Novel N Chegou

Summary

Affiliation: University of Stellenbosch
Country: South Africa

Publications

  1. pmc Utility of host markers detected in Quantiferon supernatants for the diagnosis of tuberculosis in children in a high-burden setting
    Novel N Chegou
    DST NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa
    PLoS ONE 8:e64226. 2013
  2. pmc Potential of host markers produced by infection phase-dependent antigen-stimulated cells for the diagnosis of tuberculosis in a highly endemic area
    Novel N Chegou
    Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
    PLoS ONE 7:e38501. 2012
  3. pmc Potential of novel Mycobacterium tuberculosis infection phase-dependent antigens in the diagnosis of TB disease in a high burden setting
    Novel N Chegou
    DST NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa
    BMC Infect Dis 12:10. 2012
  4. pmc Host markers in QuantiFERON supernatants differentiate active TB from latent TB infection: preliminary report
    Novel N Chegou
    Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences, University of Stellenbosch, Cape Town, Western Cape Province, Tygerberg 7505, South Africa
    BMC Pulm Med 9:21. 2009
  5. doi request reprint Serologic diagnosis of tuberculosis by combining Ig classes against selected mycobacterial targets
    Ralf Baumann
    DST NRF Centre of Excellence for Biomedical TB Research and MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, P O Box 19063, Tygerberg 7505, South Africa Lionex Diagnostics and Therapeutics, 38126 Braunschweig, Germany
    J Infect 69:581-9. 2014
  6. pmc Differential expression of host biomarkers in saliva and serum samples from individuals with suspected pulmonary tuberculosis
    Khutso G Phalane
    DST NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Stellenbosch, P O Box 19063, Francie van Zijl Drive, Tygerberg 7505, South Africa
    Mediators Inflamm 2013:981984. 2013
  7. pmc Host cytokine responses induced after overnight stimulation with novel M. tuberculosis infection phase-dependent antigens show promise as diagnostic candidates for TB disease
    Paulin N Essone
    DST NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa
    PLoS ONE 9:e102584. 2014
  8. doi request reprint Bifunctional T-cell-derived cytokines for the diagnosis of tuberculosis and treatment monitoring
    Paulin N Essone
    DST NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa
    Respiration 88:251-61. 2014
  9. doi request reprint Serodiagnostic markers for the prediction of the outcome of intensive phase tuberculosis therapy
    Ralf Baumann
    DST NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, P O Box 19063, Tygerberg 7505, South Africa
    Tuberculosis (Edinb) 93:239-45. 2013
  10. doi request reprint Evaluation of adapted whole-blood interferon-gamma release assays for the diagnosis of pleural tuberculosis
    Novel N Chegou
    Department of Biomedical Sciences, Division of Molecular Biology and Human Genetics, DST NRF Centre of Excellence for Biomedical Tuberculosis Research, US MRC Centre for Molecular and Cellular Biology, Stellenbosch University, Cape Town, South Africa
    Respiration 76:131-8. 2008

