Anneke C Hesseling

Summary

Affiliation: University of Stellenbosch
Country: South Africa

Publications

  1. pmc High prevalence of drug resistance amongst HIV-exposed and -infected children in a tuberculosis prevention trial
    A C Hesseling
    Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Tygerberg, South Africa
    Int J Tuberc Lung Dis 16:192-5. 2012
  2. ncbi request reprint A critical review of diagnostic approaches used in the diagnosis of childhood tuberculosis
    A C Hesseling
    Department of Paediatrics and Child Health, Faculty of Health Sciences of Stellenbosch University, Tygerberg Children s Hospital, Tygerberg, South Africa
    Int J Tuberc Lung Dis 6:1038-45. 2002
  3. ncbi request reprint Consensus statement on the revised World Health Organization recommendations for BCG vaccination in HIV-infected infants
    A C Hesseling
    Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Tygerberg, South Africa
    Int J Tuberc Lung Dis 12:1376-9. 2008
  4. doi request reprint Highly discordant T cell responses in individuals with recent exposure to household tuberculosis
    A C Hesseling
    Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Tygerberg, 7505, South Africa
    Thorax 64:840-6. 2009
  5. pmc Disseminated bacille Calmette-Guérin disease in HIV-infected South African infants
    A C Hesseling
    Desmond Tutu TB Centre, Stellenbosch University, Tygerberg, South Africa
    Bull World Health Organ 87:505-11. 2009
  6. ncbi request reprint Baseline sputum time to detection predicts month two culture conversion and relapse in non-HIV-infected patients
    A C Hesseling
    Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa
    Int J Tuberc Lung Dis 14:560-70. 2010
  7. doi request reprint High incidence of tuberculosis among HIV-infected infants: evidence from a South African population-based study highlights the need for improved tuberculosis control strategies
    A C Hesseling
    Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, PO Box 19063, Tygerberg, South Africa
    Clin Infect Dis 48:108-14. 2009
  8. ncbi request reprint Bacille Calmette-Guérin vaccine-induced disease in HIV-infected and HIV-uninfected children
    A C Hesseling
    Desmond Tutu TB Centre, Department of Pediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
    Clin Infect Dis 42:548-58. 2006
  9. ncbi request reprint A child with neurobrucellosis
    A C Hesseling
    Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Western Cape Province, South Africa
    Ann Trop Paediatr 23:145-8. 2003
  10. ncbi request reprint Mycobacterial genotype is associated with disease phenotype in children
    A C Hesseling
    Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
    Int J Tuberc Lung Dis 14:1252-8. 2010

