Robin A Emsley

Summary

Affiliation: University of Stellenbosch
Country: South Africa

Publications

  1. doi request reprint Long-acting injectable risperidone in the treatment of subjects with recent-onset psychosis: a preliminary study
    Robin Emsley
    University of Stellenbosch, Tygerberg, Cape Town, South Africa
    J Clin Psychopharmacol 28:210-3. 2008
  2. doi request reprint Symptom recurrence following intermittent treatment in first-episode schizophrenia successfully treated for 2 years: a 3-year open-label clinical study
    Robin Emsley
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    J Clin Psychiatry 73:e541-7. 2012
  3. pmc Internet addiction, reality substitution and longitudinal changes in psychotic-like experiences in young adults
    Vijay A Mittal
    Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, Colorado 80309, USA
    Early Interv Psychiatry 7:261-9. 2013
  4. doi request reprint Long-acting injectable antipsychotics in early psychosis: a literature review
    Robin Emsley
    Department of Psychiatry, Faculty of Heath Sciences, University of Stellenbosch, Cape Town, South Africa
    Early Interv Psychiatry 7:247-54. 2013
  5. doi request reprint The evidence for illness progression after relapse in schizophrenia
    Robin Emsley
    Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, 7505, Cape Town, South Africa
    Schizophr Res 148:117-21. 2013
  6. pmc The nature of relapse in schizophrenia
    Robin Emsley
    Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, 7505, South Africa
    BMC Psychiatry 13:50. 2013
  7. doi request reprint Comparison of treatment response in second-episode versus first-episode schizophrenia
    Robin Emsley
    Department of Psychiatry, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    J Clin Psychopharmacol 33:80-3. 2013
  8. doi request reprint Treatment response after relapse in a placebo-controlled maintenance trial in schizophrenia
    Robin Emsley
    University of Stellenbosch, Tygerberg 7500, Cape Town, South Africa
    Schizophr Res 138:29-34. 2012
  9. ncbi request reprint The effects of eicosapentaenoic acid in tardive dyskinesia: a randomized, placebo-controlled trial
    Robin Emsley
    Department of Psychiatry, Faculty of Health Sciences, University of Stellenbosch, PO Box 19063, Tygerberg 7505, Cape Town, South Africa
    Schizophr Res 84:112-20. 2006
  10. ncbi request reprint Neurological abnormalities in first-episode schizophrenia: temporal stability and clinical and outcome correlates
    Robin Emsley
    Department of Psychiatry, Faculty of Health Sciences, University of Stellenbosch, P O Box 19063, Tygerberg 7505, Cape Town, South Africa
    Schizophr Res 75:35-44. 2005

Detail Information

Publications44

  1. doi request reprint Long-acting injectable risperidone in the treatment of subjects with recent-onset psychosis: a preliminary study
    Robin Emsley
    University of Stellenbosch, Tygerberg, Cape Town, South Africa
    J Clin Psychopharmacol 28:210-3. 2008
    ..5 mg for 30%, and 50 mg for 16%. This preliminary study suggests that RLAI was overall well tolerated and appears to be effective in recent-onset psychosis. Further investigation is warranted...
  2. doi request reprint Symptom recurrence following intermittent treatment in first-episode schizophrenia successfully treated for 2 years: a 3-year open-label clinical study
    Robin Emsley
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    J Clin Psychiatry 73:e541-7. 2012
    ..We also investigated antecedents of recurrence, as well as demographic and baseline clinical predictors of early recurrence, and we compared the psychopathology of the recurrence episode with that of the first episode...
  3. pmc Internet addiction, reality substitution and longitudinal changes in psychotic-like experiences in young adults
    Vijay A Mittal
    Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, Colorado 80309, USA
    Early Interv Psychiatry 7:261-9. 2013
    ..Because the experience of PLEs is considered a risk "behaviour" for formal psychosis, it is crucial to understand how patterns of Internet use may be tied to the progression of illness...
