Marli C Lombard

Summary

Affiliation: North-West University
Country: South Africa

Publications

  1. pmc Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids
    Marli C Lombard
    Pharmaceutical Chemistry, North West University, Potchefstroom 2531, South Africa
    Malar J 12:71. 2013
  2. doi Antimalarial and anticancer activities of artemisinin-quinoline hybrid-dimers and pharmacokinetic properties in mice
    Marli C Lombard
    Pharmaceutical Chemistry, North West University, South Africa
    Eur J Pharm Sci 47:834-41. 2012
  3. doi Synthesis, in vitro antimalarial and cytotoxicity of artemisinin-aminoquinoline hybrids
    Marli C Lombard
    Department of Pharmaceutical Chemistry, North West University, Potchefstroom, South Africa
    Bioorg Med Chem Lett 21:1683-6. 2011
  4. doi Artemisinin-quinoline hybrid-dimers: synthesis and in vitro antiplasmodial activity
    Marli C Lombard
    Department of Pharmaceutical Chemistry, North West University, Potchefstroom, South Africa
    Bioorg Med Chem Lett 20:6975-7. 2010

Detail Information

Publications5

  1. pmc Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids
    Marli C Lombard
    Pharmaceutical Chemistry, North West University, Potchefstroom 2531, South Africa
    Malar J 12:71. 2013
    ..A snapshot pharmacokinetic analysis was carried out on one of the hybrids to obtain an indication of the pharmacokinetic properties of this class of anti-malarial drugs...
  2. doi Antimalarial and anticancer activities of artemisinin-quinoline hybrid-dimers and pharmacokinetic properties in mice
    Marli C Lombard
    Pharmaceutical Chemistry, North West University, South Africa
    Eur J Pharm Sci 47:834-41. 2012
    ..45 vs. 43.33 μM, 2.21 vs. 45.52 μM and 2.99 vs. >100 μM, respectively). The 1,3-diaminopropane linker, present in hybrid-dimer 1, was therefore identified as the optimum linker...
  3. doi Synthesis, in vitro antimalarial and cytotoxicity of artemisinin-aminoquinoline hybrids
    Marli C Lombard
    Department of Pharmaceutical Chemistry, North West University, Potchefstroom, South Africa
    Bioorg Med Chem Lett 21:1683-6. 2011
    ..12 nM; 20.76 nM vs 157.9 nM). An optimum chain length was identified having 2 or 3 Cs with or without an extra methylene substituent...
  4. doi Artemisinin-quinoline hybrid-dimers: synthesis and in vitro antiplasmodial activity
    Marli C Lombard
    Department of Pharmaceutical Chemistry, North West University, Potchefstroom, South Africa
    Bioorg Med Chem Lett 20:6975-7. 2010
    ..Hybrid-dimer 8 showed the highest antiplasmodial activity, inheriting the optimum chain length of three carbon atoms...