Research Topics
Species | Glenda E GraySummaryAffiliation: University of the Witwatersrand Country: South Africa Publications
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Detail Information
Publications
Effect of HIV on womenGlenda E Gray
Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
AIDS Read 16:365-8, 373-7. 2006..In addition, women are more likely to have antiretroviral treatment side effects, and certain antiretroviral regimens may impair contraceptive efficacy. Prevention strategies are presently not female-controlled...- Pain in women with HIV/AIDSGlenda Gray
Perinatal HIV Research Unit, University of Witwatersrand, Chris Hani Baragwanath Hosoital, Old Potch Road, Soweto, 1864 Johannesburg, Gauteng, South Africa
Pain 132:S13-21. 2007..Unless the conditions under which women live are addressed, and attempts made to empower them in their daily lives, their limited ability to access treatment, care and pain relief will continue to be unacceptable... 
Development of a whole blood intracellular cytokine staining assay for mapping CD4(+) and CD8(+) T-cell responses across the HIV-1 genomeStephen Meddows-Taylor
AIDS Virus Research Unit, National Institute for Communicable Diseases, and Department of Virology, University of the Witwatersrand, Johannesburg, South Africa
J Virol Methods 144:115-21. 2007....- HIV surveillance in a large, community-based study: results from the pilot study of Project Accept (HIV Prevention Trials Network 043)Estelle Piwowar-Manning
Dept of Pathology, Johns Hopkins Univ, School of Medicine, Baltimore, MD, USA
BMC Infect Dis 11:251. 2011..We evaluated the accuracy of in-country HIV rapid testing and determined HIV prevalence in the Project Accept pilot study... - Immune-based prevention of mother-to-child HIV-1 transmissionGlenda E Gray
University of the Witwatersrand, Perinatal HIV Research Unit, Chris Hani Baragwanath Hospital, Soweto, Johannesburg, South Africa
Curr Opin Mol Ther 9:168-75. 2007.... - Overview of STEP and Phambili trial results: two phase IIb test-of-concept studies investigating the efficacy of MRK adenovirus type 5 gag/pol/nef subtype B HIV vaccineGlenda Gray
Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
Curr Opin HIV AIDS 5:357-61. 2010.... - A randomized trial of two postexposure prophylaxis regimens to reduce mother-to-child HIV-1 transmission in infants of untreated mothersGlenda E Gray
Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg South Africa
AIDS 19:1289-97. 2005..Where women do not access antenatal care or HIV testing, postexposure prophylaxis to the infant may be an important preventative strategy... - Antiviral activity of nucleoside analogues during short-course monotherapy or dual therapy: its role in preventing HIV infection in infantsGlenda Gray
Perinatal HIV Research Unit, University of the Witwatersrand, South Africa
J Acquir Immune Defic Syndr 42:169-76. 2006.... - Safety and efficacy of the HVTN 503/Phambili study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomised, placebo-controlled test-of-concept phase 2b studyGlenda E Gray
Perinatal HIV Research Unit, University of Witwatersrand, Johannesburg, South Africa
Lancet Infect Dis 11:507-15. 2011..We aim to assess the safety and efficacy of the vaccine in South Africa, where the major circulating clade is subtype C... - HIV and pregnancyGlenda E Gray
Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
BMJ 334:950-3. 2007 - Natural killer cells that respond to human immunodeficiency virus type 1 (HIV‐1) peptides are associated with control of HIV‐1 infectionCaroline T Tiemessen
AIDS Virus Research Unit, National Institute for Communicable Diseases and Department of Virology, Coronation Women and Children Hospital, Enhancing Childhood HIV Outcomes, University of the Witwatersrand, Johannesburg, South Africa
J Infect Dis 202:1444-53. 2010..Peptide‐specific natural killer cells are associated with markers of less severe disease progression among HIV‐1-infected women (lower viral load and higher CD4 T cell count) and with stronger HIV‐specific T cell responses... - Host CCL3L1 gene copy number in relation to HIV-1-specific CD4+ and CD8+ T-cell responses and viral load in South African womenSharon Shalekoff
