K Dheda

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. ncbi request reprint A historical review of XDR tuberculosis in the Western Cape province of South Africa
    Gregory Symons
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town
    S Afr Med J 101:636-8. 2011
  2. ncbi request reprint Global control of tuberculosis: from extensively drug-resistant to untreatable tuberculosis
    Keertan Dheda
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa Electronic address
    Lancet Respir Med 2:321-38. 2014
  3. pmc Correlation of mycobacterium tuberculosis specific and non-specific quantitative Th1 T-cell responses with bacillary load in a high burden setting
    Grant Theron
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 7:e37436. 2012
  4. pmc Drug-associated adverse events and their relationship with outcomes in patients receiving treatment for extensively drug-resistant tuberculosis in South Africa
    Karen Shean
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 8:e63057. 2013
  5. pmc Can point-of-care urine LAM strip testing for tuberculosis add value to clinical decision making in hospitalised HIV-infected persons?
    Jonathan G Peter
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 8:e54875. 2013
  6. pmc What is the cost of diagnosis and management of drug resistant tuberculosis in South Africa?
    Anil Pooran
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 8:e54587. 2013
  7. pmc The diagnostic accuracy of urine-based Xpert MTB/RIF in HIV-infected hospitalized patients who are smear-negative or sputum scarce
    Jonathan G Peter
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 7:e39966. 2012
  8. pmc Comparison of quantitative techniques including Xpert MTB/RIF to evaluate mycobacterial burden
    Richard N van Zyl-Smit
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 6:e28815. 2011
  9. pmc Comparison of a clinical prediction rule and a LAM antigen-detection assay for the rapid diagnosis of TBM in a high HIV prevalence setting
    Vinod B Patel
    Department of Neurology, University of KwaZulu Natal, Berea, South Africa
    PLoS ONE 5:e15664. 2010
  10. pmc Feasibility and diagnostic utility of antigen-specific interferon-gamma responses for rapid immunodiagnosis of tuberculosis using induced sputum
    Tamaryn J Cashmore
    Lung Infection and Immunity Unit, Division of Pulmonology, UCT Lung Institute and Clinical Immunology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 5:e10389. 2010

Collaborators

Detail Information

Publications41

  1. ncbi request reprint A historical review of XDR tuberculosis in the Western Cape province of South Africa
    Gregory Symons
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town
    S Afr Med J 101:636-8. 2011
    ..8 months. XDR-TB has therefore been present in the Western Cape at least since 1992. These data inform public health policy relevant to the introduction of new anti-TB drug regimens...
  2. ncbi request reprint Global control of tuberculosis: from extensively drug-resistant to untreatable tuberculosis
    Keertan Dheda
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa Electronic address
    Lancet Respir Med 2:321-38. 2014
    ....
  3. pmc Correlation of mycobacterium tuberculosis specific and non-specific quantitative Th1 T-cell responses with bacillary load in a high burden setting
    Grant Theron
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 7:e37436. 2012
    ....
  4. pmc Drug-associated adverse events and their relationship with outcomes in patients receiving treatment for extensively drug-resistant tuberculosis in South Africa
    Karen Shean
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 8:e63057. 2013
    ..However, data about the type, frequency and severity of presumed drug-associated adverse events (AEs) and their association with treatment-related outcomes in patients with XDR-TB are scarce...
  5. pmc Can point-of-care urine LAM strip testing for tuberculosis add value to clinical decision making in hospitalised HIV-infected persons?
    Jonathan G Peter
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 8:e54875. 2013
    ....
  6. pmc What is the cost of diagnosis and management of drug resistant tuberculosis in South Africa?
    Anil Pooran
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 8:e54587. 2013
    ....
  7. pmc The diagnostic accuracy of urine-based Xpert MTB/RIF in HIV-infected hospitalized patients who are smear-negative or sputum scarce
    Jonathan G Peter
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 7:e39966. 2012
    ..We investigated the sensitivity of urine-based methods (Xpert MTB/RIF, LAM strip test and LAM ELISA) in such patients...
  8. pmc Comparison of quantitative techniques including Xpert MTB/RIF to evaluate mycobacterial burden
    Richard N van Zyl-Smit
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 6:e28815. 2011
    ..We hypothesized that newer techniques would perform as well as solid media culture to quantify mycobacterial burden in laboratory specimens...
