Collet Dandara

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. ncbi request reprint Cytochrome P450 pharmacogenetics in African populations: implications for public health
    Collet Dandara
    University of Cape Town, Faculty of Health Sciences, Pharmacogenetics and Cancer Research Group, Division of Human Genetics, Department of Clinical Laboratory Sciences, Anzio Road Observatory, 7925, Cape Town, South Africa 27 21 406 6506
    Expert Opin Drug Metab Toxicol 10:769-85. 2014
  2. pmc ABCB1 4036A>G and 1236C>T Polymorphisms Affect Plasma Efavirenz Levels in South African HIV/AIDS Patients
    Marelize Swart
    Division of Human Genetics, Faculty of Health Sciences, University of Cape Town Observatory, Cape Town, South Africa
    Front Genet 3:236. 2012
  3. pmc Mitochondrial DNA subhaplogroups L0a2 and L2a modify susceptibility to peripheral neuropathy in malawian adults on stavudine containing highly active antiretroviral therapy
    Elizabeth Kampira
    Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa and Department of Pathology, Department of Medicine, and Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Malawi
    J Acquir Immune Defic Syndr 63:647-52. 2013
  4. doi request reprint Direct-to-consumer genetic testing: to test or not to test, that is the question
    Collet Dandara
    Division of Human Genetics, University of Cape Town, South Africa
    S Afr Med J 103:510-2. 2013
  5. ncbi request reprint Confirmation of the recurrent ACVR1 617G>A mutation in South Africans with fibrodysplasia ossificans progressiva
    Collet Dandara
    Faculty of Health Sciences, University of Cape Town Medical School, South Africa
    S Afr Med J 102:631-3. 2012
  6. doi request reprint High predictive value of CYP2B6 SNPs for steady-state plasma efavirenz levels in South African HIV/AIDS patients
    Marelize Swart
    Department of Clinical Laboratory Science, Division of Human Genetics, University of Cape Town, Cape Town, South Africa
    Pharmacogenet Genomics 23:415-27. 2013
  7. ncbi request reprint Mitochondrial subhaplogroups and differential risk of stavudine-induced lipodystrophy in Malawian HIV/AIDS patients
    Elizabeth Kampira
    Division of Human Genetics, Department of Clinical Laboratory Sciences, Faculty of Health Science, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    Pharmacogenomics 14:1999-2004. 2013
  8. doi request reprint CASP8 promoter polymorphism is associated with high-risk HPV types and abnormal cytology but not with cervical cancer
    Koushik Chatterjee
    Division of Medical Virology and Institute of Infectious Disease and Molecular Medicine IIDMM, University of Cape Town, Cape Town, Republic of South Africa
    J Med Virol 83:630-6. 2011
  9. ncbi request reprint Gene-environment interaction: the role of SULT1A1 and CYP3A5 polymorphisms as risk modifiers for squamous cell carcinoma of the oesophagus
    Collet Dandara
    UCT MRC Oesophageal Cancer Research Group, Division of Medical Biochemistry, Institute of Infectious Disease and Molecular Medicine IIDMM, Groote Schuur Hospital, Faculty of Health Sciences, University of Cape Town, South Africa
    Carcinogenesis 27:791-7. 2006
  10. pmc PXR and CAR single nucleotide polymorphisms influence plasma efavirenz levels in South African HIV/AIDS patients
    Marelize Swart
    Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Observatory, South Africa
    BMC Med Genet 13:112. 2012

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Cytochrome P450 pharmacogenetics in African populations: implications for public health
    Collet Dandara
    University of Cape Town, Faculty of Health Sciences, Pharmacogenetics and Cancer Research Group, Division of Human Genetics, Department of Clinical Laboratory Sciences, Anzio Road Observatory, 7925, Cape Town, South Africa 27 21 406 6506
    Expert Opin Drug Metab Toxicol 10:769-85. 2014
    ..More than 80% of therapeutic drugs used in the management of these diseases/conditions are metabolized by CYP enzymes that exhibit genetic polymorphisms...
