Mark Hatherill

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. ncbi request reprint The lactate:pyruvate ratio following open cardiac surgery in children
    Mark Hatherill
    Division of Critical Care and Children s Heart Disease, School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa
    Intensive Care Med 33:822-9. 2007
  2. ncbi request reprint Safety and reactogenicity of BCG revaccination with isoniazid pretreatment in TST positive adults
    Mark Hatherill
    South African Tuberculosis Vaccine Initiative SATVI, Institute of Infectious Disease and Molecular Medicine, School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa Electronic address
    Vaccine 32:3982-8. 2014
  3. pmc Comparison of mantoux and tine tuberculin skin tests in BCG-vaccinated children investigated for tuberculosis
    Wenli Pan
    Department of Health, Haikou, Hainan Province, China
    PLoS ONE 4:e8085. 2009
  4. ncbi request reprint Consensus statement on diagnostic end points for infant tuberculosis vaccine trials
    Mark Hatherill
    South African Tuberculosis Vaccine Initiative, University of Cape Town, South Africa
    Clin Infect Dis 54:493-501. 2012
  5. doi request reprint Prospects for elimination of childhood tuberculosis: the role of new vaccines
    Mark Hatherill
    South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, and School of Child and Adolescent Health, Faculty of Health Sciences, University of Cape Town, Room 2 10, Wernher Beit North, Anzio Road, Cape Town 7925, South Africa
    Arch Dis Child 96:851-6. 2011
  6. pmc Structured approaches for the screening and diagnosis of childhood tuberculosis in a high prevalence region of South Africa
    Mark Hatherill
    School of Child and Adolescent Health, University of Cape Town, Anzio Road, Cape Town, 7925, South Africa
    Bull World Health Organ 88:312-20. 2010
  7. doi request reprint Induced sputum or gastric lavage for community-based diagnosis of childhood pulmonary tuberculosis?
    M Hatherill
    South African Tuberculosis Vaccine Initiative SATVI, Institute of Infectious Disease and Molecular Medicine IIDMM, University of Cape Town, Cape Town, South Africa
    Arch Dis Child 94:195-201. 2009
  8. doi request reprint Screening for TB in high school adolescents in a high burden setting in South Africa
    Hassan Mahomed
    South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Tuberculosis (Edinb) 93:357-62. 2013
  9. doi request reprint Phenotypic variability in childhood TB: implications for diagnostic endpoints in tuberculosis vaccine trials
    Humphrey Mulenga
    South African Tuberculosis Vaccine Initiative, University of Cape Town, Cape Town, South Africa
    Vaccine 29:4316-21. 2011
  10. ncbi request reprint Dose-finding study of the novel tuberculosis vaccine, MVA85A, in healthy BCG-vaccinated infants
    Thomas J Scriba
    South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine, and School of Child and Adolescent Health, University of Cape Town, South Africa
    J Infect Dis 203:1832-43. 2011

Collaborators

Detail Information

Publications38

  1. ncbi request reprint The lactate:pyruvate ratio following open cardiac surgery in children
    Mark Hatherill
    Division of Critical Care and Children s Heart Disease, School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa
    Intensive Care Med 33:822-9. 2007
    ..To explore the relationship between lactate:pyruvate ratio, hyperlactataemia, metabolic acidosis, and morbidity...
  2. ncbi request reprint Safety and reactogenicity of BCG revaccination with isoniazid pretreatment in TST positive adults
    Mark Hatherill
    South African Tuberculosis Vaccine Initiative SATVI, Institute of Infectious Disease and Molecular Medicine, School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa Electronic address
    Vaccine 32:3982-8. 2014
    ..The safety profile of live mycobacterial vaccines in latently infected adults with prior infant BCG vaccination is unknown...
  3. pmc Comparison of mantoux and tine tuberculin skin tests in BCG-vaccinated children investigated for tuberculosis
    Wenli Pan
    Department of Health, Haikou, Hainan Province, China
    PLoS ONE 4:e8085. 2009
    ..We aimed to compare agreement between the intradermal Mantoux and multipuncture percutaneous Tine methods and to quantify risk factors for a positive test result...
  4. ncbi request reprint Consensus statement on diagnostic end points for infant tuberculosis vaccine trials
    Mark Hatherill
    South African Tuberculosis Vaccine Initiative, University of Cape Town, South Africa
    Clin Infect Dis 54:493-501. 2012
    ..We aimed to identify areas of consensus or debate on potential end points for tuberculosis vaccine trials among human immunodeficiency virus-uninfected children...
