John A Joska

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. pmc Clade C HIV-1 isolates circulating in Southern Africa exhibit a greater frequency of dicysteine motif-containing Tat variants than those in Southeast Asia and cause increased neurovirulence
    Vasudev R Rao
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Retrovirology 10:61. 2013
  2. pmc Comparing the accuracy of brief versus long depression screening instruments which have been validated in low and middle income countries: a systematic review
    Dickens Akena
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    BMC Psychiatry 12:187. 2012
  3. doi request reprint Integrating mental health into general health care: lessons from HIV
    J A Joska
    Department of Psychiatry and Mental Health, Division of Neuropsychiatry, University of Cape Town, South Africa
    Afr J Psychiatry (Johannesbg) 15:420-3. 2012
  4. ncbi request reprint The neurobiology of HIV dementia: implications for practice in South Africa
    J A Joska
    Department of Psychiatry and Mental Health, University of Cape Town, South Africa
    Afr J Psychiatry (Johannesbg) 14:17-22. 2011
  5. pmc Neuropsychological outcomes in adults commencing highly active anti-retroviral treatment in South Africa: a prospective study
    John A Joska
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 12:39. 2012
  6. pmc Normative scores for a brief neuropsychological battery for the detection of HIV-associated neurocognitive disorder (HAND) among South Africans
    Dinesh Singh
    Department of Psychiatry, University of Kwa Zulu Natal, Durban, South Africa
    BMC Res Notes 3:28. 2010
  7. pmc Assessing the efficacy of a modified assertive community-based treatment programme in a developing country
    Ulla A Botha
    Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    BMC Psychiatry 10:73. 2010
  8. doi request reprint Association between apolipoprotein E4 genotype and human immunodeficiency virus-associated dementia in younger adults starting antiretroviral therapy in South Africa
    John A Joska
    Department of Psychiatry and Mental Health, University of Cape Town, South Africa
    J Neurovirol 16:377-83. 2010
  9. doi request reprint Validity of the International HIV Dementia Scale in South Africa
    John A Joska
    Department of Psychiatry and Mental Health, University of Cape Town, South Africa
    AIDS Patient Care STDS 25:95-101. 2011
  10. doi request reprint Characterization of HIV-Associated Neurocognitive Disorders among individuals starting antiretroviral therapy in South Africa
    John A Joska
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    AIDS Behav 15:1197-203. 2011

