Ronald A Asherson

Summary

Affiliation: University of the Witwatersrand
Country: South Africa

Publications

  1. ncbi request reprint The catastrophic antiphospholipid (Asherson's) syndrome
    Ronald A Asherson
    Division of Immunology, School of Pathology, University of the Witwatersrand, PO Box 1038, Johannesburg, South Africa
    Autoimmun Rev 6:64-7. 2006
  2. ncbi request reprint Catastrophic antiphospholipid (Asherson's) syndrome and genetic thrombophilic disorders in obstetrics
    A Makatsariya
    Department of Obstetrics and Gynecology of Moscow Medical Academy, Noviy Arbat 7, 119017 Moscow, Russia
    Autoimmun Rev 6:89-93. 2006
  3. ncbi request reprint Recurrent pulmonary thromboembolism in a patient with systemic lupus erythematosus and HIV-1 infection associated with the presence of antibodies to prothrombin: a case report
    Ronald A Asherson
    Rheumatic Diseases Unit, Faculty of Medicine, University of Cape Town Health Sciences Center, Cape Town, South Africa
    Clin Infect Dis 41:e89-92. 2005
  4. ncbi request reprint "Primary" antiphospholipid syndrome evolving into Waldenstrom's macroglobulinaemia: a case report
    R A Asherson
    Division Immunology, School of Pathology, University of the Witswatersrand, Johannesburg, 2000, South Africa
    Clin Rheumatol 26:278-80. 2007
  5. ncbi request reprint Peripheral vascular occlusions leading to gangrene and amputations in antiphospholipid antibody positive patients
    Ronald A Asherson
    Division of Immunology, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa
    Ann N Y Acad Sci 1108:515-29. 2007
  6. ncbi request reprint Ehlers-Danlos syndrome type IV in a young man
    Ronald A Asherson
    Division of Immunology, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa
    J Rheumatol 33:2091-6. 2006
  7. doi request reprint Antiphospholipid antibodies and the antiphospholipid syndrome: clinical significance and treatment
    Ronald A Asherson
    Division of Immunology, The School of Pathology, University of the Witwatersrand, The Netcare Rosebank Hospital, Rosebank, Johannesburg, South Africa
    Semin Thromb Hemost 34:256-66. 2008
  8. ncbi request reprint Vascular occlusions in a patient with low positive antiphospholipid antibodies and subsequent development of breast carcinoma: a diagnostic dilemma
    Ronald A Asherson
    Division of Immunology, School of Pathology, University of the Witwatersrand, Johannesburg 2000, South Africa
    Clin Rheumatol 26:1531-3. 2007
  9. ncbi request reprint Dramatic response of severe headaches to anticoagulation in a patient with antiphospholipid syndrome
    R A Asherson
    The Division of Immunology, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa
    J Clin Rheumatol 13:173-4. 2007
  10. ncbi request reprint New subsets of the antiphospholipid syndrome in 2006: "PRE-APS" (probable APS) and microangiopathic antiphospholipid syndromes ("MAPS")
    Ronald A Asherson
    Division of Immunology, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa 2000
    Autoimmun Rev 6:76-80. 2006

Detail Information

Publications44

  1. ncbi request reprint The catastrophic antiphospholipid (Asherson's) syndrome
    Ronald A Asherson
    Division of Immunology, School of Pathology, University of the Witwatersrand, PO Box 1038, Johannesburg, South Africa
    Autoimmun Rev 6:64-7. 2006
    ..The mortality is high, although with early and effective therapies, including full parenteral anticoagulation, corticosteroids, plasma exchanges and IV globulins, an improvement in this high death rate has been noted recently...
  2. ncbi request reprint Catastrophic antiphospholipid (Asherson's) syndrome and genetic thrombophilic disorders in obstetrics
    A Makatsariya
    Department of Obstetrics and Gynecology of Moscow Medical Academy, Noviy Arbat 7, 119017 Moscow, Russia
    Autoimmun Rev 6:89-93. 2006
    ..Low-molecular-weight heparin is the drug of choice for preventing obstetric complications and CAPS due to its anticoagulant and anti-inflammatory properties...
