Research Topics
| Lynnette DennySummaryAffiliation: University of Cape Town Country: South Africa Publications
| Collaborators
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Detail Information
Publications
Intravaginal practices, HIV and other sexually transmitted diseases among South African womenLandon Myer
School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
Sex Transm Dis 31:174-9. 2004....- Cervical cancer prevention - a paradigm shift?Lynnette Denny
University of Cape Town, Groote Schuur Hospital, H 45, Old Main Building, Observatory 7925, South Africa
Gynecol Oncol 99:S12. 2005 
More men than women make mucosal IgA antibodies to Human papillomavirus type 16 (HPV-16) and HPV-18: a study of oral HPV and oral HPV antibodies in a normal healthy populationDianne J Marais
Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, 7925, Cape Town, South Africa
BMC Infect Dis 6:95. 2006..The present study aimed to further evaluate the effectiveness of oral fluid testing for detecting the mucosal humoral response to HPV infection and to advance our limited understanding of the immune response to HPV...- HIV and pre-neoplastic and neoplastic lesions of the cervix in South Africa: a case-control studyJennifer R Moodley
School of Public Health and Family Medicine, Women s Health Research Unit, University of Cape Town, 7925, South Africa
BMC Cancer 6:135. 2006..The aim of this study was to determine the risk of cervical pre-cancer and cancer among HIV positive women in South Africa... - Cervical cancer: the South African perspective. FIGO 6th Annual Report on the Results of Treatment in Gynecological CancerL Denny
Groote Schuur Hospital, Dept. of Gynaecological Oncology, H 45 OMB, Observatory, 7925 Cape Town, South Africa
Int J Gynaecol Obstet 95:S211-4. 2006 
Human papillomavirus infection and cervical disease in human immunodeficiency virus-1-infected womenLynette Denny
Department Obstetrics and Gynaecology, University of Cape Town, Groote Schuur Hospital, Cape Town, South Africa
Obstet Gynecol 111:1380-7. 2008..To report on the natural history of high-risk human papillomavirus (HPV) infection and cervical disease in human immunodeficiency virus (HIV)-1-infected women living in Cape Town, South Africa...- Chapter 8: Screening for cervical cancer in developing countriesLynette Denny
Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa
Vaccine 24:S3/71-7. 2006..Country-specific solutions need to be found, while being cognizant of the criteria that have enabled successful screening programmes... - Management of cervical disease in HIV-infected womenLynette Denny
University of Cape Town, South Africa
Gynecol Oncol 99:S14-5. 2005 - Human papillomavirus testing and screeningL A Denny
Department of Obstetrics and Gynaecology, University of Cape Town, H45, Old Main Building, Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa
Best Pract Res Clin Obstet Gynaecol 19:501-15. 2005.... - Cervicovaginal, oral, and serum IgG and IgA responses to human papillomavirus type 16 in women with cervical intraepithelial neoplasiaJo Ann S Passmore
Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
J Med Virol 79:1375-80. 2007..An HPV-16 specific antibody response in one mucosal compartment in women with CIN is therefore not predictive of a response at another... - Bacterial vaginosis and susceptibility to HIV infection in South African women: a nested case-control studyLandon Myer
Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
J Infect Dis 192:1372-80. 2005..01 [95% CI, 1.12-3.62]). CONCLUSIONS: BV may account for a substantial fraction of new HIV infections in this setting. Treatment of BV and other interventions to promote normal vaginal flora warrant attention for HIV prevention... - Comparison of cervical and blood T-cell responses to human papillomavirus-16 in women with human papillomavirus-associated cervical intraepithelial neoplasiaJo Ann S Passmore
Division of Medical Virology, Department Clinical Laboratory Science and Institute of Infectious Disease and Molecular Medicine, Cape Town, South Africa
Immunology 119:507-14. 2006.... - Prospective study of hormonal contraception and women's risk of HIV infection in South AfricaLandon Myer
Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
Int J Epidemiol 36:166-74. 2007..We investigated associations between HIV incidence and use of combined oral contraceptives (COC), norethindrone enanthate (NET-EN) or depot medroxyprogesterone acetate (DMPA) in a cohort of South African women... - Cervical and oral human papillomavirus types in HIV-1 positive and negative women with cervical disease in South AfricaDianne J Marais
Division of Medical Virology, Department of Clinical Laboratory Science, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa
J Med Virol 80:953-9. 2008..HIV+ women had more multiple HPV infections and those with severe cervical disease a similar prevalence of HIV-16 but a lower HPV-18 prevalence than HIV- women... - Impact of human immunodeficiency virus 1 infection and inflammation on the composition and yield of cervical mononuclear cells in the female genital tractNonhlanhla N Nkwanyana
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
Immunology 128:e746-57. 2009..In conclusion, we suggest that inflammation at the cervix and HIV infection are likely to be key determinants in the absolute number of mucosal immune cells recovered by cervical cytobrushing... - Intravaginal practices, bacterial vaginosis, and women's susceptibility to HIV infection: epidemiological evidence and biological mechanismsLandon Myer
Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
Lancet Infect Dis 5:786-94. 2005..Further research into factors that increase women's susceptibility to HIV will help to inform the design of vaginal microbicides and other HIV prevention interventions... - Prevention of cervical cancerLynette Denny
Department of Obstetrics and Gynaecology, Faculty of Health Sciences, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa
Reprod Health Matters 16:18-31. 2008..Finally, possible alternative approaches to cervical cytology for the prevention of cervical cancer are briefly reviewed... - Nested case-control study of cervical mucosal lesions, ectopy, and incident HIV infection among women in Cape Town, South AfricaLandon Myer
Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, South Africa
Sex Transm Dis 33:683-7. 2006..Protection of the mucosa of the cervix may provide an important approach for new HIV prevention technologies... - Distinguishing the temporal association between women's intravaginal practices and risk of human immunodeficiency virus infection: a prospective study of South African womenLandon Myer
Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
Am J Epidemiol 163:552-60. 2006..Intravaginal practices appear unlikely to be a cofactor in the male-to-female transmission of HIV in this setting... - Screen-and-treat approaches for cervical cancer prevention in low-resource settings: a randomized controlled trialLynette Denny
Department of Obstetrics and Gynaecology, University of Cape Town, Cape Town, South Africa
JAMA 294:2173-81. 2005..Trial Registration http://clinicaltrials.gov Identifier: NCT00233727... - Determinants of sexual activity and its relation to cervical cancer risk among South African womenDiane Cooper
Women s Health Research Unit, School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, 7925, Cape Town, South Africa
BMC Public Health 7:341. 2007..Invasive cervical cancer is the commonest cause of cancer morbidity and mortality in South African women. This study provides information on adult women's sexual activity and cervical cancer risk in South Africa... - Evaluation of CD103 (αEβ7) integrin expression by CD8 T cells in blood as a surrogate marker to predict cervical T cell responses in the female genital tract during HIV infectionAgano Kiravu
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa
Clin Immunol 141:143-51. 2011..Despite this, the magnitude of Gag-specific IFN-γ responses by CD103+CD8+ T cells in blood did not predict similar Gag-specific responses at the cervix... - Association of serum and mucosal neutralizing antibodies to human papillomavirus type 16 (HPV-16) with HPV-16 infection and cervical diseaseZizipho Z A Mbulawa
Institute of Infectious Disease and Molecular Medicine, University of Cape Town Medical School, Observatory, Cape Town 7925, South Africa
J Gen Virol 89:910-4. 2008..In conclusion, serum and cervical HPV-16-neutralizing antibodies were found to correlate with HPV-16 infection, but not with cervical disease... - Human papillomavirus-based cervical cancer prevention: long-term results of a randomized screening trialLynette Denny
Department of Obstetrics and Gynecology, University of Cape Town, Cape Town, South Africa
J Natl Cancer Inst 102:1557-67. 2010..We evaluated the efficacy of two screen-and-treat approaches through 36 months of follow-up in a randomized trial... - High prevalence of HPV 16 in South African women with cancer of the cervix and cervical intraepithelial neoplasiaPatti Kay
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa
J Med Virol 71:265-73. 2003.... - CD57 expression by T cells in the female genital tract of HIV-zx1 infected womenLenine J Liebenberg
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, 7925 Cape Town, South Africa
Clin Immunol 135:137-45. 2010..No impairment in IFN-gamma production by CD57+ T cells from the genital tract was observed. We conclude that increased T cell senescence does not appear to be a hallmark of genital mucosal HIV-1 infection... - Direct visual inspection for cervical cancer screening: an analysis of factors influencing test performanceLynette Denny
Department of Obstetrics and Gynecology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Cancer 94:1699-707. 2002..CONCLUSIONS: This study confirmed the utility of DVI as a primary screening test. Evaluation of the clinical effectiveness of screening with this low-cost and simple test in low-resource settings is necessary... - Detection of HPV 16 and HPV 18 DNA in the blood of patients with cervical cancerPatti Kay
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa
J Med Virol 75:435-9. 2005..The results of our study indicate that the role of HPV DNA in the circulatory system appears not be of diagnostic significance and HPV DNA is only detectable in women with more advanced cervical cancers... - Impact of mucosal inflammation on cervical human immunodeficiency virus (HIV-1)-specific CD8 T-cell responses in the female genital tract during chronic HIV infectionPamela P Gumbi
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa
J Virol 82:8529-36. 2008..In addition, we further show that inflammatory cytokines are associated with increased levels of HIV-specific CD8 effector cells at the genital mucosa but that these were not able to control genital HIV shedding... - Comparison of polyclonal expansion methods to improve the recovery of cervical cytobrush-derived T cells from the female genital tract of HIV-infected womenAlfred Bere
Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
J Immunol Methods 354:68-79. 2010..Irrespective of the expansion method used, the T cell memory profile was altered following expansion... - Polyclonal expansion of cervical cytobrush-derived T cells to investigate HIV-specific responses in the female genital tractAlfred Bere
Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, South Africa
Immunology 130:23-33. 2010..We conclude that cervical Gag-specific T-cell responses in expanded lines are most easily detectable in women who have corresponding high-magnitude Gag-specific T-cell responses in blood... - The agreement between cervical abnormalities identified by cytology and detection of high-risk types of human papillomavirusBruce R Allan
Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
S Afr Med J 96:1186-90. 2006..When costs decrease, HC2 could be introduced as an adjunct to Pap smears in identifying women at risk for high-grade cervical disease and could be useful in the maintenance of cervical health in those who remain Pap smear negative...