Lynette Denny

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. ncbi request reprint Safety and immunogenicity of the HPV-16/18 AS04-adjuvanted vaccine in HIV-positive women in South Africa: a partially-blind randomised placebo-controlled study
    Lynette Denny
    Department of Obstetrics and Gynaecology, Groote Schuur Hospital University of Cape Town, Cape Town, South Africa Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa Electronic address
    Vaccine 31:5745-53. 2013
  2. doi request reprint Human papillomavirus, human immunodeficiency virus and immunosuppression
    Lynette A Denny
    Department Obstetrics and Gynaecology and Institute of Infectious Diseases and Molecular Medicine, University of Cape Town Groote Schuur Hospital, Cape Town, South Africa
    Vaccine 30:F168-74. 2012
  3. ncbi request reprint Cervical cancer: prevention and treatment
    Lynette Denny
    Department of Obstetrics and Gynaecology, University of Cape Town, Cape Town, South Africa
    Discov Med 14:125-31. 2012
  4. ncbi request reprint Cervical cancer prevention: new opportunities for primary and secondary prevention in the 21st century
    Lynette Denny
    Department of Obstetrics and Gynecology, Gynecology Oncology Unit, Groote Schuur Hospital University of Cape Town, Cape Town, South Africa
    Int J Gynaecol Obstet 119:S80-4. 2012
  5. doi request reprint Cervical cancer in Africa
    Lynette Denny
    Department of Obstetrics and Gynaecology, University of Cape Town Groote Schuur Hospital, Cape Town, South Africa
    Cancer Epidemiol Biomarkers Prev 21:1434-8. 2012
  6. pmc Reduced acquisition and reactivation of human papillomavirus infections among older women treated with cryotherapy: results from a randomized trial in South Africa
    Sylvia Taylor
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    BMC Med 8:40. 2010
  7. doi request reprint Cervical cancer treatment in Africa
    Lynette Denny
    Department Obstetrics and Gynaecology, University of Cape Town Groote Schuur Hospital, Cape Town, South Africa
    Curr Opin Oncol 23:469-74. 2011
  8. doi request reprint Prevention of cervical cancer
    Lynette Denny
    Department of Obstetrics and Gynaecology, Faculty of Health Sciences, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa
    Reprod Health Matters 16:18-31. 2008
  9. pmc Impact of human immunodeficiency virus 1 infection and inflammation on the composition and yield of cervical mononuclear cells in the female genital tract
    Nonhlanhla N Nkwanyana
    Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Immunology 128:e746-57. 2009
  10. ncbi request reprint Screen-and-treat approaches for cervical cancer prevention in low-resource settings: a randomized controlled trial
    Lynette Denny
    Department of Obstetrics and Gynaecology, University of Cape Town, Cape Town, South Africa
    JAMA 294:2173-81. 2005

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Safety and immunogenicity of the HPV-16/18 AS04-adjuvanted vaccine in HIV-positive women in South Africa: a partially-blind randomised placebo-controlled study
    Lynette Denny
    Department of Obstetrics and Gynaecology, Groote Schuur Hospital University of Cape Town, Cape Town, South Africa Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa Electronic address
    Vaccine 31:5745-53. 2013
    ..In conclusion, the HPV-16/18 AS04-adjuvanted vaccine appears immunogenic and well-tolerated in women with HIV infection. Study ID: 107863/NCT00586339...
  2. doi request reprint Human papillomavirus, human immunodeficiency virus and immunosuppression
    Lynette A Denny
    Department Obstetrics and Gynaecology and Institute of Infectious Diseases and Molecular Medicine, University of Cape Town Groote Schuur Hospital, Cape Town, South Africa
    Vaccine 30:F168-74. 2012
    ..This article forms part of a special supplement entitled "Comprehensive Control of HPV Infections and Related Diseases" Vaccine Volume 30, Supplement 5, 2012...
  3. ncbi request reprint Cervical cancer: prevention and treatment
    Lynette Denny
    Department of Obstetrics and Gynaecology, University of Cape Town, Cape Town, South Africa
    Discov Med 14:125-31. 2012
    ..Ongoing efforts to refine the characteristics of screening tests continue, as does implementation of current HPV vaccines for the primary prevention of cervical cancer...
