Sandrine Lecour

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. ncbi request reprint The red wine hypothesis: from concepts to protective signalling molecules
    Lionel H Opie
    Department of Medicine, Faculty of Health Sciences, Hatter Cardiovascular Research Institute, University of Cape Town, Private Bag 3, Observatory, South Africa
    Eur Heart J 28:1683-93. 2007
  2. ncbi request reprint Ceramide attenuates hypoxic cell death via reactive oxygen species signaling
    Sandrine Lecour
    Hatter Institute for Cardiology Research, University of Cape Town, South Africa
    J Cardiovasc Pharmacol 47:158-63. 2006
  3. ncbi request reprint Pharmacological preconditioning with tumor necrosis factor-alpha activates signal transducer and activator of transcription-3 at reperfusion without involving classic prosurvival kinases (Akt and extracellular signal-regulated kinase)
    Sandrine Lecour
    Department of Medicine, Hatter Institute for Cardiology Research, Cape Heart Centre, Faculty of Health Sciences, University of Cape Town, South Africa
    Circulation 112:3911-8. 2005
  4. ncbi request reprint Ceramide-induced preconditioning involves reactive oxygen species
    Sandrine Lecour
    Hatter Institute for Cardiology Research, Department of Medicine, University of Cape Town Medical School, Cape Town, South Africa
    Life Sci 78:1702-6. 2006
  5. ncbi request reprint Free radicals trigger TNF alpha-induced cardioprotection
    Sandrine Lecour
    Hatter Institute for Cardiology Research, Department of Medicine, University of Cape Town Medical School Observatory, 7925 Cape Town, South Africa
    Cardiovasc Res 65:239-43. 2005
  6. ncbi request reprint [Sphingolipid signaling: a potential pathway for TNF-alpha induced preconditioning]
    S Lecour
    Hatter Institute for Cardiology Research, MRC Inter University Cape Heart Group, Chris Barnard Building, University of Cape Town Medical School, Cape Town 7925, Afrique du Sud
    Ann Cardiol Angeiol (Paris) 52:363-9. 2003
  7. doi request reprint Ethanolamine is a novel STAT-3 dependent cardioprotective agent
    Roisin F Kelly
    Hatter Cardiovascular Research Institute, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Basic Res Cardiol 105:763-70. 2010
  8. doi request reprint Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway
    Lydia Lacerda
    Hatter Cardiovascular Research Institute, Cardioprotection Group, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Observatory 7925, Cape Town, South Africa
    Cardiovasc Res 84:201-8. 2009
  9. doi request reprint Is red wine a SAFE sip away from cardioprotection? Mechanisms involved in resveratrol- and melatonin-induced cardioprotection
    Kim T Lamont
    Hatter Institute for Cardiovascular Research, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Pineal Res 50:374-80. 2011
  10. ncbi request reprint TNFalpha-induced cytoprotection requires the production of free radicals within mitochondria in C2C12 myotubes
    Lydia Lacerda
    Hatter Institute for Cardiology Research, University of Cape Town, South Africa
    Life Sci 79:2194-201. 2006

