Anne Von Gottberg

Summary

Affiliation: National Institute for Communicable Diseases
Country: South Africa

Publications

  1. doi request reprint Emergence of levofloxacin-non-susceptible Streptococcus pneumoniae and treatment for multidrug-resistant tuberculosis in children in South Africa: a cohort observational surveillance study
    Anne Von Gottberg
    National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa
    Lancet 371:1108-13. 2008
  2. doi request reprint Epidemiology of invasive pneumococcal disease in the pre-conjugate vaccine era: South Africa, 2003-2008
    Anne Von Gottberg
    National Institute for Communicable Diseases NICD of the National Health Laboratory Service NHLS, Johannesburg, South Africa School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, Johannesburg, South Africa Electronic address
    Vaccine 31:4200-8. 2013
  3. doi request reprint Invasive disease due to Haemophilus influenzae serotype b ten years after routine vaccination, South Africa, 2003-2009
    Anne Von Gottberg
    National Institute for Communicable Diseases NICD of the National Health Laboratory Service NHLS, Johannesburg, South Africa
    Vaccine 30:565-71. 2012
  4. pmc Impact of conjugate Haemophilus influenzae type b (Hib) vaccine introduction in South Africa
    A Von Gottberg
    Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, National Health Laboratory Service, Gauteng, South Africa
    Bull World Health Organ 84:811-8. 2006
  5. doi request reprint Emergence of endemic serogroup W135 meningococcal disease associated with a high mortality rate in South Africa
    Anne Von Gottberg
    Respiratory and Meningeal Pathogens Research, National Institute for Communicable Diseases, Private Bag X4, Sandringham, 2131, Gauteng, South Africa
    Clin Infect Dis 46:377-86. 2008
  6. pmc An unusual pneumococcal sequence type is the predominant cause of serotype 3 invasive disease in South Africa
    Kedibone M Mothibeli
    Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, Medical Research Council, University of the Witwatersrand, Johannesburg, South Africa
    J Clin Microbiol 48:184-91. 2010
  7. pmc Neisseria meningitidis intermediately resistant to penicillin and causing invasive disease in South Africa in 2001 to 2005
    Mignon du Plessis
    National Institute for Communicable Diseases of the National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa
    J Clin Microbiol 46:3208-14. 2008
  8. pmc Molecular characterization of emerging non-levofloxacin-susceptible pneumococci isolated from children in South Africa
    Nicole Wolter
    Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, Sandringham, Gauteng, South Africa
    J Clin Microbiol 47:1319-24. 2009
  9. doi request reprint Serotype 6C is associated with penicillin-susceptible meningeal infections in human immunodeficiency virus (HIV)-infected adults among invasive pneumococcal isolates previously identified as serotype 6A in South Africa
    Mignon du Plessis
    National Institute for Communicable Diseases, Sandringham, South Africa
    Int J Antimicrob Agents 32:S66-70. 2008
  10. pmc Clonal analysis of Neisseria meningitidis serogroup B strains in South Africa, 2002 to 2006: emergence of new clone ST-4240/6688
    Chivonne Moodley
    Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa
    J Clin Microbiol 50:3678-86. 2012

