Mhairi Maskew

Summary

Country: South Africa

Publications

  1. pmc Gender differences in mortality and CD4 count response among virally suppressed HIV-positive patients
    Mhairi Maskew
    Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    J Womens Health (Larchmt) 22:113-20. 2013
  2. pmc Effectiveness and safety of 30 mg versus 40 mg stavudine regimens: a cohort study among HIV-infected adults initiating HAART in South Africa
    Mhairi Maskew
    Clinical HIV Research Unit, Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    J Int AIDS Soc 15:13. 2012
  3. pmc The importance of clinic attendance in the first six months on antiretroviral treatment: a retrospective analysis at a large public sector HIV clinic in South Africa
    Alana T Brennan
    Center for Global Health and Development, Boston University, Boston, MA, USA
    J Int AIDS Soc 13:49. 2010
  4. pmc Kaposi's Sarcoma Associated-Herpes Virus (KSHV) Seroprevalence in Pregnant Women in South Africa
    Babatyi I Malope-Kgokong
    Viral Oncology Section, AIDS and Cancer Virus Program, SAIC Frederick, NCI Frederick, Frederick MD, USA
    Infect Agent Cancer 5:14. 2010
  5. pmc Prevalence and predictors of kaposi sarcoma herpes virus seropositivity: a cross-sectional analysis of HIV-infected adults initiating ART in Johannesburg, South Africa
    Mhairi Maskew
    Clinical HIV Research Unit, Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand York Avenue, Johannesburg 2193, South Africa
    Infect Agent Cancer 6:22. 2011
  6. pmc Occult hepatitis B virus infection in patients with isolated core antibody and HIV co-infection in an urban clinic in Johannesburg, South Africa
    Cynthia Firnhaber
    Clinical HIV Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
    Int J Infect Dis 13:488-92. 2009
  7. doi request reprint Impact of choice of NRTI in first-line antiretroviral therapy: a cohort analysis of stavudine vs. tenofovir
    Alana T Brennan
    Center for Global Health and Development, Boston University, Boston, MA, USA Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    Trop Med Int Health 19:490-8. 2014
  8. pmc Initiating antiretroviral therapy when presenting with higher CD4 cell counts results in reduced loss to follow-up in a resource-limited setting
    Kate Clouse
    Department of Internal Medicine, University of the Witwatersrand, Johannesburg, South Africa
    AIDS 27:645-50. 2013
  9. pmc Loss to follow-up before and after delivery among women testing HIV positive during pregnancy in Johannesburg, South Africa
    Kate Clouse
    Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    Trop Med Int Health 18:451-60. 2013
  10. pmc Increases in regimen durability associated with the introduction of tenofovir at a large public-sector clinic in Johannesburg, South Africa
    Alana T Brennan
    Center for Global Health and Development, Boston University, Boston, MA, USA Health Economics and Epidemiology Research Office, Faculty of Health Sciences, Department of Internal Medicine, School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South Africa
    J Int AIDS Soc 16:18794. 2013

Collaborators

Detail Information

Publications37

  1. pmc Gender differences in mortality and CD4 count response among virally suppressed HIV-positive patients
    Mhairi Maskew
    Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    J Womens Health (Larchmt) 22:113-20. 2013
    ..We investigated the gender differences in treatment response among HIV-positive patients virally suppressed within 6 months of treatment initiation...
  2. pmc Effectiveness and safety of 30 mg versus 40 mg stavudine regimens: a cohort study among HIV-infected adults initiating HAART in South Africa
    Mhairi Maskew
    Clinical HIV Research Unit, Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    J Int AIDS Soc 15:13. 2012
    ....
  3. pmc The importance of clinic attendance in the first six months on antiretroviral treatment: a retrospective analysis at a large public sector HIV clinic in South Africa
    Alana T Brennan
    Center for Global Health and Development, Boston University, Boston, MA, USA
    J Int AIDS Soc 13:49. 2010
    ..Adherence to care and treatment are essential for HIV-infected individuals to benefit from antiretroviral therapy (ART). We sought to quantify the effects on treatment outcomes of missing visits soon after initiating ART...
