A Boulle

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. doi request reprint Effectiveness of antiretroviral treatment in a South African program: a cohort study
    Lara R Fairall
    Knowledge Translation Unit, University of Cape Town Lung Institute, University of Cape Town, Cape Town, South Africa
    Arch Intern Med 168:86-93. 2008
  2. pmc Public-health and individual approaches to antiretroviral therapy: township South Africa and Switzerland compared
    Olivia Keiser
    Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    PLoS Med 5:e148. 2008
  3. pmc Elevation and cholera: an epidemiological spatial analysis of the cholera epidemic in Harare, Zimbabwe, 2008-2009
    Miguel A Luque Fernández
    Centre of Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa
    BMC Public Health 12:442. 2012
  4. pmc Mean CD4 cell count changes in patients failing a first-line antiretroviral therapy in resource-limited settings
    Alexandra Calmy
    HIV Unit, Geneva University Hospital, Geneva, Switzerland
    BMC Infect Dis 12:147. 2012
  5. pmc High yield of culture-based diagnosis in a TB-endemic setting
    Anne Marie Demers
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    BMC Infect Dis 12:218. 2012
  6. pmc Short-term risk of anaemia following initiation of combination antiretroviral treatment in HIV-infected patients in countries in sub-Saharan Africa, Asia-Pacific, and central and South America
    Jialun Zhou
    The Kirby Institute, The University of New South Wales, Sydney, NSW, Australia
    J Int AIDS Soc 15:5. 2012
  7. pmc Efficacy of sulphadoxine-pyrimethamine with or without artesunate for the treatment of uncomplicated Plasmodium falciparum malaria in southern Mozambique: a randomized controlled trial
    Elizabeth N Allen
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, South Africa
    Malar J 8:141. 2009
  8. pmc Adherence to antiretroviral therapy in young children in Cape Town, South Africa, measured by medication return and caregiver self-report: a prospective cohort study
    Mary Ann Davies
    Red Cross War Memorial Children s Hospital and the School of Child and Adolescent Health, University of Cape Town, Cape Town, The Republic of South Africa
    BMC Pediatr 8:34. 2008
  9. pmc Reduced referral and case fatality rates for severe symptomatic hyperlactataemia in a South African public sector antiretroviral programme: a retrospective observational study
    Charlotte Schutz
    Infectious Diseases Unit, GF Jooste Hospital, Duinefontein Road, Manenberg, 7764, Cape Town, South Africa
    AIDS Res Ther 7:13. 2010
  10. doi request reprint Seven-year experience of a primary care antiretroviral treatment programme in Khayelitsha, South Africa
    Andrew Boulle
    School of Public Health and Family Medicine, University of Cape Town, Anzio Road, Cape Town, South Africa
    AIDS 24:563-72. 2010

Detail Information

Publications50

  1. doi request reprint Effectiveness of antiretroviral treatment in a South African program: a cohort study
    Lara R Fairall
    Knowledge Translation Unit, University of Cape Town Lung Institute, University of Cape Town, Cape Town, South Africa
    Arch Intern Med 168:86-93. 2008
    ....
  2. pmc Public-health and individual approaches to antiretroviral therapy: township South Africa and Switzerland compared
    Olivia Keiser
    Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    PLoS Med 5:e148. 2008
    ..We compared virologic response, changes to first-line regimens, and mortality in HIV-infected patients starting HAART in South Africa and Switzerland...
  3. pmc Elevation and cholera: an epidemiological spatial analysis of the cholera epidemic in Harare, Zimbabwe, 2008-2009
    Miguel A Luque Fernández
    Centre of Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa
    BMC Public Health 12:442. 2012
    ..This study aims to analyze the association between topographic elevation and the distribution of cholera cases in Harare during the cholera epidemic in 2008 and 2009...
  4. pmc Mean CD4 cell count changes in patients failing a first-line antiretroviral therapy in resource-limited settings
    Alexandra Calmy
    HIV Unit, Geneva University Hospital, Geneva, Switzerland
    BMC Infect Dis 12:147. 2012
    ..We assessed the impact of on-going HIV-RNA replication on CD4 cell count slopes in patients treated with a first-line combination ART...
