Research Topics
| K DhedaSummaryAffiliation: University of Cape Town Country: South Africa Publications
| Collaborators
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Detail Information
Publications
A historical review of XDR tuberculosis in the Western Cape province of South AfricaGregory Symons
Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town
S Afr Med J 101:636-8. 2011..8 months. XDR-TB has therefore been present in the Western Cape at least since 1992. These data inform public health policy relevant to the introduction of new anti-TB drug regimens...
Point-of-care diagnosis of tuberculosis: past, present and futureKeertan Dheda
Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
Respirology 18:217-32. 2013..We also discuss future applications, including the potential POC diagnosis of drug-resistant TB and presumed latent TB infection. Challenges to the development and roll-out of POC tests for TB are also reviewed...- Do adjunct tuberculosis tests, when combined with Xpert MTB/RIF, improve accuracy and the cost of diagnosis in a resource-poor setting?Grant Theron
Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Dept of Medicine, University of Cape Town, Cape Town, South Africa
Eur Respir J 40:161-8. 2012..In MTB/RIF-negative individuals, CXR has poor rule-in value but can reliably rule out TB in approximately one in four cases. These data inform upon the programmatic utility of MTB/RIF in high-burden settings... 
Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosisKerryn Matthews
Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa
Tuberculosis (Edinb) 91:587-93. 2011..We propose that our findings support a role for IL-22 in TB-induced pathology or the resulting repair process...- Different screening strategies (single or dual) for the diagnosis of suspected latent tuberculosis: a cost effectiveness analysisAnil Pooran
Division of Infection and Immunity, Centre for Infectious Diseases and International Health, University College London Medical School, University College London, 43 Cleveland Street, London W1T 4JF, UK
BMC Pulm Med 10:7. 2010..tb... - Extensively drug-resistant tuberculosis: epidemiology and management challengesKeertan Dheda
Lung Infection and Immunity Unit, Division of Pulmonology and Clinical Immunology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
Infect Dis Clin North Am 24:705-25. 2010..Given the past global trends in MDR-TB, if aggressive preventive and management strategies are not implemented, XDR-TB has the potential to severely cripple global control efforts of TB... - Early treatment outcomes and HIV status of patients with extensively drug-resistant tuberculosis in South Africa: a retrospective cohort studyKeertan Dheda
Lung Infection and Immunity Unit, Division of Pulmonology and University of Cape Town Lung Institute, Department of Medicine, Cape Town, South Africa
Lancet 375:1798-807. 2010.... - The immunology of tuberculosis: from bench to bedsideKeertan Dheda
Division of Pulmonology and Clinical Immunology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
Respirology 15:433-50. 2010..An immunologically orientated approach to tackling TB can only succeed with concurrent efforts to alleviate poverty and reduce the global burden of HIV... - Clinical utility of a commercial LAM-ELISA assay for TB diagnosis in HIV-infected patients using urine and sputum samplesKeertan Dheda
Lung Infection and Immunity Unit, Department of Medicine, Division of Pulmonology and Clinical Immunology, UCT Lung Institute, University of Cape Town, Cape Town, South Africa
PLoS ONE 5:e9848. 2010..The utility of LAM in sputum samples has, hitherto, not been evaluated... - Utility of a novel lipoarabinomannan assay for the diagnosis of tuberculous meningitis in a resource-poor high-HIV prevalence settingVinod B Patel
Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, South Africa
Cerebrospinal Fluid Res 6:13. 2009..Current diagnostic tools for TBM perform sub-optimally. In particular, the rapid diagnosis of TBM is challenging because smear microscopy has a low yield and PCR is not widely available in resource-poor settings... - Quantitative lung T cell responses aid the rapid diagnosis of pulmonary tuberculosisK Dheda
Lung Infection and Immunity Unit and CTBRI, UCT Lung Institute and Division of Pulmonology, Department of Medicine, University of Cape Town, South Africa
Thorax 64:847-53. 2009..The diagnosis of smear-negative pulmonary tuberculosis (TB) is problematic. There are limited data on the profile of alveolar TB antigen-specific T cells, and their utility for the rapid immunodiagnosis of pulmonary TB is unclear... - Interpretation of Mycobacterium tuberculosis antigen-specific IFN-gamma release assays (T-SPOT.TB) and factors that may modulate test resultsK Dheda
Division of Pulmonology, Department of Medicine, University of Cape Town, South Africa
J Infect 55:169-73. 2007..Thus, the utility of IGRAs as a surrogate marker of mycobacterial burden remain unclear... - Clinical diagnostic utility of IP-10 and LAM antigen levels for the diagnosis of tuberculous pleural effusions in a high burden settingKeertan Dheda
Lung Infection and Immunity Unit and CTBRI, UCT Lung Institute and Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa
PLoS ONE 4:e4689. 2009..Detection of LAM antigen has not previously been evaluated in pleural fluid... - Utility of quantitative T-cell responses versus unstimulated interferon-{gamma} for the diagnosis of pleural tuberculosisK Dheda
Lung Infection and Immunity Unit, Division of Pulmonology, Dept of Medicine, University of Cape Town, J flr, Old Main Bldg, Groote Schuur Hospital, Observatory, Cape Town 7925, South Africa
Eur Respir J 34:1118-26. 2009..The antigen-specific T-cell IGRAs were limited by suboptimal accuracy and the inability to isolate sufficient mononuclear cells to perform the assay... - T-cell interferon-gamma release assays for the rapid immunodiagnosis of tuberculosis: clinical utility in high-burden vs. low-burden settingsKeertan Dheda