  2. pmc ABCB1 4036A>G and 1236C>T Polymorphisms Affect Plasma Efavirenz Levels in South African HIV/AIDS Patients
    Marelize Swart
    Division of Human Genetics, Faculty of Health Sciences, University of Cape Town Observatory, Cape Town, South Africa
    Front Genet 3:236. 2012
    ..ABCB1 plays a role in determining the plasma concentrations of efavirenz and should be taken into account in future design of assays for genotype-based dosing of efavirenz-containing regimens...
  3. pmc Mitochondrial DNA subhaplogroups L0a2 and L2a modify susceptibility to peripheral neuropathy in malawian adults on stavudine containing highly active antiretroviral therapy
    Elizabeth Kampira
    Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa and Department of Pathology, Department of Medicine, and Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Malawi
    J Acquir Immune Defic Syndr 63:647-52. 2013
    ..We investigated mtDNA haplogroups and their role in susceptibility to stavudine-induced peripheral in Malawian patients on ART...
  4. doi request reprint Direct-to-consumer genetic testing: to test or not to test, that is the question
    Collet Dandara
    Division of Human Genetics, University of Cape Town, South Africa
    S Afr Med J 103:510-2. 2013
    ..Guidelines and recommendations for DTC genetic testing in South Africa (SA) are currently lacking. We provide recommendations that seek to protect consumers and healthcare providers in SA from possible exploitation. ..
  5. ncbi request reprint Confirmation of the recurrent ACVR1 617G>A mutation in South Africans with fibrodysplasia ossificans progressiva
    Collet Dandara
    Faculty of Health Sciences, University of Cape Town Medical School, South Africa
    S Afr Med J 102:631-3. 2012
    ..The aim of the project was to determine whether or not this mutation is present in affected persons in South Africa...
  6. doi request reprint High predictive value of CYP2B6 SNPs for steady-state plasma efavirenz levels in South African HIV/AIDS patients
    Marelize Swart
    Department of Clinical Laboratory Science, Division of Human Genetics, University of Cape Town, Cape Town, South Africa
    Pharmacogenet Genomics 23:415-27. 2013
    ....
  7. ncbi request reprint Mitochondrial subhaplogroups and differential risk of stavudine-induced lipodystrophy in Malawian HIV/AIDS patients
    Elizabeth Kampira
    Division of Human Genetics, Department of Clinical Laboratory Sciences, Faculty of Health Science, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    Pharmacogenomics 14:1999-2004. 2013
    ..We set out to investigate whether mtDNA variation is associated with the development of stavudine-induced lipodystrophy among adult Malawian HIV/AIDS patients on antiretroviral therapy that included stavudine...
  8. doi request reprint CASP8 promoter polymorphism is associated with high-risk HPV types and abnormal cytology but not with cervical cancer
    Koushik Chatterjee
    Division of Medical Virology and Institute of Infectious Disease and Molecular Medicine IIDMM, University of Cape Town, Cape Town, Republic of South Africa
    J Med Virol 83:630-6. 2011
    ..This result points towards an important role of CASP8 in HPV infection and in the development of pre-cancers...
  9. ncbi request reprint Gene-environment interaction: the role of SULT1A1 and CYP3A5 polymorphisms as risk modifiers for squamous cell carcinoma of the oesophagus
    Collet Dandara
    UCT MRC Oesophageal Cancer Research Group, Division of Medical Biochemistry, Institute of Infectious Disease and Molecular Medicine IIDMM, Groote Schuur Hospital, Faculty of Health Sciences, University of Cape Town, South Africa
    Carcinogenesis 27:791-7. 2006
    ..The genotype results show that SULT1A1*2/*2 genotype is associated with increased risk for OC among subjects exposed to tobacco-smoke-related carcinogens...
  10. pmc PXR and CAR single nucleotide polymorphisms influence plasma efavirenz levels in South African HIV/AIDS patients
    Marelize Swart
    Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Observatory, South Africa
    BMC Med Genet 13:112. 2012
    ....
  11. pmc CCR2-V64I polymorphism is associated with increased risk of cervical cancer but not with HPV infection or pre-cancerous lesions in African women
    Koushik Chatterjee
    Division of Medical Virology and Institute of Infectious Disease and Molecular Medicine IIDMM, University of Cape Town, Cape Town, Republic of South Africa
    BMC Cancer 10:278. 2010
    ..CCR2-V64I polymorphism has been previously reported to influence the progression to cervical cancer in some populations and has also been associated with decreased progression from HIV infection to AIDS...
