Heather B Jaspan

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. ncbi request reprint Inclusion of adolescents in preventive HIV vaccine trials: public health policy and research design at a crossroads
    Heather B Jaspan
    Desmond Tutu HIV Centre, University of Cape Town, South Africa
    J Acquir Immune Defic Syndr 47:86-92. 2008
  2. ncbi request reprint Adolescent HIV prevalence, sexual risk, and willingness to participate in HIV vaccine trials
    Heather B Jaspan
    Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa
    J Adolesc Health 39:642-8. 2006
  3. ncbi request reprint Brief report: methods for collecting sexual behaviour information from South African adolescents--a comparison of paper versus personal digital assistant questionnaires
    Heather B Jaspan
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town Faculty of Health Sciences, PO Box 13801 Mowbray 7705, South Africa
    J Adolesc 30:353-9. 2007
  4. pmc Community perspectives on the ethical issues surrounding adolescent HIV vaccine trials in South Africa
    Heather B Jaspan
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa
    Vaccine 26:5679-83. 2008
  5. doi request reprint Delayed BCG vaccination results in minimal alterations in T cell immunogenicity of acellular pertussis and tetanus immunizations in HIV-exposed infants
    Anna K Blakney
    Department of Bioengineering, University of Washington, United States Division of Immunology, Institute of Infectious Disease and Molecular Medicine and Clinical Laboratory Sciences, University of Cape Town, South Africa
    Vaccine 33:4782-9. 2015
  6. pmc Sexual health, HIV risk, and retention in an adolescent HIV-prevention trial preparatory cohort
    Heather B Jaspan
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    J Adolesc Health 49:42-6. 2011
  7. pmc Bacterial disease and antimicrobial susceptibility patterns in HIV-infected, hospitalized children: a retrospective cohort study
    Heather B Jaspan
    University of Cape Town School of Child and Adolescent Health, Cape Town, South Africa
    PLoS ONE 3:e3260. 2008
  8. doi request reprint Relationship between female genital tract infections, mucosal interleukin-17 production and local T helper type 17 cells
    Lindi Masson
    Institute of Infectious Diseases and Molecular Medicine, University of Cape Town Medical School, Cape Town, South Africa
    Immunology 146:557-67. 2015
  9. doi request reprint Two-year outcomes of children on non-nucleoside reverse transcriptase inhibitor and protease inhibitor regimens in a South African pediatric antiretroviral program
    Heather B Jaspan
    School of Child and Adolescent Health, University of Cape Town, South Africa
    Pediatr Infect Dis J 27:993-8. 2008
  10. pmc Effect of caregivers' depression and alcohol use on child antiretroviral adherence in South Africa
    Heather B Jaspan
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    AIDS Patient Care STDS 25:595-600. 2011

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Inclusion of adolescents in preventive HIV vaccine trials: public health policy and research design at a crossroads
    Heather B Jaspan
    Desmond Tutu HIV Centre, University of Cape Town, South Africa
    J Acquir Immune Defic Syndr 47:86-92. 2008
    ..This article examines these issues and proposes specific next steps to facilitate the routine inclusion of this high-priority population in preventive HIV vaccine trials as early and seamlessly as possible...
  2. ncbi request reprint Adolescent HIV prevalence, sexual risk, and willingness to participate in HIV vaccine trials
    Heather B Jaspan
    Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa
    J Adolesc Health 39:642-8. 2006
    ..To determine human immunodeficiency virus (HIV) prevalence, sexual risk behaviors, and attitudes toward HIV vaccine trials among 11-19 year-olds in a peri-urban community near Cape Town, South Africa...
  3. ncbi request reprint Brief report: methods for collecting sexual behaviour information from South African adolescents--a comparison of paper versus personal digital assistant questionnaires
    Heather B Jaspan
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town Faculty of Health Sciences, PO Box 13801 Mowbray 7705, South Africa
    J Adolesc 30:353-9. 2007
    ..Subjectively, adolescents found the use of PDA to be simple and confidential. PDA may be a useful method to collect sensitive, self-reported information from adolescents in resource-limited settings...