  9. pmc Comparison of a clinical prediction rule and a LAM antigen-detection assay for the rapid diagnosis of TBM in a high HIV prevalence setting
    Vinod B Patel
    Department of Neurology, University of KwaZulu Natal, Berea, South Africa
    PLoS ONE 5:e15664. 2010
    ....
  10. pmc Feasibility and diagnostic utility of antigen-specific interferon-gamma responses for rapid immunodiagnosis of tuberculosis using induced sputum
    Tamaryn J Cashmore
    Lung Infection and Immunity Unit, Division of Pulmonology, UCT Lung Institute and Clinical Immunology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 5:e10389. 2010
    ..tuberculosis infection. The feasibility and diagnostic utility of this rapid immunodiagnostic assay, using cells from induced sputum, is unknown...
  11. pmc ICU-associated Acinetobacter baumannii colonisation/infection in a high HIV-prevalence resource-poor setting
    Ntobeko B A Ntusi
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    PLoS ONE 7:e52452. 2012
    ..There are hardly any data about the incidence, risk factors and outcomes of ICU-associated A.baumannii colonisation/infection in HIV-infected and uninfected persons from resource-poor settings like Africa...
  12. ncbi request reprint Comparison of same day diagnostic tools including Gene Xpert and unstimulated IFN-γ for the evaluation of pleural tuberculosis: a prospective cohort study
    Richard Meldau
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
    BMC Pulm Med 14:58. 2014
    ..The accuracy of currently available same-day diagnostic tools (smear microscopy and conventional nucleic acid amplification tests) for pleural tuberculosis (TB) is sub-optimal. Newer technologies may offer improved detection...
  13. doi request reprint Point-of-care diagnosis of tuberculosis: past, present and future
    Keertan Dheda
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Respirology 18:217-32. 2013
    ..We also discuss future applications, including the potential POC diagnosis of drug-resistant TB and presumed latent TB infection. Challenges to the development and roll-out of POC tests for TB are also reviewed...
  14. doi request reprint Do adjunct tuberculosis tests, when combined with Xpert MTB/RIF, improve accuracy and the cost of diagnosis in a resource-poor setting?
    Grant Theron
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Dept of Medicine, University of Cape Town, Cape Town, South Africa
    Eur Respir J 40:161-8. 2012
    ..In MTB/RIF-negative individuals, CXR has poor rule-in value but can reliably rule out TB in approximately one in four cases. These data inform upon the programmatic utility of MTB/RIF in high-burden settings...
  15. pmc Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosis
    Kerryn Matthews
    Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa
    Tuberculosis (Edinb) 91:587-93. 2011
    ..We propose that our findings support a role for IL-22 in TB-induced pathology or the resulting repair process...
  16. pmc Different screening strategies (single or dual) for the diagnosis of suspected latent tuberculosis: a cost effectiveness analysis
    Anil Pooran
    Division of Infection and Immunity, Centre for Infectious Diseases and International Health, University College London Medical School, University College London, 43 Cleveland Street, London W1T 4JF, UK
    BMC Pulm Med 10:7. 2010
    ..tb...
  17. pmc Utility of a novel lipoarabinomannan assay for the diagnosis of tuberculous meningitis in a resource-poor high-HIV prevalence setting
    Vinod B Patel
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, South Africa
    Cerebrospinal Fluid Res 6:13. 2009
    ..Current diagnostic tools for TBM perform sub-optimally. In particular, the rapid diagnosis of TBM is challenging because smear microscopy has a low yield and PCR is not widely available in resource-poor settings...
  18. ncbi request reprint Utility of quantitative T-cell responses versus unstimulated interferon-{gamma} for the diagnosis of pleural tuberculosis
    K Dheda
    Lung Infection and Immunity Unit, Division of Pulmonology, Dept of Medicine, University of Cape Town, J flr, Old Main Bldg, Groote Schuur Hospital, Observatory, Cape Town 7925, South Africa
    Eur Respir J 34:1118-26. 2009
    ..The antigen-specific T-cell IGRAs were limited by suboptimal accuracy and the inability to isolate sufficient mononuclear cells to perform the assay...
  19. pmc Clinical diagnostic utility of IP-10 and LAM antigen levels for the diagnosis of tuberculous pleural effusions in a high burden setting
    Keertan Dheda
    Lung Infection and Immunity Unit and CTBRI, UCT Lung Institute and Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 4:e4689. 2009
    ..Detection of LAM antigen has not previously been evaluated in pleural fluid...
