Ashraf Coovadia

Summary

Affiliation: National Institute for Communicable Diseases
Country: South Africa

Publications

  1. pmc Surveillance of transmitted HIV-1 drug resistance in Gauteng and KwaZulu-Natal Provinces, South Africa, 2005-2009
    G M Hunt
    National Institute for Communicable Diseases, Johannesburg, South Africa
    Clin Infect Dis 54:S334-8. 2012
  2. doi request reprint HIV-1 drug resistance at antiretroviral treatment initiation in children previously exposed to single-dose nevirapine
    Gillian M Hunt
    AIDS Virus Research Unit, National Institute for Communicable Diseases, Johannesburg, South Africa
    AIDS 25:1461-9. 2011
  3. doi request reprint Reuse of nevirapine in exposed HIV-infected children after protease inhibitor-based viral suppression: a randomized controlled trial
    Ashraf Coovadia
    Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Johannesburg, South Africa
    JAMA 304:1082-90. 2010
  4. pmc Timing of maternal HIV testing and uptake of prevention of mother-to-child transmission interventions among women and their infected infants in Johannesburg, South Africa
    Karl Günter Technau
    Empilweni Services and Research Unit, Department of Paediatrics and Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa Wits Reproductive Health and HIV Institute, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa HIV Center for Clinical and Behavioral Studies, Division of Gender Sexuality and Health, Department of Psychiatry, Columbia University and the New York State Psychiatric Institute, New York, NY ICAP, Mailman School of Public Health, and Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY and Gertrude H Sergievsky Center, College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY
    J Acquir Immune Defic Syndr 65:e170-8. 2014
  5. pmc Lipid profiles in young HIV-infected children initiating and changing antiretroviral therapy
    Renate Strehlau
    Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, University of the Witwatersrand, Johannesburg, South Africa
    J Acquir Immune Defic Syndr 60:369-76. 2012
  6. pmc Absence seizures associated with efavirenz initiation
    Renate Strehlau
    Empilweni Services and Research Unit ESRU, Rahima Moosa Mother and Child Hospital, Johannesburg, South Africa
    Pediatr Infect Dis J 30:1001-3. 2011
  7. pmc Poor early virologic performance and durability of abacavir-based first-line regimens for HIV-infected children
    Karl Günter Technau
    Empilweni Services and Research Unit, Department of Paediatrics and Child Health, Rahima Moosa Mother and Child Hospital, Coronationville, Johannesburg, Gauteng, South Africa
    Pediatr Infect Dis J 32:851-5. 2013
  8. pmc Persistent minority K103N mutations among women exposed to single-dose nevirapine and virologic response to nonnucleoside reverse-transcriptase inhibitor-based therapy
    Ashraf Coovadia
    Empilweni Clinic, Coronation Women and Children Hospital, Johannesburg, South Africa
    Clin Infect Dis 48:462-72. 2009
  9. pmc Effect of Maternal HIV-1 Status and Antiretroviral Drugs on Haematological Profiles of South African Infants in Early Life
    Diana B Schramm
    AIDS Virus Research Unit, National Institute for Communicable Diseases and Department of Virology, University of the Witwatersrand, Gauteng, South Africa
    Open AIDS J 4:156-65. 2010
  10. doi request reprint The neurodevelopment of HIV-infected infants on HAART compared to HIV-exposed but uninfected infants
    Nicole Whitehead
    a Faculty of Health Sciences, Department of Physiotherapy, University of the Witwatersrand, Johannesburg, South Africa
    AIDS Care 26:497-504. 2014