  4. pmc Community perspectives on the ethical issues surrounding adolescent HIV vaccine trials in South Africa
    Heather B Jaspan
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa
    Vaccine 26:5679-83. 2008
    ..In general, ethical adolescent HIV vaccine trials will be feasible in this community...
  5. doi request reprint Delayed BCG vaccination results in minimal alterations in T cell immunogenicity of acellular pertussis and tetanus immunizations in HIV-exposed infants
    Anna K Blakney
    Department of Bioengineering, University of Washington, United States Division of Immunology, Institute of Infectious Disease and Molecular Medicine and Clinical Laboratory Sciences, University of Cape Town, South Africa
    Vaccine 33:4782-9. 2015
    ..We aimed to explore whether delaying BCG vaccination by 8 weeks, in utero or perinatal HIV infection is excluded, affected T-cell responses to B. pertussis (BP) and tetanus toxoid (TT), in HIV-exposed, uninfected infants...
  6. pmc Sexual health, HIV risk, and retention in an adolescent HIV-prevention trial preparatory cohort
    Heather B Jaspan
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    J Adolesc Health 49:42-6. 2011
    ..Although adolescents are at high risk for human immunodeficiency virus (HIV) infection, they have not been, included in HIV vaccine trials...
  7. pmc Bacterial disease and antimicrobial susceptibility patterns in HIV-infected, hospitalized children: a retrospective cohort study
    Heather B Jaspan
    University of Cape Town School of Child and Adolescent Health, Cape Town, South Africa
    PLoS ONE 3:e3260. 2008
    ..The use of antibiotic prophylaxis and the emergence of multi-drug resistant bacteria necessitate examination of responsible organisms and their antibiotic susceptibility...
  8. doi request reprint Relationship between female genital tract infections, mucosal interleukin-17 production and local T helper type 17 cells
    Lindi Masson
    Institute of Infectious Diseases and Molecular Medicine, University of Cape Town Medical School, Cape Town, South Africa
    Immunology 146:557-67. 2015
    ..Decreased IL-17 associated with candidal infections suggests that candida may actively suppress IL-17 production or women with dampened IL-17 responses may be more susceptible to candidal outgrowth. ..
  9. doi request reprint Two-year outcomes of children on non-nucleoside reverse transcriptase inhibitor and protease inhibitor regimens in a South African pediatric antiretroviral program
    Heather B Jaspan
    School of Child and Adolescent Health, University of Cape Town, South Africa
    Pediatr Infect Dis J 27:993-8. 2008
    ..Few data exist on the efficacy of the limited regimens for children with HIV, which are available in sub-Saharan Africa...
  10. pmc Effect of caregivers' depression and alcohol use on child antiretroviral adherence in South Africa
    Heather B Jaspan
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    AIDS Patient Care STDS 25:595-600. 2011
    ..99). Pediatric adherence is affected by caregiver alcohol use, but caregiver relationship to the child is most important. This small study suggests that interventions should aim to keep mothers healthy and alive, as well as alcohol-free...
  11. ncbi request reprint Scientific justification for the participation of children and adolescents in HIV-1 vaccine trials in South Africa
    Heather B Jaspan
    Desmond Tutu HIV Centre, University of Cape Town, South Africa
    S Afr Med J 95:685-7. 2005
  12. pmc The role of polyclonal intravenous immunoglobulin in treating HIV-infected children with severe bacterial infections: a retrospective cohort study
    Lyen C Huang
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    BMC Infect Dis 8:127. 2008
    ..We examined the impact of IVIG as an adjuvant therapy in reducing mortality and length of hospital stay in HIV-infected children with serious bacterial infections...
