Research Topics
| Anne Von GottbergSummaryAffiliation: National Institute for Communicable Diseases Country: South Africa Publications
| Collaborators
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Detail Information
Publications
Emergence of levofloxacin-non-susceptible Streptococcus pneumoniae and treatment for multidrug-resistant tuberculosis in children in South Africa: a cohort observational surveillance studyAnne Von Gottberg
National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa
Lancet 371:1108-13. 2008..Our aim was to estimate the incidence of, and risk factors for, invasive pneumococcal disease caused by fluoroquinolone-resistant Streptococcus pneumoniae in children in South Africa...- Invasive disease due to Haemophilus influenzae serotype b ten years after routine vaccination, South Africa, 2003-2009Anne Von Gottberg
National Institute for Communicable Diseases NICD of the National Health Laboratory Service NHLS, Johannesburg, South Africa
Vaccine 30:565-71. 2012..Following initial declines in Hib disease, national surveillance has identified increasing numbers of Hib disease episodes in fully vaccinated children... 
Impact of conjugate Haemophilus influenzae type b (Hib) vaccine introduction in South AfricaA Von Gottberg
Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, National Health Laboratory Service, Gauteng, South Africa
Bull World Health Organ 84:811-8. 2006..To analyse trends in reported invasive Haemophilus influenzae disease in South Africa within the first five years of introduction of conjugate Haemophilus influenzae type b (Hib) vaccine in the routine child immunization schedule...- Emergence of endemic serogroup W135 meningococcal disease associated with a high mortality rate in South AfricaAnne Von Gottberg
Respiratory and Meningeal Pathogens Research, National Institute for Communicable Diseases, Private Bag X4, Sandringham, 2131, Gauteng, South Africa
Clin Infect Dis 46:377-86. 2008..In the African meningitis belt, Neisseria meningitidis serogroup W135 has emerged as a cause of epidemic disease. The establishment of W135 as the predominant cause of endemic disease has not been described... - An unusual pneumococcal sequence type is the predominant cause of serotype 3 invasive disease in South AfricaKedibone M Mothibeli
Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, Medical Research Council, University of the Witwatersrand, Johannesburg, South Africa
J Clin Microbiol 48:184-91. 2010..We have therefore identified ST458 as predominating in South Africa, but with an invasive potential similar to that of the predominant global clone ST180... - Neisseria meningitidis intermediately resistant to penicillin and causing invasive disease in South Africa in 2001 to 2005Mignon du Plessis
National Institute for Communicable Diseases of the National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa
J Clin Microbiol 46:3208-14. 2008..This is the first report describing the prevalence and molecular epidemiology of Pen(i) meningococcal isolates from sub-Saharan Africa... - Molecular characterization of emerging non-levofloxacin-susceptible pneumococci isolated from children in South AfricaNicole Wolter
Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, Sandringham, Gauteng, South Africa
J Clin Microbiol 47:1319-24. 2009..These data suggest that a low-level non-levofloxacin-susceptible strain transformed into a highly resistant strain under antibiotic pressure and underwent capsular switching in order to have increased fitness... - Serotype 6C is associated with penicillin-susceptible meningeal infections in human immunodeficiency virus (HIV)-infected adults among invasive pneumococcal isolates previously identified as serotype 6A in South AfricaMignon du Plessis
National Institute for Communicable Diseases, Sandringham, South Africa
Int J Antimicrob Agents 32:S66-70. 2008..Our data from the vaccine efficacy trial suggest that cross-protection of the conjugate vaccine is against true serotype 6A strains... - Clonal analysis of Neisseria meningitidis serogroup B strains in South Africa, 2002 to 2006: emergence of new clone ST-4240/6688Chivonne Moodley
Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa
J Clin Microbiol 50:3678-86. 2012..Overall, 15 PorA and 12 FetA types were identified. MenB isolates were mostly diverse with no single dominant clone; however, CC32 and CC41/44 accounted for 35% and the new CC4240/6688 was the third most prevalent clone... - Molecular basis and clonal nature of increasing pneumococcal macrolide resistance in South Africa, 2000-2005Nicole Wolter
Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, Medical Research Council and University of the Witwatersrand, Sandringham, South Africa
Int J Antimicrob Agents 32:62-7. 2008..Routine use of the 7-valent pneumococcal conjugate vaccine (PCV-7) could reduce the burden of macrolide-resistant pneumococcal disease in South Africa... - Increased incidence of meningococcal disease in HIV-infected individuals associated with higher case-fatality ratios in South AfricaCheryl Cohen
National Institute for Communicable Diseases, Johannesburg, South Africa
AIDS 24:1351-60. 2010..We aimed to compare the incidence of meningococcal disease amongst HIV-infected and uninfected individuals and to evaluate whether HIV is a risk factor for mortality and bacteremia amongst patients with meningococcal disease... - Distribution of factor H binding protein beyond serogroup B: variation among five serogroups of invasive Neisseria meningitidis in South AfricaKedibone M Mothibeli
National Institute for Communicable Diseases, Division of National Health Laboratory Service, Johannesburg, South Africa
Vaccine 29:2187-92. 2011..Our data highlight that non-MenB meningococcal isolates also harbor fHBP... - Population snapshot of invasive serogroup B meningococci in South Africa from 2005 to 2008Mignon du Plessis
Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa
J Clin Microbiol 50:2577-84. 2012..04). Capsular switching was observed in 8/242 (3%) strains. The newly assigned clonal complex ST-4240/6688 was more common in young children... - Persistent high burden of invasive pneumococcal disease in South African HIV-infected adults in the era of an antiretroviral treatment programMarta C Nunes