  4. pmc Kaposi's Sarcoma Associated-Herpes Virus (KSHV) Seroprevalence in Pregnant Women in South Africa
    Babatyi I Malope-Kgokong
    Viral Oncology Section, AIDS and Cancer Virus Program, SAIC Frederick, NCI Frederick, Frederick MD, USA
    Infect Agent Cancer 5:14. 2010
    ..We measured the seroprevalence of KSHV in relation to HIV, syphilis, and demographic factors among pregnant women attending public antenatal clinics in the Gauteng province of South Africa...
  5. pmc Prevalence and predictors of kaposi sarcoma herpes virus seropositivity: a cross-sectional analysis of HIV-infected adults initiating ART in Johannesburg, South Africa
    Mhairi Maskew
    Clinical HIV Research Unit, Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand York Avenue, Johannesburg 2193, South Africa
    Infect Agent Cancer 6:22. 2011
    ..abstract:..
  6. pmc Occult hepatitis B virus infection in patients with isolated core antibody and HIV co-infection in an urban clinic in Johannesburg, South Africa
    Cynthia Firnhaber
    Clinical HIV Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
    Int J Infect Dis 13:488-92. 2009
    ..However, sensitive molecular techniques for detecting HBV DNA in serum can detect occult HBV infection. We report the first observational prospective study of occult HBV infection in HIV-positive people in South Africa...
  7. doi request reprint Impact of choice of NRTI in first-line antiretroviral therapy: a cohort analysis of stavudine vs. tenofovir
    Alana T Brennan
    Center for Global Health and Development, Boston University, Boston, MA, USA Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    Trop Med Int Health 19:490-8. 2014
    ..We examined treatment outcomes over 24 months amongst patients initiated on tenofovir-based vs. stavudine-based first-line regimens...
  8. pmc Initiating antiretroviral therapy when presenting with higher CD4 cell counts results in reduced loss to follow-up in a resource-limited setting
    Kate Clouse
    Department of Internal Medicine, University of the Witwatersrand, Johannesburg, South Africa
    AIDS 27:645-50. 2013
    ..Mortality and morbidity are known to be reduced when initiating at higher CD4 levels; we explored the impact on patient loss to follow-up...
  9. pmc Loss to follow-up before and after delivery among women testing HIV positive during pregnancy in Johannesburg, South Africa
    Kate Clouse
    Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    Trop Med Int Health 18:451-60. 2013
    ..HIV-positive pregnant women are at heightened risk of becoming lost to follow-up (LTFU) from HIV care. We examined LTFU before and after delivery among pregnant women newly diagnosed with HIV...
  10. pmc Increases in regimen durability associated with the introduction of tenofovir at a large public-sector clinic in Johannesburg, South Africa
    Alana T Brennan
    Center for Global Health and Development, Boston University, Boston, MA, USA Health Economics and Epidemiology Research Office, Faculty of Health Sciences, Department of Internal Medicine, School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South Africa
    J Int AIDS Soc 16:18794. 2013
    ..We evaluated changes over time in regimen durability at the Themba Lethu Clinic, Johannesburg, South Africa...
  11. pmc Poorer ART outcomes with increasing age at a large public sector HIV clinic in Johannesburg, South Africa
    Mhairi Maskew
    1Department of Medicine, Clinical HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
    J Int Assoc Physicians AIDS Care (Chic) 11:57-65. 2012
    ..As the current HIV-positive population ages, the absolute number of patients >50 years on treatment is increasing...
  12. pmc Treatment response and mortality among patients starting antiretroviral therapy with and without Kaposi sarcoma: a cohort study
    Mhairi Maskew
    Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    PLoS ONE 8:e64392. 2013
    ..However, the effect of KS on response to ART is not well-described in Southern Africa. We assessed the effect of KS on survival and immunologic and virologic treatment responses at 6- and 12-months after initiation of ART...