  5. pmc High yield of culture-based diagnosis in a TB-endemic setting
    Anne Marie Demers
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    BMC Infect Dis 12:218. 2012
    ..In most of the world, microbiologic diagnosis of tuberculosis (TB) is limited to microscopy. Recent guidelines recommend culture-based diagnosis where feasible...
  6. pmc Short-term risk of anaemia following initiation of combination antiretroviral treatment in HIV-infected patients in countries in sub-Saharan Africa, Asia-Pacific, and central and South America
    Jialun Zhou
    The Kirby Institute, The University of New South Wales, Sydney, NSW, Australia
    J Int AIDS Soc 15:5. 2012
    ....
  7. pmc Efficacy of sulphadoxine-pyrimethamine with or without artesunate for the treatment of uncomplicated Plasmodium falciparum malaria in southern Mozambique: a randomized controlled trial
    Elizabeth N Allen
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, South Africa
    Malar J 8:141. 2009
    ..An artemisinin-based combination therapy, artesunate (AS) plus sulphadoxine-pyrimethamine (SP), was compared to SP monotherapy to provide evidence of further treatment options in southern Mozambique...
  8. pmc Adherence to antiretroviral therapy in young children in Cape Town, South Africa, measured by medication return and caregiver self-report: a prospective cohort study
    Mary Ann Davies
    Red Cross War Memorial Children s Hospital and the School of Child and Adolescent Health, University of Cape Town, Cape Town, The Republic of South Africa
    BMC Pediatr 8:34. 2008
    ..This study describes the utility of different measures of adherence in detecting lapses in infants and young children in Cape Town, South Africa...
  9. pmc Reduced referral and case fatality rates for severe symptomatic hyperlactataemia in a South African public sector antiretroviral programme: a retrospective observational study
    Charlotte Schutz
    Infectious Diseases Unit, GF Jooste Hospital, Duinefontein Road, Manenberg, 7764, Cape Town, South Africa
    AIDS Res Ther 7:13. 2010
    ..This study assessed trends in referral rate, severity at presentation and case fatality rate for severe SHL...
  10. doi request reprint Seven-year experience of a primary care antiretroviral treatment programme in Khayelitsha, South Africa
    Andrew Boulle
    School of Public Health and Family Medicine, University of Cape Town, Anzio Road, Cape Town, South Africa
    AIDS 24:563-72. 2010
    ..We report on outcomes after 7 years of a community-based antiretroviral therapy (ART) programme in Khayelitsha, South Africa, with death registry linkages to correct for mortality under-ascertainment...
  11. ncbi request reprint Outcomes of nevirapine- and efavirenz-based antiretroviral therapy when coadministered with rifampicin-based antitubercular therapy
    Andrew Boulle
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    JAMA 300:530-9. 2008
    ..Rifampicin-based antitubercular therapy reduces the plasma concentrations of nevirapine and efavirenz. The virological consequences of these interactions are not well described...
  12. ncbi request reprint Substitutions due to antiretroviral toxicity or contraindication in the first 3 years of antiretroviral therapy in a large South African cohort
    Andrew Boulle
    Infectious Disease Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    Antivir Ther 12:753-60. 2007
    ..The patterns and reasons for antiretroviral therapy (ART) drug substitutions are poorly described in resource-limited settings...
  13. ncbi request reprint Exploring HIV risk perception and behaviour in the context of antiretroviral treatment: results from a township household survey
    A Boulle
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    AIDS Care 20:771-81. 2008
    ..Even greater coverage of preventive interventions is required, together with a national social and political environment that builds on the availability of both preventive and treatment services...
  14. pmc Antiretroviral therapy and early mortality in South Africa
    Andrew Boulle
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    Bull World Health Organ 86:678-87. 2008
    ..To describe province-wide outcomes and temporal trends of the Western Cape Province antiretroviral treatment (ART) programme 5 years since inception, and to demonstrate the utility of the WHO monitoring system for ART...
  15. ncbi request reprint Risk factors for and clinical characteristics of severe hyperlactataemia in patients receiving antiretroviral therapy: a case-control study
    Meg Osler
    Infectious Disease Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    HIV Med 11:121-9. 2010
    ..Symptomatic hyperlactataemia and lactic acidosis (SHLA) are potentially life-threatening complications associated with stavudine (d4T), an antiretroviral therapy (ART) drug widely used in developing countries...