  3. ncbi request reprint Recurrent pulmonary thromboembolism in a patient with systemic lupus erythematosus and HIV-1 infection associated with the presence of antibodies to prothrombin: a case report
    Ronald A Asherson
    Rheumatic Diseases Unit, Faculty of Medicine, University of Cape Town Health Sciences Center, Cape Town, South Africa
    Clin Infect Dis 41:e89-92. 2005
    ..Antiphospholipid antibodies are demonstrable in patients with both conditions, but clinical manifestations of the antiphospholipid syndrome (APS) in HIV-infected patients, although reported, are uncommon...
  4. ncbi request reprint "Primary" antiphospholipid syndrome evolving into Waldenstrom's macroglobulinaemia: a case report
    R A Asherson
    Division Immunology, School of Pathology, University of the Witswatersrand, Johannesburg, 2000, South Africa
    Clin Rheumatol 26:278-80. 2007
    ....
  5. ncbi request reprint Peripheral vascular occlusions leading to gangrene and amputations in antiphospholipid antibody positive patients
    Ronald A Asherson
    Division of Immunology, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa
    Ann N Y Acad Sci 1108:515-29. 2007
    ..Complicating vasculitis was present in seven of the patients. Five of the patients developed severe peripheral vascular disease during the course of the catastrophic antiphospholipid (Asherson's) syndrome...
  6. ncbi request reprint Ehlers-Danlos syndrome type IV in a young man
    Ronald A Asherson
    Division of Immunology, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa
    J Rheumatol 33:2091-6. 2006
    ..The coincidental finding of transient aPL elevations combined to make this a difficult diagnostic and clinical management problem...
  7. doi request reprint Antiphospholipid antibodies and the antiphospholipid syndrome: clinical significance and treatment
    Ronald A Asherson
    Division of Immunology, The School of Pathology, University of the Witwatersrand, The Netcare Rosebank Hospital, Rosebank, Johannesburg, South Africa
    Semin Thromb Hemost 34:256-66. 2008
    ..Current treatments of the antiphospholipid syndrome are briefly reviewed...
  8. ncbi request reprint Vascular occlusions in a patient with low positive antiphospholipid antibodies and subsequent development of breast carcinoma: a diagnostic dilemma
    Ronald A Asherson
    Division of Immunology, School of Pathology, University of the Witwatersrand, Johannesburg 2000, South Africa
    Clin Rheumatol 26:1531-3. 2007
    ..An alternative explanation is that the antibodies may have presaged the development of the malignancy. To favour any one of these explanations remains highly speculative...
  9. ncbi request reprint Dramatic response of severe headaches to anticoagulation in a patient with antiphospholipid syndrome
    R A Asherson
    The Division of Immunology, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa
    J Clin Rheumatol 13:173-4. 2007
  10. ncbi request reprint New subsets of the antiphospholipid syndrome in 2006: "PRE-APS" (probable APS) and microangiopathic antiphospholipid syndromes ("MAPS")
    Ronald A Asherson
    Division of Immunology, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa 2000
    Autoimmun Rev 6:76-80. 2006
    ..Disseminated intravascular coagulation (DIC) has also been reported with demonstrable antiphospholipid antibodies and also manifests severe thrombocytopenia and small vessel occlusions. It may cause problems in differential diagnosis...
  11. ncbi request reprint Pulmonary hypertension, antiphospholipid antibodies, and syndromes
    Ronald A Asherson
    Division of Immunology, School of Pathology, University of the Witwatersrand and the Rosebank Clinic, Johannesburg, 2000, South Africa
    Clin Rev Allergy Immunol 32:153-8. 2007
    ..Genetic and chromosomal aspects of PHT are also discussed...
