Lynnette Denny

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. ncbi Intravaginal practices, HIV and other sexually transmitted diseases among South African women
    Landon Myer
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    Sex Transm Dis 31:174-9. 2004
  2. ncbi Cervical cancer prevention - a paradigm shift?
    Lynnette Denny
    University of Cape Town, Groote Schuur Hospital, H 45, Old Main Building, Observatory 7925, South Africa
    Gynecol Oncol 99:S12. 2005
  3. pmc More men than women make mucosal IgA antibodies to Human papillomavirus type 16 (HPV-16) and HPV-18: a study of oral HPV and oral HPV antibodies in a normal healthy population
    Dianne J Marais
    Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, 7925, Cape Town, South Africa
    BMC Infect Dis 6:95. 2006
  4. pmc HIV and pre-neoplastic and neoplastic lesions of the cervix in South Africa: a case-control study
    Jennifer R Moodley
    School of Public Health and Family Medicine, Women s Health Research Unit, University of Cape Town, 7925, South Africa
    BMC Cancer 6:135. 2006
  5. ncbi Cervical cancer: the South African perspective. FIGO 26th Annual Report on the Results of Treatment in Gynecological Cancer
    L Denny
    Groote Schuur Hospital, Dept of Gynaecological Oncology, H 45 OMB, Observatory, 7925 Cape Town, South Africa
    Int J Gynaecol Obstet 95:S211-4. 2006
  6. doi Human papillomavirus infection and cervical disease in human immunodeficiency virus-1-infected women
    Lynette Denny
    Department Obstetrics and Gynaecology, University of Cape Town, Groote Schuur Hospital, Cape Town, South Africa
    Obstet Gynecol 111:1380-7. 2008
  7. ncbi Chapter 8: Screening for cervical cancer in developing countries
    Lynette Denny
    Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa
    Vaccine 24:S3/71-7. 2006
  8. ncbi Management of cervical disease in HIV-infected women
    Lynette Denny
    University of Cape Town, South Africa
    Gynecol Oncol 99:S14-5. 2005
  9. ncbi Human papillomavirus testing and screening
    L A Denny
    Department of Obstetrics and Gynaecology, University of Cape Town, H45, Old Main Building, Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa
    Best Pract Res Clin Obstet Gynaecol 19:501-15. 2005
  10. ncbi Cervicovaginal, oral, and serum IgG and IgA responses to human papillomavirus type 16 in women with cervical intraepithelial neoplasia
    Jo Ann S Passmore
    Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Med Virol 79:1375-80. 2007