  4. doi request reprint Long-acting injectable antipsychotics in early psychosis: a literature review
    Robin Emsley
    Department of Psychiatry, Faculty of Heath Sciences, University of Stellenbosch, Cape Town, South Africa
    Early Interv Psychiatry 7:247-54. 2013
    ..There are sound reasons for considering the use of long-acting injectable antipsychotics early in the course of schizophrenia. We reviewed available literature on the subject...
  5. doi request reprint The evidence for illness progression after relapse in schizophrenia
    Robin Emsley
    Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, 7505, Cape Town, South Africa
    Schizophr Res 148:117-21. 2013
    ....
  6. pmc The nature of relapse in schizophrenia
    Robin Emsley
    Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, 7505, South Africa
    BMC Psychiatry 13:50. 2013
    ..Multiple relapses characterise the course of illness in most patients with schizophrenia, yet the nature of these episodes has not been extensively researched and clinicians may not always be aware of important implications...
  7. doi request reprint Comparison of treatment response in second-episode versus first-episode schizophrenia
    Robin Emsley
    Department of Psychiatry, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    J Clin Psychopharmacol 33:80-3. 2013
    ..Most notably, emergent treatment nonresponsiveness was observed in 5 participants (16%), consistent with the hypothesis that relapse may be biologically harmful in a subset of patients...
  8. doi request reprint Treatment response after relapse in a placebo-controlled maintenance trial in schizophrenia
    Robin Emsley
    University of Stellenbosch, Tygerberg 7500, Cape Town, South Africa
    Schizophr Res 138:29-34. 2012
    ..These findings may help inform decisions regarding the future of placebo-controlled trials in schizophrenia...
  9. ncbi request reprint The effects of eicosapentaenoic acid in tardive dyskinesia: a randomized, placebo-controlled trial
    Robin Emsley
    Department of Psychiatry, Faculty of Health Sciences, University of Stellenbosch, PO Box 19063, Tygerberg 7505, Cape Town, South Africa
    Schizophr Res 84:112-20. 2006
    ..The primary objective of the present study was to compare the efficacy of EPA versus placebo in reducing symptoms of TD...
  10. ncbi request reprint Neurological abnormalities in first-episode schizophrenia: temporal stability and clinical and outcome correlates
    Robin Emsley
    Department of Psychiatry, Faculty of Health Sciences, University of Stellenbosch, P O Box 19063, Tygerberg 7505, Cape Town, South Africa
    Schizophr Res 75:35-44. 2005
    ..We also examined their relationships with psychiatric symptoms, medication effects and treatment outcome...
  11. ncbi request reprint The factor structure for the Positive and Negative Syndrome Scale (PANSS) in recent-onset psychosis
    Robin Emsley
    Department of Psychiatry, University of Stellenbosch, P O Box 19063, 7505 Tygerberg, Cape Town, South Africa
    Schizophr Res 61:47-57. 2003
    ..The results of this study partially support the use of a five-factor model for the PANSS, but suggest that scales for catatonia, depressive and anxiety syndromes should be included in future studies...
  12. doi request reprint Subjective awareness of tardive dyskinesia and insight in schizophrenia
    R Emsley
    Department of Psychiatry, Faculty of Health Sciences, University of Stellenbosch, PO Box 19063, Tygerberg 7505, Cape Town, South Africa
    Eur Psychiatry 26:293-6. 2011
    ..Lack of awareness of tardive dyskinesia (TD) and poor insight into mental illness are common in schizophrenia, raising the possibility that these phenomena are manifestations of a common underlying dysfunction...
  13. doi request reprint Drugs in development for the treatment of schizophrenia
    Robin Emsley
    Faculty of Health Sciences, University of Stellenbosch, Department of Psychiatry, PO Box 19063, Tygerberg 7505, Cape Town, South Africa
    Expert Opin Investig Drugs 18:1103-18. 2009
    ..While no exciting breakthroughs appear imminent, several drugs in early development have great potential...
