G J Hofmeyr

Summary

Affiliation: University of the Witwatersrand
Country: South Africa

Publications

  1. doi What (not) to do before delivery? Prevention of fetal meconium release and its consequences
    G J Hofmeyr
    Effective Care Research Unit, Eastern Cape Department of Health, University of the Witwatersrand, University of Fort Hare, South Africa
    Early Hum Dev 85:611-5. 2009
  2. ncbi Side-effects of oral misoprostol in the third stage of labour--a randomised placebo-controlled trial
    G J Hofmeyr
    Department of Obstetrics and Gynaecology, Coronation Hospital and Effective Care Research Unit, University of the Witwatersrand, Johannesburg
    S Afr Med J 91:432-5. 2001
  3. ncbi Uterine massage and postpartum blood loss
    H Abdel-Aleem
    Department of Obstetrics and Gynecology, Assiut University Hospital, Assiut, Egypt
    Int J Gynaecol Obstet 93:238-9. 2006
  4. doi Obstetric care in low-resource settings: what, who, and how to overcome challenges to scale up?
    G Justus Hofmeyr
    Effective Care Research Unit, Eastern Cape Department of Health, Universities of the Witwatersrand and Fort Hare, South Africa
    Int J Gynaecol Obstet 107:S21-44, S44-5. 2009
  5. doi Misoprostol for the prevention and treatment of postpartum haemorrhage
    G Justus Hofmeyr
    Effective Care Research Unit, University of the Witwatersrand University of Fort Hare East London Hospital Complex, South Africa
    Best Pract Res Clin Obstet Gynaecol 22:1025-41. 2008
  6. pmc Making stillbirths count, making numbers talk - issues in data collection for stillbirths
    J Frederik Frøen
    Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, P O Box 4404 Nydalen, N 0403 Oslo, Norway
    BMC Pregnancy Childbirth 9:58. 2009
  7. pmc Promoting childbirth companions in South Africa: a randomised pilot study
    Heather Brown
    Worthing Hospital, Lyndhurst Road, Worthing, W Sussex, UK
    BMC Med 5:7. 2007
  8. doi Calcium supplementation during pregnancy for preventing hypertensive disorders is not associated with changes in platelet count, urate, and urinary protein: a randomized control trial
    G J Hofmeyr
    Effective Care Research Unit, East London Hospital Complex University of the Witwatersrand University of Fort Hare, East London, South Africa
    Hypertens Pregnancy 27:299-304. 2008
  9. pmc Misoprostol to prevent and treat postpartum haemorrhage: a systematic review and meta-analysis of maternal deaths and dose-related effects
    G Justus Hofmeyr
    East London Hospital Complex and University of the Witwatersrand, East London, South Africa
    Bull World Health Organ 87:666-77. 2009
  10. ncbi Dietary calcium supplementation for prevention of pre-eclampsia and related problems: a systematic review and commentary
    G J Hofmeyr
    Effective Care Research Unit, East London Hospital Complex, University of the Witwatersrand University of Fort Hare, East London, South Africa
    BJOG 114:933-43. 2007