  12. doi request reprint Fibrodysplasia ossificans progressiva in South Africa: difficulties in management in a developing country
    Chris Scott
    Department of Paediatrics, Red Cross Children s Hospital, Klipfontein Road, Cape Town, South Africa
    J Clin Rheumatol 17:37-41. 2011
    ..In addition to describing the manifestations and natural history of the disorder in Africa, we discuss the challenge of management of this condition in the South African context...
  13. ncbi request reprint Peripheral Blood Mitochondrial DNA/Nuclear DNA (mtDNA/nDNA) Ratio as a Marker of Mitochondrial Toxicities of Stavudine Containing Antiretroviral Therapy in HIV-Infected Malawian Patients
    Elizabeth Kampira
    1 Division of Human Genetics, University of Cape Town, Cape Town, South Africa
    OMICS 18:438-45. 2014
    ..This could open the prospect to select a substantial group of patients who will not have problematic side effects from stavudine, an affordable and effective antiretroviral drug that is being phased out in Africa due to its toxicity. ..
  14. ncbi request reprint In Search of Genetic Markers for Nonsyndromic Deafness in Africa: A Study in Cameroonians and Black South Africans with the GJB6 and GJA1 Candidate Genes
    Jason Bosch
    1 Division of Human Genetics, Department of Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    OMICS 18:481-5. 2014
    ..Currently, there is no sufficient evidence to support their testing in a clinical setting for individuals of African ancestry. ..
  15. pmc The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer
    Dongping Li
    International Centre for Genetic Engineering and Biotechnology ICGEB, UCT Campus, Anzio Road Observatory 7925, Cape Town, South Africa
    BMC Genet 11:47. 2010
    ..Genetic polymorphisms in GSTs were investigated in 245 patients and 288 controls samples by PCR-RFLP analysis...
  16. ncbi request reprint How Does Mother-to-Child Transmission of HIV Differ Among African Populations? Lessons from MBL2 Genetic Variation in Zimbabweans
    Kudakwashe Mhandire
    1 Pharmacogenetics Research Group, Division of Human Genetics, Department of Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town, South Africa
    OMICS 18:454-60. 2014
    ....
  17. doi request reprint A Fas gene polymorphism influences herpes simplex virus type 2 infection in South African women
    Koushik Chatterjee
    Division of Medical Virology, Department of Clinical Laboratory Sciences and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    J Med Virol 82:2082-6. 2010
    ..There was no significant association found with FasR-670A > G and FasL-844T > C polymorphisms and risk of HSV-2 infection. This is, to our knowledge, the first time a non-HLA genetic link with HSV-2 infection has been reported...
  18. pmc Heterozygous p.Asp50Asn mutation in the GJB2 gene in two Cameroonian patients with keratitis-ichthyosis-deafness (KID) syndrome
    Ambroise Wonkam
    Division of Human Genetics, Department of Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    BMC Med Genet 14:81. 2013
    ..KID appears to be genetically heterogeneous and most cases are caused by GJB2 mutations. Mutations in African patients have been rarely described...
  19. pmc 9β Polymorphism of the glucocorticoid receptor gene appears to have limited impact in patients with Addison's disease
    Ian Louis Ross
    Division of Endocrinology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 9:e86350. 2014
    ..We explored the impact of this polymorphism in patients with AD...
  20. pmc Effect of rifampicin-based antitubercular therapy and the cytochrome P450 2B6 516G>T polymorphism on efavirenz concentrations in adults in South Africa
    Karen Cohen
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Antivir Ther 14:687-95. 2009
    ..We explored the effect of rifampicin-based antitubercular therapy and the 516G>T polymorphism on efavirenz concentrations in HIV-infected patients in South Africa...
  21. ncbi request reprint CYP3A5 genotypes and risk of oesophageal cancer in two South African populations
    Collet Dandara
    MRC UCT Oesophageal Cancer Research Group, Division of Medical Biochemistry, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town 7925, South Africa
    Cancer Lett 225:275-82. 2005
    ..025). Individuals homozygous for defective CYP3A5 had reduced risk of developing oesophageal cancer (P=0.032)...