Research Topics
Genomes and GenesSpecies | Christine LochnerSummaryAffiliation: University of Stellenbosch Country: South Africa Publications
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Detail Information
Publications
Childhood trauma in obsessive-compulsive disorder, trichotillomania, and controlsChristine Lochner
MRC Unit on Stress and Anxiety Disorders, University of Stellenbosch, Tygerberg, Cape Town, South Africa
Depress Anxiety 15:66-8. 2002....- Investigating the possible effects of trauma experiences and 5-HTT on the dissociative experiences of patients with OCD using path analysis and multiple regressionChristine Lochner
MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
Neuropsychobiology 56:6-13. 2007..Here, two different but related statistical techniques (multiple regression and partial least squares), confirmed that physical neglect and the 5-HTT genotype jointly play a role in predicting dissociation in OCD... - Trichotillomania and skin-picking: a phenomenological comparisonChristine Lochner
Department of Psychiatry, MRC Unit on Stress and Anxiety Disorder, University of Stellenbosch, Tygerberg, Cape Town, South Africa
Depress Anxiety 15:83-6. 2002..Future work to assess the implications of overlap for clinical evaluation and intervention in the two conditions may be useful... - Hoarding in obsessive-compulsive disorder: clinical and genetic correlatesChristine Lochner
MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
J Clin Psychiatry 66:1155-60. 2005..The clinical and genetic correlates of hoarding in OCD therefore deserve additional investigation... - Cluster analysis of obsessive-compulsive spectrum disorders in patients with obsessive-compulsive disorder: clinical and genetic correlatesChristine Lochner
MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, PO Box 19063, Tygerberg, 7505, Cape Town, South Africa
Compr Psychiatry 46:14-9. 2005..Comorbidity of the putative OCSDs in OCD has, however, not often been systematically investigated... - Early- versus late-onset obsessive-compulsive disorder: investigating genetic and clinical correlatesSian M J Hemmings
MRC Unit on Anxiety and Stress Disorders, University of Stellenbosch, Medical School, PO Box 19063, Tygerberg 7505, South Africa
Psychiatry Res 128:175-82. 2004..These data support a role for the dopaminergic system, which may be relevant to the development of early-onset OCD... - Corrigendum to "gender in obsessive-compulsive disorder: clinical and genetic findings" [Eur. Neuropsychopharmacol. 14 (2004) 105-113]Christine Lochner
MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, Cape Town, South Africa
Eur Neuropsychopharmacol 14:437-45. 2004..There is increasing recognition that obsessive-compulsive disorder (OCD) is not a homogeneous entity. It has been suggested that gender may contribute to the clinical and biological heterogeneity of OCD... - Gender in obsessive-compulsive disorder: clinical and genetic findingsChristine Lochner
MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, P O Box 19063, Tygerberg 7505, Cape Town, South Africa
Eur Neuropsychopharmacol 14:105-13. 2004..There is increasing recognition that obsessive-compulsive disorder (OCD) is not a homogeneous entity. It has been suggested that gender may contribute to the clinical and biological heterogeneity of OCD... - Genetic correlates in trichotillomania--A case-control association study in the South African Caucasian populationSian M J Hemmings
MRC US Centre for Molecular and Cellular Biology, University of Stellenbosch, Tygerberg, South Africa
Isr J Psychiatry Relat Sci 43:93-101. 2006..Some have argued, however, that TTM is an obsessive-compulsive spectrum disorder (OCSD). There is some evidence that both disorders (OCD and TTM) are mediated by serotonergic (5-HT) and dopaminergic pathways... 
Comorbid obsessive-compulsive personality disorder in obsessive-compulsive disorder (OCD): a marker of severityChristine Lochner
MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
Prog Neuropsychopharmacol Biol Psychiatry 35:1087-92. 2011..It remains unclear, however, whether OCPD in OCD represents a distinct subtype of OCD or whether it is simply a marker of severity in OCD...- Investigating SAPAP3 variants in the etiology of obsessive-compulsive disorder and trichotillomania in the South African white populationLeigh Boardman
Division of Molecular Biology and Human Genetics, Department Biomedical Sciences, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa
Compr Psychiatry 52:181-7. 2011..Results from a recent knockout animal model suggest that SAP90/PSD95-associated protein 3 (SAPAP3) may be involved in the pathophysiology of both disorders... - Dissociative experiences in obsessive-compulsive disorder and trichotillomania: clinical and genetic findingsChristine Lochner
Medical Research Council Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenboch, Cape Town, South Africa
Compr Psychiatry 45:384-91. 2004..g., lower age) and comorbidity profile (e.g., increased incidence of impulse dyscontrol disorders). Additional work is necessary before conclusions about the role of monoaminergic systems in mediating such dissociation can be drawn... - Chronic hair-pulling: phenomenology-based subtypesChristine Lochner
MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
J Anxiety Disord 24:196-202. 2010..Future work, incorporating further investigation of the role of gender and psychobiological and treatment outcomes, is needed before definitive conclusions about hair-pulling subtypes can be drawn... 