Collaborators

Detail Information

Publications32

  1. ncbi Intravaginal practices, HIV and other sexually transmitted diseases among South African women
    Landon Myer
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    Sex Transm Dis 31:174-9. 2004
    ..However, data on the prevalence of these practices, and associations with HIV and other sexually transmitted diseases (STD), are limited...
  2. ncbi Cervical cancer prevention - a paradigm shift?
    Lynnette Denny
    University of Cape Town, Groote Schuur Hospital, H 45, Old Main Building, Observatory 7925, South Africa
    Gynecol Oncol 99:S12. 2005
  3. pmc More men than women make mucosal IgA antibodies to Human papillomavirus type 16 (HPV-16) and HPV-18: a study of oral HPV and oral HPV antibodies in a normal healthy population
    Dianne J Marais
    Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, 7925, Cape Town, South Africa
    BMC Infect Dis 6:95. 2006
    ..The present study aimed to further evaluate the effectiveness of oral fluid testing for detecting the mucosal humoral response to HPV infection and to advance our limited understanding of the immune response to HPV...
  4. pmc HIV and pre-neoplastic and neoplastic lesions of the cervix in South Africa: a case-control study
    Jennifer R Moodley
    School of Public Health and Family Medicine, Women s Health Research Unit, University of Cape Town, 7925, South Africa
    BMC Cancer 6:135. 2006
    ..The aim of this study was to determine the risk of cervical pre-cancer and cancer among HIV positive women in South Africa...
  5. ncbi Cervical cancer: the South African perspective. FIGO 26th Annual Report on the Results of Treatment in Gynecological Cancer
    L Denny
    Groote Schuur Hospital, Dept of Gynaecological Oncology, H 45 OMB, Observatory, 7925 Cape Town, South Africa
    Int J Gynaecol Obstet 95:S211-4. 2006
  6. doi Human papillomavirus infection and cervical disease in human immunodeficiency virus-1-infected women
    Lynette Denny
    Department Obstetrics and Gynaecology, University of Cape Town, Groote Schuur Hospital, Cape Town, South Africa
    Obstet Gynecol 111:1380-7. 2008
    ..To report on the natural history of high-risk human papillomavirus (HPV) infection and cervical disease in human immunodeficiency virus (HIV)-1-infected women living in Cape Town, South Africa...
  7. ncbi Chapter 8: Screening for cervical cancer in developing countries
    Lynette Denny
    Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa
    Vaccine 24:S3/71-7. 2006
    ..Country-specific solutions need to be found, while being cognizant of the criteria that have enabled successful screening programmes...
  8. ncbi Management of cervical disease in HIV-infected women
    Lynette Denny
    University of Cape Town, South Africa
    Gynecol Oncol 99:S14-5. 2005
  9. ncbi Human papillomavirus testing and screening
    L A Denny
    Department of Obstetrics and Gynaecology, University of Cape Town, H45, Old Main Building, Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa
    Best Pract Res Clin Obstet Gynaecol 19:501-15. 2005
    ....
  10. ncbi Cervicovaginal, oral, and serum IgG and IgA responses to human papillomavirus type 16 in women with cervical intraepithelial neoplasia
    Jo Ann S Passmore
    Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Med Virol 79:1375-80. 2007
    ..An HPV-16 specific antibody response in one mucosal compartment in women with CIN is therefore not predictive of a response at another...
  11. ncbi Bacterial vaginosis and susceptibility to HIV infection in South African women: a nested case-control study
    Landon Myer
    Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    J Infect Dis 192:1372-80. 2005
    ..Bacterial vaginosis (BV) may increase women's susceptibility to HIV infection, but there are few prospective data...
  12. pmc Comparison of cervical and blood T-cell responses to human papillomavirus-16 in women with human papillomavirus-associated cervical intraepithelial neoplasia
    Jo Ann S Passmore
    Division of Medical Virology, Department Clinical Laboratory Science and Institute of Infectious Disease and Molecular Medicine, Cape Town, South Africa
    Immunology 119:507-14. 2006
    ....
  13. ncbi Prospective study of hormonal contraception and women's risk of HIV infection in South Africa
    Landon Myer
    Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    Int J Epidemiol 36:166-74. 2007
    ..We investigated associations between HIV incidence and use of combined oral contraceptives (COC), norethindrone enanthate (NET-EN) or depot medroxyprogesterone acetate (DMPA) in a cohort of South African women...
  14. doi Cervical and oral human papillomavirus types in HIV-1 positive and negative women with cervical disease in South Africa
    Dianne J Marais
    Division of Medical Virology, Department of Clinical Laboratory Science, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa
    J Med Virol 80:953-9. 2008
    ..HIV+ women had more multiple HPV infections and those with severe cervical disease a similar prevalence of HIV-16 but a lower HPV-18 prevalence than HIV- women...
  15. pmc Impact of human immunodeficiency virus 1 infection and inflammation on the composition and yield of cervical mononuclear cells in the female genital tract
    Nonhlanhla N Nkwanyana
    Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Immunology 128:e746-57. 2009
    ..In conclusion, we suggest that inflammation at the cervix and HIV infection are likely to be key determinants in the absolute number of mucosal immune cells recovered by cervical cytobrushing...
  16. doi Prevention of cervical cancer
    Lynette Denny
    Department of Obstetrics and Gynaecology, Faculty of Health Sciences, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa
    Reprod Health Matters 16:18-31. 2008
    ..Finally, possible alternative approaches to cervical cytology for the prevention of cervical cancer are briefly reviewed...
  17. ncbi Nested case-control study of cervical mucosal lesions, ectopy, and incident HIV infection among women in Cape Town, South Africa
    Landon Myer
    Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, South Africa
    Sex Transm Dis 33:683-7. 2006
    ..The objective of this study was to test whether cervical mucosal lesions and ectopy increase women's susceptibility to HIV infection...