  14. doi request reprint Remission in patients with first-episode schizophrenia receiving assured antipsychotic medication: a study with risperidone long-acting injection
    Robin Emsley
    University of Stellenbosch, Tygerberg, South Africa
    Int Clin Psychopharmacol 23:325-31. 2008
    ..Double-blind-controlled studies using long-acting injectable antipsychotics in early psychosis are warranted to further test this...
  15. doi request reprint Safety of the omega-3 fatty acid, eicosapentaenoic acid (EPA) in psychiatric patients: results from a randomized, placebo-controlled trial
    Robin Emsley
    Department of Psychiatry, University of Stellenbosch Faculty of Health Sciences, Tygerberg, Cape Town, South Africa
    Psychiatry Res 161:284-91. 2008
    ..Total cholesterol and HDL levels were significantly decreased. EPA 2 g/day is generally well tolerated. Clinicians should be aware of possible increases in bleeding time, as well as changes in weight and lipid metabolism...
  16. ncbi request reprint Effects of quetiapine and haloperidol on body mass index and glycaemic control: a long-term, randomized, controlled trial
    Robin Emsley
    Department of Psychiatry, Faculty of Health Sciences, University of Stellenbosch, Cape Town, South Africa
    Int J Neuropsychopharmacol 8:175-82. 2005
    ..The study also highlights the high incidence of unrecognized glucose dysregulation in patients with schizophrenia receiving conventional antipsychotic treatment...
  17. doi request reprint New advances in pharmacotherapy for early psychosis
    Robin Emsley
    Department of Psychiatry, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    Early Interv Psychiatry 3:S8-12. 2009
    ..This review examines the use of antipsychotic medication during the early years of psychosis...
  18. doi request reprint Oral versus injectable antipsychotic treatment in early psychosis: post hoc comparison of two studies
    Robin Emsley
    University of Stellenbosch, Tygerberg, Cape Town, South Africa
    Clin Ther 30:2378-86. 2008
    ..Long-acting injectable antipsychotics-developed specifically to address the problem of adherence-might have an important role to play in treating early psychosis...
  19. doi request reprint The concepts of remission and recovery in schizophrenia
    Robin Emsley
    Department of Psychiatry, University of Stellenbosch, Tygerberg Campus, Cape Town, South Africa
    Curr Opin Psychiatry 24:114-21. 2011
    ..The purpose of this review is to examine recent studies on these topics and to assess whether progress has been made towards a broader definition of remission and recovery...
  20. ncbi request reprint Evidence-based pharmacotherapy of schizophrenia
    Robin Emsley
    Department of Psychiatry, Stellenbosch University, Cape Town, South Africa
    Int J Neuropsychopharmacol 7:219-38. 2004
    ..Finally, specific areas of current clinical interest are dealt with. These are: conventional vs. new-generation antipsychotics, head-to-head comparisons of new-generation antipsychotics, and side-effect profiles...
  21. ncbi request reprint Randomized, placebo-controlled study of ethyl-eicosapentaenoic acid as supplemental treatment in schizophrenia
    Robin Emsley
    Department of Psychiatry, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    Am J Psychiatry 159:1596-8. 2002
    ..The study investigated the efficacy and tolerability of ethyl-eicosapentaenoic acid (E-EPA) as add-on treatment in chronic, severe schizophrenia...
  22. ncbi request reprint Clinical potential of omega-3 fatty acids in the treatment of schizophrenia
    Robin Emsley
    Department of Psychiatry, Faculty of Health Sciences, University of Stellenbosch, Tygerberg 7505, Cape Town, South Africa
    CNS Drugs 17:1081-91. 2003
    ..Taken together, there is considerable evidence to suggest abnormalities of EFAs in cell membranes of patients with schizophrenia, and there is preliminary evidence that EPA is an effective adjunct to antipsychotics...
  23. ncbi request reprint Differential effect of quetiapine on depressive symptoms in patients with partially responsive schizophrenia
    Robin A Emsley
    Department of Psychiatry, Faculty of Medicine, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    J Psychopharmacol 17:210-5. 2003
    ..These findings extend the evidence for an antidepressant effect for the novel antipsychotics in schizophrenia, and suggest that this is not limited to acutely psychotic patients...
