W C Gelderblom

Summary

Affiliation: Medical Research Council
Country: South Africa

Publications

  1. pmc Fumonisin-induced hepatocarcinogenesis: mechanisms related to cancer initiation and promotion
    W C Gelderblom
    Programme on Mycotoxins and Experimental Carcinogenesis, Medical Research Council, Tygerberg, South Africa
    Environ Health Perspect 109:291-300. 2001
  2. pmc Interleukin-1α Induction in Human Keratinocytes (HaCaT): An In Vitro Model for Chemoprevention in Skin
    T Magcwebeba
    Programme on Mycotoxins and Experimental Carcinogenesis PROMEC Unit, Medical Research Council, P O Box 19070, Tygerberg 7505, South Africa
    J Skin Cancer 2012:393681. 2012
  3. doi Controversies in fumonisin mycotoxicology and risk assessment
    W C A Gelderblom
    PROMEC Unit, Medical Research Council, Tygerberg, South Africa
    Hum Exp Toxicol 31:215-35. 2012
  4. doi Cancer initiating properties of fumonisin B1 in a short-term rat liver carcinogenesis assay
    W C A Gelderblom
    Program on Mycotoxins and Experimental Carcinogenesis, Medical Research Council, PO Box 19070, Tygerberg 7505, South Africa
    Toxicology 250:89-95. 2008
  5. ncbi Fumonisin contamination of a corn sample associated with the induction of hepatocarcinogenesis in rats-role of dietary deficiencies
    W C A Gelderblom
    PROMEC Unit, Medical Research Council, PO Box 19070, Tygerberg 7505, South Africa
    Food Chem Toxicol 42:471-9. 2004
  6. ncbi Lipids and delta6-desaturase activity alterations in rat liver microsomal membranes induced by fumonisin B1
    W C A Gelderblom
    PROMEC Unit, Medical Research Council, Tygerberg 7505, South Africa
    Lipids 37:869-77. 2002
  7. ncbi Interaction of fumonisin B(1) and aflatoxin B(1) in a short-term carcinogenesis model in rat liver
    W C A Gelderblom
    PROMEC Unit, Medical Research Council, P O Box 19070, 7505, Tygerberg, South Africa
    Toxicology 171:161-73. 2002
  8. ncbi Cancer initiation by fumonisin B(1) in rat liver--role of cell proliferation
    W C Gelderblom
    Programme on Mycotoxins and Experimental Carcinogenesis, P O Box 19070, 7505, Tygerberg, South Africa
    Cancer Lett 169:127-37. 2001
  9. pmc Toxicity of culture material of Fusarium verticillioides strain MRC 826 to nonhuman primates
    W C Gelderblom
    Programme on Mycotoxins and Experimental Carcinogenesis, Medical Research Council, Tygerberg, South Africa
    Environ Health Perspect 109:267-76. 2001
  10. ncbi Toxicological effects in rats chronically fed low dietary levels of fumonisin B(1)
    W C Gelderblom
    Programme on Mycotoxins and Experimental Carcinogenesis, P O Box 19070, 7505, Tygerberg, South Africa
    Toxicology 161:39-51. 2001

