Malcolm Collins

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. ncbi request reprint Application of genomics in the prevention, treatment and management of Achilles tendinopathy and anterior cruciate ligament ruptures
    A V September
    UCT MRC Research Unit for Exercise Science and Sports Medicine of the Department of Human Biology, University of Cape Town, South Africa
    Recent Pat DNA Gene Seq 6:216-23. 2012
  2. doi request reprint The COL5A1 genotype is associated with range of motion measurements
    M Collins
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Scand J Med Sci Sports 19:803-10. 2009
  3. doi request reprint Genetic risk factors for musculoskeletal soft tissue injuries
    Malcolm Collins
    MRC UCT Research Unit for Exercise Science and Sports Medicine of the South African Medical Research Council, University of Cape Town, Cape Town, South Africa
    Med Sport Sci 54:136-49. 2009
  4. doi request reprint Type V collagen genotype and exercise-related phenotype relationships: a novel hypothesis
    Malcolm Collins
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town and the South African Medical Research Council, Newlands 7925, South Africa
    Exerc Sport Sci Rev 39:191-8. 2011
  5. doi request reprint The COL1A1 gene and acute soft tissue ruptures
    Malcolm Collins
    South African Medical Research Council, Cape Town, South Africa
    Br J Sports Med 44:1063-4. 2010
  6. ncbi request reprint Dipsogenic genes associated with weight changes during Ironman Triathlons
    Colleen J Saunders
    Medical Research Council of South Africa, MRC UCT Research Unit for Exercise Science and Sports Medicine, University of Cape Town, Newlands 7725, South Africa
    Hum Mol Genet 15:2980-7. 2006
  7. doi request reprint Association between the 4 bp proinsulin gene insertion polymorphism (IVS-69) and body composition in black South African women
    Peter Berman
    Division of Chemical Pathology, UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa
    Obesity (Silver Spring) 17:1298-300. 2009
  8. doi request reprint Tumor necrosis factor-alpha gene -308 G/A polymorphism modulates the relationship between dietary fat intake, serum lipids, and obesity risk in black South African women
    Yael T Joffe
    University of Cape Town Medical Research Council Research Unit for Exercise Science and Sports Medicine, Cape Town, South Africa
    J Nutr 140:901-7. 2010
  9. doi request reprint Polymorphisms within the COL5A1 3'-UTR that alters mRNA structure and the MIR608 gene are associated with Achilles tendinopathy
    Yoonus Abrahams
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Newlands, South Africa
    Ann Hum Genet 77:204-14. 2013
  10. doi request reprint Investigation of the Sp1-binding site polymorphism within the COL1A1 gene in participants with Achilles tendon injuries and controls
    Michael Posthumus
    UCT MRC Research Unit for Exercise Science and Sports Medicine of the Department of Human Biology, Faculty of Health Sciences, University of Cape Town, South Africa
    J Sci Med Sport 12:184-9. 2009

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Application of genomics in the prevention, treatment and management of Achilles tendinopathy and anterior cruciate ligament ruptures
    A V September
    UCT MRC Research Unit for Exercise Science and Sports Medicine of the Department of Human Biology, University of Cape Town, South Africa
    Recent Pat DNA Gene Seq 6:216-23. 2012
    ....
  2. doi request reprint The COL5A1 genotype is associated with range of motion measurements
    M Collins
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Scand J Med Sci Sports 19:803-10. 2009
    ..8% of the variance, were weight (P=0.004), age (P<0.001) and the BstUI RFLP (P=0.001). These data suggest that the COL5A1 BstUI RFLP is independently associated with lower limb ROM within the cohort investigated in this study...
  3. doi request reprint Genetic risk factors for musculoskeletal soft tissue injuries
    Malcolm Collins
    MRC UCT Research Unit for Exercise Science and Sports Medicine of the South African Medical Research Council, University of Cape Town, Cape Town, South Africa
    Med Sport Sci 54:136-49. 2009
    ..Clinicians could eventually use these models to develop personalised training programmes to reduce the risk of injury as well as to develop treatment and rehabilitation regimens for the injured individual...