Collaborators

Detail Information

Publications24

  1. ncbi request reprint The red wine hypothesis: from concepts to protective signalling molecules
    Lionel H Opie
    Department of Medicine, Faculty of Health Sciences, Hatter Cardiovascular Research Institute, University of Cape Town, Private Bag 3, Observatory, South Africa
    Eur Heart J 28:1683-93. 2007
    ..Mechanistic feasibility strengthens the case for prospective therapeutic trials of alcohol vs. red wine vs. resveratrol, for example in those with heart failure...
  2. ncbi request reprint Ceramide attenuates hypoxic cell death via reactive oxygen species signaling
    Sandrine Lecour
    Hatter Institute for Cardiology Research, University of Cape Town, South Africa
    J Cardiovasc Pharmacol 47:158-63. 2006
    ..Collectively, these data demonstrate that ceramide induces a cell survival program through ROS signaling activated, in part, via cyclooxygenase and the mitochondrial respiratory chain...
  3. ncbi request reprint Pharmacological preconditioning with tumor necrosis factor-alpha activates signal transducer and activator of transcription-3 at reperfusion without involving classic prosurvival kinases (Akt and extracellular signal-regulated kinase)
    Sandrine Lecour
    Department of Medicine, Hatter Institute for Cardiology Research, Cape Heart Centre, Faculty of Health Sciences, University of Cape Town, South Africa
    Circulation 112:3911-8. 2005
    ....
  4. ncbi request reprint Ceramide-induced preconditioning involves reactive oxygen species
    Sandrine Lecour
    Hatter Institute for Cardiology Research, Department of Medicine, University of Cape Town Medical School, Cape Town, South Africa
    Life Sci 78:1702-6. 2006
    ..Ceramide is known to generate reactive oxygen species (ROS) in cells. Since mechanisms triggering the ceramide-induced cardioprotection remain unknown, we investigated the role of ROS in the genesis of this protective mechanism...
  5. ncbi request reprint Free radicals trigger TNF alpha-induced cardioprotection
    Sandrine Lecour
    Hatter Institute for Cardiology Research, Department of Medicine, University of Cape Town Medical School Observatory, 7925 Cape Town, South Africa
    Cardiovasc Res 65:239-43. 2005
    ..Paradoxically, we have recently demonstrated that low doses of TNF alpha can induce cardiac preconditioning (PC). We hypothesized that the production of free radicals participates in this cardioprotective program...
  6. ncbi request reprint [Sphingolipid signaling: a potential pathway for TNF-alpha induced preconditioning]
    S Lecour
    Hatter Institute for Cardiology Research, MRC Inter University Cape Heart Group, Chris Barnard Building, University of Cape Town Medical School, Cape Town 7925, Afrique du Sud
    Ann Cardiol Angeiol (Paris) 52:363-9. 2003
    ..Moreover, new studies have given the evidence that the exploration of cytokine-activated sphingolipid signalling pathways may enhance our understanding of the preconditioning program...
  7. doi request reprint Ethanolamine is a novel STAT-3 dependent cardioprotective agent
    Roisin F Kelly
    Hatter Cardiovascular Research Institute, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Basic Res Cardiol 105:763-70. 2010
    ..75 ± 0.08 vs. Etn 1.50 ± 0.09 arbitrary units; P < 0.05]. Our findings suggest a novel cardioprotective role for ethanolamine against I/R injury via activation of STAT-3...
  8. doi request reprint Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway
    Lydia Lacerda
    Hatter Cardiovascular Research Institute, Cardioprotection Group, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Observatory 7925, Cape Town, South Africa
    Cardiovasc Res 84:201-8. 2009
    ....
  9. doi request reprint Is red wine a SAFE sip away from cardioprotection? Mechanisms involved in resveratrol- and melatonin-induced cardioprotection
    Kim T Lamont
    Hatter Institute for Cardiovascular Research, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Pineal Res 50:374-80. 2011
    ..001 versus control). Our data demonstrate that both melatonin and resveratrol, as found in red wine, protect the heart in an experimental model of myocardial infarction via the SAFE pathway...
  10. ncbi request reprint TNFalpha-induced cytoprotection requires the production of free radicals within mitochondria in C2C12 myotubes
    Lydia Lacerda
    Hatter Institute for Cardiology Research, University of Cape Town, South Africa
    Life Sci 79:2194-201. 2006
    ..In conclusion, TNFalpha-induced ROS generation can occur within the mitochondria, resulting in temporal mitochondrial perturbations which may initiate the cytoprotective effect of TNFalpha...
  11. ncbi request reprint TNFalpha is required to confer protection in an in vivo model of classical ischaemic preconditioning
    Graeme A Deuchar
    Hatter Institute for Cardiology Research, Department of Medicine, Cape Heart Centre, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa
    Life Sci 80:1686-91. 2007
    ..In addition, exogenous TNFalpha mimics IPC by providing a dose-dependent cardioprotective effect against ischaemia-reperfusion injury in vivo...
  12. doi request reprint Interplay between SAFE and RISK pathways in sphingosine-1-phosphate-induced cardioprotection
    Sarin J Somers
    Hatter Cardiovascular Research Institute, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Cardiovasc Drugs Ther 26:227-37. 2012
    ....
