Linda Gail Bekker

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. ncbi request reprint Is it time to change our HIV testing policy in health care facilities?
    L G Bekker
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, UCT, South Africa
    S Afr Med J 96:1235-6. 2006
  2. pmc Mobile phone text messaging for promoting adherence to anti-tuberculosis treatment: a systematic review protocol
    Mweete D Nglazi
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine and the Department of Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, 7925, Cape Town, South Africa
    Syst Rev 2:6. 2013
  3. pmc HIV risk and associations of HIV infection among men who have sex with men in peri-urban Cape Town, South Africa
    Stefan Baral
    Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD, USA
    BMC Public Health 11:766. 2011
  4. ncbi request reprint Adolescents and HIV vaccine trials: what are the clinical trial site issues?
    Linda Gail Bekker
    The Desmond Tutu HIV Centre, The Institute of Infectious Disease and Molecular Medicine, University of Cape Town Faculty of Health Sciences, Cape Town 7925, South Africa
    J Int Assoc Physicians AIDS Care (Chic) 4:93-7. 2005
  5. doi request reprint The changing natural history of tuberculosis and HIV coinfection in an urban area of hyperendemicity
    Linda Gail Bekker
    The Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Health Science Faculty, University of Cape Town, Cape Town, South Africa
    Clin Infect Dis 50:S208-14. 2010
  6. ncbi request reprint Rapid scale-up of a community-based HIV treatment service: programme performance over 3 consecutive years in Guguletu, South Africa
    Linda Gail Bekker
    Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, University of Cape Town
    S Afr Med J 96:315-20. 2006
  7. pmc Tuberculosis during the first year of antiretroviral therapy in a South African cohort using an intensive pretreatment screening strategy
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    AIDS 24:1323-8. 2010
  8. ncbi request reprint Conservation of first-line antiretroviral treatment regimen where therapeutic options are limited
    Catherine Orrell
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    Antivir Ther 12:83-8. 2007
  9. pmc Antiretroviral program associated with reduction in untreated prevalent tuberculosis in a South African township
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Am J Respir Crit Care Med 182:1080-5. 2010
  10. pmc Increasing transfers-out from an antiretroviral treatment service in South Africa: patient characteristics and rates of virological non-suppression
    Mweete D Nglazi
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, and the Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    PLoS ONE 8:e57907. 2013

Detail Information

Publications98

  1. ncbi request reprint Is it time to change our HIV testing policy in health care facilities?
    L G Bekker
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, UCT, South Africa
    S Afr Med J 96:1235-6. 2006
  2. pmc Mobile phone text messaging for promoting adherence to anti-tuberculosis treatment: a systematic review protocol
    Mweete D Nglazi
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine and the Department of Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, 7925, Cape Town, South Africa
    Syst Rev 2:6. 2013
    ..We, therefore, propose to conduct a review of current best evidence for the use of mobile phone text messaging to promote patient adherence to TB treatment...
  3. pmc HIV risk and associations of HIV infection among men who have sex with men in peri-urban Cape Town, South Africa
    Stefan Baral
    Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD, USA
    BMC Public Health 11:766. 2011
    ..The study presented here represents the first evaluation of HIV prevalence and associations of HIV infection among MSM in the peri-urban townships of Cape Town...
  4. ncbi request reprint Adolescents and HIV vaccine trials: what are the clinical trial site issues?
    Linda Gail Bekker
    The Desmond Tutu HIV Centre, The Institute of Infectious Disease and Molecular Medicine, University of Cape Town Faculty of Health Sciences, Cape Town 7925, South Africa
    J Int Assoc Physicians AIDS Care (Chic) 4:93-7. 2005
    ..Finally, a number of trial design options exist, and researchers will need to balance the risks and benefits of each, as for all issues surrounding the involvement of adolescents in HIV vaccine trials...
  5. doi request reprint The changing natural history of tuberculosis and HIV coinfection in an urban area of hyperendemicity
    Linda Gail Bekker
    The Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Health Science Faculty, University of Cape Town, Cape Town, South Africa
    Clin Infect Dis 50:S208-14. 2010
    ..There is a need for better understanding of the transmission dynamics of TB and the intensity of social interactions, which have exacerbated an HIV and TB epidemic in this community of hyperendemicity...
  6. ncbi request reprint Rapid scale-up of a community-based HIV treatment service: programme performance over 3 consecutive years in Guguletu, South Africa
    Linda Gail Bekker
    Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, University of Cape Town
    S Afr Med J 96:315-20. 2006
    ..Despite rapid expansion of antiretroviral therapy (ART) in sub-Saharan Africa there are few longitudinal data describing programme performance during rapid scale-up...