  4. doi request reprint Type V collagen genotype and exercise-related phenotype relationships: a novel hypothesis
    Malcolm Collins
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town and the South African Medical Research Council, Newlands 7925, South Africa
    Exerc Sport Sci Rev 39:191-8. 2011
    ..We therefore hypothesize that variants in the COL5A1 gene alter fibril architecture and structure and, thereby, mechanical properties...
  5. doi request reprint The COL1A1 gene and acute soft tissue ruptures
    Malcolm Collins
    South African Medical Research Council, Cape Town, South Africa
    Br J Sports Med 44:1063-4. 2010
    ..0001) groups. This combined analysis indicates that the TT genotype appears to be protective against acute soft tissue ruptures and should be incorporated into multifactorial models determining risk of acute soft tissue ruptures...
  6. ncbi request reprint Dipsogenic genes associated with weight changes during Ironman Triathlons
    Colleen J Saunders
    Medical Research Council of South Africa, MRC UCT Research Unit for Exercise Science and Sports Medicine, University of Cape Town, Newlands 7725, South Africa
    Hum Mol Genet 15:2980-7. 2006
    ..These findings suggest the involvement of the serotonergic pathways in the control of thirst and drinking behaviour and provide further evidence for the dipsogenic effect of circulating bradykinin...
  7. doi request reprint Association between the 4 bp proinsulin gene insertion polymorphism (IVS-69) and body composition in black South African women
    Peter Berman
    Division of Chemical Pathology, UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa
    Obesity (Silver Spring) 17:1298-300. 2009
    ..In conclusion, the 4 bp proinsulin gene insertion allele is associated with extreme obesity, reflected by greater fat-free soft tissue mass and fat mass, particularly SAT, in obese black South African women...
  8. doi request reprint Tumor necrosis factor-alpha gene -308 G/A polymorphism modulates the relationship between dietary fat intake, serum lipids, and obesity risk in black South African women
    Yael T Joffe
    University of Cape Town Medical Research Council Research Unit for Exercise Science and Sports Medicine, Cape Town, South Africa
    J Nutr 140:901-7. 2010
    ..The TNFA -308 G/A polymorphism modified the relationship between dietary fat intake, obesity risk, and serum lipid concentrations in black SA women...
  9. doi request reprint Polymorphisms within the COL5A1 3'-UTR that alters mRNA structure and the MIR608 gene are associated with Achilles tendinopathy
    Yoonus Abrahams
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Newlands, South Africa
    Ann Hum Genet 77:204-14. 2013
    ..The COL5A1 polymorphisms appear to alter the predicted secondary structure of the 3'-UTR. We propose that the secondary structure plays a role in the regulation of the COL5A1 mRNA stability and by implication type V collagen production...
  10. doi request reprint Investigation of the Sp1-binding site polymorphism within the COL1A1 gene in participants with Achilles tendon injuries and controls
    Michael Posthumus
    UCT MRC Research Unit for Exercise Science and Sports Medicine of the Department of Human Biology, Faculty of Health Sciences, University of Cape Town, South Africa
    J Sci Med Sport 12:184-9. 2009
    ..In conclusion, this study has shown that there is no association between the Sp1-binding site polymorphism within the first intron of COL1A1 and Achilles tendinopathy or Achilles tendon rupture within the population studied...
  11. doi request reprint The COL5A1 gene is associated with increased risk of anterior cruciate ligament ruptures in female participants
    Michael Posthumus
    Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Am J Sports Med 37:2234-40. 2009
    ..The COL5A1 gene, which encodes for the alpha1 chain of type V collagen, has been shown to be associated with Achilles tendon injuries...
