David D N'Da

Summary

Affiliation: North-West University
Country: South Africa

Publications

  1. ncbi request reprint Synthesis and in vitro transdermal penetration of methoxypoly(ethylene glycol) carbonate and carbamate derivatives of lamivudine (3TC)
    Jaco van Heerden
    Pharmaceutical Chemistry, North West University, Potchefstroom 2520, South Africa
    Med Chem 6:91-9. 2010
  2. ncbi request reprint Synthesis, cytotoxicity and antimalarial activity of ferrocenyl amides of 4-aminoquinolines
    David D N'Da
    Department of Pharmaceutical Chemistry, School Pharmacy, North West University, Potchefstroom, South Africa
    Arzneimittelforschung 60:627-35. 2010
  3. ncbi request reprint Antiplasmodial activity and cytotoxicity of 10β-aminoquinolinylethylethers of artemisinin
    D D N'da
    North West University, Potchefstroom, South Africa
    Drug Res (Stuttg) 63:104-8. 2013
  4. ncbi request reprint Synthesis and in vitro transdermal penetration of methoxypoly(ethylene glycol) carbonate derivatives of stavudine
    David D N'Da
    Pharmaceutical Chemistry, School of Pharmacy, Statistical Consultation Services, North West University, Potchefstroom 2520, South Africa
    Med Chem 5:497-506. 2009
  5. ncbi request reprint Synthesis and in vitro antiplasmodial activity of quinoline-ferrocene esters
    David D N'Da
    Department of Pharmaceutical Chemistry, School of Pharmacy, North West University, Potchefstroom, South Africa
    Arzneimittelforschung 61:358-65. 2011
  6. doi request reprint Synthesis and in vitro human skin penetration of oligo- and polymeric ethylene glycol carbonates of zidovudine and stavudine
    David D N'Da
    Department of Pharmaceutical Chemistry, School of Pharmacy, North West University, Potchefstroom, South Africa
    Arzneimittelforschung 60:575-82. 2010
  7. pmc Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids
    Marli C Lombard
    Pharmaceutical Chemistry, North West University, Potchefstroom 2531, South Africa
    Malar J 12:71. 2013
  8. ncbi request reprint Transdermal penetration of cytarabine and its 5'-O alkyl ester derivatives
    Lesetja J Legoabe
    Unit for Drug Research and Development, North West University, Private Bag X 6001, Potchefstroom, 2520, South Africa
    Med Chem 6:108-13. 2010
  9. ncbi request reprint Synthesis and in vitro antimalarial activity of a series of bisquinoline and bispyrrolo[1,2a]quinoxaline compounds
    Lezanne van Heerden
    Department of Pharmaceutical Chemistry, North West University, Potchefstroom 2520, South Africa
    Eur J Med Chem 55:335-45. 2012
  10. doi request reprint Mono-, di- and trisubstituted derivatives of eflornithine: synthesis for in vivo delivery of DL-alpha-difluoromethylornithine in plasma
    Theunis T Cloete
    Department of Pharmaceutical Chemistry, North West University, Potchefstroom, South Africa
    Arzneimittelforschung 61:317-25. 2011

Collaborators

  • Lesetja J Legoabe
  • Lubbe Wiesner
  • Michael Ashton
  • J A Clark
  • Marli C Lombard
  • Jeanetta du Plessis
  • Theunis T Cloete
  • Peter J Smith
  • Jaco C Breytenbach
  • Carmen de Kock
  • J Wilma Breytenbach
  • Juan P Joubert
  • Stefan I Pretorius
  • Wilma J Breytenbach
  • Lezanne van Heerden
  • Minette Steyn
  • Carl C Johansson
  • Kevin J Helena
  • Jaco van Heerden
  • Lissinda du Plessis
  • Frans J Smit
  • Michele C Connelly
  • Henk J Krebs
  • R Kiplin Guy
  • Amy Orcutt
  • Martina S Sigal
  • Suman Kumar Vodnala
  • Sandra Meredith
  • Martin E Rottenberg
  • Jan L du Preez