AIDS Virus Research Unit, National Institute for Communicable Diseases, Johannesburg, South Africa
J Acquir Immune Defic Syndr 48:245-54. 2008..017), and women who had CD4 and CD8 Gag-specific responses had significantly lower viral loads (P=0.004) and higher CCL3L1 copy number (P=0.015) than those women with only CD8 Gag-specific responses... - Efficacy of short-course AZT plus 3TC to reduce nevirapine resistance in the prevention of mother-to-child HIV transmission: a randomized clinical trialJames A McIntyre
Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
PLoS Med 6:e1000172. 2009.... - Natural killer cell responses to HIV-1 peptides are associated with more activating KIR genes and HLA-C genes of the C1 allotypeCaroline T Tiemessen
National Institute for Communicable Diseases, Johannesburg, South Africa
J Acquir Immune Defic Syndr 57:181-9. 2011..What characterizes individuals whose natural killer (NK) cells are able to respond to HIV-1 peptides is not known... - In vivo effects of HIV-1 exposure in the presence and absence of single-dose nevirapine on cellular plasma activation markers of infants born to HIV-1-seropositive mothersDiana B Schramm
AIDS Virus Research Unit, National Institute for Communicable Diseases and Department of Virology, University of the Witwatersrand, Gauteng, South Africa
J Acquir Immune Defic Syndr 42:545-53. 2006.... - KIR-HLA and maternal-infant HIV-1 transmission in sub-Saharan AfricaMaria Paximadis
AIDS Virus Research Unit, National Institute for Communicable Diseases, Johannesburg, South Africa
PLoS ONE 6:e16541. 2011..In conclusion this study has identified a number of significant associations that suggest an important role for NK cells in maternal-to-infant HIV-1 transmission... - Combining PMTCT with active case finding for tuberculosisPaula B N Kali
Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
J Acquir Immune Defic Syndr 42:379-81. 2006..We conclude that rates of TB in HIV-infected pregnant women are high, and screening for TB during routine antenatal care should be implemented in high HIV-prevalence settings... - Progression and regression of premalignant cervical lesions in HIV-infected women from Soweto: a prospective cohortTanvier Omar
Department of Anatomical Pathology, University of the Witwatersrand, Johannesburg, South Africa
AIDS 25:87-94. 2011..To ascertain progression and regression of cervical dysplasia in HIV-infected women in Soweto... - Pregnancy incidence and correlates during the HVTN 503 Phambili HIV vaccine trial conducted among South African womenMary H Latka
The Aurum Institute, Johannesburg, South Africa
PLoS ONE 7:e31387. 2012..Using data from the HVTN 503/"Phambili" vaccine trial, we report pregnancy incidence during and after the vaccination period and identify factors, measured at screening, associated with incident pregnancy... - Low maternal viral loads and reduced granulocyte-macrophage colony-stimulating factor levels characterize exposed, uninfected infants who develop protective human immunodeficiency virus type 1-specific responsesDiana B Schramm
AIDS Virus Research Unit, National Institute for Communicable Diseases, Department of Virology, University of the Witwatersrand, Gauteng, South Africa
Clin Vaccine Immunol 14:348-54. 2007.... - Reduced ability of newborns to produce CCL3 is associated with increased susceptibility to perinatal human immunodeficiency virus 1 transmissionStephen Meddows-Taylor
AIDS Virus Research Unit, National Institute for Communicable Diseases, Department of Virology, University of the Witwatersrand, Sandringham, Johannesburg 2131, South Africa
J Gen Virol 87:2055-65. 2006..Our findings suggest that infants who display a deficient-production phenotype of CCL3 are at increased risk of acquiring HIV-1, indicating that this chemokine in particular plays an essential role in protective immunity... - High rates of HIV in surgical patients in Soweto, South Africa: impact on resource utilisation and recommendations for HIV testingNeil A Martinson
