DM Lombardi

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. ncbi Rate of response of individual asthma control measures varies and may overestimate asthma control: an analysis of the goal study
    Eric D Bateman
    University of Cape Town, Cape Town, South Africa
    J Asthma 44:667-73. 2007
  2. doi Stability of asthma control with regular treatment: an analysis of the Gaining Optimal Asthma controL (GOAL) study
    E D Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Allergy 63:932-8. 2008
  3. pmc Validation of a guideline-based composite outcome assessment tool for asthma control
    Sally Spencer
    Brunel University, Uxbridge, UK
    Respir Res 8:26. 2007
  4. pmc Diagnostic accuracy of an integrated respiratory guideline in identifying patients with respiratory symptoms requiring screening for pulmonary tuberculosis: a cross-sectional study
    Rene G English
    Knowledge Translation Unit, University of Cape Town Lung Institute, George Street, Mowbray, 7700, Cape Town, South Africa
    BMC Pulm Med 6:22. 2006
  5. ncbi Guideline for the management of chronic obstructive pulmonary disease (COPD): 2004 revision
    E D Bateman
    University of Cape Town Lung Institute
    S Afr Med J 94:559-75. 2004
  6. doi Global strategy for asthma management and prevention: GINA executive summary
    E D Bateman
    University of Cape Town Lung Institute, PO Box 34560, Groote School, 7700 Mowbray, Cape Town, South Africa
    Eur Respir J 31:143-78. 2008
  7. ncbi Comparable spirometric efficacy of tiotropium compared with salmeterol plus fluticasone in patients with COPD: a pilot study
    E D Bateman
    Division of Pulmonology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, PO Box 34560, Groote Schuur 7937, Cape Town, South Africa
    Pulm Pharmacol Ther 21:20-5. 2008
  8. pmc Budesonide/formoterol and formoterol provide similar rapid relief in patients with acute asthma showing refractoriness to salbutamol
    E D Bateman
    University of Cape Town Lung Institute, Cape Town, South Africa
    Respir Res 7:13. 2006
  9. ncbi The correlation between asthma control and health status: the GOAL study
    E D Bateman
    University of Cape Town, Cape Town, South Africa
    Eur Respir J 29:56-62. 2007
  10. ncbi Ciclesonide reduces the need for oral steroid use in adult patients with severe, persistent asthma
    Eric Bateman
    University of Cape Town Lung Institute, PO Box 34560, Groote Schuur 7937, Cape Town, South Africa
    Chest 129:1176-87. 2006

Detail Information

Publications56

  1. ncbi Rate of response of individual asthma control measures varies and may overestimate asthma control: an analysis of the goal study
    Eric D Bateman
    University of Cape Town, Cape Town, South Africa
    J Asthma 44:667-73. 2007
    ....
  2. doi Stability of asthma control with regular treatment: an analysis of the Gaining Optimal Asthma controL (GOAL) study
    E D Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Allergy 63:932-8. 2008
    ....
  3. pmc Validation of a guideline-based composite outcome assessment tool for asthma control
    Sally Spencer
    Brunel University, Uxbridge, UK
    Respir Res 8:26. 2007
    ..The purpose of this study was to validate two new guideline-based composite measures of asthma control, defined as totally controlled (TC) asthma and well controlled (WC) asthma...
  4. pmc Diagnostic accuracy of an integrated respiratory guideline in identifying patients with respiratory symptoms requiring screening for pulmonary tuberculosis: a cross-sectional study
    Rene G English
    Knowledge Translation Unit, University of Cape Town Lung Institute, George Street, Mowbray, 7700, Cape Town, South Africa
    BMC Pulm Med 6:22. 2006
    ....
  5. ncbi Guideline for the management of chronic obstructive pulmonary disease (COPD): 2004 revision
    E D Bateman
    University of Cape Town Lung Institute
    S Afr Med J 94:559-75. 2004
    ..The development of both long-acting beta2-agonist and anticholinergic drugs for use in COPD. Emerging evidence on a limited role for inhaled corticosteroids in the treatment of COPD...