  13. pmc The interplay between CD4 cell count, viral load suppression and duration of antiretroviral therapy on mortality in a resource-limited setting
    Alana T Brennan
    Center for Global Health and Development, Boston University, Boston, MA, USA Health Economics and Epidemiology Research Office, University of the Witwatersrand, Johannesburg, South Africa
    Trop Med Int Health 18:619-31. 2013
    ..To examine the interaction between CD4 cell count, viral load suppression and duration of antiretroviral therapy (ART) on mortality...
  14. pmc Treatment outcomes of HIV-infected adolescents attending public-sector HIV clinics across Gauteng and Mpumalanga, South Africa
    Denise Evans
    Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South Africa
    AIDS Res Hum Retroviruses 29:892-900. 2013
    ..Interventions are needed to help improve outcomes and retention in care in this unique population...
  15. pmc Outcomes of stable HIV-positive patients down-referred from a doctor-managed antiretroviral therapy clinic to a nurse-managed primary health clinic for monitoring and treatment
    Alana T Brennan
    Health Economics and Epidemiology Research Office, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    AIDS 25:2027-36. 2011
    ....
  16. pmc The impact of choice of NNRTI on short-term treatment outcomes among HIV-infected patients prescribed tenofovir and lamivudine in Johannesburg, South Africa
    Kate Shearer
    Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    PLoS ONE 8:e71719. 2013
    ..We sought to compare outcomes among those taking nevirapine vs. efavirenz with tenofovir and lamivudine...
  17. pmc Kaposi sarcoma-associated herpes virus and response to antiretroviral therapy: a prospective study of HIV-infected adults
    Mhairi Maskew
    Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South
    J Acquir Immune Defic Syndr 63:442-8. 2013
    ..The possible impact of coinfection with the Kaposi sarcoma-associated herpes virus (KSHV) on the response to antiretroviral therapy (ART) is unknown. Prospective studies are rare, particularly in Africa...
  18. pmc Increased risk of mortality and loss to follow-up among HIV-positive patients with oropharyngeal candidiasis and malnutrition before antiretroviral therapy initiation: a retrospective analysis from a large urban cohort in Johannesburg, South Africa
    Denise Evans
    Clinical HIV Research Unit, Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    Oral Surg Oral Med Oral Pathol Oral Radiol 113:362-72. 2012
    ..We investigated the effect of oropharyngeal candidiasis (OC) and body mass index (BMI) before antiretroviral therapy (ART) initiation on treatment outcomes of human immunodeficiency virus (HIV)-positive patients...
  19. pmc The relation between efavirenz versus nevirapine and virologic failure in Johannesburg, South Africa
    Kate Shearer
    Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    J Int AIDS Soc 17:19065. 2014
    ..We investigated this hypothesis in a cohort of HIV-positive patients at a large HIV treatment clinic in South Africa...
  20. pmc Tenofovir use and pregnancy among women initiating HAART
    Mhairi Maskew
    Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    AIDS 26:2393-7. 2012
    ..Here, our objective was to determine among HIV-positive women whether use of tenofovir at HAART initiation or thereafter is associated with subsequent changes in incidence of pregnancy...
  21. doi request reprint Prevalence of peripheral neuropathy in antiretroviral therapy naïve HIV-positive patients and the impact on treatment outcomes--a retrospective study from a large urban cohort in Johannesburg, South Africa
    Denise Evans
    Health Economics and Epidemiology Research Office, Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 2041, South Africa
    J Neurovirol 18:162-71. 2012
    ..Completion of TB treatment may reduce the risk of persistent PN in patients with TB-related PN. Use of HIV drugs, even neurotoxic ones, may overall limit neuropathy...
  22. pmc Patient retention from HIV diagnosis through one year on antiretroviral therapy at a primary health care clinic in Johannesburg, South Africa
    Kate Clouse
    Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    J Acquir Immune Defic Syndr 62:e39-46. 2013
    ..To compare patient retention at 3 stages of pre-antiretroviral (ART) care and 2 stages of post-ART care to identify when greatest attrition occurs...
