M Faadiel Essop

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. ncbi Hypoxia-induced decrease of UCP3 gene expression in rat heart parallels metabolic gene switching but fails to affect mitochondrial respiratory coupling
    M Faadiel Essop
    Hatter Institute for Cardiology Research, University of Cape Town Faculty of Health Sciences, 7925 Observatory, South Africa
    Biochem Biophys Res Commun 314:561-4. 2004
  2. doi Chronic treatment with the peroxisome proliferator-activated receptor alpha agonist Wy-14,643 attenuates myocardial respiratory capacity and contractile function
    Makhosazane Zungu
    Hatter Heart Research Institute, Department of Medicine, University of Cape Town Faculty of Health Sciences, Cape Town, South Africa
    Mol Cell Biochem 330:55-62. 2009
  3. pmc Expression of mitochondrial regulatory genes parallels respiratory capacity and contractile function in a rat model of hypoxia-induced right ventricular hypertrophy
    Makhosazane Zungu
    Hatter Heart Research Institute, Department of Medicine, University of Cape Town Faculty of Health Sciences, Cape Town, South Africa
    Mol Cell Biochem 318:175-81. 2008
  4. ncbi Genomic modulation of mitochondrial respiratory genes in the hypertrophied heart reflects adaptive changes in mitochondrial and contractile function
    Makhosazane Zungu
    Hatter Heart Research Institute, Department of Medicine, University of Cape Town Faculty of Health Sciences, Cape Town, South Africa
    Am J Physiol Heart Circ Physiol 293:H2819-25. 2007
  5. ncbi Counter-regulatory effects of incremental hypoxia on the transcription of a cardiac fatty acid oxidation enzyme-encoding gene
    Kholiswa C Ngumbela
    Hatter Institute for Cardiology Research, University of Cape Town Medical School, Cape Town, South Africa
    Mol Cell Biochem 250:151-8. 2003
  6. pmc PKCε promotes cardiac mitochondrial and metabolic adaptation to chronic hypobaric hypoxia by GSK3β inhibition
    Joy McCarthy
    Hatter Institute for Cardiovascular Research, University of Cape Town Medical School, Cape Town, South Africa
    J Cell Physiol 226:2457-68. 2011
  7. ncbi PKCepsilon activation augments cardiac mitochondrial respiratory post-anoxic reserve--a putative mechanism in PKCepsilon cardioprotection
    Joy McCarthy
    Hatter Institute for Cardiology Research, University of Cape Town Medical School, Cape Town, South Africa
    J Mol Cell Cardiol 38:697-700. 2005
  8. ncbi Upstream stimulatory factor 1 transactivates the human gene promoter of the cardiac isoform of acetyl-CoA carboxylase
    Siyanda Makaula
    Hatter Heart Research Institute, University of Cape Town Faculty of Health Sciences, Observatory 7925, South Africa
    Arch Biochem Biophys 446:91-100. 2006
  9. ncbi Metabolic gene switching in the murine female heart parallels enhanced mitochondrial respiratory function in response to oxidative stress
    M Faadiel Essop
    Department of Physiological Sciences, Stellenbosch University, South Africa
    FEBS J 274:5278-84. 2007
  10. ncbi Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle
    Melissa A Stavinoha
    Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 2121 W Holcombe Blvd, IBT 1011B, Houston, TX 77030, USA
    Am J Physiol Endocrinol Metab 287:E888-95. 2004

