Research Topics
Genomes and Genes
Species | Salim S Abdool KarimSummaryAffiliation: University of KwaZulu-Natal Country: South Africa Publications
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Detail Information
Publications
Durban 2000 to Toronto 2006: the evolving challenges in implementing AIDS treatment in AfricaSalim S Abdool Karim
Centre for the AIDS Programme of Research in South Africa (CAPRISA, University of KwaZulu-Natal and Columbia University, Congella 4013
AIDS 20:N7-9. 2006- Global epidemiology of HIV-AIDSSalim S Abdool Karim
Centre for the AIDS Program of Research in South Africa CAPRISA, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Private Bag X7, Congella, 4013 Durban, South Africa
Infect Dis Clin North Am 21:1-17, vii. 2007..This article describes the modes of HIV transmission, geographic distribution of the evolving AIDS pandemic, and case studies of each of the three types of HIV epidemics, and presents global trends in AIDS and mortality... 
Association of TRIM22 with the type 1 interferon response and viral control during primary HIV-1 infectionRavesh Singh
Doris Duke Medical Research Institute, University of KwaZulu Natal, Private Bag X7, Congella, Durban 4001, South Africa
J Virol 85:208-16. 2011..Collectively, these data suggest concordance between type 1 IFN and TRIM22 but not huTRIM5α expression in PBMCs and that TRIM22 likely acts as an antiviral effector in vivo...- Overview of microbicides for the prevention of human immunodeficiency virusSalim S Abdool Karim
CAPRISA Centre of AIDS Programme of Research in South Africa, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Private Bag X7, Congella 4013, Durban, South Africa
Best Pract Res Clin Obstet Gynaecol 26:427-39. 2012..Microbicides, which fill an important gap for women-controlled prevention methods, have the potential to alter the course of the HIV pandemic... - Conserved positive selection signals in gp41 across multiple subtypes and difference in selection signals detectable in gp41 sequences sampled during acute and chronic HIV-1 subtype C infectionGama P Bandawe
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa
Virol J 5:141. 2008..Besides being targeted by both the humoral and cellular arms of the immune system this protein mediates fusion between viral and target cell membranes and is likely to be a primary determinant of HIV transmissibility... - Recruitment of high risk women for HIV prevention trials: baseline HIV prevalence and sexual behavior in the CAPRISA 004 tenofovir gel trialQuarraisha Abdool Karim
Centre for the AIDS Programme of Research in South Africa CAPRISA, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
Trials 12:67. 2011..Microbicides could fill an important HIV prevention gap for sexually active women who are unable to successfully negotiate mutual monogamy or condom use... - HIV infection and tuberculosis in South Africa: an urgent need to escalate the public health responseSalim S Abdool Karim
Centre for the AIDS Programme of Research in South Africa CAPRISA, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
Lancet 374:921-33. 2009..Strong leadership, political will, social mobilisation, adequate human and financial resources, and sustainable development of health-care services are needed for successful implementation of these approaches... - Implementing antiretroviral therapy in resource-constrained settings: opportunities and challenges in integrating HIV and tuberculosis careSalim S Abdool-Karim
CAPRISA, University of KwaZulu-Natal, South Africa
AIDS 18:975-9. 2004 - Stabilizing HIV prevalence masks high HIV incidence rates amongst rural and urban women in KwaZulu-Natal, South AfricaQuarraisha Abdool Karim
Centre for the AIDS Programme of Research in South Africa, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
Int J Epidemiol 40:922-30. 2011..In mature generalized human immunodeficiency virus (HIV) epidemics, as survival from accessing antiretroviral treatment (ART) increases, HIV prevalence data may be suboptimal and difficult to interpret without HIV incidence rates... - Integration of antiretroviral therapy with tuberculosis treatmentSalim S Abdool Karim
Centre for the AIDS Programme of Research in South Africa, Durban, South Africa
N Engl J Med 365:1492-501. 2011..We previously reported that integrating antiretroviral therapy (ART) with tuberculosis treatment reduces mortality. However, the timing for the initiation of ART during tuberculosis treatment remains unresolved... - Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in womenQuarraisha Abdool Karim
Centre for the AIDS Program of Research in South Africa CAPRISA, Durban 4013, South Africa
Science 329:1168-74. 2010..Tenofovir gel could potentially fill an important HIV prevention gap, especially for women unable to successfully negotiate mutual monogamy or condom use... - Establishing a cohort at high risk of HIV infection in South Africa: challenges and experiences of the CAPRISA 002 acute infection studyFrancois van Loggerenberg
Centre for the AIDS Programme of Research in South Africa CAPRISA, University of KwaZulu Natal, Durban, South Africa
PLoS ONE 3:e1954. 2008..To describe the baseline demographic data, clinical characteristics and HIV-incidence rates of a cohort at high risk for HIV infection in South Africa as well as the challenges experienced in establishing and maintaining the cohort... 