Collaborators

Detail Information

Publications21

  1. pmc Fumonisin-induced hepatocarcinogenesis: mechanisms related to cancer initiation and promotion
    W C Gelderblom
    Programme on Mycotoxins and Experimental Carcinogenesis, Medical Research Council, Tygerberg, South Africa
    Environ Health Perspect 109:291-300. 2001
    ....
  2. pmc Interleukin-1α Induction in Human Keratinocytes (HaCaT): An In Vitro Model for Chemoprevention in Skin
    T Magcwebeba
    Programme on Mycotoxins and Experimental Carcinogenesis PROMEC Unit, Medical Research Council, P O Box 19070, Tygerberg 7505, South Africa
    J Skin Cancer 2012:393681. 2012
    ....
  3. doi Controversies in fumonisin mycotoxicology and risk assessment
    W C A Gelderblom
    PROMEC Unit, Medical Research Council, Tygerberg, South Africa
    Hum Exp Toxicol 31:215-35. 2012
    ....
  4. doi Cancer initiating properties of fumonisin B1 in a short-term rat liver carcinogenesis assay
    W C A Gelderblom
    Program on Mycotoxins and Experimental Carcinogenesis, Medical Research Council, PO Box 19070, Tygerberg 7505, South Africa
    Toxicology 250:89-95. 2008
    ..The underlying mechanism(s) involved in the genesis of the initiated hepatocytes is not known at present...
  5. ncbi Fumonisin contamination of a corn sample associated with the induction of hepatocarcinogenesis in rats-role of dietary deficiencies
    W C A Gelderblom
    PROMEC Unit, Medical Research Council, PO Box 19070, Tygerberg 7505, South Africa
    Food Chem Toxicol 42:471-9. 2004
    ....
  6. ncbi Lipids and delta6-desaturase activity alterations in rat liver microsomal membranes induced by fumonisin B1
    W C A Gelderblom
    PROMEC Unit, Medical Research Council, Tygerberg 7505, South Africa
    Lipids 37:869-77. 2002
    ..Disruption of microsomal lipid metabolism at different levels by FB1 could play an important role in the alteration of growth regulatory effects in the liver...
  7. ncbi Interaction of fumonisin B(1) and aflatoxin B(1) in a short-term carcinogenesis model in rat liver
    W C A Gelderblom
    PROMEC Unit, Medical Research Council, P O Box 19070, 7505, Tygerberg, South Africa
    Toxicology 171:161-73. 2002
    ..The co-occurrence of AFB(1) and FB(1) in corn consumed as a staple diet could pose an increased risk and should be included in establishing risk assessment parameters in humans...
  8. ncbi Cancer initiation by fumonisin B(1) in rat liver--role of cell proliferation
    W C Gelderblom
    Programme on Mycotoxins and Experimental Carcinogenesis, P O Box 19070, 7505, Tygerberg, South Africa
    Cancer Lett 169:127-37. 2001
    ..Cognizance of the enhancing role of cell proliferation during cancer initiation by FB(1) is required in assessing the risks posed by this mycotoxin to humans...
  9. pmc Toxicity of culture material of Fusarium verticillioides strain MRC 826 to nonhuman primates
    W C Gelderblom
    Programme on Mycotoxins and Experimental Carcinogenesis, Medical Research Council, Tygerberg, South Africa
    Environ Health Perspect 109:267-76. 2001
    ..The present study provides important information about the diversity of lesions induced by culture material of F. verticillioides in vervet monkeys and the dosage levels of fumonisins to be used in long-term studies in nonhuman primates...
  10. ncbi Toxicological effects in rats chronically fed low dietary levels of fumonisin B(1)
    W C Gelderblom
    Programme on Mycotoxins and Experimental Carcinogenesis, P O Box 19070, 7505, Tygerberg, South Africa
    Toxicology 161:39-51. 2001
    ....
  11. ncbi Oxidative damage and fumonisin B1-induced toxicity in primary rat hepatocytes and rat liver in vivo
    S Abel
    Programme on Mycotoxins and Experimental Carcinogenesis PROMEC Medical Research Council, Tygerberg, South Africa
    Toxicology 131:121-31. 1998
    ..The hepatotoxic effects and resultant oxidative damage induced by FB1 may be important during cancer induction in rat liver by this apparently non-genotoxic compound...
  12. ncbi Assessing chronic exposure to fumonisin mycotoxins: the use of hair as a suitable noninvasive matrix
    V Sewram
    PROMEC Unit, Medical Research Council, Tygerberg, South Africa
    J Anal Toxicol 25:450-5. 2001
    ..This relationship indicates that hair can provide an easily applicable non-invasive matrix for assessing chronic exposure to fumonisin mycotoxins...
