Lydia Lacerda

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. pmc TNFα protects cardiac mitochondria independently of its cell surface receptors
    Lydia Lacerda
    Cardioprotection Group, Hatter Cardiovascular Research Institute, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    Basic Res Cardiol 105:751-62. 2010
  2. doi Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway
    Lydia Lacerda
    Hatter Cardiovascular Research Institute, Cardioprotection Group, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Observatory 7925, Cape Town, South Africa
    Cardiovasc Res 84:201-8. 2009
  3. doi Ethanolamine is a novel STAT-3 dependent cardioprotective agent
    Roisin F Kelly
    Hatter Cardiovascular Research Institute, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Basic Res Cardiol 105:763-70. 2010
  4. ncbi Pharmacological preconditioning with tumor necrosis factor-alpha activates signal transducer and activator of transcription-3 at reperfusion without involving classic prosurvival kinases (Akt and extracellular signal-regulated kinase)
    Sandrine Lecour
    Department of Medicine, Hatter Institute for Cardiology Research, Cape Heart Centre, Faculty of Health Sciences, University of Cape Town, South Africa
    Circulation 112:3911-8. 2005
  5. doi Interplay between SAFE and RISK pathways in sphingosine-1-phosphate-induced cardioprotection
    Sarin J Somers
    Hatter Cardiovascular Research Institute, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Cardiovasc Drugs Ther 26:227-37. 2012
  6. ncbi Diazoxide-induced respiratory inhibition - a putative mitochondrial K(ATP) channel independent mechanism of pharmacological preconditioning
    Jan Minners
    Hatter Institute for Cardiology Research, MRC Inter University Cape Heart Group, University of Cape Town Medical School, Cape Town, South Africa
    Mol Cell Biochem 294:11-8. 2007
  7. doi Is red wine a SAFE sip away from cardioprotection? Mechanisms involved in resveratrol- and melatonin-induced cardioprotection
    Kim T Lamont
    Hatter Institute for Cardiovascular Research, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Pineal Res 50:374-80. 2011
  8. pmc Influence of tumour necrosis factor alpha on the outcome of ischaemic postconditioning in the presence of obesity and diabetes
    Lydia Lacerda
    Cardioprotection Group, Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa
    Exp Diabetes Res 2012:502654. 2012
  9. ncbi TNFalpha-induced cytoprotection requires the production of free radicals within mitochondria in C2C12 myotubes
    Lydia Lacerda
    Hatter Institute for Cardiology Research, University of Cape Town, South Africa
    Life Sci 79:2194-201. 2006
  10. ncbi Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning
    Robert M Smith
    Hatter Institute for Cardiology Research, Faculty of Health Sciences, University of Cape Town Observatory, Cape Heart Centre, Chris Barnard Building, Cape Town 7925, South Africa
    Cardiovasc Res 63:611-6. 2004

Collaborators

Detail Information

Publications11

  1. pmc TNFα protects cardiac mitochondria independently of its cell surface receptors
    Lydia Lacerda
    Cardioprotection Group, Hatter Cardiovascular Research Institute, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    Basic Res Cardiol 105:751-62. 2010
    ..This effect appears to be independent of its cell surface receptors, but is likely to be mediated by ROS and sphingolipids...
  2. doi Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway
    Lydia Lacerda
    Hatter Cardiovascular Research Institute, Cardioprotection Group, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Observatory 7925, Cape Town, South Africa
    Cardiovasc Res 84:201-8. 2009
    ....
  3. doi Ethanolamine is a novel STAT-3 dependent cardioprotective agent
    Roisin F Kelly
    Hatter Cardiovascular Research Institute, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Basic Res Cardiol 105:763-70. 2010
    ..75 ± 0.08 vs. Etn 1.50 ± 0.09 arbitrary units; P < 0.05]. Our findings suggest a novel cardioprotective role for ethanolamine against I/R injury via activation of STAT-3...
  4. ncbi Pharmacological preconditioning with tumor necrosis factor-alpha activates signal transducer and activator of transcription-3 at reperfusion without involving classic prosurvival kinases (Akt and extracellular signal-regulated kinase)
    Sandrine Lecour
    Department of Medicine, Hatter Institute for Cardiology Research, Cape Heart Centre, Faculty of Health Sciences, University of Cape Town, South Africa
    Circulation 112:3911-8. 2005
    ....
  5. doi Interplay between SAFE and RISK pathways in sphingosine-1-phosphate-induced cardioprotection
    Sarin J Somers
    Hatter Cardiovascular Research Institute, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Cardiovasc Drugs Ther 26:227-37. 2012
    ....
  6. ncbi Diazoxide-induced respiratory inhibition - a putative mitochondrial K(ATP) channel independent mechanism of pharmacological preconditioning
    Jan Minners
    Hatter Institute for Cardiology Research, MRC Inter University Cape Heart Group, University of Cape Town Medical School, Cape Town, South Africa
    Mol Cell Biochem 294:11-8. 2007
    ..Collectively these data support the hypothesis that diazoxide-mediated cytoprotection is independent of the conductance of the mK(ATP) channel and rather implicate mitochondrial respiratory inhibition-triggered ROS signaling...
  7. doi Is red wine a SAFE sip away from cardioprotection? Mechanisms involved in resveratrol- and melatonin-induced cardioprotection
    Kim T Lamont
    Hatter Institute for Cardiovascular Research, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Pineal Res 50:374-80. 2011
    ..001 versus control). Our data demonstrate that both melatonin and resveratrol, as found in red wine, protect the heart in an experimental model of myocardial infarction via the SAFE pathway...
  8. pmc Influence of tumour necrosis factor alpha on the outcome of ischaemic postconditioning in the presence of obesity and diabetes
    Lydia Lacerda
    Cardioprotection Group, Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa
    Exp Diabetes Res 2012:502654. 2012
    ..Our data confirm a bidirectional role for TNFα associated with the severity of concomitant comorbidities and suggest that diabetic and/or modestly obese patients may still benefit from IPostC...
  9. ncbi TNFalpha-induced cytoprotection requires the production of free radicals within mitochondria in C2C12 myotubes
    Lydia Lacerda
    Hatter Institute for Cardiology Research, University of Cape Town, South Africa
    Life Sci 79:2194-201. 2006
    ..In conclusion, TNFalpha-induced ROS generation can occur within the mitochondria, resulting in temporal mitochondrial perturbations which may initiate the cytoprotective effect of TNFalpha...
  10. ncbi Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning
    Robert M Smith
    Hatter Institute for Cardiology Research, Faculty of Health Sciences, University of Cape Town Observatory, Cape Heart Centre, Chris Barnard Building, Cape Town 7925, South Africa
    Cardiovasc Res 63:611-6. 2004
    ..To evaluate the functional requirement of signal transducer and activator of transcription-3 (STAT-3) in cardiac myocyte tolerance to ischemia (I) and in classical preconditioning...
  11. doi Relationship between left ventricular geometry and soluble ST2 in a cohort of hypertensive patients
    Dike B Ojji
    Cardiology Unit, Department of Medicine, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria Department of Medicine, Faculty of Health Sciences, Hatter Institute for Cardiovascular Research in Africa, University of Cape Town, Cape Town, South Africa
    J Clin Hypertens (Greenwich) 15:899-904. 2013
    ..4±8.4 ng/mL vs 14.3±5.4 ng/mL, P<.002). Therefore, soluble ST2 level is not only affected by hypertensive LV, but may be a future biomarker in differentiating concentric hypertrophy from normal geometry in hypertension. ..