  16. pmc Early adherence to antiretroviral medication as a predictor of long-term HIV virological suppression: five-year follow up of an observational cohort
    Nathan Ford
    Medecins Sans Frontieres, Cape Town, South Africa
    PLoS ONE 5:e10460. 2010
    ..Previous studies have demonstrated a cross-sectional relationship between antiretroviral adherence and HIV virological suppression. We assessed the predictive value of baseline adherence in determining long-term virological failure...
  17. pmc Monitoring the South African National Antiretroviral Treatment Programme, 2003-2007: the IeDEA Southern Africa collaboration
    Morna Cornell
    Infectious Disease Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town
    S Afr Med J 99:653-60. 2009
    ....
  18. ncbi request reprint Provision of antiretroviral therapy to children within the public sector of South Africa
    Peter Bock
    School of Public Health and Family Medicine, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa
    Trans R Soc Trop Med Hyg 102:905-11. 2008
    ..The higher death rates at level 2 & 3 facilities are most likely due to recruitment of sicker patients at this level...
  19. pmc Interferon release does not add discriminatory value to smear-negative HIV-tuberculosis algorithms
    M X Rangaka
    Centre for Infectious Disease and Epidemiology Research School of Health Sciences, University of Cape Town, Observatory, 7925, Cape Town, South Africa
    Eur Respir J 39:163-71. 2012
    ..Evaluation of new TB diagnostics for clinical relevance should follow a multivariable process that goes beyond test accuracy...
  20. ncbi request reprint Evaluation of a diagnostic algorithm for smear-negative pulmonary tuberculosis in HIV-infected adults
    P Saranchuk
    Medecins Sans Frontieres, Cape Town, South Africa
    S Afr Med J 97:517-23. 2007
    ..To evaluate the diagnostic accuracy of and reduction in diagnostic delay attributable to a clinical algorithm used for the diagnosis of smear-negative pulmonary tuberculosis (SNPTB) in HIV-infected adults...
  21. ncbi request reprint Promoting adherence to antiretroviral therapy: the experience from a primary care setting in Khayelitsha, South Africa
    David Coetzee
    Infectious Disease Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    AIDS 18:S27-31. 2004
    ..To describe the approach used to promote adherence to antiretroviral therapy (ART) and to present the outcomes in the first primary care public sector ART project in South Africa...
  22. doi request reprint Autoimmunity predominates in a large South African cohort with Addison's disease of mainly European descent despite long-standing disease and is associated with HLA DQB*0201
    Ian Ross
    Division of Endocrinology, University of Cape Town, Observatory, Cape Town, South Africa
    Clin Endocrinol (Oxf) 73:291-8. 2010
    ..We sought to determine whether autoimmunity is the predominant cause of Addison's disease in South Africa and whether human leucocyte antigen (HLA) DQ association exists...
  23. ncbi request reprint Severe hyperlactataemia complicating stavudine first-line antiretroviral therapy in South Africa
    David Stead
    GF Jooste Hospital, Cape Town, South Africa
    Antivir Ther 13:937-43. 2008
    ..In the public sector antiretroviral therapy (ART) programme in South Africa the standardized first-line regimen includes stavudine (d4T). Severe symptomatic hyperlactataemia (SHL) is a potentially life-threatening complication of d4T...
  24. pmc Effectiveness of the first district-wide programme for the prevention of mother-to-child transmission of HIV in South Africa
    David Coetzee
    Infectious Disease Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    Bull World Health Organ 83:489-94. 2005
    ....
  25. pmc Orphans of the AIDS epidemic? The extent, nature and circumstances of child-headed households in South Africa
    Helen Meintjes
    Children s Institute, University of Cape Town, South Africa
    AIDS Care 22:40-9. 2010
    ....
  26. pmc Outcomes of the South African National Antiretroviral Treatment Programme for children: the IeDEA Southern Africa collaboration
    Mary Ann Davies
    School of Public Health and Family Medicine, University of Cape Town
    S Afr Med J 99:730-7. 2009
    ..To assess paediatric antiretroviral treatment (ART) outcomes and their associations from a collaborative cohort representing 20% of the South African national treatment programme...
