Research Topics
| A BoulleSummaryAffiliation: University of Cape Town Country: South Africa Publications
| Collaborators
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Detail Information
Publications
Effectiveness of antiretroviral treatment in a South African program: a cohort studyLara R Fairall
Knowledge Translation Unit, University of Cape Town Lung Institute, University of Cape Town, Cape Town, South Africa
Arch Intern Med 168:86-93. 2008....
Public-health and individual approaches to antiretroviral therapy: township South Africa and Switzerland comparedOlivia Keiser
Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
PLoS Med 5:e148. 2008..We compared virologic response, changes to first-line regimens, and mortality in HIV-infected patients starting HAART in South Africa and Switzerland...- Short-term risk of anaemia following initiation of combination antiretroviral treatment in HIV-infected patients in countries in sub-Saharan Africa, Asia-Pacific, and central and South AmericaJialun Zhou
The Kirby Institute, The University of New South Wales, Sydney, NSW, Australia
J Int AIDS Soc 15:5. 2012.... - Efficacy of sulphadoxine-pyrimethamine with or without artesunate for the treatment of uncomplicated Plasmodium falciparum malaria in southern Mozambique: a randomized controlled trialElizabeth N Allen
Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, South Africa
Malar J 8:141. 2009..An artemisinin-based combination therapy, artesunate (AS) plus sulphadoxine-pyrimethamine (SP), was compared to SP monotherapy to provide evidence of further treatment options in southern Mozambique... - Adherence to antiretroviral therapy in young children in Cape Town, South Africa, measured by medication return and caregiver self-report: a prospective cohort studyMary Ann Davies
Red Cross War Memorial Children s Hospital and the School of Child and Adolescent Health, University of Cape Town, Cape Town, The Republic of South Africa
BMC Pediatr 8:34. 2008..This study describes the utility of different measures of adherence in detecting lapses in infants and young children in Cape Town, South Africa... - Reduced referral and case fatality rates for severe symptomatic hyperlactataemia in a South African public sector antiretroviral programme: a retrospective observational studyCharlotte Schutz
Infectious Diseases Unit, GF Jooste Hospital, Duinefontein Road, Manenberg, 7764, Cape Town, South Africa
AIDS Res Ther 7:13. 2010..This study assessed trends in referral rate, severity at presentation and case fatality rate for severe SHL... - Seven-year experience of a primary care antiretroviral treatment programme in Khayelitsha, South AfricaAndrew Boulle
School of Public Health and Family Medicine, University of Cape Town, Anzio Road, Cape Town, South Africa
AIDS 24:563-72. 2010..We report on outcomes after 7 years of a community-based antiretroviral therapy (ART) programme in Khayelitsha, South Africa, with death registry linkages to correct for mortality under-ascertainment... - Outcomes of nevirapine- and efavirenz-based antiretroviral therapy when coadministered with rifampicin-based antitubercular therapyAndrew Boulle
School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
JAMA 300:530-9. 2008..Rifampicin-based antitubercular therapy reduces the plasma concentrations of nevirapine and efavirenz. The virological consequences of these interactions are not well described... - Exploring HIV risk perception and behaviour in the context of antiretroviral treatment: results from a township household surveyA Boulle
School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
AIDS Care 20:771-81. 2008..Even greater coverage of preventive interventions is required, together with a national social and political environment that builds on the availability of both preventive and treatment services... - Antiretroviral therapy and early mortality in South AfricaAndrew Boulle
School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
Bull World Health Organ 86:678-87. 2008..To describe province-wide outcomes and temporal trends of the Western Cape Province antiretroviral treatment (ART) programme 5 years since inception, and to demonstrate the utility of the WHO monitoring system for ART... 
