Mark F Cotton

Summary

Affiliation: University of Stellenbosch
Country: South Africa

Publications

  1. ncbi request reprint Tuberculosis exposure in HIV-exposed infants in a high-prevalence setting
    M F Cotton
    Department of Paediatrics and Child Health and Children s Infectious Diseases Clinical Research Unit KID CRU, Tygerberg Children s Hospital and Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
    Int J Tuberc Lung Dis 12:225-7. 2008
  2. ncbi request reprint Early antiretroviral therapy improves neurodevelopmental outcomes in infants
    Barbara Laughton
    Children s Infectious Diseases Clinical Research Unit, Department of Paediatrics and Child Health, Stellenbosch University and Tygerberg Children s Hospital, Cape Town, South Africa
    AIDS 26:1685-90. 2012
  3. ncbi request reprint Early time-limited antiretroviral therapy versus deferred therapy in South African infants infected with HIV: results from the children with HIV early antiretroviral (CHER) randomised trial
    Mark F Cotton
    Children s Infectious Diseases Clinical Research Unit, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa Electronic address
    Lancet 382:1555-63. 2013
  4. pmc Minimizing the risk of non-vertical, non-sexual HIV infection in children--beyond mother to child transmission
    Mark F Cotton
    Division of Paediatric Infectious Diseases, Tygerberg Children s Hospital, Stellenbosch University, Cape Town, South Africa
    J Int AIDS Soc 15:17377. 2012
  5. pmc Adherence to isoniazid prophylaxis among HIV-infected children: a randomized controlled trial comparing two dosing schedules
    Stanzi M le Roux
    School of Child and Adolescent Health, University of Cape Town, South Africa
    BMC Med 7:67. 2009
  6. pmc Early Antiretroviral Therapy reduces the incidence of otorrhea in a randomized study of early and deferred antiretroviral therapy: Evidence from the Children with HIV Early Antiretroviral Therapy (CHER) Study
    Clotilde Hainline
    Department of Paediatrics and Child Health and Children s Infectious Diseases Clinical Research Unit KID CRU, Tygerberg Children s Hospital and Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
    BMC Res Notes 4:448. 2011
  7. pmc High incidence of antimicrobial resistant organisms including extended spectrum beta-lactamase producing Enterobacteriaceae and methicillin-resistant Staphylococcus aureus in nasopharyngeal and blood isolates of HIV-infected children from Cape Town, South
    Mark F Cotton
    Department of Paediatrics, Faculty of Health Sciences, Stellenbosch University, Cape Town South Africa
    BMC Infect Dis 8:40. 2008
  8. doi request reprint Antiretroviral regimens containing a single protease inhibitor increase risk of virologic failure in young HIV-infected children
    Elisabetta Walters
    Department of Paediatrics and Child Health, Desmond Tutu TB Centre, Stellenbosch University, South Africa
    Pediatr Infect Dis J 32:361-3. 2013
  9. pmc Biceps skin-fold thickness may detect and predict early lipoatrophy in HIV-infected children
    Steve Innes
    Children s Infectious Diseases Clinical Research Unit, Tygerberg Children s Hospital, and Department of Paediatrics, Stellenbosch University, Cape Town, South Africa
    Pediatr Infect Dis J 32:e254-62. 2013
  10. pmc It is time to consider third-line options in antiretroviral-experienced paediatric patients?
    Gert U van Zyl
    Division of Medical Virology, Stellenbosch University, and National Health Laboratory Service Tygerberg, Parow, Cape Town, South Africa
    J Int AIDS Soc 14:55. 2011

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Tuberculosis exposure in HIV-exposed infants in a high-prevalence setting
    M F Cotton
    Department of Paediatrics and Child Health and Children s Infectious Diseases Clinical Research Unit KID CRU, Tygerberg Children s Hospital and Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
    Int J Tuberc Lung Dis 12:225-7. 2008
    ..High exposure may contribute to high rates of TB in HIV-exposed infants. Programs to prevent mother-to-child transmission of HIV offer an important opportunity to screen for TB. In-depth assessment is required for evaluating TB exposure...