Collaborators

Detail Information

Publications27

  1. doi What (not) to do before delivery? Prevention of fetal meconium release and its consequences
    G J Hofmeyr
    Effective Care Research Unit, Eastern Cape Department of Health, University of the Witwatersrand, University of Fort Hare, South Africa
    Early Hum Dev 85:611-5. 2009
    ..Meconium-stained amniotic fluid is a common occurrence which places the mother at risk of escalating obstetric interventions, and the baby at risk of meconium aspiration syndrome...
  2. ncbi Side-effects of oral misoprostol in the third stage of labour--a randomised placebo-controlled trial
    G J Hofmeyr
    Department of Obstetrics and Gynaecology, Coronation Hospital and Effective Care Research Unit, University of the Witwatersrand, Johannesburg
    S Afr Med J 91:432-5. 2001
    ..Large randomised trials are needed to assess the effectiveness of misoprostol in the prevention of postpartum haemorrhage, against which the disadvantages demonstrated here can be weighed...
  3. ncbi Uterine massage and postpartum blood loss
    H Abdel-Aleem
    Department of Obstetrics and Gynecology, Assiut University Hospital, Assiut, Egypt
    Int J Gynaecol Obstet 93:238-9. 2006
  4. doi Obstetric care in low-resource settings: what, who, and how to overcome challenges to scale up?
    G Justus Hofmeyr
    Effective Care Research Unit, Eastern Cape Department of Health, Universities of the Witwatersrand and Fort Hare, South Africa
    Int J Gynaecol Obstet 107:S21-44, S44-5. 2009
    ..Each year, approximately 2 million babies die because of complications of childbirth, primarily in settings where effective care at birth, particularly prompt cesarean delivery, is unavailable...
  5. doi Misoprostol for the prevention and treatment of postpartum haemorrhage
    G Justus Hofmeyr
    Effective Care Research Unit, University of the Witwatersrand University of Fort Hare East London Hospital Complex, South Africa
    Best Pract Res Clin Obstet Gynaecol 22:1025-41. 2008
    ..To date, there is very limited evidence for the effectiveness of misoprostol, the lowest effective dose and the magnitude of adverse effects, both direct and indirect. The need for further research is a matter of great urgency...
  6. pmc Making stillbirths count, making numbers talk - issues in data collection for stillbirths
    J Frederik Frøen
    Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, P O Box 4404 Nydalen, N 0403 Oslo, Norway
    BMC Pregnancy Childbirth 9:58. 2009
    ..This information will guide efforts to prevent stillbirths and improve quality of care...
  7. pmc Promoting childbirth companions in South Africa: a randomised pilot study
    Heather Brown
    Worthing Hospital, Lyndhurst Road, Worthing, W Sussex, UK
    BMC Med 5:7. 2007
    ..We piloted a multi-faceted intervention to encourage uptake of childbirth companions in state hospitals, and hypothesised that lay carers would improve the behaviour of health professionals...
  8. doi Calcium supplementation during pregnancy for preventing hypertensive disorders is not associated with changes in platelet count, urate, and urinary protein: a randomized control trial
    G J Hofmeyr
    Effective Care Research Unit, East London Hospital Complex University of the Witwatersrand University of Fort Hare, East London, South Africa
    Hypertens Pregnancy 27:299-304. 2008
    ..To test the hypothesis that calcium supplementation inhibits the underlying pathological processes in women with preeclampsia...
  9. pmc Misoprostol to prevent and treat postpartum haemorrhage: a systematic review and meta-analysis of maternal deaths and dose-related effects
    G Justus Hofmeyr
    East London Hospital Complex and University of the Witwatersrand, East London, South Africa
    Bull World Health Organ 87:666-77. 2009
    ..To review maternal deaths and the dose-related effects of misoprostol on blood loss and pyrexia in randomized trials of misoprostol use for the prevention or treatment of postpartum haemorrhage...
  10. ncbi Dietary calcium supplementation for prevention of pre-eclampsia and related problems: a systematic review and commentary
    G J Hofmeyr
    Effective Care Research Unit, East London Hospital Complex, University of the Witwatersrand University of Fort Hare, East London, South Africa
    BJOG 114:933-43. 2007
    ..Calcium supplementation during pregnancy may reduce the risk of hypertensive disorders of pregnancy...
  11. ncbi Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems
    G J Hofmeyr
    University of the Witwatersrand, University of Fort Hare, Eastern Cape Department of Health, Frere and Cecilia Makiwane Hospitals, Private Bag X 9047, East London, Eastern Cape, South Africa 5200
    Cochrane Database Syst Rev 3:CD001059. 2006
    ..Pre-eclampsia and eclampsia are common causes of serious morbidity and death. Calcium supplementation may reduce the risk of pre-eclampsia through a number of mechanisms, and may help to prevent preterm labour...
  12. pmc Proteinuria as a predictor of complications of pre-eclampsia
    G Justus Hofmeyr
    Effective Care Research Unit, Eastern Cape Department of Health, Universities of the Witwatersrand and Fort Hare, South Africa
    BMC Med 7:11. 2009
    ..The systematic review of 16 primary papers including over 6700 patients by Thangaratinam and colleagues published this month in BMC Medicine suggests otherwise. This finding may influence our management of pre-eclampsia...
  13. ncbi Evidence-based intrapartum care
    G J Hofmeyr
    Effective Care Research Unit, East London Hospital Complex, University of the Witwatersrand University of Fort Hare Eastern Cape Department of Health, P Bag X9047, East London 5201, South Africa