  12. ncbi request reprint Multiorgan failure and antiphospholipid antibodies: the catastrophic antiphospholipid (Asherson's) syndrome
    Ronald A Asherson
    Rheumatic Diseases Unit, University of Cape Town Health Sciences Centre, and The Rosebank Clinic, Rosebank, Johannesburg 2196, South Africa
    Immunobiology 210:727-33. 2005
    ..Antifungal therapy may also be indicated with prolonged treatment and the use of the monoclonal anti-CD20 molecule, Rituximab, has proven useful in those patients where thrombocytopenia poses a major risk of hemorrhage...
  13. ncbi request reprint Relapsing catastrophic antiphospholipid syndrome: report of three cases
    Ronald A Asherson
    Division of Immunology, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa
    Semin Arthritis Rheum 37:366-72. 2008
    ..Relapses in patients with the CAPS are very uncommon...
  14. doi request reprint The primary, secondary, catastrophic, and seronegative variants of the antiphospholipid syndrome: a personal history long in the making
    Ronald A Asherson
    Division of Immunology, The School of Pathology, University of the Witwatersrand, The Netcare Rosebank Hospital, Rosebank, Johannesburg, South Africa
    Semin Thromb Hemost 34:227-35. 2008
    ..This article documents a personal account of the events that took place in relation to the description of these syndromes...
  15. doi request reprint Amputation of digits or limbs in patients with antiphospholipid syndrome
    Ronald A Asherson
    Division of Immunology, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa
    Semin Arthritis Rheum 38:124-31. 2008
    ..To describe the characteristics of patients with peripheral vascular disease leading to amputation of digits or limbs encountered in patients with the antiphospholipid syndrome (APS)...
  16. ncbi request reprint Acute respiratory distress syndrome and other unusual manifestations of the catastrophic antiphospholipid (Asherson's) syndrome
    Ronald A Asherson
    Rheumatic Diseases Unit, Department of Medicine, Faculty of Health Sciences, University of Cape, Cape Town, South Africa
    Isr Med Assoc J 6:360-3. 2004
  17. doi request reprint Microvascular and microangiopathic antiphospholipid-associated syndromes ("MAPS"): semantic or antisemantic?
    Ronald A Asherson
    Division of Immunology, School of Pathology, University of the Witwatersrand the Netcare Rosebank Hospital, Johannesburg, South Africa
    Autoimmun Rev 7:164-7. 2008
    ..This may be occurring in patients with the catastrophic antiphospholipid syndrome (CAPS/Asherson's syndrome). The term "MAPS" is suggested for these two groups of conditions...
  18. ncbi request reprint Partial HELLP syndrome in pregnancy complicated by recurrent deep vein thromboses and palmar skin lesions in a patient with prothrombin gene 20210a mutation and antiphospholipid antibodies: an unusual case
    Ronald A Asherson
    Division of Immunology, School of Pathology, University of the Witwatersrand School of Medicine, Johannesburg, South Africa
    Clin Rheumatol 27:245-8. 2008
    ..A Greenfield filter was inserted into the inferior vena cava. On low molecular weight heparin, her next pregnancy was uneventful and without any complications...
  19. ncbi request reprint The antiphospholipid syndrome: multiple faces beyond the classical presentation
    Ronald A Asherson
    Rheumatic Diseases Unit, Department of Medicine, University of Cape Town School of Medicine, Cape Town, South Africa
    Autoimmun Rev 2:140-51. 2003
  20. ncbi request reprint Unusual manifestations of the antiphospholipid syndrome
    Ronald A Asherson
    Rheumatic Diseases Unit, Department of Medicine, University of Cape Town School of Medicine, Cape Town, South Africa
    Clin Rev Allergy Immunol 25:61-78. 2003
    ..In this article, some of these "unusual" manifestations are reviewed...
  21. ncbi request reprint The catastrophic antiphospholipid (Asherson's) syndrome in 2004--a review
    Ronald A Asherson
    Rheumatic Diseases Unit, University of Cape Town Health Sciences Center, Groote Schuur Hospital, Cape Town, South Africa
    Autoimmun Rev 4:48-54. 2005
    ..Despite seemingly adequate therapy (parenteral heparin, steroids, antibiotics), the mortality remains high (approximately 50%)...