  12. doi request reprint Association of type XI collagen genes with chronic Achilles tendinopathy in independent populations from South Africa and Australia
    Melanie Hay
    MRC UCT Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa
    Br J Sports Med 47:569-74. 2013
    ..We investigated the association of these three polymorphisms with Achilles tendinopathy (AT) and whether these polymorphisms interact with COL5A1 to modulate the risk of AT...
  13. ncbi request reprint Investigation of variants within the COL27A1 and TNC genes and Achilles tendinopathy in two populations
    Colleen J Saunders
    MRC UCT Research Unit for Exercise Science and Sports Medicine of the Department of Human Biology, Faculty of Health Sciences, University of Cape Town, PO Box 115, Newlands 7725, South Africa
    J Orthop Res 31:632-7. 2013
    ..This region may have functional effects on the transcription, structure and properties of tenascin-C and the alpha-1 chain of type XXVII collagen...
  14. doi request reprint The apoptosis pathway and the genetic predisposition to Achilles tendinopathy
    Erica Mari Nell
    MRC UCT Research Unit for Exercise Science and Sports Medicine, Faculty of Health Sciences, Department of Human Biology, University of Cape Town, Newlands, South Africa
    J Orthop Res 30:1719-24. 2012
    ..Collectively, these results further implicate the apoptosis signaling cascade as one of the biological pathways involved in the development of AT...
  15. doi request reprint Comparison of body fatness measurements by near-infrared reactance and dual-energy X-ray absorptiometry in normal-weight and obese black and white women
    Courtney L Jennings
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, PO Box 115, Newlands 7725, Cape Town, South Africa
    Br J Nutr 103:1065-9. 2010
    ..The results of single-site NIR as a measure of BF % should therefore be interpreted with caution, particularly in women of African descent and in those with very high levels of adiposity...
  16. doi request reprint Increased running speed and previous cramps rather than dehydration or serum sodium changes predict exercise-associated muscle cramping: a prospective cohort study in 210 Ironman triathletes
    Martin P Schwellnus
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa
    Br J Sports Med 45:650-6. 2011
    ..Despite the high prevalence of exercise-associated muscle cramping (EAMC) in endurance athletes, the aetiology and risk factors for this condition are not fully understood...
  17. doi request reprint The atypical presentation of the metabolic syndrome components in black African women: the relationship with insulin resistance and the influence of regional adipose tissue distribution
    Courtney L Jennings
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, PO Box 115, Newlands 7725, South Africa
    Metabolism 58:149-57. 2009
    ..The measurement of waist circumference, as an indicator of disease risk, should therefore be encouraged in the public health setting...
  18. doi request reprint No association between COL3A1, COL6A1 or COL12A1 gene variants and range of motion
    KEVIN O'CONNELL
    MRC UCT Research Unit for Exercise Science and Sports Medicine, University of Cape Town, Human Biology, Cape Town, South Africa
    J Sports Sci 31:181-7. 2013
    ..Further studies are required to identify additional intrinsic and extrinsic factors that may determine range of motion, including the genetic component...
  19. doi request reprint The interleukin-6, serotonin transporter, and monoamine oxidase A genes and endurance performance during the South African Ironman Triathlon
    Liesl de Milander
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Appl Physiol Nutr Metab 34:858-65. 2009
    ..The neurogenetic basis of the central governor requires further investigation...
  20. ncbi request reprint The COL5A1 gene, ultra-marathon running performance, and range of motion
    James C Brown
    Department of Human Biology, University of Cape Town, Cape Town, South Africa
    Int J Sports Physiol Perform 6:485-96. 2011
    ..The aim of this study was to investigate whether COL5A1 is associated with ultra-marathon running performance and whether this relationship could be partly explained by prerace SR ROM...