    Best Pract Res Clin Obstet Gynaecol 19:103-15. 2005
    ....
  14. ncbi Obstructed labor: using better technologies to reduce mortality
    G J Hofmeyr
    East London Hospital Complex, Effective Care Research Unit, University of Witwatersrand, South Africa
    Int J Gynaecol Obstet 85:S62-72. 2004
    ..To identify, from the best available evidence, underutilized and promising technologies that may reduce maternal mortality from obstructed labor...
  15. ncbi Induction of labour with an unfavourable cervix
    G Justus Hofmeyr
    East London Hospital Complex, South Africa Effective Care Research Unit, Frere Maternity Hospital, University of the Witwatersrand, East London
    Best Pract Res Clin Obstet Gynaecol 17:777-94. 2003
    ..Very large trials are needed to evaluate rare adverse outcomes.Extra-amniotic saline infusion is an effective method which appears to reduce the risk of uterine hyperstimulation that occurs with the use of exogenous uterotonics...
  16. ncbi Titrated oral misoprostol solution for induction of labour: a multi-centre, randomised trial
    G J Hofmeyr
    Department of Obstetrics and Gynaecology, Frere/Cecilia Makiwane Hospitals and Effective Care Research Unit, University of Witwatersrand, South Africa
    BJOG 108:952-9. 2001
    ..Misoprostol is not registered for use in pregnant women, and further research is needed to confirm optimal and safe dosages...
  17. ncbi Calcium supplementation to prevent pre-eclampsia--a systematic review
    G J Hofmeyr
    Effective Care Research Unit, East London Hospital Complex, University of the Witwatersrand, Johannesburg Fort Hare University, East London, E Cape
    S Afr Med J 93:224-8. 2003
    ..Calcium supplementation during pregnancy may prevent high blood pressure and preterm labour...
  18. ncbi Titrated oral misoprostol solution--a new method of labour induction
    G J Hofmeyr
    Department of Obstetrics and Gynaecology, Coronation Hospital, Effective Care Research Unit, University of the Witwatersrand, Johannesburg
    S Afr Med J 91:775-6. 2001
    ..A multicentre randomised trial of this method is underway. We emphasise the dangers inherent in the current unregistered use of misoprostol in clinical practice...
  19. ncbi Hypovolaemic shock
    G J Hofmeyr
    Effective Care Research Unit, Cecilia Makiwane and Frere Hospitals, University of the Witwatersrand, East London 5200, Eastern Cape, South Africa
    Best Pract Res Clin Obstet Gynaecol 15:645-62. 2001
    ..Bedside diagnostic ultrasound has several applications in the evaluation of obstetric hypovolaemic shock...
  20. ncbi Induction of labour with misoprostol
    G J Hofmeyr
    East London Hospital Complex, East London 5200, South Africa
    Curr Opin Obstet Gynecol 13:577-81. 2001
    ..Using small dosages appears to reduce adverse outcomes. Very large trials are needed to evaluate rare adverse outcomes...
  21. ncbi Misoprostol to treat postpartum haemorrhage: a systematic review
    G Justus Hofmeyr
    Effective Care Research Unit, University of the Witwatersrand University of Fort Hare, East London Hospital Complex, South Africa
    BJOG 112:547-53. 2005
  22. ncbi Labor induction and meconium: in vitro effects of oxytocin, dinoprostone and misoprostol on rat ileum relative to myometrium
    Baron B Matonhodze
    Effective Care Research Unit, University of the Witwatersrand, Parktown, Johannesburg, South Africa
    J Perinat Med 30:405-10. 2002
    ..These adverse effects may be caused by stimulation of bowel smooth muscle in the mother and in the fetus...
  23. ncbi WHO systematic review of maternal mortality and morbidity: the prevalence of uterine rupture
    G Justus Hofmeyr
    Effective Care Research Unit, Eastern Cape Department of Health University of Witwatersrand University of Fort Hare, South Africa
    BJOG 112:1221-8. 2005
    ..To determine the prevalence of uterine rupture worldwide...
  24. doi Chlorhexidine maternal-vaginal and neonate body wipes in sepsis and vertical transmission of pathogenic bacteria in South Africa: a randomised, controlled trial
    Clare L Cutland
    Department of Science and Technology National Research Foundation, Vaccine Preventable Diseases and Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, University of Witwatersrand, Soweto, South Africa
    Lancet 374:1909-16. 2009
    ..We therefore assessed the efficacy of chlorhexidine in early-onset neonatal sepsis and vertical transmission of group B streptococcus...
  25. ncbi Misoprostol for induction of labor with a live fetus
    A Weeks
    School of Reproductive and Developmental Medicine, University of Liverpool, Liverpool Women s Hospital, Liverpool, UK
    Int J Gynaecol Obstet 99:S194-7. 2007
    ..Reports of uterine rupture in women with previous cesarean sections mean that it remains contraindicated in this group...
  26. ncbi Caesarean section for non-medical reasons at term
    T Lavender
    University of Central Lancashire, Department of Midwifery Studies, Preston, UK PR1 2HE
    Cochrane Database Syst Rev 3:CD004660. 2006
    ..An unbiased assessment of advantages and disadvantages would assist discussion of what has become a contentious issue in modern obstetrics...
  27. ncbi Management of breech presentation in areas with high prevalence of HIV infection
    W R Holmes
    Centre for International Health, Macfarlane Burnet Institute for Medical Research and Public Health, GPO Box 2284, Melbourne 3001, Australia
    Int J Gynaecol Obstet 87:272-6. 2004
    ..To provide recommendations for the management of breech presentation in areas of high prevalence of human immunodeficiency virus (HIV) infection...