  7. pmc Tuberculosis during the first year of antiretroviral therapy in a South African cohort using an intensive pretreatment screening strategy
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    AIDS 24:1323-8. 2010
    ....
  8. ncbi request reprint Conservation of first-line antiretroviral treatment regimen where therapeutic options are limited
    Catherine Orrell
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    Antivir Ther 12:83-8. 2007
    ....
  9. pmc Antiretroviral program associated with reduction in untreated prevalent tuberculosis in a South African township
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Am J Respir Crit Care Med 182:1080-5. 2010
    ..Prevalent untreated TB is the main source of transmission. In settings with large burdens of human immunodeficiency virus (HIV) and TB, highly active antiretroviral therapy (HAART) may contribute to TB control...
  10. pmc Increasing transfers-out from an antiretroviral treatment service in South Africa: patient characteristics and rates of virological non-suppression
    Mweete D Nglazi
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, and the Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    PLoS ONE 8:e57907. 2013
    ..To determine the proportion, characteristics and outcomes of patients who transfer-out from an antiretroviral therapy (ART) service in a South African township...
  11. ncbi request reprint Determinants of mortality and nondeath losses from an antiretroviral treatment service in South Africa: implications for program evaluation
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Clin Infect Dis 43:770-6. 2006
    ..Understanding the determinants of key outcome measures--including death and nondeath losses--would assist in program evaluation and development...
  12. pmc Community perspectives on the ethical issues surrounding adolescent HIV vaccine trials in South Africa
    Heather B Jaspan
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa
    Vaccine 26:5679-83. 2008
    ..In general, ethical adolescent HIV vaccine trials will be feasible in this community...
  13. ncbi request reprint When to initiate highly active antiretroviral therapy in sub-Saharan Africa? A South African cost-effectiveness study
    Motasim Badri
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, Department of Medicine, University of Cape Town, South Africa
    Antivir Ther 11:63-72. 2006
    ..However, cost-effectiveness of initiating treatment at different CD4 count thresholds has not been explored in resource-poor settings...
  14. pmc Undiagnosed tuberculosis in a community with high HIV prevalence: implications for tuberculosis control
    Robin Wood
    The Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Health Science Faculty, UCT Observatory, Cape Town 7925, South Africa
    Am J Respir Crit Care Med 175:87-93. 2007
    ..We conducted a cross-sectional survey of pulmonary TB (PTB) and HIV infection in a community of 13,000 with high HIV prevalence and high TB notification rate and a well-functioning DOTS TB control program...
  15. ncbi request reprint Burden of tuberculosis in an antiretroviral treatment programme in sub-Saharan Africa: impact on treatment outcomes and implications for tuberculosis control
    Stephen D Lawn
    Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, South Africa
    AIDS 20:1605-12. 2006
    ..To determine burden and risk factors for tuberculosis (TB) in an antiretroviral treatment (ART) programme and its impact on ART outcomes...
  16. ncbi request reprint Low prevalence of renal dysfunction in HIV-infected pregnant women: implications for guidelines for the prevention of mother-to-child transmission of HIV
    Landon Myer
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Trop Med Int Health 18:1400-5. 2013
    ....
  17. ncbi request reprint Tuberculosis-associated immune reconstitution disease: incidence, risk factors and impact in an antiretroviral treatment service in South Africa
    Stephen D Lawn
    Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    AIDS 21:335-41. 2007
    ..To determine the burden and impact of immune reconstitution disease (IRD) associated with tuberculosis (TB) among patients initiating antiretroviral treatment (ART) in sub-Saharan Africa...
  18. pmc Indoor social networks in a South African township: potential contribution of location to tuberculosis transmission
    Robin Wood
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 7:e39246. 2012
    ..We therefore quantified time spent and contacts met in indoor locations and public transport by residents of a South African township with a very high TB burden...
  19. pmc Adjunctive interferon-γ immunotherapy for the treatment of HIV-associated cryptococcal meningitis: a randomized controlled trial
    Joseph N Jarvis
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Infectious Diseases Unit, GF Jooste Hospital, Cape Town, South Africa
    AIDS 26:1105-13. 2012
    ..We performed a randomized controlled trial to determine whether addition of IFNγ to standard therapy increased the rate of clearance of cryptococcal infection in HIV-associated cryptococcal meningitis...