Collaborators

Detail Information

Publications19

  1. ncbi Hypoxia-induced decrease of UCP3 gene expression in rat heart parallels metabolic gene switching but fails to affect mitochondrial respiratory coupling
    M Faadiel Essop
    Hatter Institute for Cardiology Research, University of Cape Town Faculty of Health Sciences, 7925 Observatory, South Africa
    Biochem Biophys Res Commun 314:561-4. 2004
    ..Moreover, the divergent hypoxia-induced regulation of UCP2 and UCP3 supports distinct mitochondrial regulatory functions of these inner mitochondrial membrane proteins in the heart in response to metabolic stress...
  2. doi Chronic treatment with the peroxisome proliferator-activated receptor alpha agonist Wy-14,643 attenuates myocardial respiratory capacity and contractile function
    Makhosazane Zungu
    Hatter Heart Research Institute, Department of Medicine, University of Cape Town Faculty of Health Sciences, Cape Town, South Africa
    Mol Cell Biochem 330:55-62. 2009
    ..This study demonstrates that chronic in vivo Wy-14,643 administration impaired cardiac contractile function in parallel with decreased mitochondrial respiratory function and increased uncoupling...
  3. pmc Expression of mitochondrial regulatory genes parallels respiratory capacity and contractile function in a rat model of hypoxia-induced right ventricular hypertrophy
    Makhosazane Zungu
    Hatter Heart Research Institute, Department of Medicine, University of Cape Town Faculty of Health Sciences, Cape Town, South Africa
    Mol Cell Biochem 318:175-81. 2008
    ..Our data show that the hypertrophied RV induces expression of mitochondrial regulatory genes linking respiratory capacity and enhanced efficiency to sustained contractile function...
  4. ncbi Genomic modulation of mitochondrial respiratory genes in the hypertrophied heart reflects adaptive changes in mitochondrial and contractile function
    Makhosazane Zungu
    Hatter Heart Research Institute, Department of Medicine, University of Cape Town Faculty of Health Sciences, Cape Town, South Africa
    Am J Physiol Heart Circ Physiol 293:H2819-25. 2007
    ....
  5. ncbi Counter-regulatory effects of incremental hypoxia on the transcription of a cardiac fatty acid oxidation enzyme-encoding gene
    Kholiswa C Ngumbela
    Hatter Institute for Cardiology Research, University of Cape Town Medical School, Cape Town, South Africa
    Mol Cell Biochem 250:151-8. 2003
    ..These data indicate that the transcriptional regulatory circuits involved in the control of MCAD gene expression under hypoxic conditions are modulated by upstream factors that are sensitive to the levels of oxygen...
  6. pmc PKCε promotes cardiac mitochondrial and metabolic adaptation to chronic hypobaric hypoxia by GSK3β inhibition
    Joy McCarthy
    Hatter Institute for Cardiovascular Research, University of Cape Town Medical School, Cape Town, South Africa
    J Cell Physiol 226:2457-68. 2011
    ..Moreover, we propose that preferential glucose utilization by PKCε hearts is orchestrated by a p-GSK3β/HIF-1α-mediated mechanism, playing a crucial role to sustain contractile function in response to chronic hypobaric hypoxia...
  7. ncbi PKCepsilon activation augments cardiac mitochondrial respiratory post-anoxic reserve--a putative mechanism in PKCepsilon cardioprotection
    Joy McCarthy
    Hatter Institute for Cardiology Research, University of Cape Town Medical School, Cape Town, South Africa
    J Mol Cell Cardiol 38:697-700. 2005
    ....
  8. ncbi Upstream stimulatory factor 1 transactivates the human gene promoter of the cardiac isoform of acetyl-CoA carboxylase
    Siyanda Makaula
    Hatter Heart Research Institute, University of Cape Town Faculty of Health Sciences, Observatory 7925, South Africa
    Arch Biochem Biophys 446:91-100. 2006
    ..Thus, USF1 transactivates the human ACCbeta promoter in the heart, likely through an E-box cis-element located close to the transcription start site...
  9. ncbi Metabolic gene switching in the murine female heart parallels enhanced mitochondrial respiratory function in response to oxidative stress
    M Faadiel Essop
    Department of Physiological Sciences, Stellenbosch University, South Africa
    FEBS J 274:5278-84. 2007
    ..As glucose is a more energetically efficient fuel substrate when oxygen is limiting, this gene program may be a crucial component that enhances tolerance to oxygen deprivation in female hearts...
  10. ncbi Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle
    Melissa A Stavinoha
    Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 2121 W Holcombe Blvd, IBT 1011B, Houston, TX 77030, USA
    Am J Physiol Endocrinol Metab 287:E888-95. 2004
    ..Alterations in cardiac and skeletal muscle ucp3 expression mirrored that of mte1 in all models investigated. In conclusion, mte1, like ucp3, is a PPAR alpha-regulated gene in cardiac and skeletal muscle...
  11. pmc Cardiac metabolic adaptations in response to chronic hypoxia
    M Faadiel Essop
    Department of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa
    J Physiol 584:715-26. 2007
    ..These compensatory protective mechanisms preserve contractile function despite hypoxia...
  12. pmc Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice
    M Faadiel Essop
    Department of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa
    Am J Physiol Heart Circ Physiol 295:H256-65. 2008
    ....
  13. pmc Rapid attenuation of circadian clock gene oscillations in the rat heart following ischemia-reperfusion
    Theodore A Kung
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA
    J Mol Cell Cardiol 43:744-53. 2007
    ..In conclusion, these data show that in a rodent model of myocardial I/R, circadian clocks within the ischemic region become rapidly impaired, through a mechanism that appears to be independent of hypoxia...
  14. ncbi Atrophy, hypertrophy, and hypoxemia induce transcriptional regulators of the ubiquitin proteasome system in the rat heart
    Peter Razeghi
    Department of Internal Medicine, Division of Cardiology, The University of Texas Health Science Center, Houston, TX, USA
    Biochem Biophys Res Commun 342:361-4. 2006
    ..In skeletal muscle, transcript levels of proteins regulating the ubiquitin proteasome system (UPS) increase with atrophy and decrease with hypertrophy. Whether the same is true for heart muscle is not known...
  15. ncbi Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice
    Ole Jakob How
    Department of Medical Physiology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Norway
    Diabetes 55:466-73. 2006
    ..Thus, by means of pressure-volume technology, we have for the first time documented decreased cardiac efficiency in diabetic hearts caused by oxygen waste for noncontractile purposes...
  16. ncbi Acclimatization to chronic hypobaric hypoxia is associated with a differential transcriptional profile between the right and left ventricle
    Julia V Adrogue
    Department of Internal Medicine, Division of Cardiology, University of Texas Houston Medical School, Houston, TX 77030, USA
    Mol Cell Biochem 278:71-8. 2005
    ..We speculate that reactivation of the fetal-metabolic program in the right ventricle is adaptive to pressure overload...
  17. ncbi Metabolic therapy for heart failure
    M Faadiel Essop
    Eur Heart J 25:1765-8. 2004
  18. ncbi Dynamic changes of gene expression in hypoxia-induced right ventricular hypertrophy
    Saumya Sharma
    Dept of Internal Medicine, Division of Cardiology, Univ of Texas Houston Medical School, 6431 Fannin, MSB 1 246, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 286:H1185-92. 2004
    ..Furthermore, myosin iso-gene and pyruvate dehydrogenase kinase-4 expression is not affected by load, suggesting that either hypoxia itself or neuroendocrine stimulation is the primary regulator of these genes...
  19. ncbi Hypoxia-induced switches of myosin heavy chain iso-gene expression in rat heart
    Peter Razeghi
    Division of Cardiology, Department of Internal Medicine, University of Texas Houston Medical School, 6431 Fannin, MSB 1 246, 77030, USA
    Biochem Biophys Res Commun 303:1024-7. 2003
    ..Hypoxia decreased MHCalpha and increased MHCbeta transcript levels, both in vivo and in vitro. We conclude that hypoxia per se induces a pattern of isoform gene expression associated with early cardiac development...