Collaborators

Detail Information

Publications30

  1. doi request reprint Emergence of levofloxacin-non-susceptible Streptococcus pneumoniae and treatment for multidrug-resistant tuberculosis in children in South Africa: a cohort observational surveillance study
    Anne Von Gottberg
    National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa
    Lancet 371:1108-13. 2008
    ..Our aim was to estimate the incidence of, and risk factors for, invasive pneumococcal disease caused by fluoroquinolone-resistant Streptococcus pneumoniae in children in South Africa...
  2. doi request reprint Epidemiology of invasive pneumococcal disease in the pre-conjugate vaccine era: South Africa, 2003-2008
    Anne Von Gottberg
    National Institute for Communicable Diseases NICD of the National Health Laboratory Service NHLS, Johannesburg, South Africa School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, Johannesburg, South Africa Electronic address
    Vaccine 31:4200-8. 2013
    ....
  3. doi request reprint Invasive disease due to Haemophilus influenzae serotype b ten years after routine vaccination, South Africa, 2003-2009
    Anne Von Gottberg
    National Institute for Communicable Diseases NICD of the National Health Laboratory Service NHLS, Johannesburg, South Africa
    Vaccine 30:565-71. 2012
    ..Following initial declines in Hib disease, national surveillance has identified increasing numbers of Hib disease episodes in fully vaccinated children...
  4. pmc Impact of conjugate Haemophilus influenzae type b (Hib) vaccine introduction in South Africa
    A Von Gottberg
    Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, National Health Laboratory Service, Gauteng, South Africa
    Bull World Health Organ 84:811-8. 2006
    ..To analyse trends in reported invasive Haemophilus influenzae disease in South Africa within the first five years of introduction of conjugate Haemophilus influenzae type b (Hib) vaccine in the routine child immunization schedule...
  5. doi request reprint Emergence of endemic serogroup W135 meningococcal disease associated with a high mortality rate in South Africa
    Anne Von Gottberg
    Respiratory and Meningeal Pathogens Research, National Institute for Communicable Diseases, Private Bag X4, Sandringham, 2131, Gauteng, South Africa
    Clin Infect Dis 46:377-86. 2008
    ..In the African meningitis belt, Neisseria meningitidis serogroup W135 has emerged as a cause of epidemic disease. The establishment of W135 as the predominant cause of endemic disease has not been described...
  6. pmc An unusual pneumococcal sequence type is the predominant cause of serotype 3 invasive disease in South Africa
    Kedibone M Mothibeli
    Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, Medical Research Council, University of the Witwatersrand, Johannesburg, South Africa
    J Clin Microbiol 48:184-91. 2010
    ..We have therefore identified ST458 as predominating in South Africa, but with an invasive potential similar to that of the predominant global clone ST180...
  7. pmc Neisseria meningitidis intermediately resistant to penicillin and causing invasive disease in South Africa in 2001 to 2005
    Mignon du Plessis
    National Institute for Communicable Diseases of the National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa
    J Clin Microbiol 46:3208-14. 2008
    ..This is the first report describing the prevalence and molecular epidemiology of Pen(i) meningococcal isolates from sub-Saharan Africa...
  8. pmc Molecular characterization of emerging non-levofloxacin-susceptible pneumococci isolated from children in South Africa
    Nicole Wolter
    Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, Sandringham, Gauteng, South Africa
    J Clin Microbiol 47:1319-24. 2009
    ..These data suggest that a low-level non-levofloxacin-susceptible strain transformed into a highly resistant strain under antibiotic pressure and underwent capsular switching in order to have increased fitness...
  9. doi request reprint Serotype 6C is associated with penicillin-susceptible meningeal infections in human immunodeficiency virus (HIV)-infected adults among invasive pneumococcal isolates previously identified as serotype 6A in South Africa
    Mignon du Plessis
    National Institute for Communicable Diseases, Sandringham, South Africa
    Int J Antimicrob Agents 32:S66-70. 2008
    ..Our data from the vaccine efficacy trial suggest that cross-protection of the conjugate vaccine is against true serotype 6A strains...
  10. pmc Clonal analysis of Neisseria meningitidis serogroup B strains in South Africa, 2002 to 2006: emergence of new clone ST-4240/6688
    Chivonne Moodley
    Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa
    J Clin Microbiol 50:3678-86. 2012
    ..Overall, 15 PorA and 12 FetA types were identified. MenB isolates were mostly diverse with no single dominant clone; however, CC32 and CC41/44 accounted for 35% and the new CC4240/6688 was the third most prevalent clone...