  22. doi request reprint A case of adult-onset Satoyoshi syndrome with gastric ulceration and eosinophilic enteritis
    Ronald A Asherson
    Division of Immunology, School of Pathology, University of Witwatersrand, and Netcare Rosebank Hospital, Johannesburg, South Africa
    Nat Clin Pract Rheumatol 4:439-44. 2008
    ..Total alopecia, muscular spasms and diarrhea developed over the following 2 years, and the patient experienced gastric ulceration in 2006. A rheumatologic opinion was sought in 2007...
  23. ncbi request reprint Microangiopathic antiphospholipid-associated syndromes revisited new concepts relating to antiphospholipid antibodies and syndromes
    Ronald A Asherson
    J Rheumatol 34:1793-5. 2007
  24. ncbi request reprint Catastrophic antiphospholipid syndrome and sepsis. A common link?
    Gerard Espinosa
    J Rheumatol 34:923-6. 2007
  25. ncbi request reprint Human immunodeficiency virus infection, antiphospholipid antibodies, and the antiphospholipid syndrome
    Ronald A Asherson
    J Rheumatol 30:214-9. 2003
  26. ncbi request reprint The HELLP syndrome, antiphospholipid antibodies, and syndromes
    Ronald A Asherson
    Clin Rheumatol 27:1-4. 2008
  27. pmc Is there a microangiopathic antiphospholipid syndrome?
    Ronald A Asherson
    Ann Rheum Dis 66:429-32. 2007
  28. ncbi request reprint Clinical and epidemiological aspects in the antiphospholipid syndrome
    Ricard Cervera
    Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain
    Immunobiology 207:5-11. 2003
    ..Systemic lupus erythematosus (SLE) is the disorder in which an APS is most commonly associated. Less frequently, aPL and, rarely, an APS may also be encountered in other groups of patients (Table 1) (1)...
  29. ncbi request reprint Nonthrombotic manifestations of the antiphospholipid syndrome: away from thrombosis?
    Ronald A Asherson
    J Rheumatol 33:1038-44. 2006
  30. ncbi request reprint Adrenal involvement in the antiphospholipid syndrome: clinical and immunologic characteristics of 86 patients
    Gerard Espinosa
    Department of Autoimmune Diseases, Institut Clinic d Infeccions i Immunologia, Institut d Investigacions Biomèdiques August Pi Sunyer, Hospital Clinic, Barcelona, Catalonia, Spain
    Medicine (Baltimore) 82:106-18. 2003
    ..An initial screening for hypoadrenalism is mandatory in any antiphospholipid antibody-positive patient who complains of abdominal pain and undue weakness or asthenia...
  31. ncbi request reprint Catastrophic antiphospholipid syndrome
    Ricard Cervera
    Department of Autoimmune Diseases, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    Rheum Dis Clin North Am 32:575-90. 2006
    ..Additionally, preventive measures in patients with APS may be effective if the development of the catastrophic APS is to be avoided...
  32. ncbi request reprint Catastrophic antiphospholipid syndrome
    Joan T Merrill
    University of Oklahoma, USA
    Nat Clin Pract Rheumatol 2:81-9. 2006
    ....
  33. pmc Catastrophic antiphospholipid syndrome during pregnancy and puerperium: maternal and fetal characteristics of 15 cases
    José A Gómez-Puerta
    Servei de Malalties Autoimmunes, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    Ann Rheum Dis 66:740-6. 2007
    ..The catastrophic variant of the antiphospholipid syndrome (APS) is a life-threatening form of presentation of this syndrome that can be triggered by several factors...