  23. pmc Prevalent pregnancy, biological sex, and virologic response to antiretroviral therapy
    Daniel Westreich
    Department of Obstetrics and Gynecology and Duke Global Health Institute, Duke University, Durham, NC 27710, USA
    J Acquir Immune Defic Syndr 60:489-94. 2012
    ..Pregnancy is a common indication for initiation of highly active antiretroviral therapy (HAART) in sub-Saharan Africa. Our objective was to evaluate how pregnancy at treatment initiation predicts virologic response to HAART...
  24. pmc Poor CD4 recovery and risk of subsequent progression to AIDS or death despite viral suppression in a South African cohort
    Simbarashe Takuva
    Clinical HIV Research Unit, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    J Int AIDS Soc 17:18651. 2014
    ..The prognostic role of CD4 response in the first six months of treatment in patients achieving early viral suppression during HIV treatment is unclear...
  25. pmc The feasibility of using screening criteria to reduce clinic visits for stable patients on antiretroviral therapy in South Africa
    William B MacLeod
    Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    J Acquir Immune Defic Syndr 62:e82-6. 2013
    ..We used routinely collected data to model whether a simple screening tool could identify stable patients who would not need to see a doctor during a scheduled medical visit...
  26. doi request reprint Prevalence of hepatitis B virus (HBV) co-infection in HBV serologically-negative South African HIV patients and retrospective evaluation of the clinical course of mono- and co-infection
    Cindy Firnhaber
    Clinical HIV Research Unit, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    Int J Infect Dis 16:e268-72. 2012
    ..This study presents the prevalence of HBV DNA in HIV-positive patients negative for all HBV serological markers and a retrospective evaluation of the clinical course of mono- and co-infection...
  27. pmc Attrition through multiple stages of pre-treatment and ART HIV care in South Africa
    Matthew P Fox
    Center for Global Health and Development, Boston University, Boston, Massachusetts, United States of America Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 9:e110252. 2014
    ..While estimates of retention on ART exist, few cohorts have data on retention from testing positive through long-term ART care...
  28. pmc CD4 criteria improves the sensitivity of a clinical algorithm developed to identify viral failure in HIV-positive patients on antiretroviral therapy
    Denise H Evans
    Health Economics and Epidemiology Research Unit, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    J Int AIDS Soc 17:19139. 2014
    ..We used data from an electronic patient management system to develop an algorithm to identify patients at risk of viral failure using a combination of accessible and inexpensive markers...
  29. pmc Incidence and predictors of herpes zoster among antiretroviral therapy-naïve patients initiating HIV treatment in Johannesburg, South Africa
    Kate Shearer
    Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Electronic address
    Int J Infect Dis 23:56-62. 2014
    ..To describe the characteristics of HIV-infected patients experiencing herpes zoster after antiretroviral therapy (ART) initiation and to describe the incidence and predictors of a herpes zoster diagnosis...
  30. pmc Brief Report: Does Most Mortality in Patients on ART Occur in Care or After Lost to Follow-Up? Evidence From the Themba Lethu Clinic, South Africa
    Eric P Budgell
    Health Economics and Epidemiology Research Office HE2RO, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Right to Care, Johannesburg, South Africa Center for Global Health and Development, Boston University, Boston, MA and Department of Epidemiology, Boston University School of Public Health, Boston University, Boston, MA
    J Acquir Immune Defic Syndr 70:323-8. 2015
    ..4% to 42.5%). Although mortality rates in patients lost were much higher than in care, most ART-related mortality occurred on treatment. ..
  31. pmc Incidence rate of Kaposi sarcoma in HIV-infected patients on antiretroviral therapy in Southern Africa: a prospective multicohort study
    Eliane Rohner
    Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Division of Infectious Diseases, Department of Medicine, University of Stellenbosch and Tygerberg Academic Hospital, Cape Town, South Africa Department of Pediatrics and Child Health, University of Stellenbosch and Tygerberg Academic Hospital, Cape Town, South Africa Khayelitsha ART Program, Medecins Sans Frontieres, Cape Town, South Africa Independent Surgery, Gaborone, Botswana Newlands Clinic, Harare, Zimbabwe Centre for Infectious Disease Research in Zambia CIDRZ, Lusaka, Zambia Boston University School of Medicine, Section of Geriatrics, Boston, MA, USA and Centre for Infectious Disease Epidemiology and Research CIDER, University of Cape Town, Cape Town, South Africa
    J Acquir Immune Defic Syndr 67:547-54. 2014
    ..We studied KS incidence rates and associated risk factors in children and adults on ART in Southern Africa...
