africa
    Cardiovasc Ultrasound 12:3. 2014
    ....
  53. ncbi request reprint Cardiac involvement in HIV-infected people living in Africa: a review
    Nombulelo P Magula
    Infectious Disease Unit, Department of Medicine, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
    Cardiovasc J S Afr 14:231-7. 2003
    ....
  54. ncbi request reprint Dextrocardia with anterior myocardial infarction
    Adriano G Cocciante
    The Cardiac Clinic, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa
    Cardiovasc J S Afr 14:204-5. 2003
  55. pmc Current status and future prospects of epidemiology and public health training and research in the WHO African region
    Jean B Nachega
    Department of Medicine and Centre for Infectious Diseases, Stellenbosch University, Cape Town, South Africa
    Int J Epidemiol 41:1829-46. 2012
    ..To date little has been published about epidemiology and public health capacity (training, research, funding, human resources) in WHO/AFRO to help guide future planning by various stakeholders...
  56. ncbi request reprint HIV infection, pulmonary arterial hypertension and pregnancy: a fatal triad
    Myat Tun Lin Nyo
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Cardiovasc J Afr 23:e4-6. 2012
    ..Histological features of pulmonary arterial hypertension were present at post mortem. This is the first report of histologically confirmed HIV-associated pulmonary arterial hypertension associated with pregnancy in Africa...
  57. pmc Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosis
    Kerryn Matthews
    Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa
    Tuberculosis (Edinb) 91:587-93. 2011
    ..We propose that our findings support a role for IL-22 in TB-induced pathology or the resulting repair process...
  58. doi request reprint 3D myocardial tissue tracking with slice followed cine DENSE MRI
    Bruce S Spottiswoode
    UCT MRC Medical Imaging Research Unit, University of Cape Town, South Africa
    J Magn Reson Imaging 27:1019-27. 2008
    ..To track three-dimensional (3D) myocardial tissue motion using slice followed cine displacement encoded imaging with stimulated echoes (DENSE)...
  59. pmc Motion-guided segmentation for cine DENSE MRI
    Bruce S Spottiswoode
    UCT MRC Medical Imaging Research Unit, University of Cape Town, South Africa
    Med Image Anal 13:105-15. 2009
    ..Motion-guided segmentation employs the displacement-encoded phase shifts intrinsic to DENSE MRI to accurately propagate a single set of pre-defined contours throughout the remaining cardiac phases...
  60. ncbi request reprint Contemporary use of adjunctive corticosteroids in tuberculous pericarditis
    Charles S Wiysonge
    Int J Cardiol 124:388-90. 2008
    ..These data provide a justification for the establishment of adequately powered randomised clinical trials to assess the effectiveness of adjunctive corticosteroids in patients with tuberculous pericarditis...
  61. ncbi request reprint Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein
    Mark A Vickers
    Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, UK
    Cardiovasc Res 53:1029-34. 2002
    ..We hypothesised that plasma CRP would be a heritable phenotype that would be influenced by genotype at this polymorphism...
  62. ncbi request reprint Association between common polymorphisms of the proopiomelanocortin gene and body fat distribution: a family study
    Michelle Baker
    Institute of Human Genetics, Central Parkway, Newcastle NE1 3BZ, UK
    Diabetes 54:2492-6. 2005
    ..These data show that genetic variants at the POMC locus influence body fat distribution within the normal range, suggesting a novel role for POMC in metabolic regulation...
  63. ncbi request reprint The C-532T polymorphism of the angiotensinogen gene is associated with pulse pressure: a possible explanation for heterogeneity in genetic association studies of AGT and hypertension
    Michelle Baker
    The Institute of Human Genetics, Newcastle University, UK
    Int J Epidemiol 36:1356-62. 2007
    ..We hypothesized that a primary effect of AGT variants on arterial stiffness (and thus pulse pressure) might explain such heterogeneity, and tested for such an effect in a family study...
  64. ncbi request reprint Acute rheumatic fever
    Innocent Monya-Tambi
    Lancet 366:1355; author reply 1355-6. 2005
  65. doi request reprint Ambulatory blood pressure is associated with polymorphic variation in P2X receptor genes
    Julian Palomino-Doza
    Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom
    Hypertension 52:980-5. 2008
    ..Other suggestive associations were found, but these were nonsignificant after correction for multiple testing. These genetic data suggest that drugs affecting P2X receptor signaling may have promise as clinical antihypertensive agents...
  66. ncbi request reprint Epidemiology and etiology of cardiomyopathy in Africa
    Karen Sliwa
    Department of Cardiology, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa
    Circulation 112:3577-83. 2005
    ..The primary objective of this review was to summarize the current state of knowledge on the epidemiology and etiology of cardiomyopathy in people living in Africa and to identify new avenues for research...
  67. ncbi request reprint Intramuscular penicillin is more effective than oral penicillin in secondary prevention of rheumatic fever--a systematic review
    Juliet Manyemba
    Clinical Age Research Unit, Guy s, King s and St Thomas s School of Medicine, King s College Hospital, London
    S Afr Med J 93:212-8. 2003
    ..Giving penicillin to these people can prevent recurrent attacks of RF and subsequent rheumatic heart disease. However, there is no agreement on the most effective method of giving penicillin...
  68. ncbi request reprint Molecular genetics of cardiomyopathy: changing times, shifting paradigms
    Johanna C Moolman-Smook
    US MRC for Molecular and Cellular Biology, Faculty of Health Science, University of Stellenbosch, Tygerburg, South Africa
    Cardiovasc J S Afr 14:145-55. 2003
    ....
  69. ncbi request reprint Origins of computed tomography
    Christopher L Vaughan
    Lancet 369:1168. 2007
  70. ncbi request reprint Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene
    Helen Imrie
    Institute of Human Genetics, Central Parkway, Newcastle NE1 3BZ, United Kingdom
    J Clin Endocrinol Metab 91:5051-6. 2006
    ..However, the relative importance of polymorphisms in CYP11B1 and CYP11B2 in determining these phenotypes is unknown...
  71. ncbi request reprint Towards a uniform plan for the control of rheumatic fever and rheumatic heart disease in Africa--the Awareness Surveillance Advocacy Prevention (A.S.A.P.) Programme
    Kate A Robertson
    New York Medical College, USA
    S Afr Med J 96:241. 2006
  72. ncbi request reprint Cardiovascular disease in sub-Saharan Africa
    Lionel H Opie
    Circulation 112:3536-40. 2005
  73. ncbi request reprint Heart failure in sub-saharan Africa: time for action
    Albertino Damasceno
    Faculdade de Medicina, Universidade Eduardo Mondlane, Maputo, Mozambique
    J Am Coll Cardiol 50:1688-93. 2007
  74. ncbi request reprint SAMJ--Africa's top open access medical journal
    Bongani M Mayosi
    S Afr Med J 95:809. 2005
  75. ncbi request reprint Rheumatic fever and rheumatic heart disease: primary prevention is the cost effective option
    James Irlam
    Indian J Pediatr 75:86; author reply 86-7. 2008