  4. ncbi request reprint Cervical cancer prevention: new opportunities for primary and secondary prevention in the 21st century
    Lynette Denny
    Department of Obstetrics and Gynecology, Gynecology Oncology Unit, Groote Schuur Hospital University of Cape Town, Cape Town, South Africa
    Int J Gynaecol Obstet 119:S80-4. 2012
    ..This article reviews these new approaches...
  5. doi request reprint Cervical cancer in Africa
    Lynette Denny
    Department of Obstetrics and Gynaecology, University of Cape Town Groote Schuur Hospital, Cape Town, South Africa
    Cancer Epidemiol Biomarkers Prev 21:1434-8. 2012
    ..Cancer is becoming an increasingly important public health problem as more people live longer. It is time to develop programs for the prevention, early detection, treatment, and palliation of cancer sufferers in Africa...
  6. pmc Reduced acquisition and reactivation of human papillomavirus infections among older women treated with cryotherapy: results from a randomized trial in South Africa
    Sylvia Taylor
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    BMC Med 8:40. 2010
    ..We investigated whether cervical cryotherapy reduces newly detected hrHPV infections among HIV-positive and HIV-negative women who were hrHPV negative when treated...
  7. doi request reprint Cervical cancer treatment in Africa
    Lynette Denny
    Department Obstetrics and Gynaecology, University of Cape Town Groote Schuur Hospital, Cape Town, South Africa
    Curr Opin Oncol 23:469-74. 2011
    ..It also reviews the natural history of cervical cancer, the new 2009 International Federation of Gynecology and Obstetrics staging, and current treatment guidelines for cervical cancer...
  8. doi request reprint Prevention of cervical cancer
    Lynette Denny
    Department of Obstetrics and Gynaecology, Faculty of Health Sciences, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa
    Reprod Health Matters 16:18-31. 2008
    ..Finally, possible alternative approaches to cervical cytology for the prevention of cervical cancer are briefly reviewed...
  9. pmc Impact of human immunodeficiency virus 1 infection and inflammation on the composition and yield of cervical mononuclear cells in the female genital tract
    Nonhlanhla N Nkwanyana
    Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Immunology 128:e746-57. 2009
    ..In conclusion, we suggest that inflammation at the cervix and HIV infection are likely to be key determinants in the absolute number of mucosal immune cells recovered by cervical cytobrushing...
  10. ncbi request reprint Screen-and-treat approaches for cervical cancer prevention in low-resource settings: a randomized controlled trial
    Lynette Denny
    Department of Obstetrics and Gynaecology, University of Cape Town, Cape Town, South Africa
    JAMA 294:2173-81. 2005
    ..Non-cytology-based screen-and-treat approaches for cervical cancer prevention have been developed for low-resource settings, but few have directly addressed efficacy...
  11. doi request reprint Cervical and oral human papillomavirus types in HIV-1 positive and negative women with cervical disease in South Africa
    Dianne J Marais
    Division of Medical Virology, Department of Clinical Laboratory Science, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa
    J Med Virol 80:953-9. 2008
    ..HIV+ women had more multiple HPV infections and those with severe cervical disease a similar prevalence of HIV-16 but a lower HPV-18 prevalence than HIV- women...
  12. ncbi request reprint Distinguishing the temporal association between women's intravaginal practices and risk of human immunodeficiency virus infection: a prospective study of South African women
    Landon Myer
    Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    Am J Epidemiol 163:552-60. 2006
    ..Intravaginal practices appear unlikely to be a cofactor in the male-to-female transmission of HIV in this setting...
  13. doi request reprint Human papillomavirus-based cervical cancer prevention: long-term results of a randomized screening trial
    Lynette Denny
    Department of Obstetrics and Gynecology, University of Cape Town, Cape Town, South Africa
    J Natl Cancer Inst 102:1557-67. 2010
    ..We evaluated the efficacy of two screen-and-treat approaches through 36 months of follow-up in a randomized trial...
  14. pmc Comparison of polyclonal expansion methods to improve the recovery of cervical cytobrush-derived T cells from the female genital tract of HIV-infected women
    Alfred Bere
    Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    J Immunol Methods 354:68-79. 2010
    ..Irrespective of the expansion method used, the T cell memory profile was altered following expansion...
  15. ncbi request reprint Human papillomavirus prevalence and type distribution in invasive cervical cancer in sub-Saharan Africa
    Lynette Denny
    Department of Obstetrics and Gynecology, University of Cape Town Groote Schuur Hospital, Cape Town, South Africa
    Int J Cancer 134:1389-98. 2014
    ..In conclusion, HPV16, 18, 45 and 35 were the most common HPV types in sub-Saharan African women with ICC and HPV infections were more common in HIV-positive women...