  21. ncbi request reprint The guanine-thymine dinucleotide repeat polymorphism within the tenascin-C gene is associated with achilles tendon injuries
    Gaonyadiwe G Mokone
    UCT MRC Research Unit for Exercise Science and Sports Medicine, University of Cape Town, PO Box 115, Newlands 7725, South Africa
    Am J Sports Med 33:1016-21. 2005
    ..The tenascin-C gene, which has been mapped to chromosome 9q32-q34, encodes for a structural component of tendons...
  22. pmc The relationship between dietary fatty acids and inflammatory genes on the obese phenotype and serum lipids
    Yael T Joffe
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, 3rd Floor, SSISA, Boundary Rd, Newlands, Cape Town 7700, South Africa
    Nutrients 5:1672-705. 2013
    ....
  23. doi request reprint Collagen genes and exercise-associated muscle cramping
    KEVIN O'CONNELL
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Clin J Sport Med 23:64-9. 2013
    ..Specifically, the aim of this study was to investigate if the COL5A1 rs12722 (C/T), COL3A1 rs1800255 (G/A), COL6A1 rs35796750 (T/C), and COL12A1 rs970547 (A/G) polymorphisms are associated with a history of EAMC...
  24. pmc Insulin response in relation to insulin sensitivity: an appropriate beta-cell response in black South African women
    Julia H Goedecke
    Department of Human Biology, UCT MRC Research Unit for Exercise Science and Sports Medicine, University of Cape Town, Cape Town, South Africa
    Diabetes Care 32:860-5. 2009
    ..The purpose of this study was to characterize differences in the acute insulin response to glucose (AIR(g)) relative to insulin sensitivity (S(I)) in black and white premenopausal normoglycemic South African women matched for body fatness...
  25. doi request reprint Determinants of insulin-resistant phenotypes in normal-weight and obese Black African women
    Courtney L Jennings
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Obesity (Silver Spring) 16:1602-9. 2008
    ..Subsets of metabolically "healthy obese" and "at-risk" normal-weight individuals have been previously identified. The aim of this study was to explore the determinants of these phenotypes in black South African (SA) women...
  26. ncbi request reprint The bradykinin beta 2 receptor (BDKRB2) and endothelial nitric oxide synthase 3 (NOS3) genes and endurance performance during Ironman Triathlons
    Colleen J Saunders
    MRC UCT Research Unit for Exercise Science and Sports Medicine of the Medical Research Council of South Africa, University of Cape Town, South Africa
    Hum Mol Genet 15:979-87. 2006
    ..6% of the variance in the overall race time for the triathlon. In conclusion, both the NOS3 and BDKRB2 genes are associated with the actual performance during the Ironman Triathlons...
  27. doi request reprint The association between the COL12A1 gene and anterior cruciate ligament ruptures
    Michael Posthumus
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Br J Sports Med 44:1160-5. 2010
    ..Type XII collagen, similarly to types I and V collagen, is a structural component of the ligament fibril and is encoded by a single gene, COL12A1...
  28. ncbi request reprint A polymorphism in a functional region of the COL5A1 gene: association with ultraendurance-running performance and joint range of motion
    Shameemah Abrahams
    UCT MRC Research Unit for Exercise Science and Sports Medicine, University of Cape Town, Cape Town, South Africa
    Int J Sports Physiol Perform 9:583-90. 2014
    ..The aim of this study was to determine whether STRP rs71746744 is independently associated with running performance and prerace sit-and-reach range of motion (SR ROM) in a cohort of ultramarathon road runners...
  29. doi request reprint Factors associated with a self-reported history of exercise-associated muscle cramps in ironman triathletes: a case-control study
    Gavin Shang
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Clin J Sport Med 21:204-10. 2011
    ..The exact cause of and risk factors for EAMC are still being investigated. The main objective of this study was to investigate factors that are associated with a self-reported history of EAMC in Ironman triathletes...