  27. ncbi request reprint CD4 T-cell responses to combination antiretroviral therapy
    Gary Maartens
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Lancet 370:366-8. 2007
  28. doi request reprint Initiation of highly active antiretroviral therapy among pregnant women in Cape Town, South Africa
    Kathryn Stinson
    Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    Trop Med Int Health 15:825-32. 2010
    ..To investigate highly active antiretroviral therapy (HAART) initiation among pregnant women and the optimum model of service delivery for integrating HAART services into antenatal care...
  29. ncbi request reprint Outcomes after two years of providing antiretroviral treatment in Khayelitsha, South Africa
    David Coetzee
    Infectious Disease Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Anzio Road, Observatory 7925, South Africa
    AIDS 18:887-95. 2004
    ....
  30. pmc Virologic failure and second-line antiretroviral therapy in children in South Africa--the IeDEA Southern Africa collaboration
    Mary Ann Davies
    School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Acquir Immune Defic Syndr 56:270-8. 2011
    ..We evaluated the probability and determinants of virologic failure and switching in children in South Africa...
  31. ncbi request reprint The nervous system effects of occupational exposure on workers in a South African manganese smelter
    Jonathan E Myers
    Occupational and Environmental Health Research Unit, School of Public Health and Primary Health Care, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, South Africa
    Neurotoxicology 24:885-94. 2003
    ....
  32. ncbi request reprint Effect of rifampicin-based antitubercular therapy on nevirapine plasma concentrations in South African adults with HIV-associated tuberculosis
    Karen Cohen
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, South Africa
    J Antimicrob Chemother 61:389-93. 2008
    ..We describe the steady-state pharmacokinetics of nevirapine during and after antitubercular therapy in South African patients...
  33. ncbi request reprint Influence of human immunodeficiency virus and CD4 count on the prevalence of human papillomavirus in heterosexual couples
    Zizipho Z A Mbulawa
    Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    J Gen Virol 91:3023-31. 2010
    ..In contrast, female genital HPV prevalence and HPV type-specific sharing were determined by their own HIV-positive status and not by that of their male partner...
  34. doi request reprint Population effect of scaling up ART in resource-poor settings
    Matthias Egger
    International epidemiological Databases to Evaluate AIDS IeDEA, Infectious Disease Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    Lancet 371:1558-9. 2008
  35. pmc Non-ignorable loss to follow-up: correcting mortality estimates based on additional outcome ascertainment
    M Schomaker
    Centre for Infectious Disease Epidemiology and Research, University of Cape Town, Falmouth Building, Observatory, 7925, South Africa
    Stat Med 33:129-42. 2014
    ..We believe the proposed estimators are readily applicable to a growing number of studies where LTFU is appreciable, but additional outcome data are available through linkage or surveys of patients LTFU...
  36. ncbi request reprint Community-based treatment of drug-resistant tuberculosis in Khayelitsha, South Africa
    H Cox
    Medecins Sans Frontieres, Khayelitsha, Cape Town, South Africa
    Int J Tuberc Lung Dis 18:441-8. 2014
    ..Khayelitsha, South Africa, a peri-urban township with high burdens of tuberculosis (TB), drug-resistant tuberculosis (DR-TB), and human immunodeficiency virus (HIV) infection...
  37. doi request reprint Measles vaccination coverage in high-incidence areas of the Western Cape, following the mass vaccination campaign
    G L Bernhardt
    University of Cape Town, South Africa
    S Afr Med J 103:181-6. 2013
    ..South Africa's control strategy includes mass vaccination campaigns about every 4 years, the last of which was conducted nationally in April 2010 and coincided with the epidemic...