  5. doi request reprint Prospects for elimination of childhood tuberculosis: the role of new vaccines
    Mark Hatherill
    South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, and School of Child and Adolescent Health, Faculty of Health Sciences, University of Cape Town, Room 2 10, Wernher Beit North, Anzio Road, Cape Town 7925, South Africa
    Arch Dis Child 96:851-6. 2011
    ..Effective pre-exposure and postexposure vaccination, in conjunction with mass campaigns, is the most promising tuberculosis control strategy to approach the elimination target by the middle of the 21st century...
  6. pmc Structured approaches for the screening and diagnosis of childhood tuberculosis in a high prevalence region of South Africa
    Mark Hatherill
    School of Child and Adolescent Health, University of Cape Town, Anzio Road, Cape Town, 7925, South Africa
    Bull World Health Organ 88:312-20. 2010
    ....
  7. doi request reprint Induced sputum or gastric lavage for community-based diagnosis of childhood pulmonary tuberculosis?
    M Hatherill
    South African Tuberculosis Vaccine Initiative SATVI, Institute of Infectious Disease and Molecular Medicine IIDMM, University of Cape Town, Cape Town, South Africa
    Arch Dis Child 94:195-201. 2009
    ..To compare the diagnostic yield of Mycobacterium tuberculosis from induced sputum (IS) and gastric lavage (GL) among children in a community setting...
  8. doi request reprint Screening for TB in high school adolescents in a high burden setting in South Africa
    Hassan Mahomed
    South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Tuberculosis (Edinb) 93:357-62. 2013
    ..The screening tools evaluated in this study may not be practical for routine use owing to low positive predictive values but may be useful in TB vaccine clinical trials...
  9. doi request reprint Phenotypic variability in childhood TB: implications for diagnostic endpoints in tuberculosis vaccine trials
    Humphrey Mulenga
    South African Tuberculosis Vaccine Initiative, University of Cape Town, Cape Town, South Africa
    Vaccine 29:4316-21. 2011
    ....
  10. ncbi request reprint Dose-finding study of the novel tuberculosis vaccine, MVA85A, in healthy BCG-vaccinated infants
    Thomas J Scriba
    South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine, and School of Child and Adolescent Health, University of Cape Town, South Africa
    J Infect Dis 203:1832-43. 2011
    ..We assessed the safety of and characterized the T cell response induced by 3 doses of the candidate vaccine, MVA85A, in BCG-vaccinated infants from a setting where tuberculosis is endemic...
  11. pmc Isolation of non-tuberculous mycobacteria in children investigated for pulmonary tuberculosis
    Mark Hatherill
    South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    PLoS ONE 1:e21. 2006
    ..To evaluate the frequency and clinical significance of non-tuberculous mycobacteria (NTM) isolates among children investigated for pulmonary tuberculosis in a rural South African community...
  12. ncbi request reprint Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial
    Michele D Tameris
    South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa
    Lancet 381:1021-8. 2013
    ..We aimed to assess safety, immunogenicity, and efficacy of MVA85A against tuberculosis and Mycobacterium tuberculosis infection in infants...
  13. pmc A phase IIa trial of the new tuberculosis vaccine, MVA85A, in HIV- and/or Mycobacterium tuberculosis-infected adults
    Thomas J Scriba
    South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine, and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa
    Am J Respir Crit Care Med 185:769-78. 2012
    ..Novel tuberculosis (TB) vaccines should be safe and effective in populations infected with Mycobacterium tuberculosis (M.tb) and/or HIV for effective TB control...
  14. doi request reprint Diagnostic features associated with culture of Mycobacterium tuberculosis among young children in a vaccine trial setting
    Kany Kany A Luabeya
    South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Pediatr Infect Dis J 31:42-6. 2012
    ..To identify diagnostic features associated with culture of Mycobacterium tuberculosis (MTB), the standard for tuberculosis (TB) diagnosis, to inform clinical end point definitions for new TB vaccine trials...
  15. pmc TB incidence in an adolescent cohort in South Africa
    Hassan Mahomed
    South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Cape Town, South Africa
    PLoS ONE 8:e59652. 2013
    ..We conducted a study to determine the TB incidence rates and risk factors for TB disease in a cohort of school-going adolescents in a high TB burden area in South Africa...
  16. ncbi request reprint SATVI - after 10 years closing in on a new and better vaccine to prevent tuberculosis
    Willem A Hanekom
    South African TB Vaccine Initiative, Faculty of Health Sciences, University of Cape Town
    S Afr Med J 102:438-41. 2012
    ..SATVI is now widely regarded as the leading TB vaccine clinical research site in the world...