  6. doi Global strategy for asthma management and prevention: GINA executive summary
    E D Bateman
    University of Cape Town Lung Institute, PO Box 34560, Groote School, 7700 Mowbray, Cape Town, South Africa
    Eur Respir J 31:143-78. 2008
    ..The importance of the patient-care giver partnership and guided self-management, along with setting goals for treatment, are also emphasised...
  7. ncbi Comparable spirometric efficacy of tiotropium compared with salmeterol plus fluticasone in patients with COPD: a pilot study
    E D Bateman
    Division of Pulmonology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, PO Box 34560, Groote Schuur 7937, Cape Town, South Africa
    Pulm Pharmacol Ther 21:20-5. 2008
    ....
  8. pmc Budesonide/formoterol and formoterol provide similar rapid relief in patients with acute asthma showing refractoriness to salbutamol
    E D Bateman
    University of Cape Town Lung Institute, Cape Town, South Africa
    Respir Res 7:13. 2006
    ..To compare the efficacy and safety of budesonide/formoterol (Symbicort) with formoterol (Oxis) in the treatment of patients with acute asthma who showed evidence of refractoriness to short-acting beta2-agonist therapy...
  9. ncbi The correlation between asthma control and health status: the GOAL study
    E D Bateman
    University of Cape Town, Cape Town, South Africa
    Eur Respir J 29:56-62. 2007
    ..The difference in Asthma Quality of Life Questionnaire scores between total control and well-controlled confirms that patients distinguish even between these high levels of control...
  10. ncbi Ciclesonide reduces the need for oral steroid use in adult patients with severe, persistent asthma
    Eric Bateman
    University of Cape Town Lung Institute, PO Box 34560, Groote Schuur 7937, Cape Town, South Africa
    Chest 129:1176-87. 2006
    ..The potential of ciclesonide, a novel ICS, to reduce OCS use in patients with severe, persistent asthma was evaluated in this study...
  11. ncbi Efficacy and safety of roflumilast in the treatment of asthma
    Eric D Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, South Africa
    Ann Allergy Asthma Immunol 96:679-86. 2006
    ..Roflumilast is an oral, once-daily phosphodiesterase type 4 inhibitor with anti-inflammatory activity in preclinical models of asthma and chronic obstructive pulmonary disease...
  12. ncbi Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study
    Eric D Bateman
    UCT Lung Institute, P O Box 34560, Groote Schuur 7937, Cape Town, South Africa
    Am J Respir Crit Care Med 170:836-44. 2004
    ..07-0.27 per patient per year) and improvement in health status were significantly better with salmeterol/fluticasone. This study confirms that the goal of guideline-derived asthma control was achieved in a majority of the patients...
  13. ncbi Combination therapy with single inhaler budesonide/formoterol compared with high dose of fluticasone propionate alone in patients with moderate persistent asthma
    Eric D Bateman
    University of Cape Town, Cape Town, South Africa
    Am J Respir Med 2:275-81. 2003
    ..The efficacy and safety of Symbicort (budesonide and formoterol in a single inhaler) were compared with those of a high dose of the commonly used corticosteroid fluticasone propionate in patients with moderate persistent asthma...
  14. ncbi Clinical equivalence of salmeterol/fluticasone propionate in combination (50/100 microg twice daily) when administered via a chlorofluorocarbon-free metered dose inhaler or dry powder inhaler to patients with mild-to-moderate asthma
    E D Bateman
    UCT Lung Institute, Groote Schuur, Cape Town, South Africa
    Respir Med 95:136-46. 2001
    ..Patients switching to SALM/FP from other MDI-based asthma treatments may now do so without a change of delivery device...