  2. ncbi request reprint Early antiretroviral therapy improves neurodevelopmental outcomes in infants
    Barbara Laughton
    Children s Infectious Diseases Clinical Research Unit, Department of Paediatrics and Child Health, Stellenbosch University and Tygerberg Children s Hospital, Cape Town, South Africa
    AIDS 26:1685-90. 2012
    ..To evaluate the effect of early versus deferred antiretroviral therapy (ART) on the neurodevelopment of infants from Cape Town participating in the Children with HIV Early Antiretroviral Therapy (CHER) trial...
  3. ncbi request reprint Early time-limited antiretroviral therapy versus deferred therapy in South African infants infected with HIV: results from the children with HIV early antiretroviral (CHER) randomised trial
    Mark F Cotton
    Children s Infectious Diseases Clinical Research Unit, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa Electronic address
    Lancet 382:1555-63. 2013
    ..In view of the few treatment options and the potential toxicity associated with lifelong ART, in the CHER trial we compared early time-limited ART with deferred ART...
  4. pmc Minimizing the risk of non-vertical, non-sexual HIV infection in children--beyond mother to child transmission
    Mark F Cotton
    Division of Paediatric Infectious Diseases, Tygerberg Children s Hospital, Stellenbosch University, Cape Town, South Africa
    J Int AIDS Soc 15:17377. 2012
    ....
  5. pmc Adherence to isoniazid prophylaxis among HIV-infected children: a randomized controlled trial comparing two dosing schedules
    Stanzi M le Roux
    School of Child and Adolescent Health, University of Cape Town, South Africa
    BMC Med 7:67. 2009
    ..We investigated adherence to isoniazid prophylaxis administered daily, compared to three times a week, and predictors of adherence amongst HIV-infected children...
  6. pmc Early Antiretroviral Therapy reduces the incidence of otorrhea in a randomized study of early and deferred antiretroviral therapy: Evidence from the Children with HIV Early Antiretroviral Therapy (CHER) Study
    Clotilde Hainline
    Department of Paediatrics and Child Health and Children s Infectious Diseases Clinical Research Unit KID CRU, Tygerberg Children s Hospital and Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
    BMC Res Notes 4:448. 2011
    ..abstract:..
  7. pmc High incidence of antimicrobial resistant organisms including extended spectrum beta-lactamase producing Enterobacteriaceae and methicillin-resistant Staphylococcus aureus in nasopharyngeal and blood isolates of HIV-infected children from Cape Town, South
    Mark F Cotton
    Department of Paediatrics, Faculty of Health Sciences, Stellenbosch University, Cape Town South Africa
    BMC Infect Dis 8:40. 2008
    ....
  8. doi request reprint Antiretroviral regimens containing a single protease inhibitor increase risk of virologic failure in young HIV-infected children
    Elisabetta Walters
    Department of Paediatrics and Child Health, Desmond Tutu TB Centre, Stellenbosch University, South Africa
    Pediatr Infect Dis J 32:361-3. 2013
    ..Ritonavir-based single protease inhibitor antiretroviral therapy regimen predicted virologic failure (adjusted odds ratio 3.7, 95% confidence interval 1.5-8.9, P = 0.004) on multivariate analysis...
  9. pmc Biceps skin-fold thickness may detect and predict early lipoatrophy in HIV-infected children
    Steve Innes
    Children s Infectious Diseases Clinical Research Unit, Tygerberg Children s Hospital, and Department of Paediatrics, Stellenbosch University, Cape Town, South Africa
    Pediatr Infect Dis J 32:e254-62. 2013
    ..Early diagnosis of lipoatrophy is essential for effective intervention to arrest progression...
  10. pmc It is time to consider third-line options in antiretroviral-experienced paediatric patients?
    Gert U van Zyl
    Division of Medical Virology, Stellenbosch University, and National Health Laboratory Service Tygerberg, Parow, Cape Town, South Africa
    J Int AIDS Soc 14:55. 2011
    ..The historic use of full-dose ritonavir as part of an unboosted protease inhibitor (PI)-based antiretroviral therapy regimen in some South African children contributes to the frequent accumulation of major PI resistance mutations...
  11. pmc Early severe HIV disease precedes early antiretroviral therapy in infants: Are we too late?