  30. doi request reprint The COL5A1 gene: a novel marker of endurance running performance
    Michael Posthumus
    UCT MRC Research Unit for Exercise Science and Sports Medicine of the Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Med Sci Sports Exerc 43:584-9. 2011
    ..Type V collagen is a quantitatively minor fibrillar collagen, which is believed to regulate fibrillogenesis within tendons and other connective tissue...
  31. doi request reprint Sequence variants within the 3'-UTR of the COL5A1 gene alters mRNA stability: implications for musculoskeletal soft tissue injuries
    Mary Jessica Laguette
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa
    Matrix Biol 30:338-45. 2011
    ..These results have important implications for our understanding of the molecular basis of musculoskeletal soft tissue injuries and other exercise-related phenotypes...
  32. pmc Interleukin-6 gene polymorphisms, dietary fat intake, obesity and serum lipid concentrations in black and white South African women
    Yael T Joffe
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town 7505, South Africa
    Nutrients 6:2436-65. 2014
    ..This study is the first to show that dietary fat intake modulates the relationship between the IL-6 -174 G>C, IVS3 +281 G>T and IVS4 +869 A>G polymorphisms on obesity and serum lipids in black and white SA women. ..
  33. doi request reprint The intrinsic risk factors for ACL ruptures: an evidence-based review
    Michael Posthumus
    UCT MRC Research Unit for Exercise Science and Sports Medicine, University of Cape Town, Cape Town, South Africa
    Phys Sportsmed 39:62-73. 2011
    ..These data should be used to establish multifactorial risk factor models designed to identify individuals at high risk of sustaining an ACL injury...
  34. doi request reprint A pathway-based approach investigating the genes encoding interleukin-1β, interleukin-6 and the interleukin-1 receptor antagonist provides new insight into the genetic susceptibility of Achilles tendinopathy
    Alison V September
    UCT MRC Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa
    Br J Sports Med 45:1040-7. 2011
    ..Achilles tendinopathy (AT) is a multifactorial condition for which genetic risk factors have been identified. A pathway-based approach was used to investigate genes within the inflammatory pathway...
  35. doi request reprint Are splanchnic hemodynamics related to the development of gastrointestinal symptoms in ironman triathletes? A prospective cohort study
    Helen Wright
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Clin J Sport Med 21:337-43. 2011
    ..To determine if prerace to postrace changes in superior mesenteric artery (SMA) and coeliac artery hemodynamics were related to the development of gastrointestinal (GI) symptoms during a triathlon...
  36. doi request reprint Skeletal muscle monocarboxylate transporter content is not different between black and white runners
    Yolande X R Harley
    Department of Human Biology, University of Cape Town, UCT MRC Research Unit for Exercise Science Sports Medicine, PO Box 115, Newlands, Cape Town 7725, South Africa
    Eur J Appl Physiol 105:623-32. 2009
    ..88, P < 0.001), but MCT1 content did not. Although whole homogenate MCT content was not different between the groups, more research is required to explain the lower plasma lactate concentrations in black runners...
  37. pmc Tendon and ligament injuries: the genetic component
    Alison V September
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Br J Sports Med 41:241-6; discussion 246. 2007
    ..In future, specific genotypes associated with increased risk of injury to specific tendons and ligaments can prevent these injuries by identifying individuals at higher risk...
  38. pmc The -308 G/A polymorphism of the tumour necrosis factor-α gene modifies the association between saturated fat intake and serum total cholesterol levels in white South African women
    Yael T Joffe
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Newlands, Cape Town, South Africa
    Genes Nutr 6:353-9. 2011
    ..The TNFA -308 G/A polymorphism appears to modify the relationship between dietary fat intake and serum total cholesterol concentrations in white SA women...
  39. doi request reprint Variants within the COMP and THBS2 genes are not associated with Achilles tendinopathy in a case-control study of South African and Australian populations
    Colleen J Saunders
    a MRC UCT Research Unit for Exercise Science and Sports Medicine of the Department of Human Biology, Faculty of Health Sciences, University of Cape Town, South Africa
    J Sports Sci 32:92-100. 2014
    ..As the selection of COMP and THBS2 as candidate genes was hypothesis driven, based on biological function, the possibility that other variants within these genes are associated with Achilles tendinopathy cannot be excluded...