  15. ncbi Measuring asthma control
    E D Bateman
    University of Cape Town, Cape Town, South Africa
    Curr Opin Allergy Clin Immunol 1:211-6. 2001
    ..The potential value of the wider use of a composite measure of clinical control is being increasingly recognized, and further attempts to develop, validate and apply a simple tool suitable for use in primary care are underway...
  16. ncbi Achieving guideline-based asthma control: does the patient benefit?
    E D Bateman
    UCT Lung Institute, University of Cape Town, South Africa
    Eur Respir J 20:588-95. 2002
    ..Guideline-based asthma control is therefore beneficial to the patient and should be tested in prospective studies...
  17. ncbi Meta-analysis: effects of adding salmeterol to inhaled corticosteroids on serious asthma-related events
    Eric Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Ann Intern Med 149:33-42. 2008
    ..Recent analyses have suggested an increased risk for serious asthma-related adverse events in patients receiving long-acting beta-agonists...
  18. pmc Efficacy and safety of tiotropium Respimat SMI in COPD in two 1-year randomized studies
    Eric Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Int J Chron Obstruct Pulmon Dis 5:197-208. 2010
    ..Tiotropium Respimat SMI 5 microg demonstrated sustained improvements in patients with COPD relative to placebo and similar to the 10 microg dose but with a lower frequency of anticholinergic adverse events...
  19. ncbi Is overall asthma control being achieved? A hypothesis-generating study
    E D Bateman
    UCT Lung Institute, University of Cape Town, South Africa
    Eur Respir J 17:589-95. 2001
    ..Future research will include a randomized controlled study designed to assess the proportion of patients able to achieve overall control of asthma when treatment is titrated appropriately...
  20. pmc Occupational allergy and asthma among salt water fish processing workers
    Mohamed F Jeebhay
    Occupational and Environmental Health Research Unit, School of Public Health and Family Medicine, University of Cape Town, Western Cape, South Africa
    Am J Ind Med 51:899-910. 2008
    ..The aim of this study was to determine the prevalence and host determinants of allergic symptoms, allergic sensitization, bronchial hyper-responsiveness and asthma among workers processing saltwater fish...
  21. doi Systems for the management of respiratory disease in primary care--an international series: South Africa
    Eric Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, and University of Cape Town Lung Institute, Cape Town, South Africa
    Prim Care Respir J 18:69-75. 2009
    ....
  22. doi Alternative mechanisms for tiotropium
    E D Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Pulm Pharmacol Ther 22:533-42. 2009
    ..This article summarizes data from a variety of investigations that provide insights into possible mechanisms to account for the effects of tiotropium. The report summarizes the discussion on basic and clinical research in this field...
  23. ncbi Poikiloderma, tendon contracture and pulmonary fibrosis: a new autosomal dominant syndrome?
    N P Khumalo
    Division of Dermatology, Groote Schuur Hospital, Cape Town, South Africa
    Br J Dermatol 155:1057-61. 2006
    ..The manifestations in this family differ from other poikilodermata and, to the best of our knowledge, have not been previously documented...
  24. doi Quantitative lung T cell responses aid the rapid diagnosis of pulmonary tuberculosis
    K Dheda
    Lung Infection and Immunity Unit and CTBRI, UCT Lung Institute and Division of Pulmonology, Department of Medicine, University of Cape Town, South Africa
    Thorax 64:847-53. 2009
    ..The diagnosis of smear-negative pulmonary tuberculosis (TB) is problematic. There are limited data on the profile of alveolar TB antigen-specific T cells, and their utility for the rapid immunodiagnosis of pulmonary TB is unclear...
  25. doi Utility of quantitative T-cell responses versus unstimulated interferon-{gamma} for the diagnosis of pleural tuberculosis
    K Dheda
    Lung Infection and Immunity Unit, Division of Pulmonology, Dept of Medicine, University of Cape Town, J flr, Old Main Bldg, Groote Schuur Hospital, Observatory, Cape Town 7925, South Africa
    Eur Respir J 34:1118-26. 2009
    ..The antigen-specific T-cell IGRAs were limited by suboptimal accuracy and the inability to isolate sufficient mononuclear cells to perform the assay...