    Steve Innes
    Children s Infectious Diseases Clinical Research Unit KID CRU, Stellenbosch University and Tygerberg Children s Hospital, Cape Town, South Africa
    J Int AIDS Soc 17:18914. 2014
    ..To describe the degree of HIV disease progression in infants initiating antiretroviral therapy (ART) by three months of age in a programmatic setting in South Africa...
  12. pmc Utility of clinical parameters to identify HIV infection in infants below ten weeks of age in South Africa: a prospective cohort study
    Heather B Jaspan
    Children s Infectious Diseases Clinical Research Unit, Department of Paediatrics and Child Health and Centre for Infectious Diseases, Stellenbosch University, Tygerberg, South Africa
    BMC Pediatr 11:104. 2011
    ..Receiver Operating Characteristic (ROC) curves were compiled using combinations of clinical findings...
  13. ncbi request reprint Surveillance of transmitted resistance to antiretroviral drug classes among young children in the Western Cape Province of South Africa
    Gert U van Zyl
    Division of Medical Virology, Stellenbosch University, Tygerberg, South Africa
    Pediatr Infect Dis J 29:370-1. 2010
    ..The estimated NRTI and protease inhibitor transmitted antiretroviral resistance prevalence is low (<5%), predicting good therapeutic response in Western Cape infants...
  14. pmc Clinical presentation and outcome of tuberculosis in human immunodeficiency virus infected children on anti-retroviral therapy
    Elisabetta Walters
    Department of Pediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa
    BMC Pediatr 8:1. 2008
    ..Little is known about the clinical presentation and outcome of TB in HIV-infected children on HAART...
  15. doi request reprint Isoniazid preventive therapy in HIV-infected and -uninfected children (0 - 14 years)
    Hendrik S Schaaf
    Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa
    S Afr Med J 103:714-5. 2013
    ..However, evidence for routine IPT without known exposure to TB in HIV-infected children is not convincing and is therefore not recommended.  ..
  16. doi request reprint Sulfamethoxazole enhances the antimycobacterial activity of rifampicin
    Lubabalo Macingwana
    DST NRF Centre of Excellence for Biomedical Tuberculosis Research, MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 19063 Francie van Zijl Drive, Tygerberg 7505, South Africa
    J Antimicrob Chemother 67:2908-11. 2012
    ....
  17. doi request reprint Radiology services for children in HIV- and TB-endemic regions: scope for greater collaboration between radiologists and clinicians caring for children
    Angela Dramowski
    Department of Paediatrics and Child Health, Tygerberg Children s Hospital, Tygerberg, South Africa
    Pediatr Radiol 39:541-4. 2009
    ..The Child-Friendly Healthcare Initiative is discussed, emphasizing opportunities to promote child friendliness in radiology services...
  18. doi request reprint Bacteremia in human immunodeficiency virus-infected children in Cape Town, South Africa
    David M le Roux
    Department of Paediatrics and Child Health, Red Cross War Memorial Children s Hospital, University of Cape Town, Cape Town, South Africa
    Pediatr Infect Dis J 30:904-6. 2011
    ..Children should be prioritized for early cART...
  19. ncbi request reprint Spastic diplegia in children with HIV encephalopathy: first description of gait and physical status
    Nelleke G Langerak
    Neurosurgery Division, Department of Surgery, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa Physiotherapy Division, Department of Interdisciplinary Health Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa
    Dev Med Child Neurol 56:686-94. 2014
    ..The aim of this study was to explore the physical status and gait patterns of children with spastic diplegia secondary to human immunodeficiency virus encephalopathy (HIVE)...
  20. doi request reprint Effect of HIV-1 exposure and antiretroviral treatment strategies in HIV-infected children on immunogenicity of vaccines during infancy
    Omphile E Simani
    aDepartment of Science and Technology National Research Foundation Vaccine Preventable Diseases Johannesburg bMedical Research Council, Respiratory and Meningeal Pathogens Research Unit, Faculty Health Sciences University of the Witwatersrand, Faculty of Health Sciences, Johannesburg cPerinatal HIV Research Unit, University of the Witwatersrand, Faculty of Health Sciences dStellenbosch University, Children s Infectious Diseases Clinical Research Unit, Tygerberg eDivision of National Health Laboratory Service, National Institute for Communicable Diseases, Centre for Vaccines and Immunology, Sandringham, South Africa
    AIDS 28:531-41. 2014
    ....