  17. pmc The tuberculin skin test versus QuantiFERON TB Gold® in predicting tuberculosis disease in an adolescent cohort study in South Africa
    Hassan Mahomed
    South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 6:e17984. 2011
    ..This study was conducted in a high tuberculosis (TB) burden area in Worcester, South Africa, with a notified all TB incidence rate of 1,400/100,000...
  18. pmc Lessons learnt from the first efficacy trial of a new infant tuberculosis vaccine since BCG
    Michele Tameris
    South African TB Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine IIDMM and School of Child and Adolescent Health, University of Cape Town, Brewelskloof Hospital, Haarlem Street, Worcester, Western Cape 6850, South Africa
    Tuberculosis (Edinb) 93:143-9. 2013
    ..A phase IIb trial of a candidate vaccine, MVA85A, was conducted in a high burden setting in South Africa to evaluate proof-of-concept efficacy for prevention of TB in infants...
  19. doi request reprint Predictive value of recent QuantiFERON conversion for tuberculosis disease in adolescents
    Shingai Machingaidze
    South African Tuberculosis Vaccine Initiative SATVI, Institute of Infectious Disease and Molecular Medicine II, University of Cape Town, Cape Town, South Africa
    Am J Respir Crit Care Med 186:1051-6. 2012
    ..Recent TST conversion is associated with an established risk of developing tuberculosis (TB) disease, but the risk associated with recent IGRA conversions is unknown...
  20. doi request reprint Knowledge and acceptability of patient-specific infection control measures for pulmonary tuberculosis
    Yulieth Gonzalez-Angulo
    South African Tuberculosis Vaccine Initiative SATVI, University of Cape Town, Cape Town, South Africa
    Am J Infect Control 41:717-22. 2013
    ..Effective infection control measures are essential to reduce tuberculosis (TB) transmission in domestic, workplace, and health care settings. Acceptability of infection control measures is key to patient adherence...
  21. pmc Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South Africa
    Tony Hawkridge
    South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine, and School of Child and Adolescent Health, University of Cape Town, Observatory, South Africa
    J Infect Dis 198:544-52. 2008
    ..We investigated the safety and immunogenicity of MVA85A in mycobacteria-exposed--but Mycobacterium tuberculosis-uninfected--healthy adults from a region of South Africa where TB is endemic...
  22. pmc Efficacy of percutaneous versus intradermal BCG in the prevention of tuberculosis in South African infants: randomised trial
    Anthony Hawkridge
    South African Tuberculosis Vaccine Initiative, University of Cape Town, South Africa
    BMJ 337:a2052. 2008
    ..To compare the incidence of tuberculosis over two years in infants vaccinated at birth with intradermal BCG or with percutaneous BCG...
  23. doi request reprint Developing vaccinology expertise for Africa: six years and counting
    Charles Shey Wiysonge
    Vaccines for Africa Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Vaccine 29:5821-3. 2011
    ....
  24. pmc Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4+ T cells
    Thomas J Scriba
    South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine, and School of Child and Adolescent Health, University of Cape Town, Observatory, South Africa
    Eur J Immunol 40:279-90. 2010
    ..This includes induction of novel Th1-cell populations that have not been previously described in humans...
  25. ncbi request reprint The candidate TB vaccine, MVA85A, induces highly durable Th1 responses
    Michele Tameris
    South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa
    PLoS ONE 9:e87340. 2014
    ..We determined if a MVA85A viral-vector boost could enhance the durability of mycobacteria-specific T cell responses above those induced by BCG alone...
  26. pmc The novel tuberculosis vaccine, AERAS-402, induces robust and polyfunctional CD4+ and CD8+ T cells in adults
    Brian Abel
    South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine and School of Child and Adolescent Health, University of Cape Town, UCT Health Sciences, Anzio Road, Observatory 7925, Cape Town, South Africa
    Am J Respir Crit Care Med 181:1407-17. 2010
    ..AERAS-402 is a novel tuberculosis vaccine designed to boost immunity primed by bacillus Calmette-Guérin (BCG), the only licensed vaccine...
  27. doi request reprint Comparison of T-SPOT.TB assay and tuberculin skin test for the evaluation of young children at high risk for tuberculosis in a community setting
    Mark P Nicol
    School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa
    Pediatrics 123:38-43. 2009
    ..TB; Oxford Immunotec, Oxford, United Kingdom) and the tuberculin skin test for the detection of tuberculosis infection in very young children being evaluated for active tuberculosis in a rural community setting...