  40. doi request reprint What makes champions? A review of the relative contribution of genes and training to sporting success
    Ross Tucker
    Department of Human Biology, Exercise Science and Sports Medicine, University of Cape Town, South Africa
    Br J Sports Med 46:555-61. 2012
    ....
  41. ncbi request reprint Mind and muscle: the cognitive-affective neuroscience of exercise
    Dan J Stein
    Department of Mental Health and Psychiatry, University of Cape Town, South Africa
    CNS Spectr 12:19-22. 2007
    ..The hypothesis that Homo sapiens evolved as a specialist endurance runner provides an intriguing context against which to research the proximal mechanisms relevant to a cognitive-affective neuroscience of exercise...
  42. doi request reprint A comparison of two treatment protocols in the management of exercise-associated postural hypotension: a randomised clinical trial
    Cameron Anley
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, South Africa
    Br J Sports Med 45:1113-8. 2011
    ..To investigate which of two commonly used treatment protocols for exercise-associated postural hypotension (EAPH) resulted in earlier discharge from the medical facility...
  43. doi request reprint Skeletal muscle telomere length in healthy, experienced, endurance runners
    Dale E Rae
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Eur J Appl Physiol 109:323-30. 2010
    ..035). Therefore, since exposure to endurance running may influence minimum TRF length, and by implication, the proliferative potential of the satellite cells, chronic endurance running may be seen as a stressor to skeletal muscle...
  44. ncbi request reprint The COL5A1 Gene, Ultra-Marathon Running Performance, and Range of Motion
    James C Brown
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Int J Sports Physiol Perform 6:485-96. 2011
    ..The aim of this study was to investigate whether COL5A1 is associated with ultra-marathon running performance and whether this relationship could be partly explained by prerace SR ROM...
  45. ncbi request reprint Maintenance of plasma volume and serum sodium concentration despite body weight loss in ironman triathletes
    Tamara Hew-Butler
    University of Capetown Medical Research Council Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa
    Clin J Sport Med 17:116-22. 2007
    ..To examine the relationship between body weight, plasma volume, and serum sodium concentration ([Na]) during prolonged endurance exercise...
  46. ncbi request reprint Dysnatremia predicts a delayed recovery in collapsed ultramarathon runners
    Tamara Hew-Butler
    Department of Human Biology, University of Cape Town, South Africa
    Clin J Sport Med 17:289-96. 2007
    ....
  47. ncbi request reprint Athletes with exercise-associated fatigue have abnormally short muscle DNA telomeres
    Malcolm Collins
    Department of Human Biology, University of Cape Town, South Africa
    Med Sci Sports Exerc 35:1524-8. 2003
    ....
  48. ncbi request reprint Weight changes, sodium levels, and performance in the South African Ironman Triathlon
    Karen Sharwood
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town and Sports Science Institute of South Africa, South Africa
    Clin J Sport Med 12:391-9. 2002
    ..To establish relationships between body weight changes and serum sodium during and after an Ironman Triathlon, and postrace fluid status and rectal temperature, including the incidence of hyponatremia...
  49. doi request reprint The genetic basis for elite running performance
    Ross Tucker
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Br J Sports Med 47:545-9. 2013
    ....
  50. doi request reprint Increased running speed and pre-race muscle damage as risk factors for exercise-associated muscle cramps in a 56 km ultra-marathon: a prospective cohort study
    Martin P Schwellnus
    Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, South Africa
    Br J Sports Med 45:1132-6. 2011
    ..Despite the high prevalence of exercise-associated muscle cramping (EAMC) in endurance runners, the aetiology and risk factors for this condition are not fully understood...