  21. ncbi request reprint Protease inhibitor resistance in South African children with virologic failure
    Gert U van Zyl
    Centre for Infectious Diseases, Division of Medical Virology, Tygerberg and Stellenbosch University, Cape Town, South Africa
    Pediatr Infect Dis J 28:1125-7. 2009
    ..We explored antiretroviral resistance mutations in pediatric patients failing PI-based antiretroviral therapy and the predictors of major PI resistance mutations (MPIRM) in these patients...
  22. doi request reprint Effect of in-utero HIV exposure and antiretroviral treatment strategies on measles susceptibility and immunogenicity of measles vaccine
    Omphile E Simani
    Department of Science and Technology National Research Foundation, Vaccine Preventable Diseases, Tygerberg, South Africa
    AIDS 27:1583-91. 2013
    ..We evaluated the effect of in-utero HIV-exposure and antiretroviral treatment (ART) strategies on measles antibody kinetics prior and following measles vaccination...
  23. pmc High prevalence of lipoatrophy in pre-pubertal South African children on antiretroviral therapy: a cross-sectional study
    Steve Innes
    Department of Paediatrics, Children s Infectious Diseases Clinical Research Unit KID CRU, Tygerberg Children s Hospital, Stellenbosch University, Cape Town, South Africa
    BMC Pediatr 12:183. 2012
    ..Lipoatrophy in sub-Saharan African children can be stigmatizing and have far-reaching consequences. The severity and extent of lipoatrophy in pre-pubertal children living in sub-Saharan Africa is unknown...
  24. pmc Bacterial disease and antimicrobial susceptibility patterns in HIV-infected, hospitalized children: a retrospective cohort study
    Heather B Jaspan
    University of Cape Town School of Child and Adolescent Health, Cape Town, South Africa
    PLoS ONE 3:e3260. 2008
    ..The use of antibiotic prophylaxis and the emergence of multi-drug resistant bacteria necessitate examination of responsible organisms and their antibiotic susceptibility...
  25. doi request reprint A proposed comprehensive classification of tuberculosis disease severity in children
    Catherine A Wiseman
    Desmond Tutu TB Centre, Department of Pediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa
    Pediatr Infect Dis J 31:347-52. 2012
    ..There is no existing approach that comprehensively characterizes the spectrum and severity of pediatric TB. This limits accurate classification of patients and comparison across cohorts...
  26. pmc Effects of postnatal interventions for the reduction of vertical HIV transmission on infant growth and non-HIV infections: a systematic review
    Moleen Zunza
    Department of Paediatrics and Child Health, Children s Infectious Disease Clinical Research Unit, Stellenbosch University, Tygerberg, South Africa
    J Int AIDS Soc 16:18865. 2013
    ....
  27. doi request reprint Premasticating food for weaning African infants: a possible vehicle for transmission of HIV
    Elke R Maritz
    Children s Infectious Diseases Clinical Research Unit, Ward J8, 8th Floor, Department of Pediatrics and Child Health, Tygerberg Academic Hospital, Francie van Zijl Ave, Tygerberg 7505, Cape Town, South Africa
    Pediatrics 128:e579-90. 2011
    ..We investigated premastication practices in Cape Town, South Africa, in lower socioeconomic status caregivers of infants below 2 years of age...
  28. ncbi request reprint Renal manifestations in children co-infected with HIV and disseminated tuberculosis
    Peter J Nourse
    School of Child and Adolescent Health, University of Cape Town, Klipfontein Road, Rondebosch, Cape Town, South Africa
    Pediatr Nephrol 25:1759-63. 2010
    ..Based on these results, we conclude that TB contributes to proteinuric renal disease in HIV-infected children and that the renal disease improves following TB treatment...
  29. doi request reprint Trough lopinavir concentrations in preterm HIV-infected infants
    Sandi L Holgate
    Department of Pediatrics and Child Health, Tygerberg Children s Hospital and Stellenbosch University, Cape Town, South Africa
    Pediatr Infect Dis J 31:602-4. 2012
    ..The median age at initiation was 27 days. Trough values guided dosing. Five infants needed doses above 300 mg/m. Although no adverse events were noted, lopinavir usage requires caution and careful monitoring...