  18. ncbi Distinguishing the temporal association between women's intravaginal practices and risk of human immunodeficiency virus infection: a prospective study of South African women
    Landon Myer
    Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    Am J Epidemiol 163:552-60. 2006
    ..Intravaginal practices appear unlikely to be a cofactor in the male-to-female transmission of HIV in this setting...
  19. ncbi Screen-and-treat approaches for cervical cancer prevention in low-resource settings: a randomized controlled trial
    Lynette Denny
    Department of Obstetrics and Gynaecology, University of Cape Town, Cape Town, South Africa
    JAMA 294:2173-81. 2005
    ..Non-cytology-based screen-and-treat approaches for cervical cancer prevention have been developed for low-resource settings, but few have directly addressed efficacy...
  20. ncbi Intravaginal practices, bacterial vaginosis, and women's susceptibility to HIV infection: epidemiological evidence and biological mechanisms
    Landon Myer
    Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    Lancet Infect Dis 5:786-94. 2005
    ..Further research into factors that increase women's susceptibility to HIV will help to inform the design of vaginal microbicides and other HIV prevention interventions...
  21. doi Evaluation of CD103 (αEβ7) integrin expression by CD8 T cells in blood as a surrogate marker to predict cervical T cell responses in the female genital tract during HIV infection
    Agano Kiravu
    Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa
    Clin Immunol 141:143-51. 2011
    ..Despite this, the magnitude of Gag-specific IFN-γ responses by CD103+CD8+ T cells in blood did not predict similar Gag-specific responses at the cervix...
  22. ncbi High prevalence of HPV 16 in South African women with cancer of the cervix and cervical intraepithelial neoplasia
    Patti Kay
    Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa
    J Med Virol 71:265-73. 2003
    ....
  23. doi Association of serum and mucosal neutralizing antibodies to human papillomavirus type 16 (HPV-16) with HPV-16 infection and cervical disease
    Zizipho Z A Mbulawa
    Institute of Infectious Disease and Molecular Medicine, University of Cape Town Medical School, Observatory, Cape Town 7925, South Africa
    J Gen Virol 89:910-4. 2008
    ..In conclusion, serum and cervical HPV-16-neutralizing antibodies were found to correlate with HPV-16 infection, but not with cervical disease...
  24. doi Human papillomavirus-based cervical cancer prevention: long-term results of a randomized screening trial
    Lynette Denny
    Department of Obstetrics and Gynecology, University of Cape Town, Cape Town, South Africa
    J Natl Cancer Inst 102:1557-67. 2010
    ..We evaluated the efficacy of two screen-and-treat approaches through 36 months of follow-up in a randomized trial...
  25. pmc Determinants of sexual activity and its relation to cervical cancer risk among South African women
    Diane Cooper
    Women s Health Research Unit, School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, 7925, Cape Town, South Africa
    BMC Public Health 7:341. 2007
    ..Invasive cervical cancer is the commonest cause of cancer morbidity and mortality in South African women. This study provides information on adult women's sexual activity and cervical cancer risk in South Africa...
  26. pmc CD57 expression by T cells in the female genital tract of HIV-zx1 infected women
    Lenine J Liebenberg
    Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, 7925 Cape Town, South Africa
    Clin Immunol 135:137-45. 2010
    ..No impairment in IFN-gamma production by CD57+ T cells from the genital tract was observed. We conclude that increased T cell senescence does not appear to be a hallmark of genital mucosal HIV-1 infection...
  27. ncbi Direct visual inspection for cervical cancer screening: an analysis of factors influencing test performance
    Lynette Denny
    Department of Obstetrics and Gynecology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Cancer 94:1699-707. 2002
    ..The authors evaluated direct visual inspection of the cervix after the application of 5% acetic acid (DVI) as a cervical cancer screening test for use in low-resource settings...
  28. ncbi Detection of HPV 16 and HPV 18 DNA in the blood of patients with cervical cancer
    Patti Kay
    Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa
    J Med Virol 75:435-9. 2005
    ..The results of our study indicate that the role of HPV DNA in the circulatory system appears not be of diagnostic significance and HPV DNA is only detectable in women with more advanced cervical cancers...
  29. pmc Impact of mucosal inflammation on cervical human immunodeficiency virus (HIV-1)-specific CD8 T-cell responses in the female genital tract during chronic HIV infection
    Pamela P Gumbi
    Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa
    J Virol 82:8529-36. 2008
    ..In addition, we further show that inflammatory cytokines are associated with increased levels of HIV-specific CD8 effector cells at the genital mucosa but that these were not able to control genital HIV shedding...
  30. pmc Comparison of polyclonal expansion methods to improve the recovery of cervical cytobrush-derived T cells from the female genital tract of HIV-infected women
    Alfred Bere
    Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    J Immunol Methods 354:68-79. 2010
    ..Irrespective of the expansion method used, the T cell memory profile was altered following expansion...
  31. pmc Polyclonal expansion of cervical cytobrush-derived T cells to investigate HIV-specific responses in the female genital tract
    Alfred Bere
    Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, South Africa
    Immunology 130:23-33. 2010
    ..We conclude that cervical Gag-specific T-cell responses in expanded lines are most easily detectable in women who have corresponding high-magnitude Gag-specific T-cell responses in blood...
  32. ncbi The agreement between cervical abnormalities identified by cytology and detection of high-risk types of human papillomavirus
    Bruce R Allan
    Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    S Afr Med J 96:1186-90. 2006
    ..Using the Digene Hybrid Capture 2 high-risk HPV test (HC2), we investigated the prevalence of high-risk HPV in cervical specimens, and compared results with those of Papanicolaou (Pap) smears taken concurrently...