  20. pmc Treatment outcomes in HIV-infected adolescents attending a community-based antiretroviral therapy clinic in South Africa
    Mweete D Nglazi
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, and the Department of Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, 7925 Cape Town, South Africa
    BMC Infect Dis 12:21. 2012
    ..The present study therefore compared the treatment outcomes in adolescents with those of young adults at a public sector community-based ART programme in Cape Town, South Africa...
  21. pmc Ocular parameters of biological ageing in HIV-infected individuals in South Africa: relationship with chronological age and systemic biomarkers of ageing
    Sophia Pathai
    International Centre for Eye Health, Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine LSHTM, Keppel Street, London WC1E 7HT, UK Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa Electronic address
    Mech Ageing Dev 134:400-6. 2013
    ..Longitudinal studies are warranted to assess the integration of retinal vascular calibre and lens density with systemic markers to develop an overall index of biological ageing in HIV infection. ..
  22. ncbi request reprint Fungal burden, early fungicidal activity, and outcome in cryptococcal meningitis in antiretroviral-naive or antiretroviral-experienced patients treated with amphotericin B or fluconazole
    Tihana Bicanic
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Cape Town, South Africa
    Clin Infect Dis 45:76-80. 2007
    ....
  23. ncbi request reprint Design and evaluation of a drama-based intervention to promote voluntary counseling and HIV testing in a South African community
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Sex Transm Dis 33:524-6. 2006
    ..Voluntary counseling and testing (VCT) services are a major component of HIV prevention and treatment efforts. We developed a drama-based intervention to promote VCT services in a peri-urban community in South Africa...
  24. pmc CD4 cell count recovery among HIV-infected patients with very advanced immunodeficiency commencing antiretroviral treatment in sub-Saharan Africa
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 6:59. 2006
    ..Patients accessing antiretroviral treatment (ART) programmes in sub-Saharan Africa frequently have very advanced immunodeficiency. Previous data suggest that such patients may have diminished capacity for CD4 cell count recovery...
  25. doi request reprint Changing patterns in HIV/AIDS stigma and uptake of voluntary counselling and testing services: the results of two consecutive community surveys conducted in the Western Cape, South Africa
    Sumaya Mall
    Department of Psychology, University of Stellenbosch, Cape Town, South Africa
    AIDS Care 25:194-201. 2013
    ..Given the role of HIV/AIDS-associated stigma in influencing choices to access HIV testing, and the benefits associated with HIV testing, interventions to reduce stigma in communities affected by this disease should be encouraged...
  26. pmc An incentivized HIV counseling and testing program targeting hard-to-reach unemployed men in Cape Town, South Africa
    Mweete D Nglazi
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, and the Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Acquir Immune Defic Syndr 59:e28-34. 2012
    ..Innovative strategies are needed to increase uptake of testing among men. This study assessed the effectiveness of incentivized mobile HCT in reaching unemployed men in Cape Town, South Africa...
  27. pmc Changes in programmatic outcomes during 7 years of scale-up at a community-based antiretroviral treatment service in South Africa
    Mweete D Nglazi
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Acquir Immune Defic Syndr 56:e1-8. 2011
    ..To assess sustainability of programmatic outcomes in a community-based antiretroviral therapy (ART) service in South Africa during 7 years of scale-up...
  28. pmc Changing mortality risk associated with CD4 cell response to antiretroviral therapy in South Africa
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    AIDS 23:335-42. 2009
    ..To determine the relationship between mortality risk and the CD4 cell response to antiretroviral therapy (ART)...
  29. pmc Sexual health, HIV risk, and retention in an adolescent HIV-prevention trial preparatory cohort
    Heather B Jaspan
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    J Adolesc Health 49:42-6. 2011
    ..Although adolescents are at high risk for human immunodeficiency virus (HIV) infection, they have not been, included in HIV vaccine trials...
  30. pmc Burden of new and recurrent tuberculosis in a major South African city stratified by age and HIV-status
    Robin Wood
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 6:e25098. 2011
    ....
  31. ncbi request reprint Initiating highly active antiretroviral therapy in sub-Saharan Africa: an assessment of the revised World Health Organization scaling-up guidelines
    Motasim Badri
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, Department of Medicine, University of Cape Town, Observatory, South Africa
    AIDS 18:1159-68. 2004
    ....
  32. ncbi request reprint Early mortality among adults accessing a community-based antiretroviral service in South Africa: implications for programme design
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Cape Town, South Africa
    AIDS 19:2141-8. 2005
    ..To determine rates, risk factors and causes of death among patients accessing a community-based antiretroviral treatment (ART) programme both prior to and following initiation of treatment...