  30. doi request reprint Tuberculosis-associated immune reconstitution inflammatory syndrome and unmasking of tuberculosis by antiretroviral therapy
    Graeme Meintjes
    Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, South Africa
    Clin Chest Med 30:797-810, x. 2009
    ..In this review the incidence, clinical features, risk factors, treatment, and prevention of TB-IRIS in adult and pediatric patients are discussed...
  31. ncbi request reprint Resistant Mycobacterium bovis Bacillus Calmette-Guérin disease: implications for management of Bacillus Calmette-Guérin Disease in human immunodeficiency virus-infected children
    Anneke C Hesseling
    Center for Tuberculosis Research and Education, Department of Pediatrics and Child Health, Tygerberg Children s Hospital, Tygerberg, South Africa
    Pediatr Infect Dis J 23:476-9. 2004
    ..Treatment guidelines for BCG disease with consideration of inherent and possible acquired drug resistance should be established in settings with high rates of vertical HIV transmission and routine BCG vaccination...
  32. doi request reprint A retrospective study of cryptosporidial diarrhea in a region with high HIV prevalence
    Etienne D Nel
    Department of Pediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University and Tygerberg Academic Hospital, Cape Town, 7505, South Africa
    J Trop Pediatr 57:289-92. 2011
    ..1) for uninfected children. Cryptosporidium is an important cause of diarrhea among younger children in the Western Cape, which occurs more frequently during the dry months of the year and has a worse outcome in HIV-infected children...
  33. doi request reprint Presumed cytomegalovirus retinitis in human immunodeficiency virus type I-infected South African children
    Natasha O'connell
    Department of Paediatrics and Child Health, Tygerberg Children s Hospital, Stellenbosch University, Cape Town, South Africa
    Pediatr Infect Dis J 30:539-40. 2011
    ..Of the 6 children, 5 had clinical features suggesting ocular disease at presentation. The child in whom retinitis was detected through preemptive screening due to systemic disease achieved normal visual outcome...
  34. ncbi request reprint Pediatric and adolescent imported malaria in Cape Town
    Taryn C Gray
    Department of Pediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa
    Pediatr Infect Dis J 28:644-6. 2009
    ..Rapid diagnosis occurred in most cases. Eleven of 42 (26%) had severe malaria. Management issues included delay to and inappropriate treatment, inadequate monitoring for hypoglycemia, and under notification to health authorities...
  35. ncbi request reprint Clinical and immunological correlates of chest X-ray abnormalities in HIV-infected South African children with limited access to anti-retroviral therapy
    Richard D Pitcher
    Division of Radiodiagnosis, Department of Medical Imaging and Clinical Oncology, Tygerberg Academic Hospital, Stellenbosch University, Cape Town, South Africa
    Pediatr Pulmonol 49:581-8. 2014
    ..The chest X-ray (CXR) abnormalities of human immunodeficiency virus (HIV)-infected children in low/middle income countries (LMIC's) have not been well studied...
  36. doi request reprint Oseltamivir use in low-birth weight infants during the 2009 nH1N1 influenza a outbreak in the Western Cape, South Africa
    Sandi L Holgate
    Department of Pediatrics and Child Health, Tygerberg Children s Hospital and Stellenbosch University, Cape Town, South Africa
    J Trop Pediatr 58:102-6. 2012
    ..A causal relationship between oseltamivir and NEC, although unlikely, cannot be confirmed or excluded...
  37. pmc Virologic failure and second-line antiretroviral therapy in children in South Africa--the IeDEA Southern Africa collaboration
    Mary Ann Davies
    School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Acquir Immune Defic Syndr 56:270-8. 2011
    ..We evaluated the probability and determinants of virologic failure and switching in children in South Africa...

Research Grants2

  1. Stellenbosch University Clinical Trial Unit, Cape Town, South Africa
    Mark Cotton; Fiscal Year: 2007
    ..James Mclntyre, Perinatal HIV Research Unit ACTG, Witwatersrand University. Though this co-mentoring partnership, the AIDs CRS is expected to be able to enroll subjects within six months of funding. ADMINISTRATIVE COMPONENT: ..