  13. doi request reprint Genital inflammation, immune activation and risk of sexual HIV acquisition
    Jo Ann S Passmore
    aInstitute of Infectious Diseases and Molecular Medicine, University of Cape Town Medical School, Cape Town bNRF DST Centre of Excellence in HIV Prevention, Centre for the AIDS Programme of Research, Durban, South Africa cSeattle Children s Hospital, Seattle, Washington, USA dNational Health Laboratory Service, Cape Town, South Africa
    Curr Opin HIV AIDS 11:156-62. 2016
    ..Women who have genital inflammation are at increased risk of sexual HIV infection. The purpose of this review is to evaluate the mechanisms for this relationship, causes of genital inflammation, and strategies to manage this condition...
  14. pmc Intra- and inter-clade cross-reactivity by HIV-1 Gag specific T-cells reveals exclusive and commonly targeted regions: implications for current vaccine trials
    Lycias Zembe
    Division of Medical Virology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 6:e26096. 2011
    ....
  15. pmc Immune activation in the female genital tract during HIV infection predicts mucosal CD4 depletion and HIV shedding
    Heather B Jaspan
    Institute of Infectious Disease and Molecular Medicine, Cape Town, South Africa
    J Infect Dis 204:1550-6. 2011
    ..These data suggest that the presence of high frequencies of activated T cells in the female genital mucosa during HIV infection facilitates both local HIV shedding and CD4 T-cell depletion...
  16. pmc In-utero exposure to maternal HIV infection alters T-cell immune responses to vaccination in HIV-uninfected infants
    Elvis B Kidzeru
    aDivision of Immunology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town bDesmond Tutu TB Centre, Faculty of Medicine and Health Sciences, Stellenbosch University, Parow cDivision of Virology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town dNational Health Laboratory Services, South Africa eDivision of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa fSeattle Biomedical Research Institute, Seattle, Washington, USA
    AIDS 28:1421-30. 2014
    ..In total, 46 HEU and 46 HIV-unexposed infants were recruited from Khayelitsha, Cape Town...
  17. doi request reprint Role of semen in altering the balance between inflammation and tolerance in the female genital tract: does it contribute to HIV risk?
    Cosnet L Rametse
    1 Division of Medical Virology, Institute of Infectious Disease and Molecular Medicine IDM, University of Cape Town, Cape Town, South Africa
    Viral Immunol 27:200-6. 2014
    ....
  18. ncbi request reprint Amniotic fluid has higher relative levels of lentivirus-specific antibodies than plasma and can contain neutralizing antibodies
    Heather B Jaspan
    Interdisciplinary Program in Molecular and Cellular Biology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    J Clin Virol 31:190-7. 2004
    ..Natural protective mechanisms involving lentivirus-specific antibodies may therefore exist to limit in utero transmission of lentiviruses...
  19. ncbi request reprint The maturing immune system: implications for development and testing HIV-1 vaccines for children and adolescents
    Heather B Jaspan
    AIDS 20:483-94. 2006
  20. ncbi request reprint Preventing neonatal HIV: a review
    Heather B Jaspan
    Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70119, USA
    Curr HIV Res 1:321-7. 2003
    ..However, post-natal transmission via breast milk remains a major challenge. As we continue to find cost-effective answers to protect infants worldwide, the search for a HIV-1 vaccine continues...
  21. pmc Quantitative competitive reverse transcription polymerase chain reaction is not a useful method for quantification of CD4 and CD8 cell status during HIV infection
    Heather B Jaspan
    Interdisciplinary Program in Molecular and Cellular Biology Tulane University School of Medicine, New Orleans, LA 70112, USA
    J Negat Results Biomed 2:2. 2003
    ..Such a method would also be useful in assessing the immune status of patients retrospectively...
  22. ncbi request reprint Expression of granzyme B mRNA is altered in human immunodeficiency virus infected patients
    Heather B Jaspan
    Molecular and Cellular Biology Program, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Exp Mol Pathol 74:13-6. 2003
    ..Cell-mediated cytotoxicity during HIV-1 infection may be impaired due to a deficient quantity of active cytotoxic granules or to their abnormal regulation...