Perinatal HIV Research Unit, University of Witwatersrand, Johannesburg, South Africa
Trans R Soc Trop Med Hyg 101:176-82. 2007..WHO clinical staging of HIV should include anal sepsis as an indicator of advanced HIV disease... - Comparative costs of inpatient care for HIV-infected and uninfected children and adults in Soweto, South AfricaLeena S Thomas
School of Public Health, University of the Witwatersrand, and Gauteng Department of Health, Johannesburg, South Africa
J Acquir Immune Defic Syndr 46:410-6. 2007..HIV/AIDS creates a massive burden of care for health systems. A better understanding of the impact of HIV infection on health care utilization and costs may enable better use of limited resources... - Age-related changes in expression of CXCR4 and CCR5 on peripheral blood leukocytes from uninfected infants born to human immunodeficiency virus type 1-infected mothersSharon Shalekoff
AIDS Virus Research Unit, National Institute for Communicable Diseases, and Department of Virology, Johannesburg, South Africa
Clin Diagn Lab Immunol 11:229-34. 2004..5 months and increased between 9 and 15 months to levels approaching those of uninfected adults. Proportions of CCR5-expressing cells, however, were very low in cord blood and subsequently increased with age... - Characterisation of near-full length genome sequences of three South African human immunodeficiency virus type 1 subtype C isolatesGillian M Hunt
AIDS Virus Research Unit, National Institute for Communicable Diseases and Department of Virology, University of the Witwatersrand, Johannesburg, South Africa
Virus Genes 26:49-56. 2003..This information contributes to our overall knowledge of circulating strains in South Africa and to the making of effective vaccines and chemotherapeutic agents... - Insensitivity of paediatric HIV-1 subtype C viruses to broadly neutralising monoclonal antibodies raised against subtype BElin Solomonovna Gray
AIDS Virus Research Unit, National Institute for Communicable Diseases, Johannesburg, South Africa
PLoS Med 3:e255. 2006..It is therefore recommended that 2G12 and 2F5 MAbs not be used for passive immunization experiments in southern Africa and other regions where HIV-1 subtype C viruses predominate... - What can we do to reduce mother to child transmission of HIV?James Mcintyre
Perinatal HIV Research Unit, University of the Witwatersrand, Chris Hani Baragwanath Hospital, PO Bertsham, Johannesburg 2013, South Africa
BMJ 324:218-21. 2002 
Male circumcision for HIV prevention: developments from sub-Saharan AfricaGuy de Bruyn
Perinatal HIV Research Unit, New Nurses Home, Chris Hani Baragwanath Hospital, Chris Hani Road, Johannesburg, South Africa
Expert Rev Anti Infect Ther 8:23-31. 2010..This perspective reviews recent research findings and provides a summary of progress in various countries...- Effect of Maternal HIV-1 Status and Antiretroviral Drugs on Haematological Profiles of South African Infants in Early LifeDiana B Schramm
AIDS Virus Research Unit, National Institute for Communicable Diseases and Department of Virology, University of the Witwatersrand, Gauteng, South Africa
Open AIDS J 4:156-65. 2010..These previously undescribed features may affect immune response capability in early life and clinical consequences of such changes need to be further investigated... - Tuberculosis active case-finding in a mother-to-child HIV transmission prevention programme in Soweto, South AfricaJean Nachega
Perinatal HIV Research Unit, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa
AIDS 17:1398-400. 2003 - Willingness to participate in biomedical HIV prevention studies after the HVTN 503/Phambili trial: a survey conducted among adolescents in Soweto, South AfricaKennedy N Otwombe
Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
J Acquir Immune Defic Syndr 58:211-8. 2011..Adolescents' overall willingness to participate (WTP) in biomedical HIV prevention trials was examined, including after the prematurely discontinued phase IIb HVTN 503/Phambili HIV vaccine trial, in Soweto, South Africa... - Low frequency of the V106M mutation among HIV-1 subtype C-infected pregnant women exposed to nevirapineLynn Morris