  26. ncbi Comparison of twice-daily inhaled ciclesonide and fluticasone propionate in patients with moderate-to-severe persistent asthma
    E D Bateman
    Division of Pulmonology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, PO Box 34560, Groote Schuur 7937, Cape Town, South Africa
    Pulm Pharmacol Ther 21:264-75. 2008
    ..To investigate the relative efficacy of ciclesonide and fluticasone propionate (FP) administered at comparable microgram doses in maintaining asthma control in patients with moderate-to-severe persistent asthma...
  27. doi A one-year trial of tiotropium Respimat plus usual therapy in COPD patients
    E D Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, Mowbray, Cape Town, South Africa
    Respir Med 104:1460-72. 2010
    ..The protocol is registered on the European Clinical Trials Database as trial number 2006-001009-27 and in the ClinicalTrials.gov database as NCT00387088...
  28. ncbi Comparison of respiratory effects of two cardioselective beta-blockers, celiprolol and atenolol, in asthmatics with mild to moderate hypertension
    A I van Zyl
    Ischaemic Heart Disease Research Unit, University of Cape Town, South Africa
    Chest 95:209-13. 1989
    ..When given acutely, celiprolol appeared to have acute bronchosparing properties, possibly providing a greater margin of respiratory safety than atenolol...
  29. doi Randomized comparison of ciclesonide 160 and 640 microg/day in severe asthma
    E D Bateman
    Division of Pulmonology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, PO Box 34560, Groote Schuur 7937, Cape Town, South Africa
    Pulm Pharmacol Ther 21:489-98. 2008
    ....
  30. ncbi Aetiology and outcome of pneumonia in human immunodeficiency virus-infected children hospitalized in South Africa
    H J Zar
    Department of Paediatrics, University of Cape Town South Africa
    Acta Paediatr 90:119-25. 2001
    ..HIV-infected children with pneumonia have a worse outcome than HIV-negative patients...
  31. ncbi An evaluation of symptom and chest radiographic screening in tuberculosis prevalence surveys
    S den Boon
    Desmond Tutu TB Centre, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa
    Int J Tuberc Lung Dis 10:876-82. 2006
    ..The population was 36,334 in 2001, and the TB notification rate was 341 per 100,000 population for new smear-positive TB in 2002...
  32. doi Global lung health: the colliding epidemics of tuberculosis, tobacco smoking, HIV and COPD
    R N van Zyl Smit
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Dept of Medicine, University of Cape Town, Cape Town, South Africa
    Eur Respir J 35:27-33. 2010
    ..These interactions deserve urgent attention and have major implications for coordinated public health planning and policy recommendations in the developing world...
  33. ncbi The Practical Approach to Lung Health in South Africa (PALSA) intervention: respiratory guideline implementation for nurse trainers
    A Bheekie
    School of Pharmacy, Discipline of Pharmacology, University of the Western Cape, Cape Town, South Africa
    Int Nurs Rev 53:261-8. 2006
    ..PALSA combines evidence-based syndromic guidelines on the management of respiratory disease in adults with group educational outreach to nurse practitioners...
  34. ncbi Keeping allergy on the agenda: integrated guidelines for respiratory disease in developing countries
    R G English
    The University of Cape Town Lung Institute, Mowbray, Cape Town, South Africa
    Allergy 62:224-9. 2007
    ..Innovative approaches are required to ensure that these diseases are not neglected...
  35. ncbi Using clinical measures of disease control to reduce the burden of asthma
    E D Bateman
    University of Cape Town Lung Institute, and University of Cape Town, South Africa
    Pharmacoeconomics 19:7-12. 2001
    ..Improving asthma control in this way is likely to be associated with significant economic benefits...