  33. ncbi request reprint Brief report: methods for collecting sexual behaviour information from South African adolescents--a comparison of paper versus personal digital assistant questionnaires
    Heather B Jaspan
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town Faculty of Health Sciences, PO Box 13801 Mowbray 7705, South Africa
    J Adolesc 30:353-9. 2007
    ..Subjectively, adolescents found the use of PDA to be simple and confidential. PDA may be a useful method to collect sensitive, self-reported information from adolescents in resource-limited settings...
  34. pmc Screening for HIV-associated tuberculosis and rifampicin resistance before antiretroviral therapy using the Xpert MTB/RIF assay: a prospective study
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    PLoS Med 8:e1001067. 2011
    ..However, its utility for routine TB screening and detection of rifampicin resistance among HIV-infected patients with advanced immunodeficiency enrolling in antiretroviral therapy (ART) services is unknown...
  35. pmc Childhood tuberculosis infection and disease: a spatial and temporal transmission analysis in a South African township
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, Department of Medicine, University of Cape Town
    S Afr Med J 99:738-43. 2009
    ..While adult TB results from both recent and past infection, childhood TB results from recent infection and reflects ongoing transmission despite current TB control strategies...
  36. ncbi request reprint Urine lipoarabinomannan assay for tuberculosis screening before antiretroviral therapy diagnostic yield and association with immune reconstitution disease
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa, and Clinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    AIDS 23:1875-80. 2009
    ..To assess the utility of urine lipoarabinomannan (LAM) detection as a diagnostic screening test for tuberculosis (TB) in HIV-infected patients with advanced immuno deficiency and high prevalence of sputum smear-negative pulmonary disease...
  37. pmc Treatment interruption in a primary care antiretroviral therapy program in South Africa: cohort analysis of trends and risk factors
    Katharina Kranzer
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Science, University of Cape Town, South Africa
    J Acquir Immune Defic Syndr 55:e17-23. 2010
    ..To investigate antiretroviral treatment (ART) interruption in a long-term treatment cohort in South Africa...
  38. pmc Linkage to HIV care and antiretroviral therapy in Cape Town, South Africa
    Katharina Kranzer
    Department of Medicine, Faculty of Health Sciences, The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 5:e13801. 2010
    ..Programme reports typically focus on loss to follow-up and mortality among patients receiving ART. However, little is known about linkage and retention in care of individuals prior to starting ART...
  39. pmc Rates of tuberculosis transmission to children and adolescents in a community with a high prevalence of HIV infection among adults
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, School of Public Health and Family Medicine, University of Cape Town, Mowbray, Cape Town, South Africa
    Clin Infect Dis 47:349-55. 2008
    ....
  40. ncbi request reprint Provider-initiated HIV testing increases access of patients with HIV-associated tuberculosis to antiretroviral treatment
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town
    S Afr Med J 101:258-62. 2011
    ..We sought to determine the impact of the introduction of provider-initiated HIV-testing in TB clinics in 2005 on subsequent referrals of patients with HIV-associated TB at a community-based ART service in Cape Town...
  41. pmc Short-term and long-term risk of tuberculosis associated with CD4 cell recovery during antiretroviral therapy in South Africa
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    AIDS 23:1717-25. 2009
    ..To determine the short-term and long-term risks of tuberculosis (TB) associated with CD4 cell recovery during antiretroviral therapy (ART)...
  42. pmc Antiretroviral therapy and TB notification rates in a high HIV prevalence South African community
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    J Acquir Immune Defic Syndr 56:263-9. 2011
    ..Antiretroviral therapy (ART) has been proposed as an intervention for reducing tuberculosis (TB) burdens in areas with high HIV prevalence. However, little data is available on the impact of ART on population-level TB...
  43. pmc Rates of switching antiretroviral drugs in a primary care service in South Africa before and after introduction of tenofovir
    Christine Njuguna
    Desmond Tutu HIV Centre, Institute for Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    PLoS ONE 8:e63596. 2013
    ..This study describes the patterns and risk factors for drug changes of these antiretroviral drugs in adults...
  44. pmc Utility of interferon-gamma ELISPOT assay responses in highly tuberculosis-exposed patients with advanced HIV infection in South Africa
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    BMC Infect Dis 7:99. 2007
    ..We studied determinants of ELISPOT responses among patients with advanced HIV infection (but without active TB) living in a South African community with very high TB notification rates...
  45. ncbi request reprint Impact of HIV infection on the epidemiology of tuberculosis in a peri-urban community in South Africa: the need for age-specific interventions
    Stephen D Lawn
    Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    Clin Infect Dis 42:1040-7. 2006
    ..Evaluation of additional control interventions requires detailed understanding of the epidemiological relationship between these diseases at the community level...