Substitutions due to antiretroviral toxicity or contraindication in the first 3 years of antiretroviral therapy in a large South African cohortAndrew Boulle
Infectious Disease Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
Antivir Ther 12:753-60. 2007..The patterns and reasons for antiretroviral therapy (ART) drug substitutions are poorly described in resource-limited settings...- Risk factors for and clinical characteristics of severe hyperlactataemia in patients receiving antiretroviral therapy: a case-control studyMeg Osler
Infectious Disease Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
HIV Med 11:121-9. 2010..Symptomatic hyperlactataemia and lactic acidosis (SHLA) are potentially life-threatening complications associated with stavudine (d4T), an antiretroviral therapy (ART) drug widely used in developing countries... - Early adherence to antiretroviral medication as a predictor of long-term HIV virological suppression: five-year follow up of an observational cohortNathan Ford
Medecins Sans Frontieres, Cape Town, South Africa
PLoS ONE 5:e10460. 2010..Previous studies have demonstrated a cross-sectional relationship between antiretroviral adherence and HIV virological suppression. We assessed the predictive value of baseline adherence in determining long-term virological failure... - Provision of antiretroviral therapy to children within the public sector of South AfricaPeter Bock
School of Public Health and Family Medicine, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa
Trans R Soc Trop Med Hyg 102:905-11. 2008..The higher death rates at level 2 & 3 facilities are most likely due to recruitment of sicker patients at this level... - Monitoring the South African National Antiretroviral Treatment Programme, 2003-2007: the IeDEA Southern Africa collaborationMorna Cornell
Infectious Disease Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town
S Afr Med J 99:653-60. 2009.... - Interferon release does not add discriminatory value to smear-negative HIV-tuberculosis algorithmsM X Rangaka
Centre for Infectious Disease and Epidemiology Research School of Health Sciences, University of Cape Town, Observatory, 7925, Cape Town, South Africa
Eur Respir J 39:163-71. 2012..Evaluation of new TB diagnostics for clinical relevance should follow a multivariable process that goes beyond test accuracy... - Evaluation of a diagnostic algorithm for smear-negative pulmonary tuberculosis in HIV-infected adultsP Saranchuk
Medecins Sans Frontieres, Cape Town, South Africa
S Afr Med J 97:517-23. 2007..To evaluate the diagnostic accuracy of and reduction in diagnostic delay attributable to a clinical algorithm used for the diagnosis of smear-negative pulmonary tuberculosis (SNPTB) in HIV-infected adults... - Outcomes after two years of providing antiretroviral treatment in Khayelitsha, South AfricaDavid Coetzee
Infectious Disease Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Anzio Road, Observatory 7925, South Africa
AIDS 18:887-95. 2004..With responsible implementation, ART is a key component of a comprehensive response to the epidemic in those communities most affected by HIV... - Severe hyperlactataemia complicating stavudine first-line antiretroviral therapy in South AfricaDavid Stead
GF Jooste Hospital, Cape Town, South Africa
Antivir Ther 13:937-43. 2008..In the public sector antiretroviral therapy (ART) programme in South Africa the standardized first-line regimen includes stavudine (d4T). Severe symptomatic hyperlactataemia (SHL) is a potentially life-threatening complication of d4T... - Outcomes of the South African National Antiretroviral Treatment Programme for children: the IeDEA Southern Africa collaborationMary Ann Davies
School of Public Health and Family Medicine, University of Cape Town
S Afr Med J 99:730-7. 2009..To assess paediatric antiretroviral treatment (ART) outcomes and their associations from a collaborative cohort representing 20% of the South African national treatment programme... - The nervous system effects of occupational exposure on workers in a South African manganese smelterJonathan E Myers
Occupational and Environmental Health Research Unit, School of Public Health and Primary Health Care, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, South Africa
Neurotoxicology 24:885-94. 2003.... - Effectiveness of the first district-wide programme for the prevention of mother-to-child transmission of HIV in South AfricaDavid Coetzee
Infectious Disease Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
Bull World Health Organ 83:489-94. 2005.... - Promoting adherence to antiretroviral therapy: the experience from a primary care setting in Khayelitsha, South AfricaDavid Coetzee
Infectious Disease Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
AIDS 18:S27-31. 2004..To describe the approach used to promote adherence to antiretroviral therapy (ART) and to present the outcomes in the first primary care public sector ART project in South Africa... - Orphans of the AIDS epidemic? The extent, nature and circumstances of child-headed households in South AfricaHelen Meintjes
Children s Institute, University of Cape Town, South Africa
AIDS Care 22:40-9. 2010.... - Autoimmunity predominates in a large South African cohort with Addison's disease of mainly European descent despite long-standing disease and is associated with HLA DQB*0201Ian Ross
Division of Endocrinology, University of Cape Town, Observatory, Cape Town, South Africa
Clin Endocrinol (Oxf) 73:291-8. 2010..We sought to determine whether autoimmunity is the predominant cause of Addison's disease in South Africa and whether human leucocyte antigen (HLA) DQ association exists... - Effect of rifampicin-based antitubercular therapy on nevirapine plasma concentrations in South African adults with HIV-associated tuberculosisKaren Cohen
Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, South Africa
J Antimicrob Chemother 61:389-93. 2008..We describe the steady-state pharmacokinetics of nevirapine during and after antitubercular therapy in South African patients... - Virologic failure and second-line antiretroviral therapy in children in South Africa--the IeDEA Southern Africa collaborationMary Ann Davies