Collaborators

Detail Information

Publications11

  1. pmc Surveillance of transmitted HIV-1 drug resistance in Gauteng and KwaZulu-Natal Provinces, South Africa, 2005-2009
    G M Hunt
    National Institute for Communicable Diseases, Johannesburg, South Africa
    Clin Infect Dis 54:S334-8. 2012
    ....
  2. doi request reprint HIV-1 drug resistance at antiretroviral treatment initiation in children previously exposed to single-dose nevirapine
    Gillian M Hunt
    AIDS Virus Research Unit, National Institute for Communicable Diseases, Johannesburg, South Africa
    AIDS 25:1461-9. 2011
    ..To describe the prevalence of HIV-1 drug resistance mutations at the time of treatment initiation in a large cohort of HIV-infected children previously exposed to single-dose nevirapine (sdNVP) for prevention of transmission...
  3. doi request reprint Reuse of nevirapine in exposed HIV-infected children after protease inhibitor-based viral suppression: a randomized controlled trial
    Ashraf Coovadia
    Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Johannesburg, South Africa
    JAMA 304:1082-90. 2010
    ..However, there are limitations of continuing PI-based therapy indefinitely and reuse of nevirapine has many advantages...
  4. pmc Timing of maternal HIV testing and uptake of prevention of mother-to-child transmission interventions among women and their infected infants in Johannesburg, South Africa
    Karl Günter Technau
    Empilweni Services and Research Unit, Department of Paediatrics and Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa Wits Reproductive Health and HIV Institute, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa HIV Center for Clinical and Behavioral Studies, Division of Gender Sexuality and Health, Department of Psychiatry, Columbia University and the New York State Psychiatric Institute, New York, NY ICAP, Mailman School of Public Health, and Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY and Gertrude H Sergievsky Center, College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY
    J Acquir Immune Defic Syndr 65:e170-8. 2014
    ..7%. We investigated the profile of newly diagnosed vertically infected children and their mothers to identify shortfalls in the PMTCT program...
  5. pmc Lipid profiles in young HIV-infected children initiating and changing antiretroviral therapy
    Renate Strehlau
    Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, University of the Witwatersrand, Johannesburg, South Africa
    J Acquir Immune Defic Syndr 60:369-76. 2012
    ..Here we examined lipid profile changes in a cohort of young children before and after suppression on an initial ritonavir-boosted lopinavir (LPV/r)-based regimen and after switch to a nevirapine (NVP)-based regimen...
  6. pmc Absence seizures associated with efavirenz initiation
    Renate Strehlau
    Empilweni Services and Research Unit ESRU, Rahima Moosa Mother and Child Hospital, Johannesburg, South Africa
    Pediatr Infect Dis J 30:1001-3. 2011
    ..Plasma efavirenz values were above therapeutic range. The child was homozygous for the CYP2B6-516T/T genotype, which is associated with poor efavirenz clearance. Seizures abated after efavirenz discontinuation...
  7. pmc Poor early virologic performance and durability of abacavir-based first-line regimens for HIV-infected children
    Karl Günter Technau
    Empilweni Services and Research Unit, Department of Paediatrics and Child Health, Rahima Moosa Mother and Child Hospital, Coronationville, Johannesburg, Gauteng, South Africa
    Pediatr Infect Dis J 32:851-5. 2013
    ..Concerns about stavudine (d4T) toxicity have led to increased use of abacavir (ABC) in first-line pediatric antiretroviral treatment (ART) regimens. Field experience with ABC in ART-naïve children is limited...
  8. pmc Persistent minority K103N mutations among women exposed to single-dose nevirapine and virologic response to nonnucleoside reverse-transcriptase inhibitor-based therapy
    Ashraf Coovadia
    Empilweni Clinic, Coronation Women and Children Hospital, Johannesburg, South Africa
    Clin Infect Dis 48:462-72. 2009
    ....
  9. pmc Effect of Maternal HIV-1 Status and Antiretroviral Drugs on Haematological Profiles of South African Infants in Early Life
    Diana B Schramm
    AIDS Virus Research Unit, National Institute for Communicable Diseases and Department of Virology, University of the Witwatersrand, Gauteng, South Africa
    Open AIDS J 4:156-65. 2010
    ..These previously undescribed features may affect immune response capability in early life and clinical consequences of such changes need to be further investigated...
  10. doi request reprint The neurodevelopment of HIV-infected infants on HAART compared to HIV-exposed but uninfected infants
    Nicole Whitehead
    a Faculty of Health Sciences, Department of Physiotherapy, University of the Witwatersrand, Johannesburg, South Africa
    AIDS Care 26:497-504. 2014
    ..There is a need for therapists to be involved in pediatric HIV clinical services in order to provide early developmental screening as well as rehabilitative services to those children in need. ..
  11. doi request reprint Paradoxical Mycobacterium tuberculosis meningitis immune reconstitution inflammatory syndrome in an HIV-infected child
    Emma Kalk
    Paediatric HIV Diagnostic Syndicate, University of the Witwatersrand, Johannesburg, South Africa
    Pediatr Infect Dis J 32:157-62. 2013
    ..We describe a fatal case of Mycobacterium tuberculosis meningitis immune reconstitution inflammatory syndrome in an HIV-infected child and review the literature...