Detail Information

Publications23

  1. ncbi request reprint Synthesis and in vitro transdermal penetration of methoxypoly(ethylene glycol) carbonate and carbamate derivatives of lamivudine (3TC)
    Jaco van Heerden
    Pharmaceutical Chemistry, North West University, Potchefstroom 2520, South Africa
    Med Chem 6:91-9. 2010
    ..passive (in PBS) or use of enhancer (Pheroid), no derivative penetrate the skin better than the parent drug itself. The use of Pheroid even appeared to significantly retard the skin permeation...
  2. ncbi request reprint Synthesis, cytotoxicity and antimalarial activity of ferrocenyl amides of 4-aminoquinolines
    David D N'Da
    Department of Pharmaceutical Chemistry, School Pharmacy, North West University, Potchefstroom, South Africa
    Arzneimittelforschung 60:627-35. 2010
    ..Derivatives which were equipotent against both strains also showed up to ten-fold increase in activity compared to primaquine...
  3. ncbi request reprint Antiplasmodial activity and cytotoxicity of 10β-aminoquinolinylethylethers of artemisinin
    D D N'da
    North West University, Potchefstroom, South Africa
    Drug Res (Stuttg) 63:104-8. 2013
    ..Derivative 11 stands as a good candidate to be further investigated primarily in vitro in comparison with an equimolar combination of chloroquine (CQ) and artemisinin to ascertain its advantages, if any, over the combination...
  4. ncbi request reprint Synthesis and in vitro transdermal penetration of methoxypoly(ethylene glycol) carbonate derivatives of stavudine
    David D N'Da
    Pharmaceutical Chemistry, School of Pharmacy, Statistical Consultation Services, North West University, Potchefstroom 2520, South Africa
    Med Chem 5:497-506. 2009
    ..1 nmol/cm(2)/h as compared to 59.15 nmol/cm(2)/h of the parent drug stavudine. Thus, no permeation enhancement was observed during this study...
  5. ncbi request reprint Synthesis and in vitro antiplasmodial activity of quinoline-ferrocene esters
    David D N'Da
    Department of Pharmaceutical Chemistry, School of Pharmacy, North West University, Potchefstroom, South Africa
    Arzneimittelforschung 61:358-65. 2011
    ..With an IC50 of 0.13 mM on the resistant strain, this ester possessed 2.5-fold higher activity than CQ (IC50 = 0.34 mM). All tested esters showed good selectivity towards P. falciparum with indexes higher than 60...
  6. doi request reprint Synthesis and in vitro human skin penetration of oligo- and polymeric ethylene glycol carbonates of zidovudine and stavudine
    David D N'Da
    Department of Pharmaceutical Chemistry, School of Pharmacy, North West University, Potchefstroom, South Africa
    Arzneimittelforschung 60:575-82. 2010
    ..The skin permeation rates of zidovudine and stavudine were enhanced by factors in the 2-4, and 1-3 range through these carbonates, respectively...
  7. pmc Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids
    Marli C Lombard
    Pharmaceutical Chemistry, North West University, Potchefstroom 2531, South Africa
    Malar J 12:71. 2013
    ..A snapshot pharmacokinetic analysis was carried out on one of the hybrids to obtain an indication of the pharmacokinetic properties of this class of anti-malarial drugs...
  8. ncbi request reprint Transdermal penetration of cytarabine and its 5'-O alkyl ester derivatives
    Lesetja J Legoabe
    Unit for Drug Research and Development, North West University, Private Bag X 6001, Potchefstroom, 2520, South Africa
    Med Chem 6:108-13. 2010
    ..2 nmol x cm(-2) x h(-1), which is significantly different to that of the parent drug cytarabine (3.70 nmol x cm(-)2 x h(-1)). No trend was found between water solubility and flux values...
  9. ncbi request reprint Synthesis and in vitro antimalarial activity of a series of bisquinoline and bispyrrolo[1,2a]quinoxaline compounds
    Lezanne van Heerden
    Department of Pharmaceutical Chemistry, North West University, Potchefstroom 2520, South Africa
    Eur J Med Chem 55:335-45. 2012
    ....
  10. doi request reprint Mono-, di- and trisubstituted derivatives of eflornithine: synthesis for in vivo delivery of DL-alpha-difluoromethylornithine in plasma
    Theunis T Cloete
    Department of Pharmaceutical Chemistry, North West University, Potchefstroom, South Africa
    Arzneimittelforschung 61:317-25. 2011
    ..Two of the monosubstituted activities were toxic for T. brucei blood stream forms...
  11. doi request reprint In-vitro transdermal penetration of cytarabine and its N4-alkylamide derivatives
    Lesetja J Legoabe
    Unit for Drug Research and Development, North West University, Potchefstroom, South Africa
    J Pharm Pharmacol 62:756-61. 2010
    ..The aim of this study was to synthesise and determine the transdermal penetration of cytarabine alkylamide derivatives and assess the correlation of flux with physicochemical properties...