Co-enrollment in multiple HIV prevention trials - experiences from the CAPRISA 004 Tenofovir gel trialQuarraisha Abdool Karim
Centre for the AIDS Program of Research in South Africa CAPRISA, Durban, South Africa
Contemp Clin Trials 32:333-8. 2011..Shared electronic database between research units was established to enable verification of each volunteer's trial participation and to prevent future co-enrollments...- Timing of initiation of antiretroviral drugs during tuberculosis therapySalim S Abdool Karim
Centre for the AIDS Programme of Research in South Africa, University of KwaZulu Natal, Durban, South Africa
N Engl J Med 362:697-706. 2010..The optimal timing for the initiation of antiretroviral therapy in relation to tuberculosis therapy remains controversial... - The influence of tuberculosis treatment on efavirenz clearance in patients co-infected with HIV and tuberculosisTanuja N Gengiah
Centre for the AIDS Programme of Research in South Africa, University of KwaZulu Natal, Durban, South Africa
Eur J Clin Pharmacol 68:689-95. 2012..Concomitant use of efavirenz (EFV) with the enzyme inducer rifampicin might be expected to increase EFV clearance. We investigated the influence of concomitant tuberculosis treatment on the plasma clearance of EFV... - HIV prevalence among high school learners - opportunities for schools-based HIV testing programmes and sexual reproductive health servicesAyesha B M Kharsany
Centre for the AIDS Programme of Research in South Africa CAPRISA, 2nd Floor, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Private Bag 7, Congella, Durban 4013, South Africa
BMC Public Health 12:231. 2012..This study aimed at determining the HIV prevalence and explored the feasibility of HIV testing among high school learners... - HIV incidence in young girls in KwaZulu-Natal, South Africa--public health imperative for their inclusion in HIV biomedical intervention trialsQuarraisha Abdool Karim
Centre for the AIDS Programme of Research in South Africa CAPRISA, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Congella, Durban 4013, South Africa
AIDS Behav 16:1870-6. 2012..90). This study demonstrates that the inclusion of young girls between the ages of 14 and 17 years in longitudinal studies is feasible and their inclusion in clinical trials would maintain scientific integrity and power of the study... - Natural killer cell function in women at high risk for HIV acquisition: insights from a microbicide trialVivek Naranbhai
Centre for the AIDS Programme of Research in South Africa, Durban, South Africa
AIDS 26:1745-53. 2012..To assess the role of natural killer (NK) cells in HIV acquisition... - A drug evaluation of 1% tenofovir gel and tenofovir disoproxil fumarate tablets for the prevention of HIV infectionTanuja N Gengiah
Centre for the AIDS Program of Research in South Africa CAPRISA, University of KwaZulu Natal, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, Congella, Durban, South Africa
Expert Opin Investig Drugs 21:695-715. 2012.... - Association of polymorphisms in the LEDGF/p75 gene (PSIP1) with susceptibility to HIV-1 infection and disease progressionParadise Madlala
HIV Pathogenesis Programme, University of KwaZulu Natal, Durban, South Africa
AIDS 25:1711-9. 2011..We investigated the influence of polymorphisms in PSIP1 on HIV-1 acquisition and disease progression in black South Africans... - Contraceptive choices, pregnancy rates, and outcomes in a microbicide trialSengeziwe Sibeko
Centre for the AIDS Programme of Research in South Africa, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
Obstet Gynecol 118:895-904. 2011.... - APOBEC3G expression is dysregulated in primary HIV-1 infection and polymorphic variants influence CD4+ T-cell counts and plasma viral loadKavidha Reddy
Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