  11. doi request reprint Molecular basis and clonal nature of increasing pneumococcal macrolide resistance in South Africa, 2000-2005
    Nicole Wolter
    Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, Medical Research Council and University of the Witwatersrand, Sandringham, South Africa
    Int J Antimicrob Agents 32:62-7. 2008
    ..Routine use of the 7-valent pneumococcal conjugate vaccine (PCV-7) could reduce the burden of macrolide-resistant pneumococcal disease in South Africa...
  12. doi request reprint Increased incidence of meningococcal disease in HIV-infected individuals associated with higher case-fatality ratios in South Africa
    Cheryl Cohen
    National Institute for Communicable Diseases, Johannesburg, South Africa
    AIDS 24:1351-60. 2010
    ..We aimed to compare the incidence of meningococcal disease amongst HIV-infected and uninfected individuals and to evaluate whether HIV is a risk factor for mortality and bacteremia amongst patients with meningococcal disease...
  13. pmc Persistent high burden of invasive pneumococcal disease in South African HIV-infected adults in the era of an antiretroviral treatment program
    Marta C Nunes
    Department of Science and Technology National Research Foundation, Vaccine Preventable Diseases and Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    PLoS ONE 6:e27929. 2011
    ..The aim of this study was to evaluate trends in IPD hospitalizations in HIV-infected adults in Soweto, South Africa, associated with up-scaling of the HAART program from 2003 to 2008...
  14. doi request reprint The impact of antiretroviral treatment on the burden of invasive pneumococcal disease in South African children: a time series analysis
    Marta C Nunes
    Medical Research Council Respiratory and Meningeal Pathogens Research Unit and Department of Science and Technology National Research Foundation Vaccine Preventable Diseases, University of the Witwatersrand, South Africa
    AIDS 25:453-62. 2011
    ..A national antiretroviral program was initiated in South Africa in 2004. This study evaluates the impact of the highly active antiretroviral therapy (HAART) treatment program on the burden of IPD among African children...
  15. doi request reprint Distribution of factor H binding protein beyond serogroup B: variation among five serogroups of invasive Neisseria meningitidis in South Africa
    Kedibone M Mothibeli
    National Institute for Communicable Diseases, Division of National Health Laboratory Service, Johannesburg, South Africa
    Vaccine 29:2187-92. 2011
    ..Our data highlight that non-MenB meningococcal isolates also harbor fHBP...
  16. pmc Inferior quantitative and qualitative immune responses to pneumococcal conjugate vaccine in infants with nasopharyngeal colonization by Streptococcus pneumoniae during the primary series of immunization
    Shabir A Madhi
    University of the Witwatersrand, Department of Science and Technology National Research Foundation Vaccine Preventable Diseases and Respiratory and Meningeal Pathogens Research Unit, Johannesburg, South Africa
    Vaccine 29:6994-7001. 2011
    ....
  17. pmc Population snapshot of invasive serogroup B meningococci in South Africa from 2005 to 2008
    Mignon du Plessis
    Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa
    J Clin Microbiol 50:2577-84. 2012
    ..04). Capsular switching was observed in 8/242 (3%) strains. The newly assigned clonal complex ST-4240/6688 was more common in young children...
  18. doi request reprint Introduction of pneumococcal conjugate vaccine into the public immunization program in South Africa: translating research into policy
    Shabir A Madhi
    National Institute for Communicable Diseases, A Division of the National Health Laboratory Service, Johannesburg, South Africa
    Vaccine 30:C21-7. 2012
    ..This schedule was largely premised on containing the cost of vaccine introduction, whilst including a booster dose of PCV to assist in prolonging the duration of protection in HIV-infected children...
  19. pmc Risk factors for multidrug-resistant invasive pneumococcal disease in South Africa, a setting with high HIV prevalence, in the prevaccine era from 2003 to 2008
    Penny Crowther-Gibson
    Division of Public Health Surveillance and Response, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa
    Antimicrob Agents Chemother 56:5088-95. 2012
    ..The effect of many of the MDR risk factors could be reduced by more judicious use of antibiotics. Because PCV13 serotypes account for most MDR infections, pneumococcal vaccination may reduce the prevalence of multidrug resistance...
  20. doi request reprint Acquisition of Streptococcus pneumoniae in pneumococcal conjugate vaccine-naïve South African children and their mothers
    Marta C Nunes
