Eric Bateman


Affiliation: University of Cape Town
Country: South Africa


  1. Bateman E, Djukanovic R, Castro M, Canvin J, Germinaro M, Noble R, et al. Predicting Responders to Reslizumab after 16 Weeks of Treatment Using an Algorithm Derived from Clinical Studies of Severe Eosinophilic Asthma Patients. Am J Respir Crit Care Med. 2018;: pubmed publisher
    ..A positive score at 16 weeks should encourage continued treatment, and a negative score prompt close monitoring to determine whether discontinuation is warranted. ..
  2. Bateman E, Esser D, Chirila C, Fernandez M, Fowler A, Moroni Zentgraf P, et al. Magnitude of effect of asthma treatments on Asthma Quality of Life Questionnaire and Asthma Control Questionnaire scores: Systematic review and network meta-analysis. J Allergy Clin Immunol. 2015;136:914-22 pubmed publisher
    ..Thus in addition to reporting mean changes of the instruments, other measurement criteria should be considered, including responder analyses. ..
  3. Meltzer E, Chervinsky P, Busse W, Ohta K, Bardin P, Bredenbröker D, et al. Roflumilast for asthma: Efficacy findings in placebo-controlled studies. Pulm Pharmacol Ther. 2015;35 Suppl:S20-7 pubmed publisher
    ..All studies were funded by Takeda. Trial registration numbers available on NCT00073177, NCT00076076, NCT00163527. ..
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    Bateman E, Linnhof A, Homik L, Freudensprung U, Smau L, Engelstätter R. Comparison of twice-daily inhaled ciclesonide and fluticasone propionate in patients with moderate-to-severe persistent asthma. Pulm Pharmacol Ther. 2008;21:264-75 pubmed
    ..Ciclesonide was associated with fewer local AEs than FP. ..
  5. Bateman E, Bousquet J, Aubier M, Bredenbröker D, O Byrne P. Roflumilast for asthma: Efficacy findings in non-placebo-controlled comparator and dosing studies. Pulm Pharmacol Ther. 2015;35 Suppl:S11-9 pubmed publisher
    ..It deserves further study as a potentially effective anti-inflammatory treatment for asthma. ..
  6. Bateman E, Chapman K, Singh D, D Urzo A, Molins E, Leselbaum A, et al. Aclidinium bromide and formoterol fumarate as a fixed-dose combination in COPD: pooled analysis of symptoms and exacerbations from two six-month, multicentre, randomised studies (ACLIFORM and AUGMENT). Respir Res. 2015;16:92 pubmed publisher
    ..Furthermore, aclidinium/formoterol 400/12 μg reduces the frequency of exacerbations compared with placebo. NCT01462942 and NCT01437397 ( ..
  7. Bateman E, Buhl R, O Byrne P, Humbert M, Reddel H, Sears M, et al. Development and validation of a novel risk score for asthma exacerbations: The risk score for exacerbations. J Allergy Clin Immunol. 2015;135:1457-64.e4 pubmed publisher
    ..Prospective validation of these predictive factors and the RSE is required. Use of these models might guide the management of asthmatic patients. ..
  8. Bateman E, Reddel H, van Zyl Smit R, Agusti A. The asthma-COPD overlap syndrome: towards a revised taxonomy of chronic airways diseases?. Lancet Respir Med. 2015;3:719-728 pubmed publisher
    ..This Review considers the epidemiology, mechanisms of disease, current attempts to define and diagnose ACOS, existing and potential treatment options, and new approaches to the phenotyping and taxonomy of airway diseases. ..
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    Bateman E, Nelson H, Bousquet J, Kral K, Sutton L, Ortega H, et al. Meta-analysis: effects of adding salmeterol to inhaled corticosteroids on serious asthma-related events. Ann Intern Med. 2008;149:33-42 pubmed