School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
J Acquir Immune Defic Syndr 56:270-8. 2011..We evaluated the probability and determinants of virologic failure and switching in children in South Africa... - Initiation of highly active antiretroviral therapy among pregnant women in Cape Town, South AfricaKathryn Stinson
Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
Trop Med Int Health 15:825-32. 2010..To investigate highly active antiretroviral therapy (HAART) initiation among pregnant women and the optimum model of service delivery for integrating HAART services into antenatal care... - CD4 T-cell responses to combination antiretroviral therapyGary Maartens
Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
Lancet 370:366-8. 2007 - Population effect of scaling up ART in resource-poor settingsMatthias Egger
International epidemiological Databases to Evaluate AIDS (IeDEA, Infectious Disease Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
Lancet 371:1558-9. 2008 - Influence of human immunodeficiency virus and CD4 count on the prevalence of human papillomavirus in heterosexual couplesZizipho Z A Mbulawa
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
J Gen Virol 91:3023-31. 2010..In contrast, female genital HPV prevalence and HPV type-specific sharing were determined by their own HIV-positive status and not by that of their male partner... - Measles vaccination coverage in high-incidence areas of the Western Cape, following the mass vaccination campaignG L Bernhardt
University of Cape Town, South Africa
S Afr Med J 103:181-6. 2013..South Africa's control strategy includes mass vaccination campaigns about every 4 years, the last of which was conducted nationally in April 2010 and coincided with the epidemic... - Commentary: Factors affecting HIV/AIDS-related stigma and discrimination by medical professionalsHarriet Deacon
History Department, University of Cape Town, Private Bag, Rondebosch 7700, South Africa
Int J Epidemiol 36:185-6. 2007 - Antiretroviral therapy in resource-poor settings: scaling up inequalities?Matthias Egger
Int J Epidemiol 34:509-12. 2005 - The ART of rationing--the need for a new approach to rationing health interventionsChristopher Kenyon
Department of Medicine, Somerset Hospital and University of Cape Town
S Afr Med J 93:56-60. 2003..The current global context that precipitates and exacerbates the parallel contouring of disease burden and poverty should be constantly challenged... - Cohort Profile: Antiretroviral Therapy in Lower Income Countries (ART-LINC): international collaboration of treatment cohortsFrancois Dabis
INSERM U 593, ISPED, Universite Victor Segalen, Bordeaux Cedex, France
Int J Epidemiol 34:979-86. 2005 - Mortality of HIV-1-infected patients in the first year of antiretroviral therapy: comparison between low-income and high-income countriesPaula Braitstein
Lancet 367:817-24. 2006..Timely diagnosis and assessment of treatment eligibility, coupled with free provision of HAART, might reduce this excess mortality... - Exploring the costs of a limited public sector antiretroviral treatment programme in South AfricaAndrew Boulle
School of Public Health and Primary Health Care, University of Cape Town
S Afr Med J 92:811-7. 2002..Such a programme is affordable within current resource constraints. The consideration of antiretroviral treatment calls for a unique public health approach to the rationing of health services in the public sector... - Tuberculosis after initiation of antiretroviral therapy in low-income and high-income countriesMartin W G Brinkhof
Institute of Social and Preventive Medicine ISPM, University of Berne, Finkenhubelweg 11, CH 3012 Bern, Switzerland
Clin Infect Dis 45:1518-21. 2007..48 (95% confidence interval, 0.36-0.64) in low-income countries and 0.36 (95% confidence interval, 0.26-0.50) in high-income countries. A low CD4 cell count at the start of therapy was the most important risk factor in both settings... - Cohort profile: the paediatric antiretroviral treatment programmes in lower-income countries (KIDS-ART-LINC) collaborationElise Arrive
Unité INSERM 593, Institut de Santé Publique, Epidémiologie et Développement ISPED, Universite Victor Segalen, Bordeaux, France
Int J Epidemiol 37:474-80. 2008 - Gender and the use of antiretroviral treatment in resource-constrained settings: findings from a multicenter collaborationPaula Braitstein
Department of Medicine, Indiana University, Indianapolis, Indiana, USA
J Womens Health (Larchmt) 17:47-55. 2008.... - Antiretroviral therapy in resource-limited settings 1996 to 2006: patient characteristics, treatment regimens and monitoring in sub-Saharan Africa, Asia and Latin AmericaOlivia Keiser
Institute of Social and Preventive Medicine ISPM, University of Bern, Finkenhubelweg 11, 3012 Bern, Switzerland
Trop Med Int Health 13:870-9. 2008..To describe temporal trends in baseline clinical characteristics, initial treatment regimens and monitoring of patients starting antiretroviral therapy (ART) in resource-limited settings... - Monitoring effectiveness of programmes to prevent mother-to-child HIV transmission in lower-income countriesElizabeth M Stringer
Centre for Infectious Disease Research in Zambia, Lusaka, Zambia
Bull World Health Organ 86:57-62. 2008..Finally, we propose a novel community survey-based approach that could be implemented widely throughout the developing world with minor modifications to ongoing Demographic and Health Surveys... - Early loss of HIV-infected patients on potent antiretroviral therapy programmes in lower-income countriesMartin W G Brinkhof
Institute of Social and Preventive Medicine, Bern, Switzerland
Bull World Health Organ 86:559-67. 2008..To analyse the early loss of patients to antiretroviral therapy (ART) programmes in resource-limited settings... - When best practice is bad medicine: a new approach to rationing tertiary health services in South AfricaChris Kenyon
Division of Infectious Diseases and HIV Medicine at Groote Schuur Hospital, Cape Town
S Afr Med J 98:350, 352, 354 passim. 2008