Detail Information

Publications40

  1. pmc High prevalence of drug resistance amongst HIV-exposed and -infected children in a tuberculosis prevention trial
    A C Hesseling
    Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Tygerberg, South Africa
    Int J Tuberc Lung Dis 16:192-5. 2012
    ..There was a high prevalence of DR-TB among HIV-exposed and -infected children. Surveillance of DR-TB among children in high-burden TB-HIV settings should be routine...
  2. ncbi request reprint A critical review of diagnostic approaches used in the diagnosis of childhood tuberculosis
    A C Hesseling
    Department of Paediatrics and Child Health, Faculty of Health Sciences of Stellenbosch University, Tygerberg Children s Hospital, Tygerberg, South Africa
    Int J Tuberc Lung Dis 6:1038-45. 2002
    ..Various attempts in the form of diagnostic approaches have been made to rationalise this diagnostic process...
  3. ncbi request reprint Consensus statement on the revised World Health Organization recommendations for BCG vaccination in HIV-infected infants
    A C Hesseling
    Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Tygerberg, South Africa
    Int J Tuberc Lung Dis 12:1376-9. 2008
    ..The document outlines requirements to implement selective BCG vaccination strategies in infants born to HIV-infected women and strategies to reduce the risk of vertical HIV transmission and disseminated BCG disease in infants...
  4. doi request reprint Highly discordant T cell responses in individuals with recent exposure to household tuberculosis
    A C Hesseling
    Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Tygerberg, 7505, South Africa
    Thorax 64:840-6. 2009
    ..There are limited data comparing interferon-gamma release assays (IGRAs) for the detection of Mycobacterium tuberculosis infection in highly endemic settings...
  5. pmc Disseminated bacille Calmette-Guérin disease in HIV-infected South African infants
    A C Hesseling
    Desmond Tutu TB Centre, Stellenbosch University, Tygerberg, South Africa
    Bull World Health Organ 87:505-11. 2009
    ....
  6. ncbi request reprint Baseline sputum time to detection predicts month two culture conversion and relapse in non-HIV-infected patients
    A C Hesseling
    Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa
    Int J Tuberc Lung Dis 14:560-70. 2010
    ..Few biomarkers are available to identify tuberculosis (TB) patients at risk of delayed sputum conversion and relapse...
  7. doi request reprint High incidence of tuberculosis among HIV-infected infants: evidence from a South African population-based study highlights the need for improved tuberculosis control strategies
    A C Hesseling
    Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, PO Box 19063, Tygerberg, South Africa
    Clin Infect Dis 48:108-14. 2009
    ..We aimed to estimate the population-based incidence of culture-confirmed tuberculosis among HIV-infected and HIV-uninfected infants in the Western Cape Province, South Africa...
  8. ncbi request reprint Bacille Calmette-Guérin vaccine-induced disease in HIV-infected and HIV-uninfected children
    A C Hesseling
    Desmond Tutu TB Centre, Department of Pediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
    Clin Infect Dis 42:548-58. 2006
    ..In addition, we present a revised classification of BCG disease in children and propose standard diagnostic and management guidelines...
  9. ncbi request reprint A child with neurobrucellosis
    A C Hesseling
    Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Western Cape Province, South Africa
    Ann Trop Paediatr 23:145-8. 2003
    ..Nerve conduction studies confirmed a proximal radiculopathy. Awareness of the condition and performance of the appropriate tests will differentiate neurobrucellosis from other chronic central nervous system infections...
  10. ncbi request reprint Mycobacterial genotype is associated with disease phenotype in children
    A C Hesseling
    Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
    Int J Tuberc Lung Dis 14:1252-8. 2010
    ..To investigate the association between mycobacterial genotype and disease phenotype in children...
  11. pmc Outcome of HIV infected children with culture confirmed tuberculosis
    A C Hesseling
    Desmond Tutu TB Centre, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa
    Arch Dis Child 90:1171-4. 2005
    ..Tuberculosis (TB) is an important disease in human immunodeficiency virus (HIV) infected children living in regions where TB is endemic. There are limited data on the outcome of culture confirmed TB in HIV infected children...
  12. ncbi request reprint Danish bacille Calmette-Guérin vaccine-induced disease in human immunodeficiency virus-infected children
    A C Hesseling
    Centre for Tuberculosis Research and Education, Department of Pediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Tygerberg Children s Hospital, Cape Town, South Africa
    Clin Infect Dis 37:1226-33. 2003
    ..Young, symptomatic, HIV-infected infants are at risk for BCG-related complications. Controlled, population-based studies are needed to assess the risk of BCG in HIV-infected children...
  13. ncbi request reprint The risk of disseminated Bacille Calmette-Guerin (BCG) disease in HIV-infected children
    Anneke C Hesseling
    Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, P O Box 19063, Tygerberg, 7505, South Africa
    Vaccine 25:14-8. 2007
    ..We estimate the risk of disseminated BCG disease in HIV-infected children in a setting highly endemic for tuberculosis and HIV...
  14. pmc Culture-confirmed childhood tuberculosis in Cape Town, South Africa: a review of 596 cases
    H Simon Schaaf
    Desmond Tutu Tuberculosis Centre, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa
    BMC Infect Dis 7:140. 2007
    ..The clinical, radiological and microbiological features of culture-confirmed childhood tuberculosis diagnosed at two referral hospitals are described...