Collaborators

Detail Information

Publications16

  1. pmc Utility of host markers detected in Quantiferon supernatants for the diagnosis of tuberculosis in children in a high-burden setting
    Novel N Chegou
    DST NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa
    PLoS ONE 8:e64226. 2013
    ..tb) infection states. In this study, the utility of such markers was investigated in children screened for TB in a setting with high TB incidence...
  2. pmc Potential of host markers produced by infection phase-dependent antigen-stimulated cells for the diagnosis of tuberculosis in a highly endemic area
    Novel N Chegou
    Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
    PLoS ONE 7:e38501. 2012
    ..In this study, the levels of 11 host markers other than IFN-γ, were evaluated in whole blood culture supernatants after stimulation with M.tb infection phase-dependent antigens, for the diagnosis of TB disease...
  3. pmc Potential of novel Mycobacterium tuberculosis infection phase-dependent antigens in the diagnosis of TB disease in a high burden setting
    Novel N Chegou
    DST NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa
    BMC Infect Dis 12:10. 2012
    ..tb infection states. In this study, we assessed the diagnostic potential of 118 different M.tb infection phase-dependent antigens in TB patients and household contacts (HHCs) in a high-burden setting...
  4. pmc Host markers in QuantiFERON supernatants differentiate active TB from latent TB infection: preliminary report
    Novel N Chegou
    Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences, University of Stellenbosch, Cape Town, Western Cape Province, Tygerberg 7505, South Africa
    BMC Pulm Med 9:21. 2009
    ..These assays however, do not discriminate between latent TB infection (LTBI) and active TB disease...
  5. doi request reprint Serologic diagnosis of tuberculosis by combining Ig classes against selected mycobacterial targets
    Ralf Baumann
    DST NRF Centre of Excellence for Biomedical TB Research and MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, P O Box 19063, Tygerberg 7505, South Africa Lionex Diagnostics and Therapeutics, 38126 Braunschweig, Germany
    J Infect 69:581-9. 2014
    ..Accurate, simple and cost-effective diagnostic tests are needed for diagnosis of active tuberculosis (TB). Serodiagnosis is attractive as it can be harnessed for point-of-care tests...
  6. pmc Differential expression of host biomarkers in saliva and serum samples from individuals with suspected pulmonary tuberculosis
    Khutso G Phalane
    DST NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Stellenbosch, P O Box 19063, Francie van Zijl Drive, Tygerberg 7505, South Africa
    Mediators Inflamm 2013:981984. 2013
    ....
  7. pmc Host cytokine responses induced after overnight stimulation with novel M. tuberculosis infection phase-dependent antigens show promise as diagnostic candidates for TB disease
    Paulin N Essone
    DST NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa
    PLoS ONE 9:e102584. 2014
    ..The aim of the present study was to evaluate the utility of these markers further, and cross-compare results with short-term antigen stimulated and unstimulated culture supernatants...
  8. doi request reprint Bifunctional T-cell-derived cytokines for the diagnosis of tuberculosis and treatment monitoring
    Paulin N Essone
    DST NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa
    Respiration 88:251-61. 2014
    ..Diagnosis and treatment monitoring of patients with tuberculosis remain challenging...
  9. doi request reprint Serodiagnostic markers for the prediction of the outcome of intensive phase tuberculosis therapy
    Ralf Baumann
    DST NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, P O Box 19063, Tygerberg 7505, South Africa
    Tuberculosis (Edinb) 93:239-45. 2013
    ..This approach holds promise and requires further evaluation for its utility in the prediction of treatment failure and relapse, the evaluation of new TB therapeutics, as well as in the care of individual patients...
  10. doi request reprint Evaluation of adapted whole-blood interferon-gamma release assays for the diagnosis of pleural tuberculosis
    Novel N Chegou
    Department of Biomedical Sciences, Division of Molecular Biology and Human Genetics, DST NRF Centre of Excellence for Biomedical Tuberculosis Research, US MRC Centre for Molecular and Cellular Biology, Stellenbosch University, Cape Town, South Africa
    Respiration 76:131-8. 2008
    ..Recently, in vitro interferon (IFN)-gamma-based assays have been introduced in the diagnosis of latent TB, but these techniques have not been established in the diagnosis of active TB disease, including pleural TB...
  11. doi request reprint Tuberculosis assays: past, present and future
    Novel N Chegou
    DST NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, University of Stellenbosch, PO Box 19063, Francie van Zijl Drive, Tygerberg 7505, South Africa
    Expert Rev Anti Infect Ther 9:457-69. 2011
    ..Host markers associated with active disease may hold promise, especially in situations where sputum diagnostics are problematic, including in children, HIV-infected individuals and in the case of extrapulmonary TB...
  12. pmc The impact of HIV exposure and maternal Mycobacterium tuberculosis infection on infant immune responses to bacille Calmette-Guérin vaccination
    Christine E Jones
    aAcademic Department of Pediatrics, Imperial College London, London, UK bInstitute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa cPaediatric Infectious Diseases Research Group, St George s, University of London, London, UK dDesmond Tutu TB Centre, Department of Pediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Stellenbosch eSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town fDST NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University gDivision of Statistics and Actuarial Sciences, Faculty of Science, University of Stellenbosch, Stellenbosch, South Africa hMRC National Institute for Medical Research, Mill Hill, London, UK iClinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa jDivision of Medicine, Imperial College London, London, UK kVaccinology Theme, Medical Research Council Unit, Banjul, The Gambia
    AIDS 29:155-65. 2015
    ..The objective of this study is to assess the effect of maternal HIV and Mycobacterium tuberculosis (Mtb) infection on cellular responses to bacille Calmette-Guérin (BCG) immunization...
  13. doi request reprint Agreement between assays of cell-mediated immunity utilizing Mycobacterium bovis-specific antigens for the diagnosis of tuberculosis in African buffaloes (Syncerus caffer)
    Wynand J Goosen
    DST NRF Centre of Excellence for Biomedical TB Research MRC Centre for Molecular and Cellular Biology Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, P O Box 19063, Tygerberg 7505, South Africa
    Vet Immunol Immunopathol 160:133-8. 2014
    ..Agreements between the two Bovigam(®) and two mQFT assays were moderate, suggesting that in its current format the mQFT assay is less sensitive than either the BEC or the BHP assays...
  14. doi request reprint Differential cytokine/chemokines and KL-6 profiles in patients with different forms of tuberculosis
    Joel Fleury Djoba Siawaya
    Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences MRC Centre for Molecular and Cellular Biology DST and NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, South Africa
    Cytokine 47:132-6. 2009
    ..Plasma levels of cytokines may therefore contribute to biosignatures of diseases like TB but the data also highlight systemic differences between pulmonary TB, pleural TB and other form of pleural effusion diseases...
  15. pmc Kolaviron, a Garcinia biflavonoid complex ameliorates hyperglycemia-mediated hepatic injury in rats via suppression of inflammatory responses
    Omolola R Ayepola
    Department of Biomedical Sciences, Cape Peninsula, Oxidative Stress Research Centre, University of Technology, Bellville, South Africa
    BMC Complement Altern Med 13:363. 2013
    ..To our knowledge, this is the first study to investigate the effect of KV on pro-inflammatory proteins in the liver of diabetic rats...
  16. doi request reprint Beyond the IFN-γ horizon: biomarkers for immunodiagnosis of infection with Mycobacterium tuberculosis
    Novel N Chegou
    Division of Molecular Biology and Human Genetics, Dept of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa
    Eur Respir J 43:1472-86. 2014
    ....