Collaborators

Detail Information

Publications26

  1. pmc Clade C HIV-1 isolates circulating in Southern Africa exhibit a greater frequency of dicysteine motif-containing Tat variants than those in Southeast Asia and cause increased neurovirulence
    Vasudev R Rao
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Retrovirology 10:61. 2013
    ..HIV-1 Tat protein is a viral determinant of neurocognitive dysfunction. Therefore, we focused our study on the variations seen in tat gene and its contribution to HIV associated neuropathogenesis...
  2. pmc Comparing the accuracy of brief versus long depression screening instruments which have been validated in low and middle income countries: a systematic review
    Dickens Akena
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    BMC Psychiatry 12:187. 2012
    ..However, it remains unknown whether the brief instruments validated in LMIC are as accurate as the long ones...
  3. doi request reprint Integrating mental health into general health care: lessons from HIV
    J A Joska
    Department of Psychiatry and Mental Health, Division of Neuropsychiatry, University of Cape Town, South Africa
    Afr J Psychiatry (Johannesbg) 15:420-3. 2012
    ..This paper discusses how lessons from HIV services may inform how to improve mental health care and integration in HIV settings, as well as in other chronic diseases...
  4. ncbi request reprint The neurobiology of HIV dementia: implications for practice in South Africa
    J A Joska
    Department of Psychiatry and Mental Health, University of Cape Town, South Africa
    Afr J Psychiatry (Johannesbg) 14:17-22. 2011
    ..Implications for PLWHA who are at risk for HIV-D in South Africa are explored, with a view to providing suggestions for improving practice and research into this area...
  5. pmc Neuropsychological outcomes in adults commencing highly active anti-retroviral treatment in South Africa: a prospective study
    John A Joska
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 12:39. 2012
    ..To date, there have been no cohort studies of the impact of highly active anti-retroviral treatment (HAART) in South Africa where clade C HIV is predominant...
  6. pmc Normative scores for a brief neuropsychological battery for the detection of HIV-associated neurocognitive disorder (HAND) among South Africans
    Dinesh Singh
    Department of Psychiatry, University of Kwa Zulu Natal, Durban, South Africa
    BMC Res Notes 3:28. 2010
    ..To assess memory and recall, we used the memory item of the International HIV Dementia Scale (IHDS)...
  7. pmc Assessing the efficacy of a modified assertive community-based treatment programme in a developing country
    Ulla A Botha
    Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    BMC Psychiatry 10:73. 2010
    ..Our study represents the first randomised controlled trial assessing the effect of a modified assertive treatment service on readmission rates and other measures of outcome in a developing country...
  8. doi request reprint Association between apolipoprotein E4 genotype and human immunodeficiency virus-associated dementia in younger adults starting antiretroviral therapy in South Africa
    John A Joska
    Department of Psychiatry and Mental Health, University of Cape Town, South Africa
    J Neurovirol 16:377-83. 2010
    ..These findings suggest that the ε4 allelic variant in HIV-positive individuals is not associated with the development of HAD in Southern Africa...
  9. doi request reprint Validity of the International HIV Dementia Scale in South Africa
    John A Joska
    Department of Psychiatry and Mental Health, University of Cape Town, South Africa
    AIDS Patient Care STDS 25:95-101. 2011
    ..Variable performance in neuropsychological testing may account for false negative screens. The inclusion of brief tests of executive function in a screening battery should be considered...
  10. doi request reprint Characterization of HIV-Associated Neurocognitive Disorders among individuals starting antiretroviral therapy in South Africa
    John A Joska
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    AIDS Behav 15:1197-203. 2011
    ..In a regression model, a lower level of education and male gender were predictive of HIV-D. These findings suggest that HAND are highly prevalent in primary care settings in South Africa where clade C HIV is predominant...
  11. doi request reprint Does highly active antiretroviral therapy improve neurocognitive function? A systematic review
    John A Joska
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    J Neurovirol 16:101-14. 2010
    ..Studies examining the long-term effects of HAART on HIV-associated neurocognitive disorders (HANDs) using uniform methods of data collection are needed, together with clear reporting of HAART regimens...
  12. doi request reprint Clinical correlates of HIV-associated neurocognitive disorders in South Africa
    John A Joska
    Department of Psychiatry and Mental Health, University of Cape Town, South Africa, Anzio Road, Observatory, Cape Town 7925, South Africa
    AIDS Behav 14:371-8. 2010
    ..This underlines the impact of HIV on the nervous system and the importance of screening for co morbid mental health conditions...
  13. ncbi request reprint Patients with severe mental illness: a new approach to testing for HIV
    John A Joska
    HIV Neuropsychiatry Service, Groote Schuur Hospital and Department of Psychiatry and Mental Health, University of Cape Town
    S Afr Med J 98:213-7. 2008
    ..Undiagnosed HIV infection in people with severe mental illness increases costs and morbidity. Since effective treatments are available, it is imperative to diagnose HIV infection early in this high-risk population...