  36. pmc Immunomodulation with recombinant interferon-gamma1b in pulmonary tuberculosis
    Rod Dawson
    Division of Pulmonology, Department of Medicine, Health Sciences Faculty, University of Cape Town, Cape Town, South Africa
    PLoS ONE 4:e6984. 2009
    ..Immune adjuvant therapy with recombinant interferon-gamma1b (rIFN-gammab) may reduce pulmonary inflammation and reduce the period of infectivity by promoting earlier sputum clearance...
  37. ncbi Changes in fatal and near-fatal asthma in an urban area of South Africa from 1980-1997
    H J Zar
    Dept of Pediatrics and Child Health, University of Cape Town, South Africa
    Eur Respir J 18:33-7. 2001
    ..However, the relatively high asthma mortality rate in people of mixed race and the predominance of deaths outside health facilities and on weekends suggest problems with access to care...
  38. ncbi Socioeconomic deprivation and asthma prevalence and severity in young adolescents
    M A Poyser
    Dept of Environmental and Geographical Sciences, University of Cape Town, South Africa
    Eur Respir J 19:892-8. 2002
    ..The impact of social mobility on asthma, including reporting of symptoms, deserves closer study...
  39. pmc Chest radiograph reading and recording system: evaluation for tuberculosis screening in patients with advanced HIV
    R Dawson
    University of Cape Town Lung Institute, Division of Pulmonology and E16 Respiratory Clinic, Groote Schuur Hospital, Cape Town, South Africa
    Int J Tuberc Lung Dis 14:52-8. 2010
    ..An antiretroviral treatment (ART) service in Gugulethu township, Cape Town, South Africa...
  40. ncbi The association of prolonged breastfeeding and allergic disease in poor urban children
    C C Obihara
    Centre for TB Research and Education, Dept of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, PO Box 19063, South Africa
    Eur Respir J 25:970-7. 2005
    ..This protective effect was not found in children with an allergic predisposition...
  41. pmc Association between smoking and tuberculosis infection: a population survey in a high tuberculosis incidence area
    S den Boon
    Centre for TB Research and Education, Department of Paediatrics and Child Health, Stellenbosch University, P O Box 19063, 7505 Tygerberg, Cape Town, South Africa
    Thorax 60:555-7. 2005
    ..The aim of this study was to determine the association between smoking and M tuberculosis infection...
  42. doi Determinants of asthma phenotypes in supermarket bakery workers
    R Baatjies
    Centre for Occupational and Environmental Health Research Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    Eur Respir J 34:825-33. 2009
    ..4, 2.0-19.8). OA is the most common phenotype among supermarket bakery workers. Analysis of risk factors contributes to defining clinical phenotypes, which will guide ongoing medical surveillance and clinical management of bakery workers...
  43. ncbi Development and evaluation of a new chest radiograph reading and recording system for epidemiological surveys of tuberculosis and lung disease
    S den Boon
    Department of Paediatrics and Child Health, Faculty of Health Sciences, Desmond Tutu TB Centre, Stellenbosch University, Cape Town, South Africa
    Int J Tuberc Lung Dis 9:1088-96. 2005
    ..The development and evaluation of a new chest radiograph reading and recording system (CRRS) for community surveys of tuberculosis (TB) and lung disease...
  44. ncbi Asthma control can be maintained when fluticasone propionate/salmeterol in a single inhaler is stepped down
    Eric D Bateman
    University of Cape Town, South Africa
    J Allergy Clin Immunol 117:563-70. 2006
    ..Asthma control is the goal of treatment, but little data exist to support treatment strategies for stepping down treatment once control has been achieved...
  45. ncbi Severity and control of severe asthma
    Eric D Bateman
    J Allergy Clin Immunol 117:519-21. 2006
  46. ncbi Identifying 'well-controlled' and 'not well-controlled' asthma using the Asthma Control Questionnaire
    Elizabeth F Juniper
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    Respir Med 100:616-21. 2006
    ....
