Charles Feldman

Summary

Affiliation: University of the Witwatersrand
Country: South Africa

Publications

  1. doi request reprint Bronchiectasis: new approaches to diagnosis and management
    Charles Feldman
    Division of Pulmonology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand, Parktown, Johannesburg, South Africa
    Clin Chest Med 32:535-46. 2011
  2. doi request reprint Pneumococcal disease in the Arabian Gulf: recognizing the challenge and moving toward a solution
    Charles Feldman
    Division of Pulmonology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Electronic address
    J Infect Public Health 6:401-9. 2013
  3. doi request reprint HIV-associated bacterial pneumonia
    Charles Feldman
    Division of Pulmonology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, 2193, Johannesburg, South Africa
    Clin Chest Med 34:205-16. 2013
  4. doi request reprint Antibiotic resistance of pathogens causing community-acquired pneumonia
    Charles Feldman
    Division of Pulmonology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa
    Semin Respir Crit Care Med 33:232-43. 2012
  5. doi request reprint The use of antiinflammatory therapy and macrolides in bronchiectasis
    Charles Feldman
    Division of Pulmonology, Department of Internal Medicine, Faculty of Health Sciences, Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand, South Africa
    Clin Chest Med 33:371-80. 2012
  6. pmc Polychromatic immunophenotypic characterization of T cell profiles among HIV-infected patients experiencing immune reconstitution inflammatory syndrome (IRIS)
    David M Murdoch
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, USA
    AIDS Res Ther 6:16. 2009
  7. doi request reprint Therapy for pneumococcal bacteremia: monotherapy or combination therapy?
    Charles Feldman
    Division of Pulmonology, Department of Medicine, Johannesburg Hospital and Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parkdown, Johannesburg, South Africa
    Curr Opin Infect Dis 22:137-42. 2009
  8. doi request reprint Bacteraemic pneumococcal pneumonia: current therapeutic options
    Charles Feldman
    Division of Pulmonology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, South Africa
    Drugs 71:131-53. 2011
  9. pmc An unusual pneumococcal sequence type is the predominant cause of serotype 3 invasive disease in South Africa
    Kedibone M Mothibeli
    Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, Medical Research Council, University of the Witwatersrand, Johannesburg, South Africa
    J Clin Microbiol 48:184-91. 2010
  10. doi request reprint Effects of cigarette smoke condensate on pneumococcal biofilm formation and pneumolysin
    N Daphney Mutepe
    Dept of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa
    Eur Respir J 41:392-5. 2013