  13. ncbi Changes in essential fatty acid patterns associated with normal liver regeneration and the progression of hepatocyte nodules in rat hepatocarcinogenesis
    S Abel
    Programme on Mycotoxins and Experimental Carcinogenesis, National Research Programme for Nutritional Intervention, Experimental Biology Programme Primate Unit, Medical Research Council MRC, PO Box 19070, Tygerberg 7505, South Africa
    Carcinogenesis 22:795-804. 2001
    ..The persistent changes in the hepatocyte nodules suggest that the lipid metabolism escapes the regulatory mechanisms required for normal cellular homeostasis at different levels...
  14. ncbi An investigation on the antimutagenic properties of South African herbal teas
    J L Marnewick
    Programme on Mycotoxins and Experimental Carcinogenesis, Medical Research Council, P O Box 19070, Tygerberg 7505, South Africa
    Mutat Res 471:157-66. 2000
    ..The present study provides the first evidence on the antimutagenic activity of honeybush tea and further evidence on the antimutagenicity of rooibos tea...
  15. ncbi Dietary modulation of fatty acid profiles and oxidative status of rat hepatocyte nodules: effect of different n-6/n-3 fatty acid ratios
    S Abel
    Medical Research Council, Tygerberg, South Africa
    Lipids 39:963-76. 2004
    ..Modulation of cancer development with low n-6/n-3 ratio diets containing specific dietary FA could be a promising tool in cancer intervention in the liver...
  16. ncbi Ex vivo modulation of chemical-induced mutagenesis by subcellular liver fractions of rats treated with rooibos (Aspalathus linearis) tea, honeybush (Cyclopia intermedia) tea, as well as green and black (Camellia sinensis) teas
    J L Marnewick
    PROMEC Unit, Medical Research Council, P O Box 19070, Tygerberg 7505, South Africa
    Mutat Res 558:145-54. 2004
    ..05) enhanced the mutagenic response of 2-AAF. None of the tea treatments significantly affected the concentration of the microsomal liver cytochrome P450...
  17. doi Altered lipid profile, oxidative status and hepatitis B virus interactions in human hepatocellular carcinoma
    S Abel
    PROMEC Unit, Medical Research Council, P O Box 19070, Tygerberg 7505, South Africa
    Prostaglandins Leukot Essent Fatty Acids 81:391-9. 2009
    ..Alterations in membrane cholesterol, phospholipids, FA parameters, C20:4omega6 membrane distribution and low lipid peroxidation are likely to be important determinants underlying the selective growth advantage of HCC cells...
  18. ncbi Dietary fumonisin exposure in a rural population of South Africa
    H M Burger
    PROMEC Unit, Medical Research Council MRC, PO Box 19070, Tygerberg 7505, South Africa
    Food Chem Toxicol 48:2103-8. 2010
    ..The assessment of fumonisin exposure and development of preventative strategies depend, not only the accurate determination of total fumonisin levels in maize, but also on the distinct dietary patterns of a specific population...
  19. doi Simple intervention method to reduce fumonisin exposure in a subsistence maize-farming community in South Africa
    L van der Westhuizen
    PROMEC Unit, Medical Research Council, Tygerberg 7505, South Africa
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 27:1582-8. 2010
    ..55 (1.94-3.35) µg kg(-1) body weight day(-1). This simple intervention method has the potential to improve food safety and health in subsistence-farming communities consuming fumonisin-contaminated maize as their staple diet...
  20. ncbi Altered lipid parameters in hepatic subcellular membrane fractions induced by fumonisin B1
    H M Burger
    PROMEC Unit, Medical Research Council, Tygerberg, South Africa
    Lipids 42:249-61. 2007
    ....
  21. ncbi A comparative study on the antimutagenic properties of aqueous extracts of Aspalathus linearis (rooibos), different Cyclopia spp. (honeybush) and Camellia sinensis teas
    J D van der Merwe
    Department of Food Science, Stellenbosch University, Private Bag X1, Matieland, Stellenbosch 7602, South Africa
    Mutat Res 611:42-53. 2006
    ..genistoides. Antimutagenic activity of the South African herbal teas was mutagen-specific, affected by fermentation and plant material, presumably due to changes and variation in phenolic composition...