  14. doi request reprint Relationship between apolipoprotein E4 genotype and white matter integrity in HIV-positive young adults in South Africa
    Jacqueline Hoare
    Department of Psychiatry and Mental Health, University of Cape Town, Anzio Road Observatory, Cape Town 7925, South Africa
    Eur Arch Psychiatry Clin Neurosci 263:189-95. 2013
    ..007). These data indicate that the ε4 allelic variant of ApoE is associated with memory impairment and white matter damage of the corpus callosum in HIV-positive subjects...
  15. doi request reprint White-Matter damage in Clade C HIV-positive subjects: a diffusion tensor imaging study
    Jacqueline Hoare
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    J Neuropsychiatry Clin Neurosci 23:308-15. 2011
    ..This study provides evidence that white-matter integrity is compromised in individuals infected with clade C HIV...
  16. doi request reprint Mental health in primary human immunodeficiency virus care in South Africa: a study of provider knowledge, attitudes, and practice
    Sumaya Mall
    Department of Psychology, University of Stellenbosch, Stellenbosch, Matieland 7602, South Africa
    J Nerv Ment Dis 201:196-201. 2013
    ..Further effort is required to educate HIV service providers about the psychobiological underpinnings of psychiatric disorders and effective treatments...
  17. doi request reprint The prevalence and predictors of stigma amongst people living with HIV/AIDS in the Western Province
    Katherine R Sorsdahl
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    AIDS Care 23:680-5. 2011
    ..There are a number of possible reasons for low reports of HIV-related stigma, including having access to treatment and not disclosing HIV status...
  18. doi request reprint A description of common mental disorders in men who have sex with men (MSM) referred for assessment and intervention at an MSM clinic in Cape Town, South Africa
    Kevin Stoloff
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    AIDS Behav 17:S77-81. 2013
    ..Adequate input into the mental health needs of this population could reduce the potential for HIV acquisition and transmission, improve adherence to treatment and care, and ensure the provision a comprehensive health service for MSM...
  19. doi request reprint White matter correlates of apathy in HIV-positive subjects: a diffusion tensor imaging study
    Jacqueline Hoare
    Department of Psychiatry and Mental Health, University of Cape Town, Anzio Road Observatory, 7925, Cape Town, South Africa
    J Neuropsychiatry Clin Neurosci 22:313-20. 2010
    ..Results of the study confirmed the hypothesis which anticipated changes associated with apathy in white matter tracts that relay through the medial prefrontal cortex...
  20. ncbi request reprint Profile and management of patients at a memory clinic
    Sebastiana Zimba Kalula
    Division of Geriatric Medicine, Institute of Ageing in Africa, Department of Medicine, Faculty of Health Sciences, University of Cape Town
    S Afr Med J 100:449-51. 2010
    ..Community-based care services too are needed to support caregivers of cognitively impaired older individuals...
  21. doi request reprint Escitalopram treatment of depression in human immunodeficiency virus/acquired immunodeficiency syndrome: a randomized, double-blind, placebo-controlled study
    Jacqueline Hoare
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa Department of Psychiatry, Faculty of Health Sciences, Stellenbosch University, Tygerberg Hospital, Cape Town, South Africa and School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    J Nerv Ment Dis 202:133-7. 2014
    ..Given the relatively high placebo response, future trials in this area need to be selective in participant recruitment and to be adequately powered. ..
  22. doi request reprint Poverty and common mental disorders in low and middle income countries: A systematic review
    Crick Lund
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    Soc Sci Med 71:517-28. 2010
    ....
  23. doi request reprint Perspectives towards mental illness in people living with HIV/AIDS in South Africa
    Katherine R Sorsdahl
    Department of Psychiatry and Mental Health, University of Cape Town, Groote Schuur Hospital, South Africa
    AIDS Care 22:1418-27. 2010
    ..Interventions designed to increase mental health literacy and reduce the stigma associated with psychiatric disorders may increase the likelihood of PLWHA seeking treatment should they suffer from these conditions...
  24. doi request reprint HIV infection and the fronto-striatal system: a systematic review and meta-analysis of fMRI studies
    Stéfan Du Plessis
    aDepartment of Psychiatry, University of Stellenbosch, Cape Town, South Africa bRudolf Magnus Institute of Neuroscience, University of Utrecht, Utrecht, The Netherlands cInstitute for Virology and Immunobiology, University of Wurzburg, Wurzburg, Germany dMedical Research Council Unit on Anxiety and Stress Disorders eDepartment of Psychiatry, University of Cape Town, Cape Town, South Africa
    AIDS 28:803-11. 2014
    ....
  25. ncbi request reprint Experience of mental disorder in the context of basic service reforms: the impact on caregiving environments in South Africa
    Alison Breen
    Department of Psychology, Stellenbosch University, South Africa
    Int J Environ Health Res 17:327-34. 2007
    ..The findings indicate that factors associated with service reforms may increase the stress and burden experienced by households and in turn impact on the primary environment in which care is received...
  26. ncbi request reprint An innovative inpatient psychotherapy unit in South Africa
    John A Joska
    Psychiatr Serv 56:1316-7. 2005