Karen Cohen

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. pmc Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections
    Ronald Gounden
    Department of Medicine, Division of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 9:26. 2009
  2. pmc The impact of the National HIV Health Care Worker Hotline on patient care in South Africa
    Briony S Chisholm
    Medicines Information Centre, University of Cape Town, Cape Town, South Africa
    AIDS Res Ther 8:4. 2011
  3. ncbi request reprint Effect of rifampicin-based antitubercular therapy on nevirapine plasma concentrations in South African adults with HIV-associated tuberculosis
    Karen Cohen
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, South Africa
    J Antimicrob Chemother 61:389-93. 2008
  4. pmc Effect of rifampicin-based antitubercular therapy and the cytochrome P450 2B6 516G>T polymorphism on efavirenz concentrations in adults in South Africa
    Karen Cohen
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Antivir Ther 14:687-95. 2009
  5. doi request reprint Outcomes of nevirapine- and efavirenz-based antiretroviral therapy when coadministered with rifampicin-based antitubercular therapy
    Andrew Boulle
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    JAMA 300:530-9. 2008
  6. doi request reprint Effectiveness and safety of antiretrovirals with rifampicin: crucial issues for high-burden countries
    Gary Maartens
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Antivir Ther 14:1039-43. 2009
  7. pmc Management of individuals requiring antiretroviral therapy and TB treatment
    Karen Cohen
    Division of Clinical Pharmacology, Department of Medicine, Cape Town, South Africa
    Curr Opin HIV AIDS 5:61-9. 2010
  8. pmc Efavirenz and rifampicin in the South African context: is there a need to dose-increase efavirenz with concurrent rifampicin therapy?
    Catherine Orrell
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Antivir Ther 16:527-34. 2011
  9. pmc Antiretroviral therapy and early mortality in South Africa
    Andrew Boulle
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    Bull World Health Organ 86:678-87. 2008
  10. ncbi request reprint Dosage adjustment in medical patients with renal impairment at Groote Schuur Hospital
    Eric Decloedt
    Division of Clinical Pharmacology, Department of Internal Medicine, UCT
    S Afr Med J 100:304-6. 2010

Detail Information

Publications12

  1. pmc Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections
    Ronald Gounden
    Department of Medicine, Division of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 9:26. 2009
    ..Nosocomial infections due to multi-drug resistant Acinetobacter baumannii are often treated with colistin, but there are few data comparing its safety and efficacy with other antimicrobials...
  2. pmc The impact of the National HIV Health Care Worker Hotline on patient care in South Africa
    Briony S Chisholm
    Medicines Information Centre, University of Cape Town, Cape Town, South Africa
    AIDS Res Ther 8:4. 2011
    ..abstract:..
  3. ncbi request reprint Effect of rifampicin-based antitubercular therapy on nevirapine plasma concentrations in South African adults with HIV-associated tuberculosis
    Karen Cohen
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, South Africa
    J Antimicrob Chemother 61:389-93. 2008
    ..We describe the steady-state pharmacokinetics of nevirapine during and after antitubercular therapy in South African patients...
  4. pmc Effect of rifampicin-based antitubercular therapy and the cytochrome P450 2B6 516G>T polymorphism on efavirenz concentrations in adults in South Africa
    Karen Cohen
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Antivir Ther 14:687-95. 2009
    ..We explored the effect of rifampicin-based antitubercular therapy and the 516G>T polymorphism on efavirenz concentrations in HIV-infected patients in South Africa...
  5. doi request reprint Outcomes of nevirapine- and efavirenz-based antiretroviral therapy when coadministered with rifampicin-based antitubercular therapy
    Andrew Boulle
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    JAMA 300:530-9. 2008
    ..Rifampicin-based antitubercular therapy reduces the plasma concentrations of nevirapine and efavirenz. The virological consequences of these interactions are not well described...
  6. doi request reprint Effectiveness and safety of antiretrovirals with rifampicin: crucial issues for high-burden countries
    Gary Maartens
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Antivir Ther 14:1039-43. 2009
    ....
  7. pmc Management of individuals requiring antiretroviral therapy and TB treatment
    Karen Cohen
    Division of Clinical Pharmacology, Department of Medicine, Cape Town, South Africa
    Curr Opin HIV AIDS 5:61-9. 2010
    ..The incidence of TB in patients established on ART remains high. Co-treatment presents several management challenges. Recent data on these management issues are reviewed...
  8. pmc Efavirenz and rifampicin in the South African context: is there a need to dose-increase efavirenz with concurrent rifampicin therapy?
    Catherine Orrell
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Antivir Ther 16:527-34. 2011
    ..Increasing efavirenz (EFV) dose from 600 mg to 800 mg daily has been suggested with concomitant rifampicin (RFN), as induction of cytochrome P450 isoenzymes may reduce EFV plasma concentrations...
  9. pmc Antiretroviral therapy and early mortality in South Africa
    Andrew Boulle
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    Bull World Health Organ 86:678-87. 2008
    ..To describe province-wide outcomes and temporal trends of the Western Cape Province antiretroviral treatment (ART) programme 5 years since inception, and to demonstrate the utility of the WHO monitoring system for ART...
  10. ncbi request reprint Dosage adjustment in medical patients with renal impairment at Groote Schuur Hospital
    Eric Decloedt
    Division of Clinical Pharmacology, Department of Internal Medicine, UCT
    S Afr Med J 100:304-6. 2010
    ..Many drugs are eliminated by the kidneys and therefore may require dose adjustment in patients with renal impairment. The need for dose adjustment is frequently neglected by prescribers...
  11. pmc Systematic review of antiretroviral-associated lipodystrophy: lipoatrophy, but not central fat gain, is an antiretroviral adverse drug reaction
    ReneƩ de Waal
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 8:e63623. 2013
    ..Lipoatrophy and/or central fat gain are observed frequently in patients on antiretroviral therapy (ART). Both are assumed to be antiretroviral adverse drug reactions...
  12. ncbi request reprint Antiretroviral therapy in a community clinic--early lessons from a pilot project
    Linda Gail Bekker
    HIV Research Unit, University of Cape Town, Provincial Administration of the Western Cape
    S Afr Med J 93:458-62. 2003
    ..To report on operational and clinical problems encountered during the first 6 months of a community-based antiretroviral therapy (ART) programme...