  20. ncbi request reprint Interpretation of Mycobacterium tuberculosis antigen-specific IFN-gamma release assays (T-SPOT.TB) and factors that may modulate test results
    K Dheda
    Division of Pulmonology, Department of Medicine, University of Cape Town, South Africa
    J Infect 55:169-73. 2007
    ..Thus, the utility of IGRAs as a surrogate marker of mycobacterial burden remain unclear...
  21. doi request reprint T-cell interferon-gamma release assays for the rapid immunodiagnosis of tuberculosis: clinical utility in high-burden vs. low-burden settings
    Keertan Dheda
    Division of Pulmonology and Clinical Immunology, Department of Medicine, University of Cape Town Lung Institute, University of Cape Town, Cape Town, South Africa
    Curr Opin Pulm Med 15:188-200. 2009
    ..low TB burden settings. Here we review the evidence supporting the utility of IGRAs in specific subgroups and compare their performance in high-burden vs. low-burden settings...
  22. doi request reprint Quantitative lung T cell responses aid the rapid diagnosis of pulmonary tuberculosis
    K Dheda
    Lung Infection and Immunity Unit and CTBRI, UCT Lung Institute and Division of Pulmonology, Department of Medicine, University of Cape Town, South Africa
    Thorax 64:847-53. 2009
    ..The diagnosis of smear-negative pulmonary tuberculosis (TB) is problematic. There are limited data on the profile of alveolar TB antigen-specific T cells, and their utility for the rapid immunodiagnosis of pulmonary TB is unclear...
  23. ncbi request reprint Early treatment outcomes and HIV status of patients with extensively drug-resistant tuberculosis in South Africa: a retrospective cohort study
    Keertan Dheda
    Lung Infection and Immunity Unit, Division of Pulmonology and University of Cape Town Lung Institute, Department of Medicine, Cape Town, South Africa
    Lancet 375:1798-807. 2010
    ....
  24. doi request reprint The immunology of tuberculosis: from bench to bedside
    Keertan Dheda
    Division of Pulmonology and Clinical Immunology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Respirology 15:433-50. 2010
    ..An immunologically orientated approach to tackling TB can only succeed with concurrent efforts to alleviate poverty and reduce the global burden of HIV...
  25. pmc Clinical utility of a commercial LAM-ELISA assay for TB diagnosis in HIV-infected patients using urine and sputum samples
    Keertan Dheda
    Lung Infection and Immunity Unit, Department of Medicine, Division of Pulmonology and Clinical Immunology, UCT Lung Institute, University of Cape Town, Cape Town, South Africa
    PLoS ONE 5:e9848. 2010
    ..The utility of LAM in sputum samples has, hitherto, not been evaluated...
  26. doi request reprint Extensively drug-resistant tuberculosis: epidemiology and management challenges
    Keertan Dheda
    Lung Infection and Immunity Unit, Division of Pulmonology and Clinical Immunology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Infect Dis Clin North Am 24:705-25. 2010
    ..Given the past global trends in MDR-TB, if aggressive preventive and management strategies are not implemented, XDR-TB has the potential to severely cripple global control efforts of TB...
  27. doi request reprint Diagnostic accuracy of induced sputum LAM ELISA for tuberculosis diagnosis in sputum-scarce patients
    J G Peter
    Lung Infection and Immunity Unit, Division of Pulmonology, University of Cape Town Lung Institute and Clinical Immunology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Int J Tuberc Lung Dis 16:1108-12. 2012
    ....
  28. doi request reprint Comparison of same day versus delayed enumeration of TB-specific T cell responses
    L M Lenders
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, University of Cape Town, Department of Medicine, H Floor, Old Main Building, Groote Schuur Hospital, Observatory, Cape Town 7925, South Africa
    J Infect 60:344-50. 2010
    ..TB). We investigated whether delayed sample processing with and without the use of T-Cell Xtend, a proprietary reagent, impacted upon test accuracy...
  29. doi request reprint Comparative cost and performance of light-emitting diode microscopy in HIV-tuberculosis-co-infected patients
    A Whitelaw
    Division of Medical Microbiology, UCT Lung Institute, University of Cape Town, Cape Town, South Africa
    Eur Respir J 38:1393-7. 2011
    ..63) compared with ZN microscopy (US$2.10). Among HIV-TB-co-infected patients, LED microscopy was cheaper and performed as well as ZN microscopy or MVFM independent of the staining (ZN or auramine O) or processing methods used...
