Sian M J Hemmings

Summary

Affiliation: University of Stellenbosch
Country: South Africa

Publications

  1. ncbi request reprint Investigating the role of dopaminergic and serotonergic candidate genes in obsessive-compulsive disorder
    Sian M J Hemmings
    MRC US Centre for Molecular and Cellular Biology, University of Stellenbosch, P O Box 19063, 7505, Tygerberg, South Africa
    Eur Neuropsychopharmacol 13:93-8. 2003
  2. ncbi request reprint BDNF Val66Met modifies the risk of childhood trauma on obsessive-compulsive disorder
    Sîan Megan Joanna Hemmings
    Department of Psychiatry, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa Electronic address
    J Psychiatr Res 47:1857-63. 2013
  3. doi request reprint BDNF Val66Met and DRD2 Taq1A polymorphisms interact to influence PTSD symptom severity: a preliminary investigation in a South African population
    Sian M J Hemmings
    Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa
    Prog Neuropsychopharmacol Biol Psychiatry 40:273-80. 2013
  4. doi request reprint Investigating SAPAP3 variants in the etiology of obsessive-compulsive disorder and trichotillomania in the South African white population
    Leigh Boardman
    Division of Molecular Biology and Human Genetics, Department Biomedical Sciences, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa
    Compr Psychiatry 52:181-7. 2011
  5. ncbi request reprint Investigating the role of the brain-derived neurotrophic factor (BDNF) val66met variant in obsessive-compulsive disorder (OCD)
    Sian M J Hemmings
    MRC US Centre for Molecular and Cellular Biology, University of Stellenbosch, Tygerberg, South Africa
    World J Biol Psychiatry 9:126-34. 2008
  6. ncbi request reprint Genetic correlates in trichotillomania--A case-control association study in the South African Caucasian population
    Sian M J Hemmings
    MRC US Centre for Molecular and Cellular Biology, University of Stellenbosch, Tygerberg, South Africa
    Isr J Psychiatry Relat Sci 43:93-101. 2006
  7. ncbi request reprint The current status of association studies in obsessive-compulsive disorder
    Sian M J Hemmings
    Department of Medical Biochemistry, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa
    Psychiatr Clin North Am 29:411-44. 2006
  8. ncbi request reprint Early- versus late-onset obsessive-compulsive disorder: investigating genetic and clinical correlates
    Sian M J Hemmings
    MRC Unit on Anxiety and Stress Disorders, University of Stellenbosch, Medical School, PO Box 19063, Tygerberg 7505, South Africa
    Psychiatry Res 128:175-82. 2004
  9. ncbi request reprint Gender in obsessive-compulsive disorder: clinical and genetic findings
    Christine Lochner
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, P O Box 19063, Tygerberg 7505, Cape Town, South Africa
    Eur Neuropsychopharmacol 14:105-13. 2004
  10. ncbi request reprint Hoarding in obsessive-compulsive disorder: clinical and genetic correlates
    Christine Lochner
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    J Clin Psychiatry 66:1155-60. 2005