Obsessive-compulsive disorder and trichotillomania: a phenomenological comparisonChristine Lochner
MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
BMC Psychiatry 5:2. 2005..Nevertheless, there is evidence of important differences between these two disorders. Some authors have conceptualized the disorders as lying on an OCD spectrum of conditions...- Genetics and personality traits in patients with social anxiety disorder: a case-control study in South AfricaChristine Lochner
MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
Eur Neuropsychopharmacol 17:321-7. 2007..to compare differences in temperament dimensions between carriers of different (dominant vs. recessive) alleles for selected polymorphisms in SAD patients... - Cluster analysis of obsessive-compulsive symptomatology: identifying obsessive-compulsive disorder subtypesChristine Lochner
MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
Isr J Psychiatry Relat Sci 45:164-76. 2008..There is increasing evidence that obsessive-compulsive disorder (OCD) is a heterogeneous disorder. Different clinical subtypes may be characterized by differing pathophysiological mechanisms and treatment outcomes... - Selective attention to fearful faces during pregnancyAnnerine Roos
MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, Stellenbosch University, P O Box 19063, Tygerberg 7505, South Africa
Prog Neuropsychopharmacol Biol Psychiatry 37:76-80. 2012.... - Changes in regional brain volumes in social anxiety disorder following 12 weeks of treatment with escitalopramNaseema Cassimjee
Department of Psychiatry, University of Stellenbosch, PO Box 19063, Tygerberg 7505, South Africa
Metab Brain Dis 25:369-74. 2010..These preliminary findings require replication to determine their reliability, and extension to determine whether or not they are disorder specific... - The validity of DSM-IV-TR criteria B and C of hair-pulling disorder (trichotillomania): evidence from a clinical studyChristine Lochner
Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
Psychiatry Res 189:276-80. 2011..Our study does not provide convincing support for the inclusion of the current diagnostic criteria B and C for TTM in DSM-5... - Obsessive compulsive disorder--prevalence in Xhosa-speaking schizophrenia patientsDana J H Niehaus
Department of Psychiatry, Stellenbosch University, Tygerberg, W Cape
S Afr Med J 95:120-2. 2005..No concordance for OCD was noted in the sibship group. Our findings differ from those in other parts of the world, and if replicated, might suggest unique protective environmental or genetic factors for OCD in certain ethnic groups... - Investigating the role of the brain-derived neurotrophic factor (BDNF) val66met variant in obsessive-compulsive disorder (OCD)Sian M J Hemmings
MRC US Centre for Molecular and Cellular Biology, University of Stellenbosch, Tygerberg, South Africa
World J Biol Psychiatry 9:126-34. 2008..The present investigation forms part of ongoing research to elucidate the genetic components involved in the aetiology of OCD and OCD-related characteristics... - Differential effects of escitalopram challenge on disgust processing in obsessive-compulsive disorderChristine Lochner
MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
Behav Brain Res 226:274-80. 2012.... - Evidence for fractional anisotropy and mean diffusivity white matter abnormalities in the internal capsule and cingulum in patients with obsessive-compulsive disorderChristine Lochner
MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
J Psychiatry Neurosci 37:193-9. 2012..In this study, we used diffusion tensor imaging (DTI) to examine white matter integrity in specific regions of interest (ROIs) in patients with OCD... - Does work on obsessive-compulsive spectrum disorders contribute to understanding the heterogeneity of obsessive-compulsive disorder?Christine Lochner
MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
Prog Neuropsychopharmacol Biol Psychiatry 30:353-61. 2006..Here, we consider the different dimensions on which obsessive-compulsive spectrum (OCSDs) lie, and focus on how the concepts from this literature may help understand the heterogeneity of obsessive-compulsive disorder (OCD)... - Escitalopram in obsessive-compulsive disorder: response of symptom dimensions to pharmacotherapyDan J Stein
Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
CNS Spectr 13:492-8. 2008..The response of OCD symptom dimensions to 12 weeks of treatment with escitalopram or placebo was investigated... - Grey matter abnormalities in social anxiety disorder: a pilot studySupriya Syal
Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
Metab Brain Dis 27:299-309. 2012..Additional work is needed to investigate the causal mechanisms involved in such structural abnormalities in SAD... - Quetiapine augmentation of serotonin reuptake inhibitors in treatment-refractory obsessive-compulsive disorder: is response to treatment predictable?Paul D Carey
Department of Psychiatry, University of Stellenbosch, Tygerberg
Int Clin Psychopharmacol 27:321-5. 2012..Other factors are, however, also likely to play an important role in predicting outcome... - DSM-5 field survey: hair-pulling disorder (trichotillomania)Christine Lochner
MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
Depress Anxiety 29:1025-31. 2012.... - Obsessive-compulsive spectrum disorders: a multidimensional approachDan J Stein
Department of Psychiatry, University of Cape Town, Cape Town, South Africa
Psychiatr Clin North Am 29:343-51. 2006..As further progress is made in understanding the cognitive-affective neuroscience of OCD and related conditions, constructs about obsessive-compulsive spectrum disorders will become increasingly sharp... - Altered prefrontal cortical function during processing of fear-relevant stimuli in pregnancyAnnerine Roos
MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, P O Box 19063, Tygerberg 7505, South Africa
Behav Brain Res 222:200-5. 2011.... - Heterogeneity of obsessive-compulsive disorder: a literature reviewChristine Lochner
MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
Harv Rev Psychiatry 11:113-32. 2003..The heterogeneity of OCD has important clinical and research implications... - Topiramate in the treatment of trichotillomania: an open-label pilot studyChristine Lochner
MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
Int Clin Psychopharmacol 21:255-9. 2006..These results suggest that topiramate may be useful in the treatment of TTM. Future studies should investigate the efficacy of topiramate in an appropriately powered randomized placebo-controlled trial... - Obsessive-compulsive spectrum disorders in obsessive-compulsive disorder and other anxiety disordersChristine Lochner
MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Stellenbosch, South Africa
Psychopathology 43:389-96. 2010..There has been debate about whether obsessive-compulsive disorder (OCD) should be classified as one of the anxiety disorders, or should rather be categorized with obsessive-compulsive spectrum conditions... - Psychometric properties of the Multidimensional Scale of Perceived Social Support in youthBelinda Bruwer
Department of Psychiatry, University of Stellenbosch, Cape Town 7505, South Africa
Compr Psychiatry 49:195-201. 2008..The psychometric properties of the MSPSS have been demonstrated in diverse samples, although its reproducibility in the South African youth has not yet been investigated... - Trichotillomania (hair pulling disorder), skin picking disorder, and stereotypic movement disorder: toward DSM-VDan J Stein
Department of Psychiatry, University of Cape Town, Rondebosch, Cape Town, South Africa
Depress Anxiety 27:611-26. 2010.... - Should OCD be classified as an anxiety disorder in DSM-V?Dan J Stein
Department of Psychiatry, University of Cape Town, Cape Town, South Africa
Depress Anxiety 27:495-506. 2010..If this change is made, the name of this category should be changed to reflect this proposed change... - White matter integrity in hair-pulling disorder (trichotillomania)Annerine Roos
MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, Stellenbosch University, PO Box 19063, Tygerberg 7505, South Africa
Psychiatry Res 211:246-50. 2013..Our findings suggest that white matter integrity in fronto-striatal-thalamic pathways in HPD is related to symptom duration and severity. The molecular basis of measures of white matter integrity in HPD deserves further exploration... - Quality of life in anxiety disorders: a comparison of obsessive-compulsive disorder, social anxiety disorder, and panic disorderChristine Lochner
MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
Psychopathology 36:255-62. 2003..There is growing recognition that the anxiety disorders are disabling disorders associated with substantial morbidity and impaired quality of life (QOL). Nevertheless, there have been few studies comparing QOL across these conditions... - Disability and quality of life in post-traumatic stress disorder: impact of drug treatmentSoraya Seedat
MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
Pharmacoeconomics 24:989-98. 2006..Further investigation of the relationship of QOL to PTSD symptom severity, disability, treatment outcome and cost, among the different drug treatment modalities, is clearly needed... - Investigating the role of dopaminergic and serotonergic candidate genes in obsessive-compulsive disorderSian M J Hemmings
MRC US Centre for Molecular and Cellular Biology, University of Stellenbosch, P O Box 19063, 7505, Tygerberg, South Africa
Eur Neuropsychopharmacol 13:93-8. 2003..Although no statistically significant genotypic or allelic associations were detected, the data yielded interesting preliminary results that warrant further discussion and investigation... - Prevalence of obsessive compulsive disorder in first- and multi-episode male patients with schizophrenia-spectrum disordersLiezl Koen
S Afr Med J 93:517-8. 2003 - A case of "ifufunyane": a xhosa culture-bound syndromeDana J H Niehaus
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
J Psychiatr Pract 11:411-3. 2005 - Initiation rites as a perceived stressor for Isixhosa males with schizophreniaRoselle le Roux
University of Stellenbosch
Transcult Psychiatry 44:292-9. 2007..Our findings suggest that initiation rituals may be perceived as a stressful life event influencing the onset and course of schizophrenia. This underlines the importance of understanding the cultural background of patients...