  16. doi request reprint Altered phenotype and function of NK cells infiltrating human papillomavirus (HPV)-associated genital warts during HIV infection
    Alfred Bere
    Institute of Infectious Disease and Molecular Medicine and Division of Medical Virology, University of Cape Town, Cape Town, South Africa
    Clin Immunol 150:210-9. 2014
    ..We conclude that wart NK cells from HIV+ women have defects in their ability to degranulate and/or secrete IFN-γ, which may provide insights into why HIV+ women fail to spontaneously resolve genital warts...
  17. pmc HIV-specific T-cell responses detected in the genital tract of chronically HIV-infected women are largely monofunctional
    Alfred Bere
    Division of Medical Virology, Faculty of Health Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Immunology 139:342-51. 2013
    ..HIV Gag-specific cervical T cells were largely monofunctional. Polyfunctional T cells were detected at the cervix in women with high blood CD4 count and low plasma viral load but these did not protect from HIV genital shedding...
  18. ncbi request reprint Prospective study of hormonal contraception and women's risk of HIV infection in South Africa
    Landon Myer
    Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    Int J Epidemiol 36:166-74. 2007
    ..We investigated associations between HIV incidence and use of combined oral contraceptives (COC), norethindrone enanthate (NET-EN) or depot medroxyprogesterone acetate (DMPA) in a cohort of South African women...
  19. ncbi request reprint Nested case-control study of cervical mucosal lesions, ectopy, and incident HIV infection among women in Cape Town, South Africa
    Landon Myer
    Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, South Africa
    Sex Transm Dis 33:683-7. 2006
    ..The objective of this study was to test whether cervical mucosal lesions and ectopy increase women's susceptibility to HIV infection...
  20. pmc Stability and transport of cervical cytobrushes for isolation of mononuclear cells from the female genital tract
    Lenine J Liebenberg
    Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa
    J Immunol Methods 367:47-55. 2011
    ..We conclude that cervical cytobrush-derived T cells are robust and can preserve their viability, phenotype and function over 24h of mock transport...
  21. ncbi request reprint Intravaginal practices, bacterial vaginosis, and women's susceptibility to HIV infection: epidemiological evidence and biological mechanisms
    Landon Myer
    Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    Lancet Infect Dis 5:786-94. 2005
    ..Further research into factors that increase women's susceptibility to HIV will help to inform the design of vaginal microbicides and other HIV prevention interventions...
  22. ncbi request reprint Management of cervical disease in HIV-infected women
    Lynette Denny
    University of Cape Town, South Africa
    Gynecol Oncol 99:S14-5. 2005
  23. pmc Polyclonal expansion of cervical cytobrush-derived T cells to investigate HIV-specific responses in the female genital tract
    Alfred Bere
    Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, South Africa
    Immunology 130:23-33. 2010
    ..We conclude that cervical Gag-specific T-cell responses in expanded lines are most easily detectable in women who have corresponding high-magnitude Gag-specific T-cell responses in blood...
  24. pmc Rapid rise in detection of human papillomavirus (HPV) infection soon after incident HIV infection among South African women
    Chunhui Wang
    Department of Pathology, College of Physicians and Surgeons, University of Cape Town, Cape Town, South Africa
    J Infect Dis 203:479-86. 2011
    ..It is well established that the prevalence of human papillomavirus (HPV) infection is increased among human immunodeficiency virus (HIV)-positive individuals, but the temporal relationships between these infections are unclear...
  25. doi request reprint Human papillomavirus infection and cervical disease in human immunodeficiency virus-1-infected women
    Lynette Denny
    Department Obstetrics and Gynaecology, University of Cape Town, Groote Schuur Hospital, Cape Town, South Africa
    Obstet Gynecol 111:1380-7. 2008
    ..To report on the natural history of high-risk human papillomavirus (HPV) infection and cervical disease in human immunodeficiency virus (HIV)-1-infected women living in Cape Town, South Africa...
  26. pmc Persistence of genital tract T cell responses in HIV-infected women on highly active antiretroviral therapy
    Nonhlanhla N Mkhize
    Division of Medical Virology, Institute of Infectious Disease and Molecular Medicine, Cape Town, South Africa
    J Virol 84:10765-72. 2010
    ..While HAART effectively suppressed both blood and cervical viremia, HIV-specific CD8 T cell responses in blood were lost, while those at the cervix were preserved...