Detail Information

Publications17

  1. ncbi request reprint Investigating the role of dopaminergic and serotonergic candidate genes in obsessive-compulsive disorder
    Sian M J Hemmings
    MRC US Centre for Molecular and Cellular Biology, University of Stellenbosch, P O Box 19063, 7505, Tygerberg, South Africa
    Eur Neuropsychopharmacol 13:93-8. 2003
    ..Although no statistically significant genotypic or allelic associations were detected, the data yielded interesting preliminary results that warrant further discussion and investigation...
  2. ncbi request reprint BDNF Val66Met modifies the risk of childhood trauma on obsessive-compulsive disorder
    Sîan Megan Joanna Hemmings
    Department of Psychiatry, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa Electronic address
    J Psychiatr Res 47:1857-63. 2013
    ..024). To our knowledge, this is one of the first studies to investigate gene-environment interactions in OCD, and the findings indicate the importance of collating genetic and environmental variables in future studies...
  3. doi request reprint BDNF Val66Met and DRD2 Taq1A polymorphisms interact to influence PTSD symptom severity: a preliminary investigation in a South African population
    Sian M J Hemmings
    Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa
    Prog Neuropsychopharmacol Biol Psychiatry 40:273-80. 2013
    ..We also investigated the interaction between the genetic variants to determine whether these variables and the interactions between the variables influenced the severity of PTSD symptoms...
  4. doi request reprint Investigating SAPAP3 variants in the etiology of obsessive-compulsive disorder and trichotillomania in the South African white population
    Leigh Boardman
    Division of Molecular Biology and Human Genetics, Department Biomedical Sciences, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa
    Compr Psychiatry 52:181-7. 2011
    ..Results from a recent knockout animal model suggest that SAP90/PSD95-associated protein 3 (SAPAP3) may be involved in the pathophysiology of both disorders...
  5. ncbi request reprint Investigating the role of the brain-derived neurotrophic factor (BDNF) val66met variant in obsessive-compulsive disorder (OCD)
    Sian M J Hemmings
    MRC US Centre for Molecular and Cellular Biology, University of Stellenbosch, Tygerberg, South Africa
    World J Biol Psychiatry 9:126-34. 2008
    ..The present investigation forms part of ongoing research to elucidate the genetic components involved in the aetiology of OCD and OCD-related characteristics...
  6. ncbi request reprint Genetic correlates in trichotillomania--A case-control association study in the South African Caucasian population
    Sian M J Hemmings
    MRC US Centre for Molecular and Cellular Biology, University of Stellenbosch, Tygerberg, South Africa
    Isr J Psychiatry Relat Sci 43:93-101. 2006
    ..Some have argued, however, that TTM is an obsessive-compulsive spectrum disorder (OCSD). There is some evidence that both disorders (OCD and TTM) are mediated by serotonergic (5-HT) and dopaminergic pathways...
  7. ncbi request reprint The current status of association studies in obsessive-compulsive disorder
    Sian M J Hemmings
    Department of Medical Biochemistry, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa
    Psychiatr Clin North Am 29:411-44. 2006
    ..Knowledge of new functional variants will emerge as researchers gain an understanding of the potential for genetic variants in the coding and regulatory regions to impact gene expression...
  8. ncbi request reprint Early- versus late-onset obsessive-compulsive disorder: investigating genetic and clinical correlates
    Sian M J Hemmings
    MRC Unit on Anxiety and Stress Disorders, University of Stellenbosch, Medical School, PO Box 19063, Tygerberg 7505, South Africa
    Psychiatry Res 128:175-82. 2004
    ..These data support a role for the dopaminergic system, which may be relevant to the development of early-onset OCD...
  9. ncbi request reprint Gender in obsessive-compulsive disorder: clinical and genetic findings
    Christine Lochner
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, P O Box 19063, Tygerberg 7505, Cape Town, South Africa
    Eur Neuropsychopharmacol 14:105-13. 2004
    ..There is increasing recognition that obsessive-compulsive disorder (OCD) is not a homogeneous entity. It has been suggested that gender may contribute to the clinical and biological heterogeneity of OCD...
  10. ncbi request reprint Hoarding in obsessive-compulsive disorder: clinical and genetic correlates
    Christine Lochner
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    J Clin Psychiatry 66:1155-60. 2005
    ..The clinical and genetic correlates of hoarding in OCD therefore deserve additional investigation...
  11. ncbi request reprint Corrigendum to "gender in obsessive-compulsive disorder: clinical and genetic findings" [Eur. Neuropsychopharmacol. 14 (2004) 105-113]
    Christine Lochner
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    Eur Neuropsychopharmacol 14:437-45. 2004
    ..There is increasing recognition that obsessive-compulsive disorder (OCD) is not a homogeneous entity. It has been suggested that gender may contribute to the clinical and biological heterogeneity of OCD...
  12. ncbi request reprint Cluster analysis of obsessive-compulsive spectrum disorders in patients with obsessive-compulsive disorder: clinical and genetic correlates
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, PO Box 19063, Tygerberg, 7505, Cape Town, South Africa
    Compr Psychiatry 46:14-9. 2005
    ..Comorbidity of the putative OCSDs in OCD has, however, not often been systematically investigated...
  13. ncbi request reprint Dissociative experiences in obsessive-compulsive disorder and trichotillomania: clinical and genetic findings
    Christine Lochner
    Medical Research Council Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenboch, Cape Town, South Africa
    Compr Psychiatry 45:384-91. 2004
    ..g., lower age) and comorbidity profile (e.g., increased incidence of impulse dyscontrol disorders). Additional work is necessary before conclusions about the role of monoaminergic systems in mediating such dissociation can be drawn...
  14. ncbi request reprint Cluster analysis of obsessive-compulsive symptomatology: identifying obsessive-compulsive disorder subtypes
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    Isr J Psychiatry Relat Sci 45:164-76. 2008
    ..There is increasing evidence that obsessive-compulsive disorder (OCD) is a heterogeneous disorder. Different clinical subtypes may be characterized by differing pathophysiological mechanisms and treatment outcomes...
  15. ncbi request reprint Investigating the possible effects of trauma experiences and 5-HTT on the dissociative experiences of patients with OCD using path analysis and multiple regression
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    Neuropsychobiology 56:6-13. 2007
    ..Here, two different but related statistical techniques (multiple regression and partial least squares), confirmed that physical neglect and the 5-HTT genotype jointly play a role in predicting dissociation in OCD...
  16. pmc The impact of voluntary exercise on relative telomere length in a rat model of developmental stress
    Martmari Botha
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa
    BMC Res Notes 5:697. 2012
    ..Behavioural analyses were conducted to assess anxiety-like behaviour and memory performance in the rats, after which relative telomere length was measured using qPCR...
  17. pmc Brain-Derived Neurotrophic Factor (BDNF) protein levels in anxiety disorders: systematic review and meta-regression analysis
    Sharain Suliman
    MRC Anxiety Disorders Unit, Department of Psychiatry, Faculty of Medicine and Health Sciences, University of Stellenbosch Cape Town, South Africa
    Front Integr Neurosci 7:55. 2013
    ..Findings are, however, limited by the lack of research in this area, and given the potential for BDNF as a biomarker of anxiety disorders, it would be useful to clarify the relationship further. ..