  30. doi request reprint Adverse events to antituberculosis therapy: influence of HIV and antiretroviral drugs
    D J B Marks
    Centre for Molecular Medicine, University College London, London, UK
    Int J STD AIDS 20:339-45. 2009
    ..008). The treatment completion did not differ significantly between the two groups (76.6% and 84.2%, P = 0.08)...
  31. doi request reprint Multiple drug hypersensitivity reactions to anti-tuberculosis drugs: five cases in HIV-infected patients
    R J Lehloenya
    Division of Dermatology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Int J Tuberc Lung Dis 16:1260-4. 2012
    ..The occurrence of hypersensitivity reactions to both the first-line and cover drugs poses a therapeutic dilemma and makes it difficult to identify the offending drug(s)...
  32. doi request reprint Outcomes of reintroducing anti-tuberculosis drugs following cutaneous adverse drug reactions
    R J Lehloenya
    Division of Dermatology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Int J Tuberc Lung Dis 15:1649-57. 2011
    ..Data regarding outcomes of tuberculosis (TB) associated cutaneous adverse drug reactions (CADR) are limited. The re-introduction of first-line anti-tuberculosis drugs after CADR is controversial and management poorly defined...
  33. doi request reprint Are interferon-γ release assays useful for diagnosing active tuberculosis in a high-burden setting?
    D I Ling
    Dept of Medicine, Groote Schuur Hospital, Observatory, Cape Town, South Africa
    Eur Respir J 38:649-56. 2011
    ..In a high-burden setting, IGRAs alone do not have value as rule-in or -out tests for active TB. In smear-negative patients, chest radiography had better NPV even in HIV-infected patients...
  34. doi request reprint High prevalence of smoking among patients with suspected tuberculosis in South Africa
    L Brunet
    Dept of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada
    Eur Respir J 38:139-46. 2011
    ..Self-reporting is an accurate measure of smoking status. These results suggest the need to actively incorporate tobacco cessation programmes into TB services in South Africa...
  35. ncbi request reprint Tuberculosis research update
    W A Hanekom
    South African Tuberculosis Vaccine Initiative, University of Cape Town, Cape Town, South Africa
    Trop Med Int Health 15:981-9. 2010
    ..In this brief review, we provide a focused update on these four key areas of TB research...
  36. doi request reprint Global lung health: the colliding epidemics of tuberculosis, tobacco smoking, HIV and COPD
    R N van Zyl Smit
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Dept of Medicine, University of Cape Town, Cape Town, South Africa
    Eur Respir J 35:27-33. 2010
    ..These interactions deserve urgent attention and have major implications for coordinated public health planning and policy recommendations in the developing world...
  37. ncbi request reprint The implications of using an inappropriate reference gene for real-time reverse transcription PCR data normalization
    K Dheda
    Centre for Infectious Diseases and International Health, Royal Free and University College Medical School, and Department of Thoracic and HIV Medicine, Royal Free Hospital, London NW3 2QG, UK
    Anal Biochem 344:141-3. 2005
  38. pmc Comparative utility of cytokine levels and quantitative RD-1-specific T cell responses for rapid immunodiagnosis of tuberculous meningitis
    Vinod B Patel
    Department of Neurology, University of KwaZulu Natal, Mayville, Durban, South Africa
    J Clin Microbiol 49:3971-6. 2011
    ..These preliminary findings will need to be confirmed in further studies...
  39. doi request reprint Evaluation of the Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis in a high HIV prevalence setting
    Grant Theron
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Am J Respir Crit Care Med 184:132-40. 2011
    ..Xpert MTB/RIF is a novel automated molecular diagnostic recently endorsed by the World Health Organization. However, performance-related data from high HIV prevalence settings are limited...
  40. doi request reprint Gene expression of IL17 and IL23 in the lungs of patients with active tuberculosis
    K Dheda
    Thorax 63:566-8. 2008
  41. ncbi request reprint Smoking and tuberculosis: the epidemiological association and immunopathogenesis
    P D O Davies
    Tuberculosis Research and Resources Unit, Cardiothoracic Centre, Thomas Drive, Liverpool L14 3PE, UK
    Trans R Soc Trop Med Hyg 100:291-8. 2006
    ....