  15. ncbi request reprint Childhood drug-resistant tuberculosis in the Western Cape Province of South Africa
    H Simon Schaaf
    Department of Paediatrics and Child Health, Tygerberg Children s Hospital and Stellenbosh University, Tygerberg, South Africa
    Acta Paediatr 95:523-8. 2006
    ..Continued surveillance of drug resistance amongst children presenting with culture-confirmed tuberculosis to a tertiary care hospital and to community clinics...
  16. ncbi request reprint Absence of an association between Mycobacterium tuberculosis genotype and clinical features in children with tuberculous meningitis
    Freda Maree
    Desmond Tutu TB Centre, Department of Pediatrics and Child Health, Stellenbosch University, Stellenbosch, South Africa
    Pediatr Infect Dis J 26:13-8. 2007
    ..We investigated mycobacterial genotypic diversity in children with TBM and analyzed the relationship among genotype, clinical presentation and outcome...
  17. doi request reprint Hearing loss in children treated for multidrug-resistant tuberculosis
    James A Seddon
    Desmond Tutu TB Centre, Faculty of Health Sciences, Stellenbosch University, South Africa
    J Infect 66:320-9. 2013
    ..Both classes of drug cause hearing loss. We aimed to determine the extent of hearing loss in children treated for MDR-TB...
  18. ncbi request reprint Use of light-emitting diode fluorescence microscopy to detect acid-fast bacilli in sputum
    Ben J Marais
    Desmond Tutu TB Centre, Cape Town, South Africa
    Clin Infect Dis 47:203-7. 2008
    ..We evaluated the diagnostic performance of fluorescence microscopy, using novel light-emitting diode (LED) technology as an alternative to the conventional mercury vapor lamp (MVP)...
  19. ncbi request reprint Radiographic signs and symptoms in children treated for tuberculosis: possible implications for symptom-based screening in resource-limited settings
    Ben J Marais
    Desmond Tutu TB Centre and the Department of Paediatrics and Child Health, Tygerberg Children s Hospital, Stellenbosch University, Cape Town, South Africa
    Pediatr Infect Dis J 25:237-40. 2006
    ....
  20. ncbi request reprint Tuberculous lymphadenitis as a cause of persistent cervical lymphadenopathy in children from a tuberculosis-endemic area
    Ben J Marais
    Desmond Tutu TB Center and Department of Paediatrics and Child Health, Tygerberg Children s Hospital, Cape Town, South Africa
    Pediatr Infect Dis J 25:142-6. 2006
    ....
  21. pmc Surveillance of antituberculosis drug resistance among children from the Western Cape Province of South Africa--an upward trend
    H Simon Schaaf
    Desmond Tutu Tuberculosis Centre, Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa
    Am J Public Health 99:1486-90. 2009
    ..We assessed the prevalence of antituberculosis drug resistance among children with tuberculosis (TB) in the Western Cape Province of South Africa...
  22. ncbi request reprint Resistant Mycobacterium bovis Bacillus Calmette-Guérin disease: implications for management of Bacillus Calmette-Guérin Disease in human immunodeficiency virus-infected children
    Anneke C Hesseling
    Center for Tuberculosis Research and Education, Department of Pediatrics and Child Health, Tygerberg Children s Hospital, Tygerberg, South Africa
    Pediatr Infect Dis J 23:476-9. 2004
    ..Treatment guidelines for BCG disease with consideration of inherent and possible acquired drug resistance should be established in settings with high rates of vertical HIV transmission and routine BCG vaccination...
  23. pmc Beijing and Haarlem genotypes are overrepresented among children with drug-resistant tuberculosis in the Western Cape Province of South Africa
    Ben J Marais
    Ukwanda Centre for Rural Health, Faculty of Health Sciences, Stellenbosch University, P O Box 19063, Tygerberg 7505, South Africa
    J Clin Microbiol 44:3539-43. 2006
    ..The overrepresentation of Beijing and Haarlem genotype families in children with drug-resistant TB demonstrates their contribution to transmitted drug resistance and their potential importance in the emergent drug-resistant TB epidemic...
  24. ncbi request reprint Recurrent culture-confirmed tuberculosis in human immunodeficiency virus-infected children
    H Simon Schaaf
    Department of Paediatrics and Child Health, Stellenbosch University, Tygerberg, South Africa
    Pediatr Infect Dis J 24:685-91. 2005
    ..Recurrent tuberculosis (TB) is more common among human immunodeficiency virus (HIV)-infected than HIV-uninfected adults. There are limited data regarding recurrence of TB in children...
  25. ncbi request reprint High treatment success in children treated for multidrug-resistant tuberculosis: an observational cohort study
    James A Seddon
    Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Desmond Tutu TB Centre, Stellenbosch University, Tygerberg, South Africa
    Thorax 69:458-64. 2014
    ..We describe the presentation, treatment and outcome in children treated for severe and non-severe MDR-TB in Cape Town, South Africa...
  26. doi request reprint Paediatric use of second-line anti-tuberculosis agents: a review
    James A Seddon
    Desmond Tutu TB Centre, Faculty of Health Sciences, Stellenbosch University, South Africa
    Tuberculosis (Edinb) 92:9-17. 2012
    ..This article reviews the available second-line drugs currently used in the treatment of MDR-TB in children and discusses medication properties and adverse effects while potential interactions with antiretroviral therapy are explored...
  27. ncbi request reprint A refined symptom-based approach to diagnose pulmonary tuberculosis in children
    Ben J Marais
    Desmond Tutu Tuberculosis Centre and Department of Paediatrics and Child Health, Tygerberg Children s Hospital, Stellenbosch University, Cape Town, South Africa
    Pediatrics 118:e1350-9. 2006
    ..This study aimed to determine the value of well-defined symptoms to diagnose childhood pulmonary tuberculosis in a tuberculosis-endemic area...