  34. ncbi request reprint Intestinal involvement secondary to the antiphospholipid syndrome (APS): clinical and immunologic characteristics of 97 patients: comparison of classic and catastrophic APS
    Ricard Cervera
    Department of Autoimmune Diseases, Institut Clinic de Medicina i Dermatologia, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Catalonia, Spain
    Semin Arthritis Rheum 36:287-96. 2007
    ..To analyze the clinical and laboratory characteristics of 97 patients with intestinal involvement secondary to the antiphospholipid syndrome (APS) (37 patients with classic APS and 60 with catastrophic APS)...
  35. ncbi request reprint Catastrophic antiphospholipid syndrome: where do we stand?
    Doruk Erkan
    Hospital for Special Surgery, Weill Medical College of Cornell University, New York, New York 10021, USA
    Arthritis Rheum 48:3320-7. 2003
  36. ncbi request reprint An unusually complicated case of primary Sjögren's syndrome: development of transient "lupus-type" autoantibodies following silicone implant rejection
    Ronald A Asherson
    J Rheumatol 31:196-7. 2004
  37. ncbi request reprint Catastrophic antiphospholipid syndrome
    Ronald A Asherson
    Department of Autoimmune Diseases, Institut Clinic d Infeccions i Immunologia, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    Curr Rheumatol Rep 5:395-400. 2003
    ..Regrettably, despite all available therapeutic options at this time, the mortality is still high (greater than 50%)...
  38. ncbi request reprint Antiphospholipid syndrome associated with infections: clinical and microbiological characteristics
    Ricard Cervera
    Department of Autoimmune Diseases, Institut Clinic de Medicina i Dermatologia, Hospital Clinic, Villaroel, 170, 08036 Barcelona, Catalonia, Spain
    Immunobiology 210:735-41. 2005
    ..Since then, many infections have been found to be associated with aPL positivity, although a pathogenic role for these antibodies was not usually obvious except in a few isolated cases...
  39. ncbi request reprint Diffuse alveolar hemorrhage: a nonthrombotic antiphospholipid lung syndrome?
    Ronald A Asherson
    Semin Arthritis Rheum 35:138-42. 2005
  40. ncbi request reprint Antiphospholipid antibodies associated with malignancies: clinical and pathological characteristics of 120 patients
    José A Gómez-Puerta
    Department of Autoimmune Diseases, Institut Clínic de Medicina i Dermatologia ICMiD, Hospital Clinic, Barcelona, Catalonia, Spain
    Semin Arthritis Rheum 35:322-32. 2006
    ..To describe the different types of malignancies associated with antiphospholipid antibodies (aPL)...
  41. ncbi request reprint Primary pulmonary arterial hypertension and the systemic autoimmune diseases
    Ricard Cervera
    Isr Med Assoc J 8:277-9. 2006
  42. ncbi request reprint Catastrophic antiphospholipid syndrome: lessons from the "CAPS Registry"--a tribute to the late Josep Font
    Ricard Cervera
    Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain
    Ann N Y Acad Sci 1108:448-56. 2007
    ..This registry can be freely consulted at the Internet (www.med.ub.es/MIMMUN/FORUM/CAPS.HTM) and it is expected that the periodical analysis of these data will allow us to increase our knowledge of this condition...
  43. ncbi request reprint Mortality in the catastrophic antiphospholipid syndrome: causes of death and prognostic factors in a series of 250 patients
    Silvia Bucciarelli
    Institut Clinic de Medicina i Dermatologia, Hospital Clinic, Barcelona, Catalonia, Spain
    Arthritis Rheum 54:2568-76. 2006
    ..To assess the main causes of death and the prognostic factors that influence mortality in patients with the catastrophic antiphospholipid syndrome (CAPS)...
  44. ncbi request reprint Catastrophic antiphospholipid syndrome
    Setu K Vora
    Pulmonary Physicians of Norwich, Norwich, Connecticut, USA
    J Intensive Care Med 21:144-59. 2006
    ..This article reviews the current information on the etiopathogenesis, clinical manifestations, diagnosis, management, and prognosis of catastrophic antiphospholipid syndrome...