Collaborators

Detail Information

Publications40

  1. doi request reprint Bronchiectasis: new approaches to diagnosis and management
    Charles Feldman
    Division of Pulmonology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand, Parktown, Johannesburg, South Africa
    Clin Chest Med 32:535-46. 2011
    ..Studies are beginning to inform decisions regarding the management of non-CF bronchiectasis, and an understanding of the best treatment options is beginning to emerge...
  2. doi request reprint Pneumococcal disease in the Arabian Gulf: recognizing the challenge and moving toward a solution
    Charles Feldman
    Division of Pulmonology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Electronic address
    J Infect Public Health 6:401-9. 2013
    ..The Gulf Advocate Group recommends following the U.S. Centers for Disease Control and Prevention (CDC) guidelines for pneumococcal vaccination [3,4]. ..
  3. doi request reprint HIV-associated bacterial pneumonia
    Charles Feldman
    Division of Pulmonology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, 2193, Johannesburg, South Africa
    Clin Chest Med 34:205-16. 2013
    ....
  4. doi request reprint Antibiotic resistance of pathogens causing community-acquired pneumonia
    Charles Feldman
    Division of Pulmonology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa
    Semin Respir Crit Care Med 33:232-43. 2012
    ....
  5. doi request reprint The use of antiinflammatory therapy and macrolides in bronchiectasis
    Charles Feldman
    Division of Pulmonology, Department of Internal Medicine, Faculty of Health Sciences, Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand, South Africa
    Clin Chest Med 33:371-80. 2012
    ....
  6. pmc Polychromatic immunophenotypic characterization of T cell profiles among HIV-infected patients experiencing immune reconstitution inflammatory syndrome (IRIS)
    David M Murdoch
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, USA
    AIDS Res Ther 6:16. 2009
    ..CONCLUSION: CD4+ and CD8+ T cell subset maturational phenotypes were heterogeneous among IRIS cases and controls. However, IRIS cases demonstrated significant increases in activation of CD8+ T cell effector subpopulations...
  7. doi request reprint Therapy for pneumococcal bacteremia: monotherapy or combination therapy?
    Charles Feldman
    Division of Pulmonology, Department of Medicine, Johannesburg Hospital and Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parkdown, Johannesburg, South Africa
    Curr Opin Infect Dis 22:137-42. 2009
    ..This review highlights recent studies that have addressed this issue...
  8. doi request reprint Bacteraemic pneumococcal pneumonia: current therapeutic options
    Charles Feldman
    Division of Pulmonology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, South Africa
    Drugs 71:131-53. 2011
    ....
  9. pmc An unusual pneumococcal sequence type is the predominant cause of serotype 3 invasive disease in South Africa
    Kedibone M Mothibeli
    Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, Medical Research Council, University of the Witwatersrand, Johannesburg, South Africa
    J Clin Microbiol 48:184-91. 2010
    ..We have therefore identified ST458 as predominating in South Africa, but with an invasive potential similar to that of the predominant global clone ST180...
  10. doi request reprint Effects of cigarette smoke condensate on pneumococcal biofilm formation and pneumolysin
    N Daphney Mutepe
    Dept of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa
    Eur Respir J 41:392-5. 2013
    ..Augmentation of biofilm formation and inactivation of pneumolysin as a consequence of smoking are likely to favour microbial colonisation and persistence, both being essential precursors of pneumococcal disease...
  11. pmc Emergence of OXA-48 and OXA-181 carbapenemases among Enterobacteriaceae in South Africa and evidence of in vivo selection of colistin resistance as a consequence of selective decontamination of the gastrointestinal tract
    Adrian J Brink
    Department of Clinical Microbiology, Ampath National Laboratory Services, Milpark Hospital, Johannesburg, South Africa
    J Clin Microbiol 51:369-72. 2013
    ....
  12. ncbi request reprint Pneumolysin as a vaccine and drug target in the prevention and treatment of invasive pneumococcal disease
    Riana Cockeran
    Department of Immunology, Faculty of Health Sciences, University of Pretoria and Tshwane Academic Division of the National Health Laboratory Service, Pretoria, South Africa
    Arch Immunol Ther Exp (Warsz) 53:189-98. 2005
    ....
  13. doi request reprint Increased incidence of meningococcal disease in HIV-infected individuals associated with higher case-fatality ratios in South Africa
    Cheryl Cohen
    National Institute for Communicable Diseases, Johannesburg, South Africa
    AIDS 24:1351-60. 2010
    ..We aimed to compare the incidence of meningococcal disease amongst HIV-infected and uninfected individuals and to evaluate whether HIV is a risk factor for mortality and bacteremia amongst patients with meningococcal disease...
  14. pmc Neisseria meningitidis intermediately resistant to penicillin and causing invasive disease in South Africa in 2001 to 2005
    Mignon du Plessis
    National Institute for Communicable Diseases of the National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa
    J Clin Microbiol 46:3208-14. 2008