    Department of Science and Technology National Research Foundation Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    Pediatr Infect Dis J 32:e192-205. 2013
    ..We investigated the dynamics of pneumococcal colonization in perinatal HIV-unexposed and HIV-exposed children and their mothers and risk factors associated with new serotypes acquisition...
  21. doi request reprint Increased risk of death in human immunodeficiency virus-infected children with pneumococcal meningitis in South Africa, 2003-2005
    Peter Nyasulu
    School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    Pediatr Infect Dis J 30:1075-80. 2011
    ..Pneumococcal disease is a major global cause of morbidity and mortality. This study evaluated risk factors for mortality in children with pneumococcal meningitis and other invasive pneumococcal diseases (IPD)...
  22. pmc Meningococcal disease in South Africa, 1999-2002
    Garry B Coulson
    National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa
    Emerg Infect Dis 13:273-81. 2007
    ..Selected isolates of serogroup A belonged to sequence type (ST)-1 (subgroup I/II) complex, serogroup B to ST-32/electrophoretic type (ET)-5 complex, and serogroup W135 to ST-11/ET-37 complex...
  23. ncbi request reprint Analysis of a temporal cluster of Shigella boydii isolates in Mpumalanga, South Africa, November to December 2007
    Anthony M Smith
    National Institute for Communicable Diseases, Johannesburg
    J Infect Dev Ctries 3:65-70. 2009
    ..In the present study, we report on the analysis of a temporal cluster of 29 S. boydii serotype 2 strains, isolated in the Mpumalanga Province of South Africa (SA) over the period of November to December 2007...
  24. ncbi request reprint Emergence of fluoroquinolone-resistant Streptococcus pneumoniae in a South African child in a tuberculosis treatment facility
    Anne Von Gottberg
    Respiratory and Memingeal Pathogens Research Unit, Medical Research Council, University of the Witwatersrand, National Institute for Communicable Diseases, Johannesburg, South Africa
    Pediatr Infect Dis J 22:1020-1. 2003
  25. pmc External quality assessment of national public health laboratories in Africa, 2002-2009
    John Frean
    National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa
    Bull World Health Organ 90:191-199A. 2012
    ..To describe findings from an external quality assessment programme involving laboratories in Africa that routinely investigate epidemic-prone diseases...
  26. doi request reprint Chlorhexidine maternal-vaginal and neonate body wipes in sepsis and vertical transmission of pathogenic bacteria in South Africa: a randomised, controlled trial
    Clare L Cutland
    Department of Science and Technology National Research Foundation, Vaccine Preventable Diseases and Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, University of Witwatersrand, Soweto, South Africa
    Lancet 374:1909-16. 2009
    ..We therefore assessed the efficacy of chlorhexidine in early-onset neonatal sepsis and vertical transmission of group B streptococcus...
  27. ncbi request reprint Gender as a risk factor for both antibiotic resistance and infection with pediatric serogroups/serotypes, in HIV-infected and -uninfected adults with pneumococcal bacteremia
    Kimberly A Buie
    Department of International Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    J Infect Dis 189:1996-2000. 2004
    ..25-2.36]) than were men. Thus, conjugate pneumococcal vaccination of children may reduce, in particular, both antibiotic resistance and the burden of conjugate vaccine serotype pneumococcal disease in young, HIV-infected women...
  28. pmc Virulence characteristics of Klebsiella and clinical manifestations of K. pneumoniae bloodstream infections
    Victor L Yu
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Emerg Infect Dis 13:986-93. 2007
    ..001). Differences in clinical features of bacteremic infection with K. pneumoniae are due to the virulence factors expressed by the organism...
  29. ncbi request reprint International prospective study of Klebsiella pneumoniae bacteremia: implications of extended-spectrum beta-lactamase production in nosocomial Infections
    David L Paterson
    Veterans Affairs Medical Center, Pittsburgh, Pennsylvania 15240, USA
    Ann Intern Med 140:26-32. 2004
    ..Commonly encountered nosocomially acquired gram-negative bacteria, especially Klebsiella pneumoniae, produce extended-spectrum beta-lactamases (ESBLs) as an antibiotic resistance mechanism...
  30. ncbi request reprint Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum beta-lactamases
    David L Paterson
    Infectious Disease Section, VA Medical Center, Pittsburgh, Pennsylvania 15240, USA
    Clin Infect Dis 39:31-7. 2004
    ..Antibiotic choice is particularly important in seriously ill patients with infections due to ESBL-producing K. pneumoniae...