  13. pmc TNFα protects cardiac mitochondria independently of its cell surface receptors
    Lydia Lacerda
    Cardioprotection Group, Hatter Cardiovascular Research Institute, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    Basic Res Cardiol 105:751-62. 2010
    ..This effect appears to be independent of its cell surface receptors, but is likely to be mediated by ROS and sphingolipids...
  14. ncbi request reprint Identification of a novel role for sphingolipid signaling in TNF alpha and ischemic preconditioning mediated cardioprotection
    Sandrine Lecour
    Hatter Institute for Cardiology Research, MRC Inter University Cape Heart Group, University of Cape Town Medical School, South Africa
    J Mol Cell Cardiol 34:509-18. 2002
    ..In conclusion, TNF alpha activates preconditioning-like tolerance against infarction and contractile dysfunction. This cardioprotection is mediated, in part, via activation of novel sphingolipid signaling intermediates...
  15. pmc Influence of tumour necrosis factor alpha on the outcome of ischaemic postconditioning in the presence of obesity and diabetes
    Lydia Lacerda
    Cardioprotection Group, Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa
    Exp Diabetes Res 2012:502654. 2012
    ..Our data confirm a bidirectional role for TNFα associated with the severity of concomitant comorbidities and suggest that diabetic and/or modestly obese patients may still benefit from IPostC...
  16. ncbi request reprint Lowering the alcohol content of red wine does not alter its cardioprotective properties
    Kim Lamont
    Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, University of Cape Town
    S Afr Med J 102:565-7. 2012
    ..Many epidemiological, clinical and laboratory studies suggest that chronic and moderate consumption of red wine benefits cardiovascular health, because of the alcoholic content or the polyphenols/flavonoids...
  17. ncbi request reprint Innate immunity and cardiac preconditioning: a putative intrinsic cardioprotective program
    Robert M Smith
    Hatter Institute for Cardiology Research, MRC Inter University Cape Heart Group, University of Cape Town Medical School, South Africa
    Cardiovasc Res 55:474-82. 2002
    ....
  18. doi request reprint Loss of cardioprotection with ischemic preconditioning in aging hearts: role of sirtuin 1?
    Tasneem Adam
    Department of Medicine, Hatter Institute for Cardiovascular Research in Africa, University of Cape Town, Cape Town, South Africa
    J Cardiovasc Pharmacol Ther 18:46-53. 2013
    ..In conclusion, although Sirt 1 deacetylase activity is increased with age during ischemia/reperfusion, our data suggest that the loss of the cardioprotective effect of IPC in older animals is likely to be independent of Sirt 1...
  19. doi request reprint Activation of the protective Survivor Activating Factor Enhancement (SAFE) pathway against reperfusion injury: Does it go beyond the RISK pathway?
    Sandrine Lecour
    Cardioprotection Group, Hatter Cardiovascular Research Institute, Department of Medicine, Chris Barnard Building, Faculty of Health Sciences, University of Cape Town, 7925 Observatory, South Africa
    J Mol Cell Cardiol 47:32-40. 2009
    ..Emerging knowledge on this novel protective path is presented here with the aim of unravelling its interaction with the RISK pathway and its potential human application to protect against lethal reperfusion injury...
  20. doi request reprint When are pro-inflammatory cytokines SAFE in heart failure?
    Sandrine Lecour
    Hatter Cardiovascular Research Institute, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Eur Heart J 32:680-5. 2011
    ..In this review, we will discuss whether targeting the SAFE pathway may be considered as a preventive and/or therapeutic measure for the treatment of heart failure...
  21. pmc Signal transducer and activator of transcription 3 is involved in the cardioprotective signalling pathway activated by insulin therapy at reperfusion
    Britt N Fuglesteg
    Dept of Medical Physiology, Faculty of Medicine, University of Tromsø, 9037, Tromsø, Norway
    Basic Res Cardiol 103:444-53. 2008
    ..To evaluate the significance of the JAK-STAT pathway in insulin-induced cardioprotection from reperfusion injury...
  22. ncbi request reprint Intrarenal detection of nitric oxide using electron spin resonance spectroscopy in hypertensive lipopolysaccharide-treated rats
    Sandrine Lecour
    Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Experimentales, Facultés de Médecine et Pharmacie, Dijon, France
    J Cardiovasc Pharmacol 40:9-17. 2002
    ..8 AU) and a larger increase in glomerular neutrophils (2.48 +/- 0.36 versus 1.36 +/- 0.41) compared with normotensive rats. These results are in agreement with a direct implication of NO during LPS-and l-NAME-induced kidney injuries...
  23. ncbi request reprint Systemic free radical activation is a major event involved in myocardial oxidative stress related to cardiopulmonary bypass
    Gaelle Clermont
    LPPCE Faculty of Medicine, Dijon, France
    Anesthesiology 96:80-7. 2002
    ..The aim of this study was to evaluate the time course and origin of radical oxygen species release, myocardial or not, in patients undergoing coronary artery surgery involving CPB...
  24. ncbi request reprint Evidence for the extrapulmonary localization of inhaled nitric oxide
    Sandrine Lecour
    LPPCE, Faculty of Medicine, IFR 100 Dijon, France
    Heart Dis 5:372-7. 2003
    ....