AIDS Virus Research Unit, National Institute for Communicable Diseases, Sandringham, Johannesburg, South Africa
AIDS 17:1698-700. 2003..V106M is a novel resistance mutation found in subtype C viruses exposed to efavirenz. This mutation is thus also induced at a low frequency in subtype C viruses exposed to single dose nevirapine... - Viral dynamics and CD4+ T cell counts in subtype C human immunodeficiency virus type 1-infected individuals from southern AfricaClive M Gray
National Institute for Communicable Diseases, Johannesburg, South Africa
AIDS Res Hum Retroviruses 21:285-91. 2005.... - Effect of HIV infection status and anti-retroviral treatment on quantitative and qualitative antibody responses to pneumococcal conjugate vaccine in infantsShabir A Madhi
Department of Science National Research Foundation, Vaccine Preventable Diseases, University of the Witwatersrand, Johannesburg, South Africa
J Infect Dis 202:355-61. 2010..Nevertheless, M-/I- infants had superior OPA responses, compared with those in HIV+/ART+ infants, who in turn had better OPA responses, compared with those in HIV+/ART- infants... - Knowledge and attitudes towards HIV vaccines among Soweto adolescentsGuy de Bruyn
Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
BMC Res Notes 1:76. 2008..All pupils within the selected schools from whom parental consent and child assent could be obtained were eligible for participation. A self-administered, facilitated questionnaire was completed by all participants... - HIV-1 subtype C reverse transcriptase sequences from drug-naive pregnant women in South AfricaCandice Pillay
AIDS Virus Research Unit, National Institute for Communicable Diseases, Sandringham 2131, Johannesburg, South Africa
AIDS Res Hum Retroviruses 18:605-10. 2002.... - Hierarchical targeting of subtype C human immunodeficiency virus type 1 proteins by CD8+ T cells: correlation with viral loadAgatha Masemola
National Institute for Communicable Diseases, Johannesburg, South Africa
J Virol 78:3233-43. 2004..These data have significance for the design of vaccines and for interpretation of vaccine-induced responses... - A steady state of CD4+ T cell memory maturation and activation is established during primary subtype C HIV-1 infectionPholo Maenetje
AIDS Research Unit, National Institute for Communicable Diseases, Johannesburg, Gauteng, South Africa
J Immunol 184:4926-35. 2010.... - A qualitative assessment of decisions affecting contraceptive utilization and fertility intentions among HIV-positive women in Soweto, South AfricaFatima Laher
Perinatal HIV Research Unit, University of the Witwatersrand, Diepkloof, P O Box 114, Johannesburg, Soweto, 1864, South Africa
AIDS Behav 13:47-54. 2009..Routine counseling about pregnancy desires and contraception should be offered to HIV-positive women... - Development of phenotypic HIV-1 drug resistance after exposure to single-dose nevirapineAdriaan E Basson
AIDS Virus Research Unit, National Institute for Communicable Diseases, Johannesburg, South Africa
J Acquir Immune Defic Syndr 49:538-43. 2008..To assess the levels of phenotypic resistance conferred by these mutations, we examined the ability of sample-derived HIV-1 reverse transcriptase to function in the presence of nevirapine (NVP)... - Genotypic and phenotypic characterization of viral isolates from HIV-1 subtype C-infected children with slow and rapid disease progressionIsaac Choge
AIDS Virus Research Unit, National Institute for Communicable Diseases, Johannesburg, South Africa
AIDS Res Hum Retroviruses 22:458-65. 2006..Similar to adults, CXCR4 usage was uncommon among HIV-1 subtype C isolates from pediatric infections... - Novel and promiscuous CTL epitopes in conserved regions of Gag targeted by individuals with early subtype C HIV type 1 infection from southern AfricaAgatha M Masemola
National Institute for Communicable Diseases, University of Witwatersrand, Johannesburg, South Africa
J Immunol 173:4607-17. 2004.... - Role of menstruation in contraceptive choice among HIV-infected women in Soweto, South AfricaFatima Laher