  38. ncbi request reprint Commentary: Factors affecting HIV/AIDS-related stigma and discrimination by medical professionals
    Harriet Deacon
    History Department, University of Cape Town, Private Bag, Rondebosch 7700, South Africa
    Int J Epidemiol 36:185-6. 2007
  39. ncbi request reprint Cohort profile: the paediatric antiretroviral treatment programmes in lower-income countries (KIDS-ART-LINC) collaboration
    Elise Arrive
    Unité INSERM 593, Institut de Santé Publique, Epidémiologie et Développement ISPED, Universite Victor Segalen, Bordeaux, France
    Int J Epidemiol 37:474-80. 2008
  40. pmc Monitoring effectiveness of programmes to prevent mother-to-child HIV transmission in lower-income countries
    Elizabeth M Stringer
    Centre for Infectious Disease Research in Zambia, Lusaka, Zambia
    Bull World Health Organ 86:57-62. 2008
    ..Finally, we propose a novel community survey-based approach that could be implemented widely throughout the developing world with minor modifications to ongoing Demographic and Health Surveys...
  41. ncbi request reprint The ART of rationing--the need for a new approach to rationing health interventions
    Christopher Kenyon
    Department of Medicine, Somerset Hospital and University of Cape Town
    S Afr Med J 93:56-60. 2003
    ..The current global context that precipitates and exacerbates the parallel contouring of disease burden and poverty should be constantly challenged...
  42. doi request reprint Gender and the use of antiretroviral treatment in resource-constrained settings: findings from a multicenter collaboration
    Paula Braitstein
    Department of Medicine, Indiana University, Indianapolis, Indiana, USA
    J Womens Health (Larchmt) 17:47-55. 2008
    ....
  43. ncbi request reprint Cohort Profile: Antiretroviral Therapy in Lower Income Countries (ART-LINC): international collaboration of treatment cohorts
    Francois Dabis
    INSERM U 593, ISPED, Universite Victor Segalen, Bordeaux Cedex, France
    Int J Epidemiol 34:979-86. 2005
  44. pmc Tuberculosis after initiation of antiretroviral therapy in low-income and high-income countries
    Martin W G Brinkhof
    Institute of Social and Preventive Medicine ISPM, University of Berne, Finkenhubelweg 11, CH 3012 Bern, Switzerland
    Clin Infect Dis 45:1518-21. 2007
    ..48 (95% confidence interval, 0.36-0.64) in low-income countries and 0.36 (95% confidence interval, 0.26-0.50) in high-income countries. A low CD4 cell count at the start of therapy was the most important risk factor in both settings...
  45. pmc Early loss of HIV-infected patients on potent antiretroviral therapy programmes in lower-income countries
    Martin W G Brinkhof
    Institute of Social and Preventive Medicine, Bern, Switzerland
    Bull World Health Organ 86:559-67. 2008
    ..To analyse the early loss of patients to antiretroviral therapy (ART) programmes in resource-limited settings...
  46. ncbi request reprint Exploring the costs of a limited public sector antiretroviral treatment programme in South Africa
    Andrew Boulle
    School of Public Health and Primary Health Care, University of Cape Town
    S Afr Med J 92:811-7. 2002
    ..This study seeks to explore the impact of these programme choices at an individual level, as well as explore the total cost of a rationed national public sector antiretroviral treatment programme...
  47. ncbi request reprint Mortality of HIV-1-infected patients in the first year of antiretroviral therapy: comparison between low-income and high-income countries
    Paula Braitstein
    Lancet 367:817-24. 2006
    ..We compared baseline characteristics and outcomes during the first year of HAART between HIV-1-infected patients in low-income and high-income settings...
  48. pmc Antiretroviral therapy in resource-limited settings 1996 to 2006: patient characteristics, treatment regimens and monitoring in sub-Saharan Africa, Asia and Latin America
    Olivia Keiser
    Institute of Social and Preventive Medicine ISPM, University of Bern, Finkenhubelweg 11, 3012 Bern, Switzerland
    Trop Med Int Health 13:870-9. 2008
    ..To describe temporal trends in baseline clinical characteristics, initial treatment regimens and monitoring of patients starting antiretroviral therapy (ART) in resource-limited settings...
  49. ncbi request reprint Antiretroviral therapy in resource-poor settings: scaling up inequalities?
    Matthias Egger
    Int J Epidemiol 34:509-12. 2005
  50. ncbi request reprint When best practice is bad medicine: a new approach to rationing tertiary health services in South Africa
    Chris Kenyon
    Division of Infectious Diseases and HIV Medicine at Groote Schuur Hospital, Cape Town
    S Afr Med J 98:350, 352, 354 passim. 2008