  27. ncbi request reprint Detection of HPV 16 and HPV 18 DNA in the blood of patients with cervical cancer
    Patti Kay
    Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa
    J Med Virol 75:435-9. 2005
    ..The results of our study indicate that the role of HPV DNA in the circulatory system appears not be of diagnostic significance and HPV DNA is only detectable in women with more advanced cervical cancers...
  28. ncbi request reprint Bacterial vaginosis and susceptibility to HIV infection in South African women: a nested case-control study
    Landon Myer
    Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    J Infect Dis 192:1372-80. 2005
    ..Bacterial vaginosis (BV) may increase women's susceptibility to HIV infection, but there are few prospective data...
  29. pmc Impact of mucosal inflammation on cervical human immunodeficiency virus (HIV-1)-specific CD8 T-cell responses in the female genital tract during chronic HIV infection
    Pamela P Gumbi
    Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa
    J Virol 82:8529-36. 2008
    ..In addition, we further show that inflammatory cytokines are associated with increased levels of HIV-specific CD8 effector cells at the genital mucosa but that these were not able to control genital HIV shedding...
  30. ncbi request reprint The prevention of cervical cancer in developing countries
    Lynette Denny
    Department of Obstetics and Gynaecology, Facult of Health and Gynaecology, Faculty of Health Science, University of Cape Town Groote Schuur Hospital, South Africa
    BJOG 112:1204-12. 2005
    ..These will be explored in this review...
  31. ncbi request reprint The agreement between cervical abnormalities identified by cytology and detection of high-risk types of human papillomavirus
    Bruce R Allan
    Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    S Afr Med J 96:1186-90. 2006
    ..Using the Digene Hybrid Capture 2 high-risk HPV test (HC2), we investigated the prevalence of high-risk HPV in cervical specimens, and compared results with those of Papanicolaou (Pap) smears taken concurrently...
  32. ncbi request reprint High prevalence of HPV 16 in South African women with cancer of the cervix and cervical intraepithelial neoplasia
    Patti Kay
    Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa
    J Med Virol 71:265-73. 2003
    ....
  33. pmc CD57 expression by T cells in the female genital tract of HIV-zx1 infected women
    Lenine J Liebenberg
    Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, 7925 Cape Town, South Africa
    Clin Immunol 135:137-45. 2010
    ..No impairment in IFN-gamma production by CD57+ T cells from the genital tract was observed. We conclude that increased T cell senescence does not appear to be a hallmark of genital mucosal HIV-1 infection...
  34. ncbi request reprint Intravaginal practices, HIV and other sexually transmitted diseases among South African women
    Landon Myer
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    Sex Transm Dis 31:174-9. 2004
    ..However, data on the prevalence of these practices, and associations with HIV and other sexually transmitted diseases (STD), are limited...
  35. pmc More men than women make mucosal IgA antibodies to Human papillomavirus type 16 (HPV-16) and HPV-18: a study of oral HPV and oral HPV antibodies in a normal healthy population
    Dianne J Marais
    Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, 7925, Cape Town, South Africa
    BMC Infect Dis 6:95. 2006
    ..The present study aimed to further evaluate the effectiveness of oral fluid testing for detecting the mucosal humoral response to HPV infection and to advance our limited understanding of the immune response to HPV...
  36. doi request reprint Cytological screening for cervical cancer prevention
    Lynette Denny
    Department Obstetrics and Gynaecology, H 45, Old Main Building, University of Cape Town and Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa
    Best Pract Res Clin Obstet Gynaecol 26:189-96. 2012
    ..In this chapter, the history of cytological screening and the challenges posed by secondary prevention strategies are reviewed...
  37. ncbi request reprint Chapter 8: Screening for cervical cancer in developing countries
    Lynette Denny
    Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa
    Vaccine 24:S3/71-7. 2006
    ..Country-specific solutions need to be found, while being cognizant of the criteria that have enabled successful screening programmes...
  38. ncbi request reprint Direct visual inspection for cervical cancer screening: an analysis of factors influencing test performance
    Lynette Denny
    Department of Obstetrics and Gynecology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Cancer 94:1699-707. 2002
    ..The authors evaluated direct visual inspection of the cervix after the application of 5% acetic acid (DVI) as a cervical cancer screening test for use in low-resource settings...