  46. pmc Lipoarabinomannan in urine during tuberculosis treatment: association with host and pathogen factors and mycobacteriuria
    Robin Wood
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town Faculty of Health Sciences, Cape Town, South Africa
    BMC Infect Dis 12:47. 2012
    ..However, the LAM-ELISA assay has demonstrated variable sensitivity in diagnosing TB in diverse clinical populations. We therefore explored pathogen and host factors potentially impacting LAM detection...
  47. doi request reprint Comparison of the early fungicidal activity of high-dose fluconazole, voriconazole, and flucytosine as second-line drugs given in combination with amphotericin B for the treatment of HIV-associated cryptococcal meningitis
    Angela Loyse
    Infectious Diseases Unit, GF Jooste Hospital, Cape Town, South Africa
    Clin Infect Dis 54:121-8. 2012
    ..Alternative, more widely available, and/or more effective antifungal combination treatment regimens are urgently needed...
  48. pmc Force of tuberculosis infection among adolescents in a high HIV and TB prevalence community: a cross-sectional observation study
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 11:156. 2011
    ..However, there are little data assessing incidence of TB infection in adolescents in these settings...
  49. pmc Social mixing patterns within a South African township community: implications for respiratory disease transmission and control
    Simon P Johnstone-Robertson
    Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Western Cape, South Africa
    Am J Epidemiol 174:1246-55. 2011
    ..High numbers of indoor contacts and intergenerational mixing in households and transport may contribute to exceptionally high rates of tuberculosis transmission reported in the community...
  50. doi request reprint Epidemiology of HIV-1 subtypes among men who have sex with men in Cape Town, South Africa
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town, Cape Town, South Africa Division of Medical Virology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa Division of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa Center for Learning and Innovation, San Francisco Department of Public Health, San Francisco, CA University of California, San Francisco and National Health Laboratory Services, Cape Town, South Africa
    J Acquir Immune Defic Syndr 65:473-80. 2014
    ..However, few recent HIV-1 subtype data are available for MSM in South Africa. We examined HIV-1 subtypes among MSM in Cape Town...
  51. pmc Resistance in pediatric patients experiencing virologic failure with first-line and second-line antiretroviral therapy
    Catherine Orrell
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town Faculty of Health Sciences, Cape Town, South Africa
    Pediatr Infect Dis J 32:644-7. 2013
    ..Nineteen percent had wild-type virus. Appropriate antiretroviral therapy sequencing in sub-Saharan African children is essential for prolong treatment options. ..
  52. pmc Temporal association between incident tuberculosis and poor virological outcomes in a South African antiretroviral treatment service
    Ankur Gupta-Wright
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom and The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Acquir Immune Defic Syndr 64:261-70. 2013
    ..The temporal relationship between incident tuberculosis (TB) and virological outcomes during antiretroviral therapy (ART) is poorly defined. This was studied in a cohort in Cape Town, South Africa...
  53. doi request reprint Safety, feasibility and efficacy of a rapid ART initiation in pregnancy pilot programme in Cape Town, South Africa
    Samantha Black
    Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa
    S Afr Med J 103:557-62. 2013
    ..However, in most South African settings, ART initiation is delayed owing to slow determination of treatment eligibility and separation of HIV and antenatal care services...
  54. pmc Cost-effectiveness of highly active antiretroviral therapy in South Africa
    Motasim Badri
    Department of Medicine, Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa
    PLoS Med 3:e4. 2006
    ..Little information exists on the impact of highly active antiretroviral therapy (HAART) on health-care provision in South Africa despite increasing scale-up of access to HAART and gradual reduction in HAART prices...
  55. ncbi request reprint Adolescent HIV prevalence, sexual risk, and willingness to participate in HIV vaccine trials
    Heather B Jaspan
    Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa
    J Adolesc Health 39:642-8. 2006
    ..To determine human immunodeficiency virus (HIV) prevalence, sexual risk behaviors, and attitudes toward HIV vaccine trials among 11-19 year-olds in a peri-urban community near Cape Town, South Africa...
  56. pmc Loss to follow-up and mortality among pregnant women referred to a community clinic for antiretroviral treatment
    Richard Kaplan
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    AIDS 22:1679-81. 2008
    ..This finding highlights the need for programmatic interventions to address retention in care for this patient population...