  28. pmc Operational challenges in managing Isoniazid Preventive Therapy in child contacts: a high-burden setting perspective
    Susan S van Wyk
    Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa
    BMC Public Health 11:544. 2011
    ..We describe the management of children under five years of age in household contact with a smear and/or culture-positive adult TB case...
  29. ncbi request reprint A proposed radiological classification of childhood intra-thoracic tuberculosis
    Ben J Marais
    Department of Paediatrics and Child Health, Centre for TB Research and Education CENTRE, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, PO Box 19063, Cape Town, South Africa
    Pediatr Radiol 34:886-94. 2004
    ..The hope is that the proposed classification will clarify concepts and stimulate discussion that may lead to future consensus...
  30. pmc Does an isoniazid prophylaxis register improve tuberculosis contact management in South African children?
    Nelda van Soelen
    Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, Western Cape, South Africa
    PLoS ONE 8:e80803. 2013
    ..We compared the change in child household contact management of pulmonary tuberculosis (TB) cases before and after the implementation of an isoniazid preventive therapy (IPT) register in an urban clinic setting in Cape Town, South Africa...
  31. pmc Effect of Ascaris Lumbricoides specific IgE on tuberculin skin test responses in children in a high-burden setting: a cross-sectional community-based study
    Nelda van Soelen
    Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
    BMC Infect Dis 12:211. 2012
    ..Our aim was to investigate whether helminth infection could influence the ability to generate an appropriate Th1 immune response that is characterized by a positive tuberculin skin test (TST), in M.tb exposed children...
  32. doi request reprint A proposed comprehensive classification of tuberculosis disease severity in children
    Catherine A Wiseman
    Desmond Tutu TB Centre, Department of Pediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa
    Pediatr Infect Dis J 31:347-52. 2012
    ..There is no existing approach that comprehensively characterizes the spectrum and severity of pediatric TB. This limits accurate classification of patients and comparison across cohorts...
  33. doi request reprint Management of children exposed to multidrug-resistant Mycobacterium tuberculosis
    James A Seddon
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Lancet Infect Dis 12:469-79. 2012
    ..We pay particular attention to assessment, existing international guidelines, possible preventive treatments, rationales for different management strategies, and the interaction with and implications of HIV infection...
  34. pmc Risk factors for infection and disease in child contacts of multidrug-resistant tuberculosis: a cross-sectional study
    James A Seddon
    Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Clinical Building, Room 0085, P, O, Box 19063, Tygerberg, South Africa
    BMC Infect Dis 13:392. 2013
    ..This study aimed to determine risk factors for M. tuberculosis infection and disease in children following exposure to adults with multidrug-resistant (MDR) tuberculosis (TB)...
  35. doi request reprint Culture-confirmed multidrug-resistant tuberculosis in children: clinical features, treatment, and outcome
    James A Seddon
    Desmond Tutu Tuberculosis Centre, Faculty of Health Sciences, Stellenbosch University, South Africa
    Clin Infect Dis 54:157-66. 2012
    ..Multidrug-resistant (MDR) tuberculosis in children is frequently associated with delayed diagnosis and treatment. There is limited evidence regarding the management and outcome of children with MDR-tuberculosis...
  36. pmc Utility of host markers detected in Quantiferon supernatants for the diagnosis of tuberculosis in children in a high-burden setting
    Novel N Chegou
    DST NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa
    PLoS ONE 8:e64226. 2013
    ..tb) infection states. In this study, the utility of such markers was investigated in children screened for TB in a setting with high TB incidence...
  37. doi request reprint Hearing loss in patients on treatment for drug-resistant tuberculosis
    James A Seddon
    Desmond Tutu TB Centre, Dept of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
    Eur Respir J 40:1277-86. 2012
    ..Finally it makes the recommendation that a standardised testing methodology and classification system should be used...
  38. ncbi request reprint Managing multidrug-resistant tuberculosis in children: review of recent developments
    H Simon Schaaf
    aDepartment of Paediatrics and Child Health, Desmond Tutu TB Centre, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa bDepartment of Paediatric Infectious Diseases, Imperial College London, London, United Kingdom
    Curr Opin Infect Dis 27:211-9. 2014
    ..Childhood multidrug-resistant (MDR) tuberculosis is an emerging disease with increasing numbers being recognized. This review presents recent developments in childhood MDR tuberculosis...
  39. pmc Delaying BCG vaccination from birth to 10 weeks of age may result in an enhanced memory CD4 T cell response
    Benjamin M N Kagina
    South African Tuberculosis Vaccine Initiative SATVI, Institute of Infectious Diseases and Molecular Medicine and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa
    Vaccine 27:5488-95. 2009
    ..The neonatal immune system is immature. Our hypothesis was that delaying BCG vaccination from birth to 10 weeks of age would enhance the vaccine-induced immune response...
  40. doi request reprint Linezolid for the treatment of drug-resistant tuberculosis in children: a review and recommendations
    Anthony J Garcia-Prats
    Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa Electronic address
    Tuberculosis (Edinb) 94:93-104. 2014
    ....