  28. doi request reprint Moxifloxacin population pharmacokinetics and model-based comparison of efficacy between moxifloxacin and ofloxacin in African patients
    Simbarashe P Zvada
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Antimicrob Agents Chemother 58:503-10. 2014
    ..Further studies should determine the optimal pharmacodynamic target for moxifloxacin in a multidrug regimen and clarify safety issues when it is administered at higher doses. ..
  29. ncbi request reprint Relationship between fluid management, changes in serum sodium and outcome in hypernatraemia associated with gastroenteritis
    Gillian Robertson
    Paediatric Intensive Care Unit, Red Cross War Memorial Children s Hospital, School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa
    J Paediatr Child Health 43:291-6. 2007
    ..To describe the relationship between fluid management, serum sodium and outcome in critically ill children with hypernatraemic gastroenteritis...
  30. pmc Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guérin vaccination of newborns
    Benjamin M N Kagina
    South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa
    Am J Respir Crit Care Med 182:1073-9. 2010
    ..Immunogenicity of new tuberculosis (TB) vaccines is commonly assessed by measuring the frequency and cytokine expression profile of T cells...
  31. doi request reprint The utility of an interferon gamma release assay for diagnosis of latent tuberculosis infection and disease in children: a systematic review and meta-analysis
    Shingai Machingaidze
    South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Pediatr Infect Dis J 30:694-700. 2011
    ..We reviewed the literature on the use of a commercial IGRA in immunocompetent children for the diagnosis of both latent tuberculosis infection (LTBI) and TB disease...
  32. ncbi request reprint Mortality and the nature of metabolic acidosis in children with shock
    Mark Hatherill
    School of Child and Adolescent Health, University of Cape Town and Red Cross War Memorial Children s Hospital, Klipfontein Road, 7700, Cape Town, South Africa
    Intensive Care Med 29:286-91. 2003
    ..Mortality in children with shock is more closely related to the nature, rather than the magnitude (base deficit/excess), of a metabolic acidosis...
  33. ncbi request reprint Transport of critically ill children in a resource-limited setting
    Mark Hatherill
    Institute of Child Health, Red Cross War Memorial Children s Hospital, Klipfontein Road, 7700 Cape Town, South Africa
    Intensive Care Med 29:1547-54. 2003
    ..To audit paediatric intensive care unit (PICU) transfer activity and transfer-related adverse events in a resource-limited setting...
  34. doi request reprint Pediatric Intensive Care in South Africa: An Account of Making Optimum Use of Limited Resources at the Red Cross War Memorial Children's Hospital*
    Andrew C Argent
    1Paediatric Intensive Care Unit, Red Cross War Memorial Children s Hospital, Cape Town, South Africa 2Division of Paediatric Critical Care and Children s Heart Disease, School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa 3Education Development Unit, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa 4Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa 5Bioethics Centre, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Pediatr Crit Care Med 15:7-14. 2014
    ..To develop explicit criteria for patient admission in order to optimize utilization of PICU facilities in the face of increasing demand outstripping resources...
  35. pmc Moxifloxacin population pharmacokinetics in patients with pulmonary tuberculosis and the effect of intermittent high-dose rifapentine
    Simbarashe P Zvada
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Antimicrob Agents Chemother 56:4471-3. 2012
    ....
  36. ncbi request reprint Clinical course of hospitalised children infected with human metapneumovirus and respiratory syncytial virus
    Brenda M Morrow
    Red Cross War Memorial Children s Hospital RCWMCH, Physiotherapy Department and Division of Associated Paediatric Disciplines, School of Child and Adolescent Health, University of Cape Town, South Africa
    J Paediatr Child Health 42:174-8. 2006
    ..To describe the clinical presentation and outcomes of hospitalised patients infected with human metapneumovirus (hMPV) and human respiratory syncytial virus (hRSV) in a tertiary hospital in Cape Town, South Africa...
  37. ncbi request reprint Sepsis predisposition in children with human immunodeficiency virus
    Mark Hatherill
    Paediatric Intensive Care Unit, School of Child and Adolescent Health, University of Cape Town, South Africa
    Pediatr Crit Care Med 6:S92-8. 2005
    ..To review predisposition to sepsis in children infected with human immunodeficiency virus (HIV) in the era of highly active antiretroviral therapy (HAART)...
  38. ncbi request reprint Hospital-acquired hyponatremia is associated with excessive administration of intravenous maintenance fluid
    Mark Hatherill
    Pediatrics 114:1368; author reply 1368-9. 2004