  12. doi request reprint Synthesis and transdermal permeation of novel N4-methoxypoly(ethylene glycol) carbamates of cytarabine
    Lesetja J Legoabe
    Unit for Drug Research and Development, North West University, Potchefstroom, South Africa
    Drug Dev Ind Pharm 36:1477-85. 2010
    ..Its clinical utility, however, is severely limited by its short plasma half-life because of the catabolic action of nucleoside deaminases...
  13. doi request reprint Synthesis, antimalarial activity and cytotoxicity of 10-aminoethylether derivatives of artemisinin
    Theunis T Cloete
    Department of Pharmaceutical Chemistry, North West University, Potchefstroom 2520, South Africa
    Bioorg Med Chem 20:4701-9. 2012
    ..44nM), containing only one nitrogen atom, while long chain polyamine derivatives were found to have the lowest activity against both strains. An interesting correlation between the IC(50), pK(a) values and resistance index (RI) was found...
  14. doi request reprint Synthesis of methoxypoly(ethylene glycol) carbonate prodrugs of zidovudine and penetration through human skin in vitro
    David D N'Da
    Pharmaceutical Chemistry, School of Pharmacy, North West University, Potchefstroom 2520, South Africa
    J Pharm Pharmacol 61:721-31. 2009
    ....
  15. doi request reprint Synthesis, in vitro antimalarial and cytotoxicity of artemisinin-aminoquinoline hybrids
    Marli C Lombard
    Department of Pharmaceutical Chemistry, North West University, Potchefstroom, South Africa
    Bioorg Med Chem Lett 21:1683-6. 2011
    ..12 nM; 20.76 nM vs 157.9 nM). An optimum chain length was identified having 2 or 3 Cs with or without an extra methylene substituent...
  16. doi request reprint Synthesis, characterization and antimalarial activity of quinoline-pyrimidine hybrids
    Stefan I Pretorius
    Department of Pharmaceutical Chemistry, North West University, Private Bag X6001, Internal Box 304, Potchefstroom 2520, South Africa
    Bioorg Med Chem 21:269-77. 2013
    ..157 vs 0.417 μM, ∼threefold), and also displayed activity comparable to that of the equimolar fixed combination of CQ and PM against both strains...
  17. doi request reprint Antimalarial and anticancer activities of artemisinin-quinoline hybrid-dimers and pharmacokinetic properties in mice
    Marli C Lombard
    Pharmaceutical Chemistry, North West University, South Africa
    Eur J Pharm Sci 47:834-41. 2012
    ..45 vs. 43.33 μM, 2.21 vs. 45.52 μM and 2.99 vs. >100 μM, respectively). The 1,3-diaminopropane linker, present in hybrid-dimer 1, was therefore identified as the optimum linker...
  18. doi request reprint Artemisinin-quinoline hybrid-dimers: synthesis and in vitro antiplasmodial activity
    Marli C Lombard
    Department of Pharmaceutical Chemistry, North West University, Potchefstroom, South Africa
    Bioorg Med Chem Lett 20:6975-7. 2010
    ..Hybrid-dimer 8 showed the highest antiplasmodial activity, inheriting the optimum chain length of three carbon atoms...
  19. doi request reprint Synthesis and antimalarial activity of ethylene glycol oligomeric ethers of artemisinin
    Minette Steyn
    Pharmaceutical Chemistry, North West University, Potchefstroom, South Africa
    J Pharm Pharmacol 63:278-86. 2011
    ....
  20. doi request reprint Antimalarial activity of 10-alkyl/aryl esters and -aminoethylethers of artemisinin
    Theunis T Cloete
    Department of Pharmaceutical Chemistry, North West University, Potchefstroom 2520, South Africa
    Bioorg Chem 46:10-6. 2013
    ....
  21. doi request reprint Effects of oral administration of synthesized delta-amides of eflornithine in the rat
    Kevin J Helena
    Department of Pharmaceutical Chemistry, North West University, Potchefstroom, South Africa
    Arzneimittelforschung 60:682-8. 2010
    ..The biological data revealed that the derivatives were either not absorbed from the gastro-intestinal tract or not metabolized into eflornithine as no parent drug was detected in the plasma...
  22. doi request reprint Synthesis, in vitro antiplasmodial activity and cytotoxicity of a series of artemisinin-triazine hybrids and hybrid-dimers
    Theunis T Cloete
    Center of Excellence for Pharmaceutical Sciences, North West University, Potchefstroom 2520, South Africa
    Eur J Med Chem 76:470-81. 2014
    ..This dimer hence showed the necessary potential as candidate for further investigation in the search for malaria transmission blocking drugs so desperately needed. ..
  23. ncbi request reprint Synthesis and in vitro biological evaluation of aminoacridines and artemisinin-acridine hybrids
    Juan P Joubert
    Department of Pharmaceutical Chemistry, North West University, Potchefstroom 2520, South Africa
    Eur J Pharm Sci 56:16-27. 2014
    ..This hybrid may therefore stand as drug candidate for further investigation in the search for new and effective drugs against malaria and cervical cancer. ..