  51. doi request reprint A Polymorphism in a Functional Region of the COL5A1 Gene: Association With Ultraendurance-Running Performance and Joint Range of Motion
    Shameemah Abrahams
    UCT MRC Research Unit for Exercise Science and Sports Medicine, University of Cape Town, Cape Town, South Africa
    Int J Sports Physiol Perform 9:583-90. 2014
    ..Further studies are needed to investigate the effect of this variant on the mechanical properties of connective tissue. ..
  52. ncbi request reprint The interaction of aging and 10 years of racing on ultraendurance running performance
    Dale E Rae
    Dept of Human Biology, University of Cape Town, Newlands, South Africa
    J Aging Phys Act 13:210-22. 2005
    ..In conclusion, these data suggest that although these runners showed similar patterns of change in race speed over a 10-year period, the extent of change in performance was greater in younger than in older runners...
  53. ncbi request reprint The science of sex verification and athletic performance
    Ross Tucker
    UCT MRC Research Unit for Exercise Science and Sports Medicine of the Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Int J Sports Physiol Perform 5:127-39. 2010
    ..This review will therefore provide the historical context of the debate and aim to discuss relevant physiological and performance aspects of the sex verification process...
  54. ncbi request reprint The association of interleukin-18 genotype and serum levels with metabolic risk factors for cardiovascular disease
    Juliet Evans
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, PO Box 115, Newlands, 7725 Cape Town, South Africa
    Eur J Endocrinol 157:633-40. 2007
    ..This study investigated the association between the circulating IL-18 levels and the -137 G/C polymorphism within the IL-18 gene with metabolic risk factors for CVD in normal-weight and obese black South African women...
  55. doi request reprint Muscle cramping in athletes--risk factors, clinical assessment, and management
    Martin P Schwellnus
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, 3rd Floor, Sports Science Institute of South Africa, Boundary Road, Newlands, Cape Town 7700, South Africa
    Clin Sports Med 27:183-94, ix-x. 2008
    ..The diagnosis of EAMC is made clinically, and the most effective immediate management of EAMC is rest and passive stretching. The key to the prevention of EAMC is to reduce the risk of developing premature muscle fatigue...
  56. ncbi request reprint Acute interleukin-6 administration impairs athletic performance in healthy, trained male runners
    Paula J Robson-Ansley
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Dept of Human Biology, Univ of Cape Town, Newlands, South Africa
    Can J Appl Physiol 29:411-8. 2004
    ....
  57. ncbi request reprint The ACE gene and endurance performance during the South African Ironman Triathlons
    Malcolm Collins
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa
    Med Sci Sports Exerc 36:1314-20. 2004
    ..The aim of this study was to determine whether the ID polymorphism is associated with the performance of the fastest finishers of the South African Ironman Triathlons...
  58. ncbi request reprint Exercise and CaMK activation both increase the binding of MEF2A to the Glut4 promoter in skeletal muscle in vivo
    James A H Smith
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, P O Box 115, Newlands 7725, South Africa
    Am J Physiol Endocrinol Metab 292:E413-20. 2007
    ..These results confirm that exercise increases the binding of MEF2A to the Glut4 promoter in vivo and provides evidence that CaMK signaling is involved in this interaction...
  59. doi request reprint Genetic risk factors for anterior cruciate ligament ruptures: COL1A1 gene variant
    M Posthumus
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Newlands 7725, Cape Town, South Africa
    Br J Sports Med 43:352-6. 2009
    ..Recently, the gene encoding for the alpha1 chain of type I collagen (COL1A1) has been shown to be associated with cruciate ligament ruptures and shoulder dislocations...
  60. doi request reprint Variants within the COL5A1 gene are associated with Achilles tendinopathy in two populations
    A V September
    MRC UCT Research Unit for Exercise Science and Sports Medicine, University of Cape Town, Newlands 7725, South Africa
    Br J Sports Med 43:357-65. 2009
    ....