More Information


  1. Bateman E, Feldman C, Mash R, Fairall L, English R, Jithoo A. Systems for the management of respiratory disease in primary care--an international series: South Africa. Prim Care Respir J. 2009;18:69-75 pubmed publisher
  2. Hall I, Fowler A, Gupta A, Tetzlaff K, Nivens M, Sarno M, et al. Efficacy of BI 671800, an oral CRTH2 antagonist, in poorly controlled asthma as sole controller and in the presence of inhaled corticosteroid treatment. Pulm Pharmacol Ther. 2015;32:37-44 pubmed publisher
    ..37% (1.57%) for montelukast (p = 0.0050 and p = 0.0657, respectively). These findings suggest that BI 671800 is associated with a small improvement in FEV1 in symptomatic controller-naïve asthma patients, and in patients on ICS. ..
  3. Bateman E, Rennard S, Barnes P, Dicpinigaitis P, Gosens R, Gross N, et al. Alternative mechanisms for tiotropium. Pulm Pharmacol Ther. 2009;22:533-42 pubmed publisher
    ..This article summarizes data from a variety of investigations that provide insights into possible mechanisms to account for the effects of tiotropium. The report summarizes the discussion on basic and clinical research in this field. ..
  4. Bateman E, Bleecker E, Lotvall J, Woodcock A, Forth R, Medley H, et al. Dose effect of once-daily fluticasone furoate in persistent asthma: a randomized trial. Respir Med. 2012;106:642-50 pubmed publisher
    ..FF 50-200 ?g/day once daily in the evening demonstrated dose-related efficacy in asthma with 100-200 ?g appearing to be the optimal doses for further evaluation. NCT00603382. ..
  5. Chervinsky P, Meltzer E, Busse W, Ohta K, Bardin P, Bredenbröker D, et al. Roflumilast for asthma: Safety findings from a pooled analysis of ten clinical studies. Pulm Pharmacol Ther. 2015;35 Suppl:S28-34 pubmed publisher
    ..This reflects the general safety profile reported previously in patients with COPD. All studies were funded by Takeda. Trial registration numbers available on NCT00073177, NCT00076076, NCT00163527. ..
  6. Bateman E, Goehring U, Richard F, Watz H. Roflumilast combined with montelukast versus montelukast alone as add-on treatment in patients with moderate-to-severe asthma. J Allergy Clin Immunol. 2016;138:142-149.e8 pubmed publisher
    ..The combination of roflumilast with montelukast compared with montelukast alone improved lung function and asthma control in patients with moderate-to-severe asthma and deserves further study for this indication. ..
  7. Kerstjens H, Moroni Zentgraf P, Tashkin D, Dahl R, Paggiaro P, Vandewalker M, et al. Tiotropium improves lung function, exacerbation rate, and asthma control, independent of baseline characteristics including age, degree of airway obstruction, and allergic status. Respir Med. 2016;117:198-206 pubmed publisher; numbers NCT00772538 and NCT00776984 URL: ..
  8. Tashkin D, Bateman E, Jones P, Zubek V, Metzdorf N, Liu D, et al. Consistent improvement in health-related quality of life with tiotropium in patients with chronic obstructive pulmonary disease: Novel and conventional responder analyses. Respir Med. 2016;120:91-100 pubmed publisher
    ..Tiotropium maintenance therapy significantly and consistently improved HRQoL in moderate-to-very severe COPD patients in a durable manner. These results may provide a benchmark for assessing benefits on HRQoL of other COPD treatments. ..
  9. Bateman E, Kornmann O, Ambery C, Norris V. Pharmacodynamics of GSK961081, a bi-functional molecule, in patients with COPD. Pulm Pharmacol Ther. 2013;26:581-7 pubmed publisher
    ..GSK961081 demonstrated sustained bronchodilation similar to TIO + SAL, but with a more rapid onset, and was well tolerated at the tested doses. ..
  10. Bateman E, Harrison T, Quirce S, Reddel H, Buhl R, Humbert M, et al. Overall asthma control achieved with budesonide/formoterol maintenance and reliever therapy for patients on different treatment steps. Respir Res. 2011;12:38 pubmed publisher
  11. Bateman E, Reddel H, Eriksson G, Peterson S, Ostlund O, Sears M, et al. Overall asthma control: the relationship between current control and future risk. J Allergy Clin Immunol. 2010;125:600-8, 608.e1-608.e6 pubmed publisher
    ..Current control predicts future risk of instability and exacerbations. Budesonide/formoterol maintenance and reliever therapy reduces exacerbations versus comparators and achieves at least similar control. ..
  12. Amaral A, Patel J, Kato B, Obaseki D, Lawin H, Tan W, et al. Airflow Obstruction and Use of Solid Fuels for Cooking or Heating: BOLD Results. Am J Respir Crit Care Med. 2017;: pubmed publisher
    ..Airflow obstruction assessed from post-bronchodilator spirometry was not associated with use of solid fuels for cooking or heating. ..
  13. Bateman E, Feldman G, Kilbride S, Brooks J, Mehta R, Harris S, et al. Efficacy and safety of the long-acting muscarinic antagonist GSK233705 delivered once daily in patients with COPD. Clin Respir J. 2012;6:248-57 pubmed publisher
    ..All doses of GSK233705 demonstrated bronchodilatory activity and were well tolerated. Although the onset of bronchodilation was rapid, it was not sustained over 24 h making it unsuitable for once-daily dosing. ..
  14. Bateman E, Rabe K, Calverley P, Goehring U, Brose M, Bredenbroker D, et al. Roflumilast with long-acting ?2-agonists for COPD: influence of exacerbation history. Eur Respir J. 2011;38:553-60 pubmed publisher
    ..No differences arose in adverse events between these subgroups. Roflumilast may be used to reduce exacerbations and improve dyspnoea and lung function, without increasing adverse events in COPD patients receiving concomitant LABAs. ..
  15. Bateman E, Guerreros A, Brockhaus F, Holzhauer B, Pethe A, Kay R, et al. Fevipiprant, an oral prostaglandin DP2 receptor (CRTh2) antagonist, in allergic asthma uncontrolled on low-dose inhaled corticosteroids. Eur Respir J. 2017;50: pubmed publisher
    ..Further investigations into the clinical role of fevipiprant in suitably designed phase III clinical trials are warranted. ..