  57. pmc Antiretroviral treatment uptake in patients with HIV-associated TB attending co-located TB and ART services
    Mweete Debra Nglazi
    University of Cape Town, South Africa
    S Afr Med J 102:936-9. 2012
    ..Delivery of integrated care for patients with HIV-associated TB is challenging. We assessed the uptake and timing of antiretroviral treatment (ART) among eligible patients attending a primary care service with co-located ART and TB clinics...
  58. pmc Tuberculosis transmission to young children in a South African community: modeling household and community infection risks
    Robin Wood
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Faculty of Health Sciences, Cape Town, South Africa
    Clin Infect Dis 51:401-8. 2010
    ..A model was used to explore the interactions between prevalence of adult tuberculosis infection, adult-to-child contacts, and household ventilation, which could result in such a high annual risk of tuberculosis infection...
  59. pmc Socio-behaviour challenges to phase III HIV vaccine trials in Sub-Saharan Africa
    Joalida Smit
    MRC Unit for Anxiety and Stress Disorders, University of Stellenbosch, Cape Town, South Africa
    Afr Health Sci 5:198-206. 2005
    ..There is a need for a review of the literature to help focus such research efforts in Sub-Saharan Africa...
  60. doi request reprint Clients' perspectives on HIV/AIDS care and treatment and reproductive health services in South Africa
    Phyllis Orner
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    AIDS Care 20:1217-23. 2008
    ..Challenges to involving men in HIV/AIDS care and treatment and SRH services and measures to address this were identified...
  61. ncbi request reprint Ethical issues in adolescent HIV research in resource-limited countries
    Linda Gail Bekker
    The Desmond Tutu HIV Centre, University of Cape Town, Cape Town HIV AIDS Vaccines Ethics Group, School of Applied Human Sciences, College of Humanities, UKZN, Pietermaritzburg, South Africa Maternal and Pediatric Infectious Disease Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD and NIH Department of Bioethics, Clinical Center and Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, MD
    J Acquir Immune Defic Syndr 65:S24-8. 2014
    ..Complex and, at times, contradictory legal and ethical requirements can be a challenge. Ethical benchmarks can be applied to ensure that research meets high-level standards and is planned for appropriately...
  62. ncbi request reprint Adolescent and adult participation in an HIV vaccine trial preparedness cohort in South Africa
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    J Adolesc Health 43:8-14. 2008
    ..We analyzed adult and adolescent data from a cohort study conducted to assess the feasibility of involving adolescents and adults in HIV vaccine-related studies...
  63. ncbi request reprint Cost of a dedicated ART clinic
    Guy Harling
    Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, University of Cape Town
    S Afr Med J 97:593-6. 2007
    ..The provision of antiretroviral therapy (ART) is being rolled out across South Africa. Little evidence exists on the cost of running clinics for ART provision...
  64. ncbi request reprint Scientific justification for the participation of children and adolescents in HIV-1 vaccine trials in South Africa
    Heather B Jaspan
    Desmond Tutu HIV Centre, University of Cape Town, South Africa
    S Afr Med J 95:685-7. 2005
  65. pmc Systemic delays in the initiation of antiretroviral therapy during pregnancy do not improve outcomes of HIV-positive mothers: a cohort study
    Landon Myer
    Centre for Infectious Diseases Epidemiologic Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    BMC Pregnancy Childbirth 12:94. 2012
    ..We examined whether delaying ART to provide pre-ART counseling was associated with improved outcomes among HIV-infected women in Cape Town, South Africa...
  66. pmc Mother-to-child transmission of HIV in a community-based antiretroviral clinic in South Africa
    Felicity C Fitzgerald
    Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town
    S Afr Med J 100:827-31. 2010
    ..To examine the uptake of ART among pregnant women referred to an ART service and the associated rates and risk factors for vertical HIV transmission...
  67. ncbi request reprint Sexual risk behaviours and HIV-1 prevalence among urban men who have sex with men in Cape Town, South Africa
    Earl Burrell
    Desmond Tutu HIV Centre, University of Cape Town, Cape Town 7705, South Africa
    Sex Health 7:149-53. 2010
    ..However, linked HIV prevalence and self-reported sexual risk behaviour data have not been reported for men who have sex with men (MSM) in Cape Town since 1986...
  68. pmc Yield of HIV-associated tuberculosis during intensified case finding in resource-limited settings: a systematic review and meta-analysis
    Katharina Kranzer
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Lancet Infect Dis 10:93-102. 2010
    ..Concerted action is needed to develop intensified case finding as an important method for control of tuberculosis...