  24. ncbi request reprint The new and evolving pharmacotherapy of schizophrenia
    Robin Emsley
    Department of Psychiatry, Room 2004, Clinical Building, Faculty of Health Sciences, Tygerberg, Stellenbosch University, Cape Town, South Africa
    Psychiatr Clin North Am 26:141-63. 2003
    ..Few maintenance RCTs have been published, and efficacy advantages for atypical antipsychotics in prospective RCTs in first-episode schizophrenia have not been reported...
  25. ncbi request reprint Depressive symptoms at baseline predict fewer negative symptoms at follow-up in patients with first-episode schizophrenia
    Piet Oosthuizen
    Department of Psychiatry, University of Stellenbosch, P O Box 19063, Tygerberg, 7505, Cape Town, South Africa
    Schizophr Res 58:247-52. 2002
    ..These findings support previous work suggesting that high baseline depressive scores predict favourable outcome...
  26. ncbi request reprint Measuring anxiety in patients with schizophrenia
    Soraya Seedat
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    J Nerv Ment Dis 195:320-4. 2007
    ..Accurate assessment is challenging yet important. More reliable measures of anxiety disorders in patients with schizophrenia and other psychotic disorders are clearly needed to allow for timely identification and treatment...
  27. ncbi request reprint Incidence of tardive dyskinesia in first-episode psychosis patients treated with low-dose haloperidol
    Piet P Oosthuizen
    Department of Psychiatry, University of Stellenbosch Faculty of Health Sciences, P O Box 19063, Tygerberg 7505, South Africa
    J Clin Psychiatry 64:1075-80. 2003
    ..This study evaluates the 12-month incidence of tardive dyskinesia in subjects with first-episode psychosis who were treated with very low doses of haloperidol...
  28. ncbi request reprint Obsessive compulsive disorder--prevalence in Xhosa-speaking schizophrenia patients
    Dana J H Niehaus
    Department of Psychiatry, Stellenbosch University, Tygerberg, W Cape
    S Afr Med J 95:120-2. 2005
    ..No concordance for OCD was noted in the sibship group. Our findings differ from those in other parts of the world, and if replicated, might suggest unique protective environmental or genetic factors for OCD in certain ethnic groups...
  29. pmc Crisis discharges and readmission risk in acute psychiatric male inpatients
    Dana J H Niehaus
    Department of Psychiatry, University of Stellenbosch, South Africa
    BMC Psychiatry 8:44. 2008
    ..The study examined the effect of this policy and length of hospital stay (LOS) on readmission rates in one psychiatric hospital in South Africa...
  30. ncbi request reprint A case of "ifufunyane": a xhosa culture-bound syndrome
    Dana J H Niehaus
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    J Psychiatr Pract 11:411-3. 2005
  31. ncbi request reprint Chromosome 22q11 in a Xhosa schizophrenia population
    Liezl Koen
    Department of Psychology, Stellenbosch University, South Africa
    S Afr Med J 102:165-6. 2012
    ..Our findings suggest that unique susceptibility loci may be present in this group...
  32. doi request reprint Predictors of abnormal involuntary movement in an african schizophrenia population
    Dana J H Niehaus
    Department of Psychiatry, University of Stellenbosch, PO Box 19090, Tygerberg 7505, South Africa
    J Neuropsychiatry Clin Neurosci 20:317-26. 2008
    ....
  33. ncbi request reprint Posttraumatic stress disorder and occupational disability in South African Security Force members
    Robin A Emsley
    Department of Psychiatry and Medical Research Council Unit for Anxiety and Stress Disorders, University of Stellenbosch, PO Box 19063, Tygerberg 7505, Cape Town, South Africa
    J Nerv Ment Dis 191:237-41. 2003
    ..These findings suggest that posttrauma factors may be as important as pretrauma and peritrauma variables in the development of PTSD...