    ..This is the first report describing the prevalence and molecular epidemiology of Pen(i) meningococcal isolates from sub-Saharan Africa...
  15. doi request reprint Calcium-dependent potentiation of the pro-inflammatory functions of human neutrophils by tigecycline in vitro
    Riana Cockeran
    Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, Faculty of Health Sciences, University of Pretoria and Tshwane Academic Division of National Health Laboratory Service, Pretoria, South Africa
    J Antimicrob Chemother 67:130-7. 2012
    ....
  16. doi request reprint New insights into pneumococcal disease
    Charles Feldman
    Division of Pulmonology, Department of Medicine, Johannesburg Hospital, University of the Witwatersrand, Johannesburg, South Africa
    Respirology 14:167-79. 2009
    ..An important advance in the prevention of pneumococcal infections has been the introduction of the pneumococcal protein conjugate vaccine...
  17. doi request reprint Montelukast: more than a cysteinyl leukotriene receptor antagonist?
    Gregory R Tintinger
    Department of Internal Medicine, Faculty of Health Sciences, University of Pretoria, South Africa
    ScientificWorldJournal 10:2403-13. 2010
    ..The primary objective of this mini-review is to present evidence for the cysteinyl leukotriene-independent mechanisms of action of montelukast and their potential clinical relevance...
  18. ncbi request reprint Pneumolysin potentiates oxidative inactivation of alpha-1-proteinase inhibitor by activated human neutrophils
    Riana Cockeran
    MRC Unit for Inflammation and Immunity, Department of Immunology, Faculty of Health Sciences, University of Pretoria and Tshwane Academic Division of the National Health Laboratory Services, PO Box 2034, Pretoria 0001, South Africa
    Respir Med 98:865-71. 2004
    ..These pro-proteolytic interactions of pneumolysin with chemoattractant-activated neutrophils may contribute to the invasiveness of the pneumococcus...
  19. pmc Montelukast inhibits neutrophil pro-inflammatory activity by a cyclic AMP-dependent mechanism
    Ronald Anderson
    Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa
    Br J Pharmacol 156:105-15. 2009
    ....
  20. pmc Pathogen- and host-directed anti-inflammatory activities of macrolide antibiotics
    Helen C Steel
    Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, Faculty of Health Sciences, University of Pretoria and Tshwane Academic Division of the National Health Laboratory Service, P O Box 2034, Pretoria 0001, South Africa
    Mediators Inflamm 2012:584262. 2012
    ..This paper is focused on the various mechanisms of macrolide-mediated anti-inflammatory activity which target both microbial pathogens and the cells of the innate and adaptive immune systems, with emphasis on their clinical relevance...
  21. pmc Docosahexaenoic acid and eicosapentaenoic acid antagonize the proinflammatory interactions of pneumolysin with human neutrophils
    Riana Cockeran
    Medical Research Council for Inflammation and Immunity, Department of Immunology, Faculty of Health Sciences, University of Pretoria, P O Box 2034, Pretoria 0001, South Africa
    Infect Immun 72:4327-9. 2004
    ..25 to 5 microg/ml). These agents may have potential in attenuating the proinflammatory properties of this pneumococcal toxin...
  22. ncbi request reprint Controversies in the treatment of pneumococcal community-acquired pneumonia
    Charles Feldman
    University of the Witwatersrand Medical School, Division of Pulmonology, Department of Medicine, Parktown, Johannesburg, South Africa
    Future Microbiol 1:271-81. 2006
    ....
  23. doi request reprint Increased risk of death in human immunodeficiency virus-infected children with pneumococcal meningitis in South Africa, 2003-2005
    Peter Nyasulu
    School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    Pediatr Infect Dis J 30:1075-80. 2011
    ..Pneumococcal disease is a major global cause of morbidity and mortality. This study evaluated risk factors for mortality in children with pneumococcal meningitis and other invasive pneumococcal diseases (IPD)...
  24. pmc Can the anti-inflammatory activities of β2-agonists be harnessed in the clinical setting?
    Annette J Theron
    Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, Faculty of Health Sciences, University of Pretoria, South Africa Tshwane Academic Division of the National Health Laboratory Service, Pretoria, South Africa
    Drug Des Devel Ther 7:1387-98. 2013
    ....
  25. ncbi request reprint Pneumonia associated with HIV infection
    Charles Feldman
    Division of Pulmonology, Department of Medicine, Johannesburg Hospital and University of the Witwatersrand, Johannesburg, South Africa
    Curr Opin Infect Dis 18:165-70. 2005
    ..Pneumonia occurs commonly in HIV-infected patients and this review highlights some of the recent findings in the epidemiology, pathogenesis, clinical features, treatment and prevention of this condition...
  26. ncbi request reprint Bacteraemic pneumococcal pneumonia: impact of HIV on clinical presentation and outcome
    Charles Feldman
    Division of Pulmonology, Department of Medicine, Johannesburg Hospital, University of the Witwatersrand, Medical School, 7 York Road, Parktown 2193, Johannesburg, South Africa
    J Infect 55:125-35. 2007
    ....
  27. doi request reprint Overview of community-acquired pneumonia and the role of inflammatory mechanisms in the immunopathogenesis of severe pneumococcal disease
    Helen C Steel
    Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, Faculty of Health Sciences, University of Pretoria and Tshwane Academic Division of the National Health Laboratory Service, P O Box 2034, Pretoria 0001, South Africa
    Mediators Inflamm 2013:490346. 2013
    ..This is focused on macrolides, corticosteroids, and statins with respect to their modes of anti-inflammatory action, current status, and limitations. ..
  28. ncbi request reprint Prevalence of anti-mycolic acid antibodies in patients with pulmonary tuberculosis co-infected with HIV
    Gunther K Schleicher
    Department of Medicine, University of the Witwatersrand, Johannesburg Hospital, South Africa
    Clin Chem Lab Med 40:882-7. 2002
    ....
  29. ncbi request reprint The spread of carbapenem-resistant Enterobacteriaceae in South Africa: risk factors for acquisition and prevention
    Adrian Brink
    Department of Clinical Microbiology, Ampath National Laboratory Services, Milpark Hospital, Johannesburg, South Africa
    S Afr Med J 102:599-601. 2012
    ....
  30. doi request reprint Antimicrobial susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in South African hospitals (SMART Study 2004-2009): impact of the new carbapenem breakpoints
    Adrian J Brink
    Department of Clinical Microbiology, Ampath National Laboratory Services, Milpark Hospital, Parktown, Johannesburg, South Africa
    Surg Infect (Larchmt) 13:43-9. 2012
    ....
  31. doi request reprint Emergence of levofloxacin-non-susceptible Streptococcus pneumoniae and treatment for multidrug-resistant tuberculosis in children in South Africa: a cohort observational surveillance study
    Anne Von Gottberg
    National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa
    Lancet 371:1108-13. 2008
    ..Our aim was to estimate the incidence of, and risk factors for, invasive pneumococcal disease caused by fluoroquinolone-resistant Streptococcus pneumoniae in children in South Africa...
  32. pmc Causes of death on antiretroviral therapy: a post-mortem study from South Africa
    Emily B Wong
    WITS Reproductive Health and HIV Institute, University of the Witwatersrand, Johannesburg, South Africa
    PLoS ONE 7:e47542. 2012
    ..Mortality in the first months of antiretroviral therapy (ART) is a significant clinical problem in sub-Saharan Africa. To date, no post-mortem study has investigated the causes of mortality in these patients...
  33. doi request reprint Severity of illness scoring systems in patients with bacteraemic pneumococcal pneumonia: implications for the intensive care unit care
    C Feldman
    Division of Pulmonology, Department of Medicine, Charlotte Maxeke Johannesburg Academic Hospital and University of the Witwatersrand, Johannesburg, South Africa
    Clin Microbiol Infect 15:850-7. 2009
    ..The low PPV of the PSI rendered it not usable as a parameter for decision-making in severely-ill patients with pneumococcal bacteraemia...
  34. ncbi request reprint Clinical relevance of antimicrobial resistance in the management of pneumococcal community-acquired pneumonia
    Charles Feldman
    Division of Pulmonology, Department of Medicine, Johannesburg Hospital and University of the Witwatersrand, Johannesburg, South Africa
    J Lab Clin Med 143:269-83. 2004
    ....
  35. ncbi request reprint Neutrophils potentiate platinum-mediated injury to human ciliated epithelium in vitro
    Charles Feldman
    Division of Pulmonology, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
    Inhal Toxicol 17:297-301. 2005
    ..If such effects also occur in vivo they may play a role, at least partly, in the pathogenesis of airway disorders that may manifest in exposed workers...
  36. doi request reprint Cigarette smoking and mechanisms of susceptibility to infections of the respiratory tract and other organ systems
    Charles Feldman
    Division of Pulmonology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital, South Africa
    J Infect 67:169-84. 2013
    ..Smoking cessation benefits patients in many ways, including reduction of the risk of infectious disease. ..
  37. ncbi request reprint Prognostic scoring systems: which one is best?
    Charles Feldman
    Division of Pulmonology, Department of Medicine, Johannesburg Hospital and University of the Witwatersrand, Johannesburg, South Africa
    Curr Opin Infect Dis 20:165-9. 2007
    ..This assessment will determine the appropriate site of care, diagnostic work-up, and choice of empiric antibiotics. A number of severity assessment tools have been developed and some of the recent findings are reviewed...
  38. ncbi request reprint The role of pneumolysin in the pathogenesis of Streptococcus pneumoniae infection
    Riana Cockeran
    Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa
    Curr Opin Infect Dis 15:235-9. 2002
    ..Pneumolysin-based vaccine strategies, although in the early stages of development and evaluation, show promise in reducing the severity of pneumococcal disease...
  39. ncbi request reprint CURB-65, PSI, and APACHE II to assess mortality risk in patients with severe sepsis and community acquired pneumonia in PROWESS
    Guy Richards
    University of Witwatersrand, Johannesburg, South Africa
    J Intensive Care Med 26:34-40. 2011
    ....
  40. doi request reprint Systems for the management of respiratory disease in primary care--an international series: South Africa
    Eric Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, and University of Cape Town Lung Institute, Cape Town, South Africa
    Prim Care Respir J 18:69-75. 2009
    ....