Department of Science and Technology National Research Foundation, Vaccine Preventable Diseases and Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
PLoS ONE 6:e27929. 2011..The aim of this study was to evaluate trends in IPD hospitalizations in HIV-infected adults in Soweto, South Africa, associated with up-scaling of the HAART program from 2003 to 2008... - Introduction of pneumococcal conjugate vaccine into the public immunization program in South Africa: translating research into policyShabir A Madhi
National Institute for Communicable Diseases, A Division of the National Health Laboratory Service, Johannesburg, South Africa
Vaccine 30:C21-7. 2012..This schedule was largely premised on containing the cost of vaccine introduction, whilst including a booster dose of PCV to assist in prolonging the duration of protection in HIV-infected children... - Inferior quantitative and qualitative immune responses to pneumococcal conjugate vaccine in infants with nasopharyngeal colonization by Streptococcus pneumoniae during the primary series of immunizationShabir A Madhi
University of the Witwatersrand, Department of Science and Technology National Research Foundation Vaccine Preventable Diseases and Respiratory and Meningeal Pathogens Research Unit, Johannesburg, South Africa
Vaccine 29:6994-7001. 2011.... - Risk factors for multidrug-resistant invasive pneumococcal disease in South Africa, a setting with high HIV prevalence, in the prevaccine era from 2003 to 2008Penny Crowther-Gibson
Division of Public Health Surveillance and Response, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa
Antimicrob Agents Chemother 56:5088-95. 2012..The effect of many of the MDR risk factors could be reduced by more judicious use of antibiotics. Because PCV13 serotypes account for most MDR infections, pneumococcal vaccination may reduce the prevalence of multidrug resistance... - Increased risk of death in human immunodeficiency virus-infected children with pneumococcal meningitis in South Africa, 2003-2005Peter Nyasulu
School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Pediatr Infect Dis J 30:1075-80. 2011..Pneumococcal disease is a major global cause of morbidity and mortality. This study evaluated risk factors for mortality in children with pneumococcal meningitis and other invasive pneumococcal diseases (IPD)... 
Analysis of a temporal cluster of Shigella boydii isolates in Mpumalanga, South Africa, November to December 2007Anthony M Smith
National Institute for Communicable Diseases, Johannesburg
J Infect Dev Ctries 3:65-70. 2009..In the present study, we report on the analysis of a temporal cluster of 29 S. boydii serotype 2 strains, isolated in the Mpumalanga Province of South Africa (SA) over the period of November to December 2007...- Meningococcal disease in South Africa, 1999-2002Garry B Coulson
National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa
Emerg Infect Dis 13:273-81. 2007..Selected isolates of serogroup A belonged to sequence type (ST)-1 (subgroup I/II) complex, serogroup B to ST-32/electrophoretic type (ET)-5 complex, and serogroup W135 to ST-11/ET-37 complex... - Emergence of fluoroquinolone-resistant Streptococcus pneumoniae in a South African child in a tuberculosis treatment facilityAnne Von Gottberg
Respiratory and Memingeal Pathogens Research Unit, Medical Research Council, University of the Witwatersrand, National Institute for Communicable Diseases, Johannesburg, South Africa
Pediatr Infect Dis J 22:1020-1. 2003 - External quality assessment of national public health laboratories in Africa, 2002-2009John Frean
National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa
Bull World Health Organ 90:191-199A. 2012..To describe findings from an external quality assessment programme involving laboratories in Africa that routinely investigate epidemic-prone diseases... - Chlorhexidine maternal-vaginal and neonate body wipes in sepsis and vertical transmission of pathogenic bacteria in South Africa: a randomised, controlled trialClare L Cutland
Department of Science and Technology National Research Foundation, Vaccine Preventable Diseases and Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, University of Witwatersrand, Soweto, South Africa
Lancet 374:1909-16. 2009..We therefore assessed the efficacy of chlorhexidine in early-onset neonatal sepsis and vertical transmission of group B streptococcus... - Virulence characteristics of Klebsiella and clinical manifestations of K. pneumoniae bloodstream infectionsVictor L Yu
University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Emerg Infect Dis 13:986-93. 2007..001). Differences in clinical features of bacteremic infection with K. pneumoniae are due to the virulence factors expressed by the organism... - Gender as a risk factor for both antibiotic resistance and infection with pediatric serogroups/serotypes, in HIV-infected and -uninfected adults with pneumococcal bacteremiaKimberly A Buie
Department of International Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
J Infect Dis 189:1996-2000. 2004..25-2.36]) than were men. Thus, conjugate pneumococcal vaccination of children may reduce, in particular, both antibiotic resistance and the burden of conjugate vaccine serotype pneumococcal disease in young, HIV-infected women... - Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum beta-lactamasesDavid L Paterson
Infectious Disease Section, VA Medical Center, Pittsburgh, Pennsylvania 15240, USA
Clin Infect Dis 39:31-7. 2004..Antibiotic choice is particularly important in seriously ill patients with infections due to ESBL-producing K. pneumoniae... - International prospective study of Klebsiella pneumoniae bacteremia: implications of extended-spectrum beta-lactamase production in nosocomial InfectionsDavid L Paterson
Veterans Affairs Medical Center, Pittsburgh, Pennsylvania 15240, USA
Ann Intern Med 140:26-32. 2004..CONCLUSIONS: Production of ESBLs by Klebsiella pneumoniae is a widespread nosocomial problem. Appropriate infection control and antibiotic management strategies are needed to stem the spread of this emerging form of resistance...