AIDS 24:195-204. 2010..We investigated the association of APOBEC3G mRNA levels and genetic variants on HIV-1 susceptibility, and early disease pathogenesis using viral load and CD4 T-cell counts as outcomes... - Uptake of provider-initiated HIV testing and counseling among women attending an urban sexually transmitted disease clinic in South Africa - missed opportunities for early diagnosis of HIV infectionAyesha B M Kharsany
Centre for the AIDS Programme of Research in South Africa, University of KwaZulu Natal, Private Bag 7 Congella, Durban 4013, South Africa
AIDS Care 22:533-7. 2010.... - Anaemia in acute HIV-1 subtype C infectionKoleka Mlisana
Centre for the AIDS Programme of Research in South Africa CAPRISA, University of KwaZulu Natal, Durban, South Africa
PLoS ONE 3:e1626. 2008.... - Who infects whom? HIV-1 concordance and discordance among migrant and non-migrant couples in South AfricaMark N Lurie
South African Medical Research Council, HIV Prevention and Vaccine Research Unit, Durban, South Africa
AIDS 17:2245-52. 2003..To measure HIV-1 discordance among migrant and non-migrant men and their rural partners, and to estimate the relative risk of infection from inside versus outside primary relationships... - When to start antiretroviral therapy during tuberculosis treatment?Kogieleum Naidoo
Centre for the AIDS Programme of Research in South Africa, University of KwaZulu Natal, Durban, South Africa
Curr Opin Infect Dis 26:35-42. 2013..This review assesses the evidence for the timing of antiretroviral therapy (ART) initiation in patients coinfected with TB... - Safety and effectiveness of BufferGel and 0.5% PRO2000 gel for the prevention of HIV infection in womenSalim S Abdool Karim
Centre for the AIDS Programme of Research in South Africa CAPRISA, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Congella, South Africa
AIDS 25:957-66. 2011..To determine the safety and effectiveness of BufferGel and 0.5% PRO2000 microbicide gels for the prevention of male-to-female HIV transmission... - The impact of migration on HIV-1 transmission in South Africa: a study of migrant and nonmigrant men and their partnersMark N Lurie
South African Medical Research Council, HIV Prevention and Vaccine Research Unit, Durban, South Africa
Sex Transm Dis 30:149-56. 2003..To investigate the association between migration and HIV infection among migrant and nonmigrant men and their rural partners... - Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black womenVeron Ramsuran
HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
Clin Infect Dis 52:1248-56. 2011..The influence of pre-seroconversion levels of peripheral blood cell counts (PBCs) on the risk of acquiring human immunodeficiency virus (HIV)-1 infection among Africans is unknown... - Enrolling adolescents in research on HIV and other sensitive issues: lessons from South AfricaJerome Amir Singh
Centre for AIDS Programme of Research in South Africa, Congella, South Africa
PLoS Med 3:e180. 2006 - Medical education after the first decade of democracy in South AfricaSalim S Abdool Karim
CAPRISA, University of KwaZulu-Natal, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban 4013, South Africa
Lancet 363:1395. 2004 - HIV incidence estimates are key to understanding the changing HIV epidemic in South AfricaSalim S Abdool Karim
S Afr Med J 97:190. 2007 - Dual HIV-1 infection associated with rapid disease progressionGeoffrey S Gottlieb
Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195 8070, USA
Lancet 363:619-22. 2004..4 and <3.1 years, respectively). Our findings should prompt larger studies to assess the effect of dual infection at the population level... - Increasing burden of pulmonary tuberculosis in young womenAyesha B M Kharsany
S Afr Med J 96:524-5. 2006 - Utilizing nucleic acid amplification to identify acute HIV infectionSalim S Abdool Karim
AIDS 21:653-5. 2007 - Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trialLut Van Damme
Institute of Tropical Medicine, Antwerp, Belgium
Lancet 360:971-7. 2002..Results of studies of its effectiveness in prevention of HIV-1 infection in women have been inconclusive. We aimed to assess effectiveness of this vaginal gel...