  34. ncbi request reprint Ethnicity and treatment response in schizophrenia: a comparison of 3 ethnic groups
    Robin A Emsley
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    J Clin Psychiatry 63:9-14. 2002
    ..Numerous cultural and ethnic factors may directly and indirectly influence treatment outcome in schizophrenia. The present study compared the response to antipsychotic treatment in 3 ethnic groups of patients with schizophrenia...
  35. ncbi request reprint Negative symptoms and HIV/AIDS risk-behavior knowledge in schizophrenia
    Liezl Koen
    Ngaphakathi Workgroup, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Psychosomatics 48:128-34. 2007
    ..Findings support the notion that existing educational programs should be adapted to target specific areas of deficit...
  36. ncbi request reprint Linking posttraumatic stress disorder and psychosis: a look at epidemiology, phenomenology, and treatment
    Soraya Seedat
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    J Nerv Ment Dis 191:675-81. 2003
    ..Future neurobiological and treatment studies may be useful in better informing the clinical management of these subgroups...
  37. ncbi request reprint Season of birth, age and negative symptoms in a Xhosa schizophrenia sample from the Southern Hemisphere
    Esme Jordaan
    MRC Biostatistics Unit, Bellville 7500, South Africa
    Aust N Z J Psychiatry 40:698-703. 2006
    ..The secondary aim was to determine whether the autumn/winter and spring/summer birth rates for schizophrenia patients of Xhosa ethnicity were similar to that of the general Xhosa population...
  38. doi request reprint Whole-genome resequencing in pharmacogenomics: moving away from past disparities to globally representative applications
    Britt I Drögemöller
    Department of Genetics, Stellenbosch University, Private Bag XI, Matieland 7602, South Africa
    Pharmacogenomics 12:1717-28. 2011
    ..Therefore, as sequencing technologies develop and decrease in cost, the ability to reliably detect variation will improve and these technologies will begin to replace other less comprehensive genotyping assays...
  39. ncbi request reprint Anxiety disorders and schizophrenia
    Jacqueline E Muller
    Medical Research Council Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, PO Box 19063, Tygerberg, Cape Town 7505, South Africa
    Curr Psychiatry Rep 6:255-61. 2004
    ..In the interim, however, the data emphasize the importance of assessing and treating comorbid anxiety symptoms and disorders in schizophrenia...
  40. ncbi request reprint Comparison of response to a selective serotonin reuptake inhibitor in children, adolescents, and adults with posttraumatic stress disorder
    Soraya Seedat
    Department of Psychiatry, MRC Unit on Anxiety and Stress Disorders, Tygerberg, Cape Town, South Africa
    J Child Adolesc Psychopharmacol 12:37-46. 2002
    ....
  41. ncbi request reprint Prevalence of obsessive compulsive disorder in first- and multi-episode male patients with schizophrenia-spectrum disorders
    Liezl Koen
    S Afr Med J 93:517-8. 2003
  42. ncbi request reprint Efficacy and tolerability of quetiapine in poorly responsive, chronic schizophrenia
    Peter F Buckley
    Department of Psychiatry and Health Behavior Medical College of Georgia, 1515 Pope Avenue, Augusta, GA 30912, USA
    Schizophr Res 66:143-50. 2004
    ..Weight gain was modest but more apparent in quetiapine-treated patients. Quetiapine is an appropriate treatment choice in patients who do not respond to prior antipsychotic treatment...
  43. ncbi request reprint Violence in the world and in South Africa--what is a doctor to do?
    Dan J Stein
    S Afr Med J 92:789-90. 2002
  44. ncbi request reprint A 12-week, double-blind comparison of olanzapine vs haloperidol in the treatment of acute mania
    Mauricio Tohen
    Lilly Research Laboratories, Indianapolis, Ind 46225, USA
    Arch Gen Psychiatry 60:1218-26. 2003
    ..This randomized controlled trial compares the efficacy and safety of olanzapine vs haloperidol, as well as the quality of life of patients taking these drugs, in patients with bipolar mania...