  69. ncbi request reprint Low acceptability of medical male circumcision as an HIV/AIDS prevention intervention within a South African community that practises traditional circumcision
    Daniella Mark
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town
    S Afr Med J 102:571-3. 2012
    ..The acceptability of circumcision as a biomedical intervention mirroring an ingrained cultural practice, as well as the age and extent of the procedure, are poorly understood...
  70. pmc Identification of losses to follow-up in a community-based antiretroviral therapy clinic in South Africa using a computerized pharmacy tracking system
    Mweete D Nglazi
    The Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Department of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    BMC Infect Dis 10:329. 2010
    ..We determined the duration of pharmacy delay that optimally identified true LTFU...
  71. pmc Molecular epidemiology of Mycobacterium tuberculosis in a South African community with high HIV prevalence
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, Cape Town, South Africa
    J Infect Dis 200:1207-11. 2009
    ..The strong association between W-Beijing and HIV infection may have important implications for tuberculosis control...
  72. pmc Linkage to HIV care from a mobile testing unit in South Africa by different CD4 count strata
    Darshini Govindasamy
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    J Acquir Immune Defic Syndr 58:344-52. 2011
    ..The linkage and barriers of linkage to facility-based HIV care from a mobile HIV testing unit have not previously been described...
  73. ncbi request reprint Immune reconstitution disease associated with mycobacterial infections in HIV-infected individuals receiving antiretrovirals
    Stephen D Lawn
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Lancet Infect Dis 5:361-73. 2005
    ..We also discuss the problem of IRD associated with mycobacterial diseases in developing countries where tuberculosis prevalence is high and access to HAART is currently expanding...
  74. doi request reprint Pilot programme for the rapid initiation of antiretroviral therapy in pregnancy in Cape Town, South Africa
    Landon Myer
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    AIDS Care 24:986-92. 2012
    ..While further research is needed, this evaluation demonstrates that a novel service delivery approach may facilitate rapid ART initiation in pregnancy...
  75. ncbi request reprint Tuberculosis in a South African prison - a transmission modelling analysis
    Simon Johnstone-Robertson
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa
    S Afr Med J 101:809-13. 2011
    ..With the use of these data, a mathematical model was developed to explore the interactions between incarceration conditions and TB control measures...
  76. pmc The impact of gender and income on survival and retention in a South African antiretroviral therapy programme
    Morna Cornell
    University of Cape Town, South Africa
    Trop Med Int Health 14:722-31. 2009
    ..We investigated the association of gender and income with survival and retention in a South African ART programme...
  77. ncbi request reprint Inclusion of adolescents in preventive HIV vaccine trials: public health policy and research design at a crossroads
    Heather B Jaspan
    Desmond Tutu HIV Centre, University of Cape Town, South Africa
    J Acquir Immune Defic Syndr 47:86-92. 2008
    ..This article examines these issues and proposes specific next steps to facilitate the routine inclusion of this high-priority population in preventive HIV vaccine trials as early and seamlessly as possible...
  78. doi request reprint High-dose amphotericin B with flucytosine for the treatment of cryptococcal meningitis in HIV-infected patients: a randomized trial
    Tihana Bicanic
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Clin Infect Dis 47:123-30. 2008
    ..A dosage range for AmB of 0.7-1 mg/kg per day is noted in current guidelines, but there are no data comparing 0.7 mg/kg per day with 1 mg/kg per day...
  79. ncbi request reprint Tuberculosis control has failed in South Africa--time to reappraise strategy
    Robin Wood
    Desmond Tutu HIV Centre, and Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town
    S Afr Med J 101:111-4. 2011
    ..This better understanding of the major drivers of the TB epidemic allows reasons to be identified for failure of the present strategy. New control strategies can also be identified, that must be accompanied by novel TB control targets...
  80. pmc Effect of caregivers' depression and alcohol use on child antiretroviral adherence in South Africa
    Heather B Jaspan
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    AIDS Patient Care STDS 25:595-600. 2011
    ..99). Pediatric adherence is affected by caregiver alcohol use, but caregiver relationship to the child is most important. This small study suggests that interventions should aim to keep mothers healthy and alive, as well as alcohol-free...
  81. doi request reprint Fertility intentions and reproductive health care needs of people living with HIV in Cape Town, South Africa: implications for integrating reproductive health and HIV care services
    Diane Cooper
    Women s Health Research Unit, School of Public Health and Family Medicine, University of Cape Town, Anzio Road Observatory, 7925, Cape Town, South Africa
    AIDS Behav 13:38-46. 2009
    ..There is an urgent need for intervention models to integrate HIV care with sexual and reproduction health counseling and services that account for the diverse reproductive needs of these populations...