  32. pmc Zidovudine impairs immunological recovery on first-line antiretroviral therapy: collaborative analysis of cohort studies in southern Africa
    Gilles Wandeler
    aDivision of International and Environmental Health, Institute of Social and Preventive Medicine ISPM, University of Bern bDepartment of Infectious Diseases, University Hospital Bern, Bern, Switzerland cCentre for Infectious Disease Research in Zambia, Lusaka, Zambia dKhayelitsha ART Programme, Medecins Sans Frontieres, Cape Town eThe Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town fThemba Lethu Clinic, Johannesburg gDivision of Infectious Diseases, Department of Medicine, University of Stellenbosch and Tygerberg Academic Hospital, Cape Town hAurum Institute for Health Research, Johannesburg, South Africa iSolidarMed Lesotho, Lucerne, Switzerland jHIV private practice, Gaborone, Botswana kSchool of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    AIDS 27:2225-32. 2013
    ..ZDV may, however, lead to anemia and impaired immunological response. We compared CD4+ cell counts over 5 years between patients starting ART with and without ZDV in southern Africa...
  33. pmc A longitudinal study of stavudine-associated toxicities in a large cohort of South African HIV infected subjects
    Colin N Menezes
    Infectious Diseases Unit, Department of Medicine, Helen Joseph Hospital, University of the Witwatersrand, Johannesburg, South Africa
    BMC Infect Dis 11:244. 2011
    ..This has brought new challenges which include the effects of stavudine-related toxicities...
  34. pmc Prevalent tuberculosis and mortality among HAART initiators
    Daniel Westreich
    Department of Obstetrics and Gynecology, Duke Global Health Institute, Duke University, Durham, North Carolina, USA
    AIDS 26:770-3. 2012
    ..In reanalysis, treatment for tuberculosis at time of HAART initiation remained unassociated with increased risks of all-cause mortality, with adjusted hazard ratios ranging from 1.00 to 1.09...
  35. pmc CD4+ gain percentile curves for monitoring response to antiretroviral therapy in HIV-infected adults
    Marcel Yotebieng
    aThe Ohio State University, College of Public Health, Division of Epidemiology, Columbus, Ohio bThe University of North Carolina at Chapel Hill, Department of Epidemiology, Chapel Hill, North Carolina, USA cDepartment of Medicine, Clinical HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
    AIDS 29:1067-75. 2015
    ..We constructed CD4 cell count gain percentile distributions standardized by baseline CD4 cell count and assessed the association between poor CD4 cell count gain and subsequent death and virological failure on antiretroviral therapy (ART)...
  36. pmc Effect of pregnancy and the postpartum period on adherence to antiretroviral therapy among HIV-infected women established on treatment
    Cassidy E Henegar
    Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa and Division of Infectious Diseases, Department of Medicine, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC
    J Acquir Immune Defic Syndr 68:477-80. 2015
    ..46, 95% confidence interval: 1.17 to 1.82) but not during pregnancy itself (weighted risk ratio: 0.95, 95% confidence interval: 0.78 to 1.17). ..
  37. pmc The prevalence of hepatitis B co-infection in a South African urban government HIV clinic
    Cynthia Firnhaber
    Clinical HIV Research Unit, University of the Witwatersrand, Johannesburg
    S Afr Med J 98:541-4. 2008
    ..Co-infection with hepatitis B and HIV can influence antiretroviral treatment and prognosis of both diseases. The purpose of this study was to evaluate the prevalence of hepatitis B/HIV coinfection...