Perinatal HIV Research Unit, Soweto, Johannesburg, Gauteng Province, South Africa
Contraception 81:547-51. 2010..It is unknown whether HIV-infected women are more sensitive to menstrual changes and how this affects contraceptive choice. This study describes perceptions toward menses and contraceptive-induced amenorrhea among HIV-infected women... - African infants' CCL3 gene copies influence perinatal HIV transmission in the absence of maternal nevirapineLouise Kuhn
Gertrude H Sergievsky Centre, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
AIDS 21:1753-61. 2007..We investigated whether maternal or infant CCL3L1 gene copy numbers are associated with perinatal HIV transmission when single-dose nevirapine is given for prevention... - The NEAT study: a 48-week open-label study to compare the antiviral efficacy and safety of GW433908 versus nelfinavir in antiretroviral therapy-naive HIV-1-infected patientsAmalia Rodriguez-French
Centro de Vacunas y Tratamiento de Enfermedades Febriles, , La Sabana, Panama
J Acquir Immune Defic Syndr 35:22-32. 2004..GW433908 was generally well tolerated and provides a convenient dosing option without food or fluid restrictions... - Transmission rates in consecutive pregnancies exposed to single-dose nevirapine in Soweto, South Africa and Abidjan, Côte d'IvoireNeil A Martinson
School of Medicine, Johns Hopkins University, Baltimore, MD, USA
J Acquir Immune Defic Syndr 45:206-9. 2007..Because sdNVP selects resistance in a high percentage of women, we compared the effectiveness of sdNVP in preventing peripartum MTCT in successive pregnancies... - Gender-based violence, relationship power, and risk of HIV infection in women attending antenatal clinics in South AfricaKristin L Dunkle
Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA
Lancet 363:1415-21. 2004..No study on women has yet assessed gender-based violence as a risk factor for HIV after adjustment for women's own high-risk behaviours, although these are known to be associated with experience of violence... - Breast-feeding, antiretroviral prophylaxis, and HIVGlenda E Gray
N Engl J Med 359:189-91. 2008 - Prevalence and patterns of gender-based violence and revictimization among women attending antenatal clinics in Soweto, South AfricaKristin L Dunkle
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48104 3028, USA
Am J Epidemiol 160:230-9. 2004..92, 4.98). This study confirms the need for increased attention by the public health community to primary and secondary prevention of gender-based violence, with a specific need to reduce risk among South African adolescents... - Predicting the impact of a partially effective HIV vaccine and subsequent risk behavior change on the heterosexual HIV epidemic in low- and middle-income countries: A South African exampleKyeen M Andersson
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06510, USA
J Acquir Immune Defic Syndr 46:78-90. 2007..Even modestly effective HIV vaccines can confer enormous benefits in terms of HIV infections averted and decreased HIV prevalence. However, programs to reduce risk behavior may be important components of successful vaccination campaigns... - Scientific justification for the participation of children and adolescents in HIV-1 vaccine trials in South AfricaHeather B Jaspan
Desmond Tutu HIV Centre, University of Cape Town, South Africa
S Afr Med J 95:685-7. 2005 - Co-trimoxazole prophylaxis in African children with HIV-1Shabir A Madhi
Lancet 365:749-50; author reply 750-1. 2005 - Walking the tightrope in prevention of mother-to-child transmission of HIV infectionGlenda E Gray
Clin Infect Dis 46:622-4. 2008 - Transactional sex among women in Soweto, South Africa: prevalence, risk factors and association with HIV infectionKristin L Dunkle
Department of Epidemiology, University of Michigan, 611 Church Street, Ann Arbor, MI 48109 3028, USA
Soc Sci Med 59:1581-92. 2004..Research, policy and programmatic initiatives should consider the role of transactional sex in women's HIV risk, with attention to the intersecting roles of violence, poverty, and substance use in shaping women's sexual behaviour...