  47. ncbi Association between passive smoking and infection with Mycobacterium tuberculosis in children
    Saskia den Boon
    Desmond Tutu TB Centre, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa
    Pediatrics 119:734-9. 2007
    ..The association between passive smoking and Mycobacterium tuberculosis infection is not well documented. The objective of this study was to examine the influence of passive smoking on M. tuberculosis infection in children...
  48. ncbi A randomized study comparing ciclesonide and fluticasone propionate in patients with moderate persistent asthma
    Louis Philippe Boulet
    Institut de cardiologie et de pneumologie de l Université Laval, Hopital Laval, 2725 Chemin Sainte Foy, Quebec City, Que, Canada G1V 4G5
    Respir Med 101:1677-86. 2007
    ..To compare the effects of once-daily ciclesonide and twice-daily fluticasone propionate in patients with moderate persistent asthma...
  49. ncbi Improvement in asthma endpoints when aiming for total control: salmeterol/fluticasone propionate versus fluticasone propionate alone
    Ashley A Woodcock
    North West Lung Centre, Wythenshawe Hospital, Manchester, UK
    Prim Care Respir J 16:155-61. 2007
    ..To investigate the magnitude of change in morning peak expiratory flow (PEF), asthma symptoms, and rescue beta2-agonist use, when the aim of treatment is to achieve guideline-defined control...
  50. pmc Effect of educational outreach to nurses on tuberculosis case detection and primary care of respiratory illness: pragmatic cluster randomised controlled trial
    Lara R Fairall
    Knowledge Translation Unit, University of Cape Town Lung Institute, University of Cape Town, Groote Schuur, South Africa
    BMJ 331:750-4. 2005
    ....
  51. ncbi Determinants of response to fluticasone propionate and salmeterol/fluticasone propionate combination in the Gaining Optimal Asthma controL study
    Søren E Pedersen
    Department of Pediatrics, University of Southern Denmark, Pediatric Research Unit, Kolding Hospital, Kolding, Denmark
    J Allergy Clin Immunol 120:1036-42. 2007
    ..Approximately two thirds of patients achieved well-controlled (WC) asthma, and one third continued to have asthma that was not well controlled (NWC)...
  52. ncbi A 6-month, placebo-controlled study comparing lung function and health status changes in COPD patients treated with tiotropium or salmeterol
    James F Donohue
    Division of Pulmonary Medicine, University of North Carolina, Chapel Hill, NC 27599 7020, USA
    Chest 122:47-55. 2002
    ..A trial was designed to examine the efficacy and safety of both compounds with multiple outcome measures, including lung function, dyspnea, and health-related quality of life (HRQoL) in patients with COPD...
  53. ncbi A review of ipratropium bromide/fenoterol hydrobromide (Berodual) delivered via Respimat Soft Mist Inhaler in patients with asthma and chronic obstructive pulmonary disease
    Frank Kässner
    Pneumologisches Zentrum Cottbus, Grobeta Gaglow, Germany
    Drugs 64:1671-82. 2004
    ..In children, Respimat SMI obviates the need for a spacer...
  54. ncbi Budesonide/formoterol combination therapy as both maintenance and reliever medication in asthma
    Paul M O'Byrne
    Firestone Institute for Respiratory Health, St Joseph s Hospital, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 171:129-36. 2005
    ..001), reduced severe exacerbation rate, and improved symptoms, awakenings, and lung function compared with both fixed dosing regimens...
  55. doi The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthma
    William W Busse
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, J5 219 CSC, Box 2454, 600 Highland Ave, Madison, WI 53792, USA
    J Allergy Clin Immunol 121:1167-74. 2008
    ....
  56. ncbi Roflumilast--an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial
    Klaus F Rabe
    Leiden University Medical Centre, Leiden, Netherlands
    Lancet 366:563-71. 2005
    ..There are few treatment options for the disease. This study assessed the efficacy and safety of roflumilast, a phosphodiesterase-4 inhibitor, in patients with moderate to severe COPD...