  82. pmc Efficacy of percutaneous versus intradermal BCG in the prevention of tuberculosis in South African infants: randomised trial
    Anthony Hawkridge
    South African Tuberculosis Vaccine Initiative, University of Cape Town, South Africa
    BMJ 337:a2052. 2008
    ..To compare the incidence of tuberculosis over two years in infants vaccinated at birth with intradermal BCG or with percutaneous BCG...
  83. pmc Virological breakthrough: a risk factor for loss to followup in a large community-based cohort on antiretroviral therapy
    Catherine Orrell
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town, Cape Town 7925, South Africa
    AIDS Res Treat 2011:469127. 2011
    ..While 67% of those who experience initial virological breakthrough resuppress after an adherence intervention, these individuals are significantly less likely be retained in care than those who remain virologically suppressed throughout...
  84. pmc Intra- and inter-clade cross-reactivity by HIV-1 Gag specific T-cells reveals exclusive and commonly targeted regions: implications for current vaccine trials
    Lycias Zembe
    Division of Medical Virology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 6:e26096. 2011
    ....
  85. ncbi request reprint HIV/AIDS vaccination in adolescents would be efficient and practical when vaccine supplies are limited
    Leigh F Johnson
    Centre for Actuarial Research, University of Cape Town, Private Bag, Rondebosch 7701, South Africa
    Vaccine 25:7502-9. 2007
    ....
  86. ncbi request reprint Earlier HIV diagnosis--are mobile services the answer?
    N van Schaik
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town
    S Afr Med J 100:671-4. 2010
    ..To assess the age and gender differences of clients accessing mobile HIV counselling and testing (HCT) compared with clients accessing facility-based testing, and to determine the difference in HIV prevalence and baseline CD4 counts...
  87. ncbi request reprint Antiretroviral therapy in a community clinic--early lessons from a pilot project
    Linda Gail Bekker
    HIV Research Unit, University of Cape Town, Provincial Administration of the Western Cape
    S Afr Med J 93:458-62. 2003
    ..To report on operational and clinical problems encountered during the first 6 months of a community-based antiretroviral therapy (ART) programme...
  88. doi request reprint Monitoring of antiretroviral therapy in low-resource settings
    Stephen D Lawn
    Lancet 372:287-8; author reply 289. 2008
  89. ncbi request reprint Promoting retention in care: an effective model in an antiretroviral treatment service in South Africa
    Stephen D Lawn
    Clin Infect Dis 45:803. 2007
  90. ncbi request reprint Antiretroviral therapy in South Africa--can we do it?
    Linda Gail Bekker
    Infectious Disease and HIV Research Units, University of Cape Town
    S Afr Med J 92:191-3. 2002
  91. ncbi request reprint Do we need a national antiretroviral treatment register?
    Linda Gail Bekker
    S Afr Med J 93:514-5. 2003
  92. ncbi request reprint Blood safety--at what cost?
    Linda Gail Bekker
    JAMA 295:557-8. 2006
  93. ncbi request reprint Antiretroviral roll-out, antifungal roll-back: access to treatment for cryptococcal meningitis
    Tihana Bicanic
    Lancet Infect Dis 5:530-1. 2005
  94. ncbi request reprint Reply to Ouattara et al.: past history of tuberculosis is not a risk factor for incident tuberculosis during antiretroviral treatment in South Africa
    Stephen D Lawn
    AIDS 21:388-9. 2007
  95. ncbi request reprint Cryptococcocal immune reconstitution disease: a major cause of early mortality in a South African antiretroviral programme
    Stephen D Lawn
    AIDS 19:2050-2. 2005
  96. ncbi request reprint How effectively does HAART restore immune responses to Mycobacterium tuberculosis? Implications for tuberculosis control
    Stephen D Lawn
    AIDS 19:1113-24. 2005
    ....
  97. ncbi request reprint A multidrug-resistant, acr1-deficient clinical isolate of Mycobacterium tuberculosis is unimpaired for replication in macrophages
    Juliano Timm
    Laboratory of Infection Biology, The Rockefeller University, New York, New York 10021, USA
    J Infect Dis 193:1703-10. 2006
    ..These observations challenge the prevailing view that MDR bacteria are less fit than drug-susceptible bacteria and indicate that Acr1 is dispensable for bacterial growth in the human lung...
  98. ncbi request reprint The maturing immune system: implications for development and testing HIV-1 vaccines for children and adolescents
    Heather B Jaspan
    AIDS 20:483-94. 2006