Division of Pulmonology and Clinical Immunology, Department of Medicine, University of Cape Town Lung Institute, University of Cape Town, Cape Town, South Africa
Curr Opin Pulm Med 15:188-200. 2009..low TB burden settings. Here we review the evidence supporting the utility of IGRAs in specific subgroups and compare their performance in high-burden vs. low-burden settings... - Diagnostic accuracy of induced sputum LAM ELISA for tuberculosis diagnosis in sputum-scarce patientsJ G Peter
Lung Infection and Immunity Unit, Division of Pulmonology, University of Cape Town Lung Institute and Clinical Immunology, Department of Medicine, University of Cape Town, Cape Town, South Africa
Int J Tuberc Lung Dis 16:1108-12. 2012.... - Comparison of same day versus delayed enumeration of TB-specific T cell responsesL M Lenders
Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, University of Cape Town, Department of Medicine, H Floor, Old Main Building, Groote Schuur Hospital, Observatory, Cape Town 7925, South Africa
J Infect 60:344-50. 2010..TB). We investigated whether delayed sample processing with and without the use of T-Cell Xtend, a proprietary reagent, impacted upon test accuracy... - Comparative cost and performance of light-emitting diode microscopy in HIV-tuberculosis-co-infected patientsA Whitelaw
Division of Medical Microbiology, UCT Lung Institute, University of Cape Town, Cape Town, South Africa
Eur Respir J 38:1393-7. 2011..63) compared with ZN microscopy (US$2.10). Among HIV-TB-co-infected patients, LED microscopy was cheaper and performed as well as ZN microscopy or MVFM independent of the staining (ZN or auramine O) or processing methods used... - Adverse events to antituberculosis therapy: influence of HIV and antiretroviral drugsD J B Marks
Centre for Molecular Medicine, University College London, London, UK
Int J STD AIDS 20:339-45. 2009..008). The treatment completion did not differ significantly between the two groups (76.6% and 84.2%, P = 0.08)... - Multiple drug hypersensitivity reactions to anti-tuberculosis drugs: five cases in HIV-infected patientsR J Lehloenya
Division of Dermatology, Department of Medicine, University of Cape Town, Cape Town, South Africa
Int J Tuberc Lung Dis 16:1260-4. 2012..The occurrence of hypersensitivity reactions to both the first-line and cover drugs poses a therapeutic dilemma and makes it difficult to identify the offending drug(s)... - Are interferon-γ release assays useful for diagnosing active tuberculosis in a high-burden setting?D I Ling
Dept of Medicine, Groote Schuur Hospital, Observatory, Cape Town, South Africa
Eur Respir J 38:649-56. 2011..In a high-burden setting, IGRAs alone do not have value as rule-in or -out tests for active TB. In smear-negative patients, chest radiography had better NPV even in HIV-infected patients... - High prevalence of smoking among patients with suspected tuberculosis in South AfricaL Brunet
Dept of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada
Eur Respir J 38:139-46. 2011..Self-reporting is an accurate measure of smoking status. These results suggest the need to actively incorporate tobacco cessation programmes into TB services in South Africa... - Tuberculosis research updateW A Hanekom
South African Tuberculosis Vaccine Initiative, University of Cape Town, Cape Town, South Africa
Trop Med Int Health 15:981-9. 2010..In this brief review, we provide a focused update on these four key areas of TB research... - Outcomes of reintroducing anti-tuberculosis drugs following cutaneous adverse drug reactionsR J Lehloenya
Division of Dermatology, Department of Medicine, University of Cape Town, Cape Town, South Africa
Int J Tuberc Lung Dis 15:1649-57. 2011..Data regarding outcomes of tuberculosis (TB) associated cutaneous adverse drug reactions (CADR) are limited. The re-introduction of first-line anti-tuberculosis drugs after CADR is controversial and management poorly defined... - Global lung health: the colliding epidemics of tuberculosis, tobacco smoking, HIV and COPDR N van Zyl Smit
Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Dept of Medicine, University of Cape Town, Cape Town, South Africa
Eur Respir J 35:27-33. 2010..These interactions deserve urgent attention and have major implications for coordinated public health planning and policy recommendations in the developing world... - The implications of using an inappropriate reference gene for real-time reverse transcription PCR data normalizationK Dheda
Centre for Infectious Diseases and International Health, Royal Free and University College Medical School, and Department of Thoracic and HIV Medicine, Royal Free Hospital, London NW3 2QG, UK
Anal Biochem 344:141-3. 2005 - Comparative utility of cytokine levels and quantitative RD-1-specific T cell responses for rapid immunodiagnosis of tuberculous meningitisVinod B Patel
Department of Neurology, University of KwaZulu Natal, Mayville, Durban, South Africa
J Clin Microbiol 49:3971-6. 2011..These preliminary findings will need to be confirmed in further studies... - Evaluation of the Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis in a high HIV prevalence settingGrant Theron
Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
Am J Respir Crit Care Med 184:132-40. 2011..Xpert MTB/RIF is a novel automated molecular diagnostic recently endorsed by the World Health Organization. However, performance-related data from high HIV prevalence settings are limited... - Gene expression of IL17 and IL23 in the lungs of patients with active tuberculosisK Dheda
Thorax 63:566-8. 2008 - Smoking and tuberculosis: the epidemiological association and immunopathogenesisP D O Davies
Tuberculosis Research and Resources Unit, Cardiothoracic Centre, Thomas Drive, Liverpool L14 3PE, UK
Trans R Soc Trop Med Hyg 100:291-8. 2006....